Research Topics
| Robert GrossSummaryAffiliation: University of Pennsylvania Country: USA Publications
| Collaborators
|
Detail Information
Publications
Managed problem solving for antiretroviral therapy adherence: a randomized trialRobert Gross
Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104 6021, USA
JAMA Intern Med 173:300-6. 2013..Implementation of MAPS should be strongly considered where resources are available. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00130273...- How long is the window of opportunity between adherence failure and virologic failure on efavirenz-based HAART?Robert Gross
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
HIV Clin Trials 9:202-6. 2008..The time between onset of nonadherence and onset of virological failure is unknown. However, this information is critical to the design, implementation, and testing of interventions aiming to forestall treatment failure... 
Modified directly observed antiretroviral therapy compared with self-administered therapy in treatment-naive HIV-1-infected patients: a randomized trialRobert Gross
Department of Medicine Infectious Diseases, Center for Clinical Epidemiology and Biostatistics, and Center for Education and Research in Therapeutics, Univ of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Arch Intern Med 169:1224-32. 2009..Success of antiretroviral therapy depends on high rates of adherence, but few interventions are effective. Our objective was to determine if modified directly observed therapy (mDOT) improves initial antiretroviral success...- Validity and comparison of two measures of days supply in Medicaid claims dataRobert Gross
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 17:1029-32. 2008..The two measures should yield the same duration, but if not, the preferred method is unknown... - Can we predict daily adherence to warfarin?: Results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) StudyAlec B Platt
MSCE, University of Pennsylvania School of Medicine, 707 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
Chest 137:883-9. 2010..Currently, no comprehensive screening tool exists to help providers assess the risk of nonadherence at the time of initiation of warfarin therapy... 
HIV-1-specific CD4+ T cell responses in chronically HIV-1 infected blippers on antiretroviral therapy in relation to viral replication following treatment interruptionEmmanouil Papasavvas
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Clin Immunol 26:40-54. 2006..04) with no difference between groups by week 24. These data support that blippers have higher anti-HIV lymphoproliferative responses while on ART but experience equal to higher viral rebound as compared to matched non-blippers upon TI...- Incidence of transaminitis among HIV-infected patients with occult hepatitis BVincent Lo Re
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Virol 43:32-6. 2008..This information is needed to determine the importance of detecting and treating occult HBV in this population... - Adherence to hepatitis C virus therapy in HIV/hepatitis C-coinfected patientsVincent Lo Re
Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
AIDS Behav 17:94-103. 2013..Among HIV/HCV patients, EVR and SVR increased with higher interferon and ribavirin adherence. Adherence to both antivirals declined over time, but more so for ribavirin... - Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE studyCatherine S Parker
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
J Gen Intern Med 22:1254-9. 2007..Patient adherence to warfarin may influence anticoagulation control; yet, adherence among warfarin users has not been rigorously studied... - Overestimates of survival after HAART: implications for global scale-up effortsGregory P Bisson
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
PLoS ONE 3:e1725. 2008..Determining definitive outcomes of these lost patients, and the effects of losses to follow-up on estimates of survival and risk factors for death after HAART, are key to monitoring the effectiveness of global HAART scale-up efforts... - Adherence to hepatitis C virus therapy and early virologic outcomesVincent Lo Re
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
Clin Infect Dis 48:186-93. 2009..We examined the relationship between adherence to pegylated interferon and ribavirin therapy, measured by pharmacy refill, and HCV suppression during the initial 12 weeks of therapy... - Risk factors for nonadherence to warfarin: results from the IN-RANGE studyAlec B Platt
Department of Medicine, University of Pennsylvania School of Medicine, PA, USA
Pharmacoepidemiol Drug Saf 17:853-60. 2008..Warfarin is widely used to prevent stroke and venous thromboembolism despite its narrow therapeutic window. Warfarin nonadherence is a substantial problem, but risk factors have not been well elucidated... - Diagnostic accuracy of CD4 cell count increase for virologic response after initiating highly active antiretroviral therapyGregory P Bisson
