Kay Grobe

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Role of protein kinase C in the phosphorylation of CD33 (Siglec-3) and its effect on lectin activity
    Kay Grobe
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Blood 99:3188-96. 2002
  2. ncbi request reprint Properties of group I allergens from grass pollen and their relation to cathepsin B, a member of the C1 family of cysteine proteinases
    Kay Grobe
    University of California San Diego, La Jolla 92093 0687, USA
    Eur J Biochem 269:2083-92. 2002
  3. ncbi request reprint Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes
    Kay Grobe
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093 0687, USA
    Biochim Biophys Acta 1573:209-15. 2002
  4. ncbi request reprint Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites
    Kay Grobe
    Department of Cellular and Molecular Medicine, Glycobiology Training and Research Center, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0687, USA
    J Biol Chem 277:30699-706. 2002
  5. ncbi request reprint Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function
    Kay Grobe
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0687, USA
    Development 132:3777-86. 2005
  6. ncbi request reprint Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling
    Miriam Ford-Perriss
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia, 3052
    Glycobiology 12:721-7. 2002
  7. ncbi request reprint Proteome analysis of maize pollen for allergy-relevant components
    Arnd Petersen
    Molecular and Clinical Allergology, Research Center Borstel, Borstel, Germany
    Proteomics 6:6317-25. 2006
  8. ncbi request reprint Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development
    Yi Pan
    Department of Medical and Molecular Genetics, Indiana University of Medicine, Indianapolis, IN 46202, USA
    Development 133:4933-44. 2006
  9. ncbi request reprint Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction
    Yi Pan
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Development 135:301-10. 2008
  10. pmc Altered heparan sulfate structure in mice with deleted NDST3 gene function
    Srinivas R Pallerla
    Department of General Zoology and Genetics, Westfalische Wilhelms Universitat Munster, Munster, Germany
    J Biol Chem 283:16885-94. 2008

Collaborators

  • Masaru Inatani
  • Arnd Petersen
  • J D Esko
  • Thomas Dresselhaus
  • Yi Pan
  • Srinivas R Pallerla
  • Xin Zhang
  • Miriam Ford-Perriss
  • Gen Sheng Feng
  • Roger Lawrence
  • Eric E Zhang
  • Uwe Schlomann
  • Andrea Powers
  • Lars Lewejohann
  • Tobias Fischer
  • Christian Carbe
  • Andrea Woodbury
  • Scott E Guimond
  • Mark Murphy
  • Koji Kimata
  • Magdalena Kita
  • Jeremy E Turnbull
  • Hiroko Habuchi
  • Una Greferath

Detail Information

Publications11

  1. ncbi request reprint Role of protein kinase C in the phosphorylation of CD33 (Siglec-3) and its effect on lectin activity
    Kay Grobe
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Blood 99:3188-96. 2002
    ..Notably, although this is the first example of serine/threonine phosphorylation in the subfamily of CD33-like Siglecs, some of the other members also have putative target sites in their cytoplasmic tails...
  2. ncbi request reprint Properties of group I allergens from grass pollen and their relation to cathepsin B, a member of the C1 family of cysteine proteinases
    Kay Grobe
    University of California San Diego, La Jolla 92093 0687, USA
    Eur J Biochem 269:2083-92. 2002
    ..These results indicate a common origin of cathepsin B and beta-expansins, especially if taken together with their previously known biochemical properties...
  3. ncbi request reprint Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes
    Kay Grobe
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093 0687, USA
    Biochim Biophys Acta 1573:209-15. 2002
    ..Here, we review the role of the four vertebrate NDSTs in HS biosynthesis as well as their regulated expression. The main emphasis is the phenotypes of mice lacking one or more of the NDSTs...
  4. ncbi request reprint Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites
    Kay Grobe
    Department of Cellular and Molecular Medicine, Glycobiology Training and Research Center, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0687, USA
    J Biol Chem 277:30699-706. 2002
    ..Because several growth factors and morphogens that bind heparan sulfate also contain structured 5'-UTRs, translational regulation may coordinate the action of these factors and their heparan sulfate co-receptors...
  5. ncbi request reprint Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function
    Kay Grobe
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0687, USA
    Development 132:3777-86. 2005
    ..Most importantly, the data suggest the possibility that defects in heparan sulfate synthesis could give rise to or contribute to a number of developmental brain and facial defects in humans...
  6. ncbi request reprint Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling
    Miriam Ford-Perriss
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia, 3052
    Glycobiology 12:721-7. 2002
    ....
  7. ncbi request reprint Proteome analysis of maize pollen for allergy-relevant components
    Arnd Petersen
    Molecular and Clinical Allergology, Research Center Borstel, Borstel, Germany
    Proteomics 6:6317-25. 2006
    ..IgE-crossreactivity was further studied using immunoblot inhibition tests. Here, timothy pollen extract completely blocked IgE binding to maize, whereas maize pollen extract blocked IgE reactivity to only some timothy pollen allergens...
  8. ncbi request reprint Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development
    Yi Pan
    Department of Medical and Molecular Genetics, Indiana University of Medicine, Indianapolis, IN 46202, USA
    Development 133:4933-44. 2006
    ..Taken together, these results establish an important role of Ndst1 function in FGF signaling during lens development...
  9. ncbi request reprint Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction
    Yi Pan
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Development 135:301-10. 2008
    ..Given the evolutionarily conserved roles of these genes, the localized activation of the Ndst-Fgfr-Shp2 genetic cascade is probably a general regulatory mechanism of FGF signaling in branching morphogenesis...
  10. pmc Altered heparan sulfate structure in mice with deleted NDST3 gene function
    Srinivas R Pallerla
    Department of General Zoology and Genetics, Westfalische Wilhelms Universitat Munster, Munster, Germany
    J Biol Chem 283:16885-94. 2008
    ....
  11. ncbi request reprint Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development
    Srinivas R Pallerla
    Institut fur Allgemeine Zoologie und Genetik, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Dev Dyn 236:556-63. 2007
    ..Our findings, therefore, suggest that defects in HS synthesis may contribute to multifactor types of congenital developmental defects in humans, including neural tube defects...