William Grizzle

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc p53 and erbB-2 are not associated in matched cases of primary and metastatic ovarian carcinomas
    Cristina Rodriguez-Burford
    Department of Pathology, The University of Alabama at Birmingham, AL 35294, USA
    Dis Markers 19:11-7. 2003
  2. pmc Serum protein expression profiling for cancer detection: validation of a SELDI-based approach for prostate cancer
    William E Grizzle
    University of Alabama at Birmingham, Birmingham, AL 35233 0007, USA
    Dis Markers 19:185-95. 2003
  3. ncbi request reprint Molecular characterization of colorectal neoplasia in translational research
    W E Grizzle
    Department of Pathology, Comprehensive Cancer Center, Bio Statistics Unit, University of Alabama at Birmingham, Birmingham, Ala 35233 0007, USA
    Arch Pathol Lab Med 125:91-8. 2001
  4. ncbi request reprint Avoiding biohazards in medical, veterinary and research laboratories
    W E Grizzle
    Department of Pathology, University of Alabama at Birmingham, 35294, USA
    Biotech Histochem 76:183-206. 2001
  5. ncbi request reprint Molecular staging of colorectal cancer in African-American and Caucasian patients using phenotypic expression of p53, Bcl-2, MUC-1 AND p27(kip-1)
    William E Grizzle
    Department of Pathology, UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35233 0007, USA
    Int J Cancer 97:403-9. 2002
  6. ncbi request reprint Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspirates
    Nirag Jhala
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Am J Clin Pathol 126:572-9. 2006
  7. ncbi request reprint Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer
    Ashka Y Pandya
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Clin Cancer Res 10:2709-19. 2004
  8. pmc Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer
    J Robert Newman
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, USA
    Arch Otolaryngol Head Neck Surg 134:1218-24. 2008
  9. pmc A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes
    Dongmei Sun
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Mol Ther 18:1606-14. 2010
  10. pmc KISS1 over-expression suppresses metastasis of pancreatic adenocarcinoma in a xenograft mouse model
    Lacey R McNally
    Department of Radiation Oncology, University of Alabama at Birmingham, 35294 2182, USA
    Clin Exp Metastasis 27:591-600. 2010

Research Grants

  1. Confocal DNA Cytometry Prostate Cancer- Age & Ethnicity
    William Grizzle; Fiscal Year: 2002
  2. Confocal DNA Cytometry Prostate Cancer- Age & Ethnicity
    William Grizzle; Fiscal Year: 2003
  3. Biomarker Reference Laboratory, EDRN
    William Grizzle; Fiscal Year: 2005
  4. Biomarker Reference Laboratory, EDRN
    William Grizzle; Fiscal Year: 2007
  5. COOPERATIVE HUMAN TISSUE NETWORK
    William Grizzle; Fiscal Year: 2007