Department of Medicine, Division of Infectious Diseases, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania19104 6021, USA
AIDS 20:1613-9. 2006..To derive and internally validate a clinical prediction rule for virologic response based on CD4 cell count increase after initiation of HAART in a resource-limited setting... - Randomized, controlled trial of therapy interruption in chronic HIV-1 infectionEmmanouil Papasavvas
The Wistar Institute, Philadelphia, Pennsylvania, USA
PLoS Med 1:e64. 2004..Based on these findings, we suggest that further clinical research on the long-term consequences of TI strategies to decrease drug exposure is warranted... - Antiretroviral failure despite high levels of adherence: discordant adherence-response relationship in BotswanaGregory P Bisson
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Acquir Immune Defic Syndr 49:107-10. 2008..Although adherence to antiretroviral therapy may be higher in sub-Saharan Africa, knowledge regarding the magnitude of adherence needed to maintain virological suppression in this setting is limited... - A simple, dynamic measure of antiretroviral therapy adherence predicts failure to maintain HIV-1 suppressionRobert Gross
Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, Center for Education and Research in Therapeutics, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
J Infect Dis 194:1108-14. 2006.... - Prevalence, risk factors, and outcomes for occult hepatitis B virus infection among HIV-infected patientsVincent Lo Re
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
J Acquir Immune Defic Syndr 44:315-20. 2007..The prevalence of occult HBV in HIV-infected patients remains controversial, and the risk factors and clinical significance are unknown... - Antiretroviral therapy interruptions result in loss of protective humoral immunity to neoantigens in HIV-infected individualsLivio Azzoni
The Wistar Institute, Philadelphia, Pennsylvania, USA
AIDS 26:1355-62. 2012..As ART interruption occur frequently in resource-constrained settings, we studied their effects on the ability to mount humoral immune responses against a neoantigen... - Pharmacy refill adherence compared with CD4 count changes for monitoring HIV-infected adults on antiretroviral therapyGregory P Bisson
Department of Medicine, Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS Med 5:e109. 2008.... - Self-reported hepatitis B and C virus infections had low sensitivity among HIV-infected patientsVincent Lo Re
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Epidemiol 60:294-9. 2007..To determine the validity of self-reported hepatitis B virus (HBV) and hepatitis C virus (HCV) in HIV-infected injection drug users (IDUs) vs. nonIDUs... - Out-of-pocket costs of HAART limit HIV treatment responses in Botswana's private sectorGregory P Bisson
Division of Infectious Disease, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
AIDS 20:1333-6. 2006..001]. HAART costs should be minimized as scale-up efforts in sub-Saharan Africa progress... - Relationship between adherence to hepatitis C virus therapy and virologic outcomes: a cohort studyVincent Lo Re
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Ann Intern Med 155:353-60. 2011..Adherence to therapy with pegylated interferon and ribavirin for hepatitis C virus (HCV) infection has been incompletely examined... - Association between efavirenz-based compared with nevirapine-based antiretroviral regimens and virological failure in HIV-infected childrenElizabeth D Lowenthal
Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
JAMA 309:1803-9. 2013..Data on the comparative effectiveness of these medications in children are limited... - Early mortality and AIDS progression despite high initial antiretroviral therapy adherence and virologic suppression in BotswanaKatherine T Steele
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS ONE 6:e20010. 2011..We sought to determine the relationship between very early ART adherence and early adverse outcomes in HIV-infected adults in Botswana... - A randomized trial of a nursing intervention for HIV disease management among persons with serious mental illnessMichael B Blank
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104 3309, USA
Psychiatr Serv 62:1318-24. 2011..The objective of this study was to test the effectiveness of a community-based advanced practice nurse (APN) intervention (PATH, Preventing AIDS Through Health) to promote adherence to HIV and psychiatric treatment regimens... - A time-to-prescription-refill measure of antiretroviral adherence predicted changes in viral load in HIVRobert Grossberg
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Epidemiol 57:1107-10. 2004..The goal of this study was to determine the validity and utility of a pharmacy-based time-to-refill measure of antiretroviral therapy adherence... - Effect of GB virus C viremia on HIV acquisition and HIV set-pointGregory P Bisson
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
