Justin L Grobe

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance
    Justin L Grobe
    Department of Internal Medicine, University of Iowa, Iowa City, 52242, USA
    Cell Metab 12:431-42. 2010
  2. pmc Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice
    Justin L Grobe
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, 3181 MERF, 375 Newton Rd, Iowa City, IA 52242, USA
    Hypertension 57:600-7. 2011
  3. pmc PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity
    Pimonrat Ketsawatsomkron
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Circ Res 111:1446-58. 2012
  4. pmc Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension
    Aline M Hilzendeger
    Department of Pharmacology, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 61:716-22. 2013
  5. pmc Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism
    Di Xu
    Interdisciplinary Genetics Program, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Physiol Genomics 43:286-94. 2011
  6. pmc Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent
    Nicole K Littlejohn
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 304:R818-28. 2013
  7. pmc A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity
    Aline M Hilzendeger
    Center on Functional Genomics of Hypertension, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 303:H197-206. 2012
  8. pmc Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice
    Justin L Grobe
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 56:981-7. 2010
  9. pmc Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase
    Christopher J Pelham
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Cell Metab 16:462-72. 2012
  10. pmc Renal proximal tubule angiotensin AT1A receptors regulate blood pressure
    Huiping Li
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1067-77. 2011

Collaborators

  • Harald M Stauss
  • Alan Daugherty
  • Andrew M Allen
  • Khristofor Agassandian
  • Giulianna R Borges
  • Lisa A Cassis
  • Curt D Sigmund
  • Aline M Hilzendeger
  • Christopher J Pelham
  • Martin D Cassell
  • Pimonrat Ketsawatsomkron
  • Deborah R Davis
  • Di Xu
  • Xuebo Liu
  • Eric T Weatherford
  • Henry L Keen
  • Huiping Li
  • Jeffrey P Coble
  • Colin M L Burnett
  • Nicole K Littlejohn
  • Allyn L Mark
  • Frank M Faraci
  • Alan Kim Johnson
  • Ralph F Johnson
  • Beth A Buehrer
  • Benjamin J Weidemann
  • Rick B Siel
  • Nicole A Pearson
  • Anthony P Thompson
  • Séverine Groh
  • David Dellsperger
  • Leonard Brooks
  • Donald A Morgan
  • Stella Rita C Ibeawuchi
  • Kamal Rahmouni
  • Ramón A Lorca
  • Willem J de Lange
  • Sarah K England
  • R Ariel Gomez
  • Maria Luisa S Sequeira Lopez
  • Baoli Yang

Detail Information

Publications15

  1. pmc The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance
    Justin L Grobe
    Department of Internal Medicine, University of Iowa, Iowa City, 52242, USA
    Cell Metab 12:431-42. 2010
    ..adrenergic blockade or restoration of circulating angiotensin-II, but not adrenalectomy, normalized metabolic rate. Our data point to contrasting mechanisms by which the brain RAS regulates fluid intake and energy expenditure...
  2. pmc Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice
    Justin L Grobe
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, 3181 MERF, 375 Newton Rd, Iowa City, IA 52242, USA
    Hypertension 57:600-7. 2011
    ..Together, these data illustrate the necessity of angiotensinergic signaling within the brain, independent of blood pressure alterations, in the metabolic consequences of DOCA-salt treatment...
  3. pmc PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity
    Pimonrat Ketsawatsomkron
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Circ Res 111:1446-58. 2012
    ..Previous studies suggest these effects may be mediated through the vasculature, but the underlying mechanisms remain unclear...
  4. pmc Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension
    Aline M Hilzendeger
    Department of Pharmacology, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 61:716-22. 2013
    ....
  5. pmc Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism
    Di Xu
    Interdisciplinary Genetics Program, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Physiol Genomics 43:286-94. 2011
    ..These data demonstrate that sREN is dispensable within the brain for normal physiological regulation of cardiovascular, hydromineral, and metabolic regulation, and thereby indirectly support the importance of icREN in brain RAS function...
  6. pmc Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent
    Nicole K Littlejohn
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 304:R818-28. 2013
    ..Together, these data support a major role for vasopressin in the hypertension of mice with brain-specific hyperactivity of the RAS and suggest a primary role of V(2) receptors...
  7. pmc A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity
    Aline M Hilzendeger
    Center on Functional Genomics of Hypertension, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 303:H197-206. 2012
    ..Captopril attenuated leptin effects on renal and BAT SNA. In conclusion, these studies provide evidence that the brain RAS selectively facilitates renal and BAT sympathetic nerve responses to leptin while sparing effects on food intake...
  8. pmc Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice
    Justin L Grobe
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 56:981-7. 2010
    ..These insights may help explain the discrepancies among observational studies that have examined roles for the -6A/235T and -6G/235M angiotensinogen haplotypes in varied human populations...
  9. pmc Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase
    Christopher J Pelham
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Cell Metab 16:462-72. 2012
    ..We conclude that Cullin-3 regulates vascular function and arterial pressure, thus providing a mechanistic link between mutations in Cullin-3 and hypertension in humans...
  10. pmc Renal proximal tubule angiotensin AT1A receptors regulate blood pressure
    Huiping Li
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1067-77. 2011
    ..These data, from two separate mouse models, provide evidence that ANG II signaling via the type 1A receptor in the renal proximal tubule is a regulator of systemic blood pressure under baseline conditions...
  11. pmc Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin
    Di Xu
    Interdisciplinary Genetics Program, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 54:1240-7. 2009
    ....
  12. pmc Metabolic rate regulation by the renin-angiotensin system: brain vs. body
    Justin L Grobe
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, 3181 MERF, 375 Newton Rd, Iowa City, IA 52242, USA
    Pflugers Arch 465:167-75. 2013
    ..Selectively modulating the peripheral RAS or brain RAS may thus provide a more effective treatment paradigm for obesity and obesity-related disorders...
  13. pmc Activity of Protein Kinase C-α Within the Subfornical Organ Is Necessary for Fluid Intake in Response to Brain Angiotensin
    Jeffrey P Coble
    From the Departments of Pharmacology J P C, J L G, C D S, Psychology R F J, A K J, and Anatomy and Cell Biology M D C, Roy J and Lucille A Carver College of Medicine, University of Iowa
    Hypertension 64:141-8. 2014
    ....
  14. pmc Direct calorimetry identifies deficiencies in respirometry for the determination of resting metabolic rate in C57Bl/6 and FVB mice
    Colin M L Burnett
    Department of Pharmacology, Center on Functional Genomics of Hypertension, Fraternal Order of Eagles Diabetes Research Center, and The Obesity Research and Education Initiative, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa
    Am J Physiol Endocrinol Metab 305:E916-24. 2013
    ..Increased use of direct calorimetry for the assessment of RMR and confirmation of respirometry results and the reexamination of previously discarded potential obesity therapeutics are warranted...
  15. pmc An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy
    Justin L Grobe
    Department of Internal Medicine, Center on Functional Genomics of Hypertension, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Physiology (Bethesda) 23:187-93. 2008
    ..We review evidence for neuronal production of angiotensin peptides and hypothesize that angiotensin may be synthesized intracellularly in neurons...