G Gronowicz

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. ncbi Response of human osteoblasts to implant materials: integrin-mediated adhesion
    G Gronowicz
    Department of Orthopaedics, University of Connecticut Health Center, Farmington 06030, USA
    J Orthop Res 14:878-87. 1996
  2. ncbi Insulin-like growth factor II induces apoptosis in osteoblasts
    Gloria A Gronowicz
    Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 35:621-8. 2004
  3. ncbi Therapeutic touch stimulates the proliferation of human cells in culture
    Gloria A Gronowicz
    Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030 3105, USA
    J Altern Complement Med 14:233-9. 2008
  4. ncbi Bone-directed expression of Col1a1 promoter-driven self-inactivating retroviral vector in bone marrow cells and transgenic mice
    M L Stover
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Mol Ther 3:543-50. 2001
  5. ncbi Conditional ablation of the osteoblast lineage in Col2.3deltatk transgenic mice
    D Visnjic
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington 06030, USA
    J Bone Miner Res 16:2222-31. 2001
  6. ncbi Osteoblastic response to the defective matrix in the osteogenesis imperfecta murine (oim) mouse
    I Kalajzic
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Endocrinology 143:1594-601. 2002
  7. ncbi Bone-targeted overexpression of Bcl-2 increases osteoblast adhesion and differentiation and inhibits mineralization in vitro
    W Zhang
    Department of Orthopedic Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Calcif Tissue Int 80:111-22. 2007
  8. ncbi RGD-tethered silk substrate stimulates the differentiation of human tendon cells
    T Kardestuncer
    Department of Orthopaedics, University of Connecticut Health Center, Farmington, USA
    Clin Orthop Relat Res 448:234-9. 2006
  9. ncbi Effect of osteoblast-targeted expression of bcl-2 in bone: differential response in male and female mice
    Alexander G Pantschenko
    Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut 06030 3105, USA
    J Bone Miner Res 20:1414-29. 2005
  10. ncbi Mice lacking the type I interleukin-1 receptor do not lose bone mass after ovariectomy
    J A Lorenzo
    VA Connecticut Healthcare System, Newington 06111, USA
    Endocrinology 139:3022-5. 1998