AIDS 19:1910-2. 2005..32; 95% confidence interval 0.6-2.6). Pre-existing GBV-C viremia at the time of HIV acquisition was also not associated with lower plasma HIV-RNA levels... - Lack of association between retrospectively collected pharmacy refill data and electronic drug monitoring of antiretroviral adherenceTrisha Acri
Department of Family and Community Medicine, Temple University, Philadelphia, PA 19140, USA
AIDS Behav 14:748-54. 2010..Reassessment of the relation between pharmacy refill data and EDM would be warranted when pharmacy refill data is collected as soon as feasible from sources with complete data capture... - Incidence and risk factors for weight loss during dual HIV/hepatitis C virus therapyVincent Lo Re
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
J Acquir Immune Defic Syndr 44:344-50. 2007..Clinical observations suggest that patients with HIV/hepatitis C virus (HCV) may lose body weight during dual therapy, but this has not been confirmed analytically... - Abacavir/lamivudine versus tenofovir DF/emtricitabine as part of combination regimens for initial treatment of HIV: final resultsPaul E Sax
Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Infect Dis 204:1191-201. 2011..Due to higher virologic failure with ABC/3TC in the high HIV RNA stratum, blinded treatment was stopped in this group, but study follow-up continued for all patients... - HIV/AIDS-specific quality of life and adherence to antiretroviral therapy over timeWilliam C Holmes
Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
J Acquir Immune Defic Syndr 46:323-7. 2007..To determine if HIV/AIDS-specific quality of life (QOL) predicts adherence to antiretroviral therapy (ART)... - Pain, mood, and substance abuse in HIV: implications for clinic visit utilization, antiretroviral therapy adherence, and virologic failureJessica S Merlin
Division of Infectious Diseases, Department of Medicine, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
J Acquir Immune Defic Syndr 61:164-70. 2012..Our objective was to investigate the relationship between pain, alone and in the context of mood disorders and substance abuse, on clinic utilization, antiretroviral therapy adherence, and virologic suppression... - Association between HIV replication and serum leptin levels: an observational study of a cohort of HIV-1-infected South African womenLivio Azzoni
The Wistar Institute, Philadelphia, PA, USA
J Int AIDS Soc 13:33. 2010..Advanced HIV infection can result in lipoatrophy and wasting, even in the absence of ongoing opportunistic infections, suggesting that HIV may directly affect adipose tissue amount and distribution... - Provider inaccuracy in assessing adherence and outcomes with newly initiated antiretroviral therapyRobert Gross
Division on of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
AIDS 16:1835-7. 2002..Therefore, HAART should not be withheld solely on provider predictions of adherence. Providers should not rely on their own assessments when attempting to determine if patients are adhering to therapy... - Use of pharmacy refill data as a measure of antiretroviral adherenceRobert Grossberg
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 804 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Curr HIV/AIDS Rep 4:187-91. 2007..Given the utility of this adherence measurement, it is likely that pharmacy refill will be the method of choice for measuring antiretroviral adherence in an increasing number of clinical and research settings... - Presence of human immunodeficiency virus-1-specific CD4 and CD8 cellular immune responses in children with full or partial virus suppressionEmmanouil Papasavvas
The Wistar Institute, Philadelphia, USA
J Infect Dis 188:873-82. 2003..Overall, a history of stable CD4(+) T cell counts, as a result of therapy that imparted full or partial virus suppression, was associated with increased levels of anti-HIV CD4(+) T helper responses and decreased T cell activation... - Pain and physical and psychological symptoms in ambulatory HIV patients in the current treatment eraJessica S Merlin
Division of Infectious Diseases, Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center, Philadelphia, PA, USA
J Pain Symptom Manage 43:638-45. 2012..HIV infection has become a manageable chronic disease. There are few studies of pain and symptoms in the current treatment era... - A tale of 2 epidemics: the intersection between obesity and HIV infection in PhiladelphiaValerianna Amorosa
Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA 19104-6073, USA
J Acquir Immune Defic Syndr 39:557-61. 2005..Women, particularly those of African American race, are at high risk. Obesity might add to metabolic abnormalities associated with HIV or its treatment and contribute to morbidity, as patients with HIV live longer... - Acceptance of hepatitis B vaccination by pregnant adolescentsMarilyn Stringer
School of Nursing, University of Pennsylvania, Philadelphia, USA