Detail Information

Publications87

  1. pmc p53 and erbB-2 are not associated in matched cases of primary and metastatic ovarian carcinomas
    Cristina Rodriguez-Burford
    Department of Pathology, The University of Alabama at Birmingham, AL 35294, USA
    Dis Markers 19:11-7. 2003
    ..Thus, the nuclear accumulation of p53 and immunostaining of p185erbB-2 in the cytoplasm or on the cellular membranes are independent...
  2. pmc Serum protein expression profiling for cancer detection: validation of a SELDI-based approach for prostate cancer
    William E Grizzle
    University of Alabama at Birmingham, Birmingham, AL 35233 0007, USA
    Dis Markers 19:185-95. 2003
    ..At the end of this validation study, the usefulness of the general SELDI-TOF-MS approach to identifying patients with PCA will be demonstrated and how it compares with PCA diagnosis by measuring prostate specific antigen...
  3. ncbi request reprint Molecular characterization of colorectal neoplasia in translational research
    W E Grizzle
    Department of Pathology, Comprehensive Cancer Center, Bio Statistics Unit, University of Alabama at Birmingham, Birmingham, Ala 35233 0007, USA
    Arch Pathol Lab Med 125:91-8. 2001
    ..To present recent advances in the use of molecular markers in diagnosis, in prognosis, in early detection, in novel therapies, and in understanding the molecular pathogenesis of colorectal neoplasia...
  4. ncbi request reprint Avoiding biohazards in medical, veterinary and research laboratories
    W E Grizzle
    Department of Pathology, University of Alabama at Birmingham, 35294, USA
    Biotech Histochem 76:183-206. 2001
    ..The issues discussed can be used to develop a general safety program as required by regulatory or accrediting agencies, including the Occupational Safety and Health Administration...
  5. ncbi request reprint Molecular staging of colorectal cancer in African-American and Caucasian patients using phenotypic expression of p53, Bcl-2, MUC-1 AND p27(kip-1)
    William E Grizzle
    Department of Pathology, UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35233 0007, USA
    Int J Cancer 97:403-9. 2002
    ..Nevertheless, nuclear accumulation of p53 (p53(nac)) and phenotypic expression of Bcl-2, MUC-1 and p27(kip-1) may be molecular markers approaching acceptance for use in molecular staging of specific subgroups of colorectal cancers...
  6. ncbi request reprint Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspirates
    Nirag Jhala
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Am J Clin Pathol 126:572-9. 2006
    ..Clusterin-beta and MUC4 can help distinguish reactive ductal epithelial cells from the cells of pancreatic adenocarcinoma in FNA samples...
  7. ncbi request reprint Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer
    Ashka Y Pandya
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Clin Cancer Res 10:2709-19. 2004
    ..Although KLF4 expression is increased in most cases of breast cancer, it was unknown whether these cases represent a distinct subtype with a different clinical outcome...
  8. pmc Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer
    J Robert Newman
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, USA
    Arch Otolaryngol Head Neck Surg 134:1218-24. 2008
    ..Tumor cell-derived EMMPRIN is highly overexpressed in HNSCC and is thought to be induced by surrounding fibroblasts to stimulate matrix metalloproteases, which modulate tumor cell invasion, growth, and angiogenesis...
  9. pmc A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes
    Dongmei Sun
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Mol Ther 18:1606-14. 2010
    ..The specificity of using exosomes as a drug carrier creates opportunities for treatments of many inflammation-related diseases without significant side effects due to innocent bystander or off-target effects...
  10. pmc KISS1 over-expression suppresses metastasis of pancreatic adenocarcinoma in a xenograft mouse model
    Lacey R McNally
    Department of Radiation Oncology, University of Alabama at Birmingham, 35294 2182, USA
    Clin Exp Metastasis 27:591-600. 2010
    ..These data suggest induction of KISS1 expression has potential as an adjuvant treatment for pancreatic cancer...
  11. ncbi request reprint Intravenous delivery of adenovirus-mediated soluble FLT-1 results in liver toxicity
    Parameshwar J Mahasreshti
    Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Clin Cancer Res 9:2701-10. 2003
    ..v. delivered, adenovirus-mediated sFLT-1 on the survival duration in a murine ovarian tumor model and to evaluate the safety of i.v.-delivered versus i.p.-delivered adenovirus-mediated sFLT-1 in non-tumor-bearing mice...
  12. pmc Gli1 promotes cell survival and is predictive of a poor outcome in ERalpha-negative breast cancer
    Lusheng Xu
    Department of Pathology, University of Alabama at Birmingham, Kaul 640B, 1530 Third Avenue South, Birmingham, AL 35294, USA
    Breast Cancer Res Treat 123:59-71. 2010
    ..005), but not ERalpha-positive cancers. In conclusion, we demonstrate a positive association between expression of Gli1 and ERalpha; however, our data indicate a greater functional effect of Gli1 in ERalpha-negative cancers...
  13. ncbi request reprint TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growth
    Leo Christopher DeRosier
    Departments of Surgery, University of Alabama at Birmingham, 1530 3rd Avenue South, Wallace Tumor Institute 674, Birmingham, AL 35294 6832, USA
    Mol Cancer Ther 6:3198-207. 2007
    ..To evaluate agonistic TRA-8 monoclonal antibody to human death receptor 5 (DR5) and gemcitabine in vitro and in an orthotopic pancreatic cancer model...
  14. pmc Recurrence and survival predictive value of phenotypic expression of Bcl-2 varies with tumor stage of colorectal adenocarcinoma
    Chakrapani Chatla
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cancer Biomark 1:241-50. 2005
    ..These findings might be useful in identifying biologically aggressive phenotypes of Stage II CRCs, and may aid the oncologist in designing maximally appropriate therapeutic regimens...
  15. doi request reprint Exosomes are endogenous nanoparticles that can deliver biological information between cells