Collaborators

Detail Information

Publications21

  1. ncbi Response of human osteoblasts to implant materials: integrin-mediated adhesion
    G Gronowicz
    Department of Orthopaedics, University of Connecticut Health Center, Farmington 06030, USA
    J Orthop Res 14:878-87. 1996
    ..The type of substrate determines which integrins and extracellular matrix proteins are expressed by osteoblasts. These data provide information on how implant materials may affect osteoblast differentiation and bone growth...
  2. ncbi Insulin-like growth factor II induces apoptosis in osteoblasts
    Gloria A Gronowicz
    Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 35:621-8. 2004
    ..Thus, IGF-II appears to promote osteoblast apoptosis, and overexpression of Bcl-2 is able to block IGF-II-induced apoptosis...
  3. ncbi Therapeutic touch stimulates the proliferation of human cells in culture
    Gloria A Gronowicz
    Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030 3105, USA
    J Altern Complement Med 14:233-9. 2008
    ..Several proliferation techniques were used to confirm the results, and the effect of multiple 10-minute TT treatments was studied...
  4. ncbi Bone-directed expression of Col1a1 promoter-driven self-inactivating retroviral vector in bone marrow cells and transgenic mice
    M L Stover
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Mol Ther 3:543-50. 2001
    ..Thus these vectors should be useful for bone-directed gene therapy...
  5. ncbi Conditional ablation of the osteoblast lineage in Col2.3deltatk transgenic mice
    D Visnjic
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington 06030, USA
    J Bone Miner Res 16:2222-31. 2001
    ....
  6. ncbi Osteoblastic response to the defective matrix in the osteogenesis imperfecta murine (oim) mouse
    I Kalajzic
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Endocrinology 143:1594-601. 2002
    ....
  7. ncbi Bone-targeted overexpression of Bcl-2 increases osteoblast adhesion and differentiation and inhibits mineralization in vitro
    W Zhang
    Department of Orthopedic Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Calcif Tissue Int 80:111-22. 2007
    ..Mineralization was significantly decreased in TG cultures, with less osteoblast apoptosis, compared to WT. Thus, Bcl-2 seems to have multiple roles in modulating osteoblast activities...
  8. ncbi RGD-tethered silk substrate stimulates the differentiation of human tendon cells
    T Kardestuncer
    Department of Orthopaedics, University of Connecticut Health Center, Farmington, USA
    Clin Orthop Relat Res 448:234-9. 2006
    ..A suture material, such as silk, decorated with RGD, may have the potential to facilitate tendon-bone healing with widespread applications in tendon reconstruction surgery...
  9. ncbi Effect of osteoblast-targeted expression of bcl-2 in bone: differential response in male and female mice
    Alexander G Pantschenko
    Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut 06030 3105, USA
    J Bone Miner Res 20:1414-29. 2005
    ..Estrogen was shown to stimulate endogenous Bcl-2 message levels. These studies suggest a link between Bcl-2 and sex regulation of bone development and age-related bone loss...
  10. ncbi Mice lacking the type I interleukin-1 receptor do not lose bone mass after ovariectomy
    J A Lorenzo
    VA Connecticut Healthcare System, Newington 06111, USA
    Endocrinology 139:3022-5. 1998
    ..Hence, therapeutic interventions that block the effects of IL-1 on bone may be beneficial for treating diseases of rapid bone loss such as post-menopausal osteoporosis...
  11. ncbi The in vitro response of human osteoblasts to polyetheretherketone (PEEK) substrates compared to commercially pure titanium
    Karen B Sagomonyants
    Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030, United States
    Biomaterials 29:1563-72. 2008
    ..Thus, differences in human osteoblast responses were found to the various samples of PEEK, but implantable grade PEEK, in general, was comparable in vitro to the bone forming capacity of rough titanium...
  12. ncbi Tendon and bone responses to a collagen-coated suture material
    Augustus D Mazzocca
    Department of Orthopaedic Surgery, University of Connecticut, Farmington, CT 06031, USA
    J Shoulder Elbow Surg 16:S222-30. 2007
    ....
  13. ncbi Transgenic mice with osteoblast-targeted insulin-like growth factor-I show increased bone remodeling
    Jin Jiang
    Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 39:494-504. 2006
    ..Thus, broad overexpression of IGF-I in cells of the osteoblast lineage increased indices of bone formation and resorption...
  14. ncbi Col1a1 promoter-targeted expression of p20 CCAAT enhancer-binding protein beta (C/EBPbeta), a truncated C/EBPbeta isoform, causes osteopenia in transgenic mice
    John R Harrison
    Department of Orthodontics, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 280:8117-24. 2005
    ..3-green fluorescent protein, demonstrating a cell-autonomous effect of the transgene. These data suggested that C/EBP transcription factors may be important determinants of osteoblast function and bone mass...
  15. ncbi The effects of patient age on human osteoblasts' response to Ti-6Al-4V implants in vitro
    Hai Zhang
    Department of Orthopaedic Surgery, MC 3105, University of Connecticut Health Center, Farmington, CT 06030-1110, USA
    J Orthop Res 22:30-8. 2004
    ..6-2.3-fold) of COL, BSP, and osteocalcin (OC) mRNAs in Y HOBs compared to M and O HOBs from female subjects. We conclude that human osteoblasts from older female patients have a decreased ability to form bone on implants...
  16. ncbi Transgenic expression of 11beta-hydroxysteroid dehydrogenase type 2 in osteoblasts reveals an anabolic role for endogenous glucocorticoids in bone
    Lorin B Sher
    Department of Medicine, MC-1850, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Endocrinology 145:922-9. 2004
    ..Our data demonstrate that endogenous glucocorticoid signaling is required for normal vertebral trabecular bone volume and architecture in female mice...
  17. ncbi Osteopenia in transgenic mice with osteoblast-targeted expression of the inducible cAMP early repressor
    Taranpreet K Chandhoke
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 43:101-9. 2008
    ..We speculate that ICER regulates the activity and/or expression of ATF/CREB factors required for normal bone formation...
  18. ncbi CREM deficiency in mice alters the response of bone to intermittent parathyroid hormone treatment
    Fei Liu
    Department of Medicine, MC 1850, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Bone 40:1135-43. 2007
    ..Crem gene may specify the anabolic response to intermittent PTH treatment by restraining PTH-induced osteoclastogenesis...
  19. ncbi Use of type I collagen green fluorescent protein transgenes to identify subpopulations of cells at different stages of the osteoblast lineage
    I Kalajzic
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington 06030, USA
    J Bone Miner Res 17:15-25. 2002
    ..In primary culture, this approach will afford isolation of subpopulations of these cells for molecular and cellular analysis...
  20. ncbi Transforming growth factor-beta 1 (TGF-beta1) prevents the age-dependent decrease in bone formation in human osteoblast/implant cultures
    Hai Zhang
    Department of Restorative Dentistry, University of Washington, Seattle, WA 98195, USA
    J Biomed Mater Res A 75:98-105. 2005
    ..In conclusion, TGF-beta1 enhances mineralization on implant materials of osteoblast cultures from elderly human subjects...
  21. ncbi Effect of Crohn's disease on bone metabolism in vitro: a role for interleukin-6
    Francisco A Sylvester
    Department of Pediatrics, Connecticut Children s Medical Center, University of Connecticut, Hartford 06106, USA
    J Bone Miner Res 17:695-702. 2002
    ..These results suggest that IL-6 is a mediator of the effects of Crohn's serum on in vitro mineralization and may be a contributing factor to the osteopenia associated with CD...