MCN Am J Matern Child Nurs 31:54-60. 2006.... - Medication beliefs as mediators of the health literacy-antiretroviral adherence relationship in HIV-infected individualsJoseph Graham
Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
AIDS Behav 11:385-92. 2007..Although the beliefs assessed do not mediate the relation between literacy and adherence, we identified low adherence norms as a potentially modifiable belief associated with adherence... - Racial disparities in hypertension control, but not treatment intensificationCraig A Umscheid
Division of General Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Hypertens 23:54-61. 2010..The objective of this study was to examine whether provider management of uncontrolled hypertension differed by patient race... - Natural history of patients with low-level HIV viremia on antiretroviral therapyVincent Lo Re
Division of Infectious Diseases, Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
AIDS Patient Care STDS 18:436-42. 2004..Higher initial HIV RNA levels and white race were predictors for virologic increase... - Risk factors and predictors for candidemia in pediatric intensive care unit patients: implications for preventionTheoklis E Zaoutis
Division of Infectious Diseases, Center for Pediatric Clinical Effectiveness, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Clin Infect Dis 51:e38-45. 2010..Few data exist on risk factors for candidemia in pediatric intensive care unit (PICU) patients... - Risk factors for medication non-adherence in an HIV infected population in the Dominican RepublicJulian Harris
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
AIDS Behav 15:1410-5. 2011..Parenting may represent a competing demand on time and resources and be an adherence barrier. Self-reported perceived lack of adherence support may be a useful marker for need for adherence interventions... - Epidemiologic studies of adverse effects of anti-retroviral drugs: how well is statistical power reportedScott D Halpern
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 14:155-61. 2005..Future research is needed to determine whether the observed paucity of industry-sponsored observational studies of anti-retroviral ADEs extends to other clinical areas, and if so, to identify the causes of this phenomenon... - Untreated hypertension and the emergency department: a chance to intervene?Craig A Umscheid
Center for Clinical Epidemiology and Biostatistics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Acad Emerg Med 15:529-36. 2008..The authors investigated the accuracy of identifying HTN in the ED, the proportion of ED patients with untreated HTN, patient characteristics predicting untreated HTN, and provider documentation of untreated HTN... - The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) StudyStephen E Kimmel
Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
Arch Intern Med 167:229-35. 2007..Warfarin sodium is a highly efficacious drug, but proper levels of anticoagulation are difficult to maintain. Conflicting data exist on the influence of patient adherence on anticoagulation control... - HIV type 1 chemokine coreceptor use among antiretroviral-experienced patients screened for a clinical trial of a CCR5 inhibitor: AIDS Clinical Trial Group A5211Timothy J Wilkin
Division of International Medicine and Infectious Diseases, Weill Cornell Medical College, New York, NY, USA
Clin Infect Dis 44:591-5. 2007..Chemokine coreceptor use impacts both the natural history of human immunodeficiency virus type 1 (HIV-1) disease and the potential use of a new class of antiretroviral agents, the CCR5 inhibitors... - The odds that clinically unrecognized poor or partial adherence confuses population pharmacokinetic/pharmacodynamic analysesBernard Vrijens
AARDEX Ltd, Zug, Switzerland
Basic Clin Pharmacol Toxicol 96:225-7. 2005..With the broadening use of electronic monitoring to estimate longitudinal drug exposure, the need exists for an explicit discipline that concerns itself with "what the patient does with the drug". It is called Pharmionics... - Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211Roy M Gulick
Weill Medical College of Cornell University, New York, New York, NY, USA
J Infect Dis 196:304-12. 2007..Vicriviroc, an investigational CCR5 inhibitor, demonstrated short-term antiretroviral activity in a phase 1 study... - Monitoring of long-term toxicities of HIV treatments: an international perspectiveGreg Bisson
AIDS 17:2407-17. 2003 - Predicting and monitoring antiretroviral adherenceRobert Gross
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA
LDI Issue Brief 13:1-4. 2007..This Issue Brief summarizes recent studies whose findings may help clinicians predict and monitor their patients' adherence before treatment failure occurs... - Adherence to HIV drug therapyRobert Gross
University of Pennsylvania, USA
LDI Issue Brief 8:1-4. 2002..This Issue Brief summarizes recent work on the effect of adherence on short-term outcomes, and the ability of providers to predict and estimate their patients' adherence to therapy...