Felix Grün

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Obesogens
    Felix Grün
    Center for Complex Biological Systems, University of California Irvine, Irvine, California 92697 2280, USA
    Curr Opin Endocrinol Diabetes Obes 17:453-9. 2010
  2. ncbi request reprint The obesogen tributyltin
    Felix Grün
    The Center for Complex Biological Systems, University of California Irvine, Irvine, California, USA Electronic address
    Vitam Horm 94:277-325. 2014
  3. ncbi request reprint Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis
    Felix Grün
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA
    Rev Endocr Metab Disord 8:161-71. 2007
  4. ncbi request reprint Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors
    Felix Grün
    Department of Developmental and Cell Biology, University of California, Irvine 92697 2300, USA
    J Biol Chem 277:43691-7. 2002
  5. ncbi request reprint Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway
    Changcheng Zhou
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697 2300, USA
    J Clin Immunol 24:623-36. 2004
  6. ncbi request reprint Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes
    Changcheng Zhou
    Department of Developmental and Cell Biology, University of California, 5205 McGaugh Hall, Irvine, CA 92697 2300, USA
    Drug Metab Dispos 32:1075-82. 2004
  7. ncbi request reprint Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates
    Felix Grün
    Department of Developmental and Cell Biology, University of California Irvine, 2113 McGaugh Hall, Irvine, California 92697 2300, USA
    Mol Endocrinol 20:2141-55. 2006
  8. ncbi request reprint Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling
    Felix Grün
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California 92697 2300, USA
    Endocrinology 147:S50-5. 2006
  9. pmc Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR)
    Michelle M Tabb
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697 2300, USA
    Environ Health Perspect 112:163-9. 2004
  10. pmc Endocrine disrupters as obesogens
    Felix Grün
    Department of Developmental and Cell Biology, University of California Irvine, 92697 2300, USA
    Mol Cell Endocrinol 304:19-29. 2009

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Obesogens
    Felix Grün
    Center for Complex Biological Systems, University of California Irvine, Irvine, California 92697 2280, USA
    Curr Opin Endocrinol Diabetes Obes 17:453-9. 2010
    ..This review focuses on recent experimental advances for candidate obesogens that target nuclear hormone receptors when a direct link between exposure, modulation of transcriptional networks and adipogenic phenotypes can be rationalized...
  2. ncbi request reprint The obesogen tributyltin
    Felix Grün
    The Center for Complex Biological Systems, University of California Irvine, Irvine, California, USA Electronic address
    Vitam Horm 94:277-325. 2014
    ..Organotins represent an important model test system for evaluating the impact and epidemiological significance of chemical insults as contributing factors for obesity and human metabolic health...
  3. ncbi request reprint Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis
    Felix Grün
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA
    Rev Endocr Metab Disord 8:161-71. 2007
    ....
  4. ncbi request reprint Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors
    Felix Grün
    Department of Developmental and Cell Biology, University of California, Irvine 92697 2300, USA
    J Biol Chem 277:43691-7. 2002
    ..Neither BXR shows the broad specificity toward steroids or xenobiotics exhibited by SXR/PXR. Therefore, we conclude that the BXRs are pharmacologically distinct from each other and unlikely to serve as xenobiotic sensors...
  5. ncbi request reprint Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway
    Changcheng Zhou
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697 2300, USA
    J Clin Immunol 24:623-36. 2004
    ..Our results suggest a previously unsuspected effect of St. John's wort in modulating the immune and inflammatory responses...
  6. ncbi request reprint Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes
    Changcheng Zhou
    Department of Developmental and Cell Biology, University of California, 5205 McGaugh Hall, Irvine, CA 92697 2300, USA
    Drug Metab Dispos 32:1075-82. 2004
    ..Our findings provide a molecular mechanism explaining how vitamin supplements affect the absorption and effectiveness of drugs. Knowledge of drug-nutrient interactions may help reduce the incidence of decreased drug efficacy...
  7. ncbi request reprint Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates
    Felix Grün
    Department of Developmental and Cell Biology, University of California Irvine, 2113 McGaugh Hall, Irvine, California 92697 2300, USA
    Mol Endocrinol 20:2141-55. 2006
    ..Developmental or chronic lifetime exposure to organotins may therefore act as a chemical stressor for obesity and related disorders...
  8. ncbi request reprint Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling
    Felix Grün
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California 92697 2300, USA
    Endocrinology 147:S50-5. 2006
    ..The linking of organotin exposure to adipocyte differentiation and obesity opens an important new area of research into potential environmental influences on human health and disease...
  9. pmc Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR)
    Michelle M Tabb
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697 2300, USA
    Environ Health Perspect 112:163-9. 2004
    ..The antagonistic PCBs are among the most stable and abundant in human tissues. These findings have important implications for understanding the biologic effects of PCB exposure and the use of animal models to predict the attendant risk...
  10. pmc Endocrine disrupters as obesogens
    Felix Grün
    Department of Developmental and Cell Biology, University of California Irvine, 92697 2300, USA
    Mol Cell Endocrinol 304:19-29. 2009
    ..This review highlights recent advances in our understanding of the molecular targets and mechanisms of action for these compounds and areas of future research needed to evaluate the significance of their contribution to obesity...
  11. pmc Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation
    Changcheng Zhou
    Department of Developmental and Cell Biology, University of California, Irvine 92697 2300, USA
    J Clin Invest 116:2280-2289. 2006
    ..This mechanistic relationship has clinical consequences for individuals undergoing therapeutic exposure to the wide variety of drugs that are also SXR agonists...
  12. pmc Minireview: the case for obesogens
    Felix Grün
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California 92697 2300, USA
    Mol Endocrinol 23:1127-34. 2009
    ..This review considers the evidence for obesogens, how they might act, and where future research is needed to clarify their relative contribution to the obesity epidemic...
  13. ncbi request reprint Identification of novel nuclear hormone receptor ligands by activity-guided purification
    Felix Grün
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697 2300, USA
    Methods Enzymol 364:3-24. 2003
  14. pmc Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species
    Matthew R Milnes
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697 2300, USA
    Environ Health Perspect 116:880-5. 2008
    ..The ligand-binding domain is principally responsible for species-specific activation of NR1I2 in response to xenobiotic exposure...
  15. ncbi request reprint Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR
    Michelle M Tabb
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697 2300, USA
    J Biol Chem 278:43919-27. 2003
    ..An important implication of this work is that a subset of SXR activators may function as effective therapeutic agents for the management of osteoporosis...