    Dongmei Sun
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Adv Drug Deliv Rev 65:342-7. 2013
    ..This review will focus on exosomes as a biological nanoparticle drug carrier with emphasis on their immune-regulatory activities...
  16. ncbi request reprint Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer model
    J Michael Straughn
    Division of Gynecologic Oncology, University of Alabama at Birmingham, 619 19th Street South, OHB Room 538, Birmingham, AL 35249, USA
    Gynecol Oncol 101:46-54. 2006
    ..We sought to determine the therapeutic potential of TRA-8 (anti-DR5 monoclonal antibody) in combination with chemotherapy and radiation therapy in a cervical cancer model...
  17. doi request reprint Experimental cancer therapy using restoration of NAD+ -linked 15-hydroxyprostaglandin dehydrogenase expression
    Lyudmila N Kaliberova
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Mol Cancer Ther 8:3130-9. 2009
    ..These results suggest that 15-PGDH-mediated regulation of PGE(2) catabolism in the tumor microenvironment represents a novel approach for therapy of human breast and colon cancer...
  18. ncbi request reprint Adenovirus-mediated FLT1-targeted proapoptotic gene therapy of human prostate cancer
    Sergey A Kaliberov
    Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Ther 10:1059-70. 2004
    ..Our results suggest that specific TRAIL delivery employing the FLT1 promoter can effectively inhibit tumor growth and demonstrate the advantage of combination radiotherapy and gene therapy for the treatment of prostate cancer...
  19. ncbi request reprint Effect of TRA-8 anti-death receptor 5 antibody in combination with chemotherapy in an ex vivo human ovarian cancer model
    Peter J Frederick
    Division of Gynecologic Oncology, Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL, USA
    Int J Gynecol Cancer 19:814-9. 2009
    ..To investigate the cytotoxicity of TRA-8, an antibody that specifically binds death receptor 5, alone and in combination with chemotherapy, using an ex vivo human ovarian cancer model...
  20. ncbi request reprint Adenoviral vector-mediated augmentation of epidermal growth factor receptor (EGFr) enhances the radiosensitization properties of anti-EGFr treatment in prostate cancer cells
    James A Bonner
    Department of Radiation Oncology, University of Alabama School of Medicine, Birmingham, Alabama, USA
    Int J Radiat Oncol Biol Phys 58:950-8. 2004
    ....
  21. ncbi request reprint Smad4 inhibits tumor growth by inducing apoptosis in estrogen receptor-alpha-positive breast cancer cells
    Qingnan Li
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Biol Chem 280:27022-8. 2005
    ..Smad4-induced apoptosis in ERalpha-positive breast cancer cells may explain the invasive nature of ERalpha-negative breast tumors, thereby providing a potential target for breast cancer intervention...
  22. ncbi request reprint A Phase I study of combined modality (90)Yttrium-CC49 intraperitoneal radioimmunotherapy for ovarian cancer
    Ronald D Alvarez
    Department of Obstetrics, University of Alabama at Birmingham Cancer Center, Birmingham, Alabama 35233, USA
    Clin Cancer Res 8:2806-11. 2002
    ..The purpose of this study was to determine the feasibility and maximum tolerated dose of (90)Yttrium-CC49 ((90)Y-CC49) as the radioimmunotherapy (RIT) component of an i.p. combined modality treatment for recurrent ovarian cancer...
  23. ncbi request reprint Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptor
    Gandham Mahendra
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cancer Gene Ther 12:26-34. 2005
    ..These studies indicate that rAAV-mediated sFlt-1 gene therapy may be a feasible approach for inhibiting tumor angiogenesis, particularly as an adjuvant/therapy...
  24. pmc Combination treatment with TRA-8 anti death receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of pancreatic cancer
    Leo Christopher DeRosier
    Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 6832, USA
    Clin Cancer Res 13:5535s-5543s. 2007
    ..Evaluate the response of human pancreatic cancer cell lines and orthotopic tumors to TRA-8, an agonistic antibody to death receptor 5, in combination with irinotecan (CPT-11)...
  25. ncbi request reprint BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model
    William E Grizzle
    Department of Pathology, University of Alabama at Birmingham, AL 35294 0007, USA
    Int J Cancer 101:270-9. 2002
    ..The T-cell immune response minimized tumor development in types III and IV since T-cell depletion of the BXD RI mice resulted in aggressively growing tumors in these strains...
  26. pmc Breast tumor xenografts: diffusion-weighted MR imaging to assess early therapy with novel apoptosis-inducing anti-DR5 antibody
    Hyunki Kim
    Department of Radiology, University of Alabama at Birmingham, 1530 3rd Ave S, BDB 11, Birmingham, AL 35294, USA
    Radiology 248:844-51. 2008
    ..To measure the early therapeutic response to a novel apoptosis-inducing antibody, TRA-8, by using diffusion-weighted magnetic resonance (MR) imaging in a mouse breast cancer model...
  27. ncbi request reprint Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia
    Kyoko Kojima
    Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cancer Res 67:8121-30. 2007
    ..This indicates that Smad4 is dispensable for normal pancreatic development but is critical for at least partial suppression of multiple Kras(G12D)-dependent disease-associated phenotypes...
  28. pmc Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts
    Xinwen Yang
    Department of Medicine, University of Alabama at Birmingham, and the Birmingham Veterans Administration Medical Center, Birmingham, AL 35294 0007, USA
    Am J Pathol 167:705-19. 2005
    ..Taken together, our findings suggest a unique role for caspase-4 in cleaving vimentin and releasing cytosolic p53 for nuclear translocation, events that may regulate the sensitivity of RASFs to receptor-mediated apoptosis...
  29. pmc Postsurgical disparity in survival between African Americans and Caucasians with colonic adenocarcinoma
    Dominik Alexander
    Department of Epidemiology, University of Alabama Birmingham, 19th Street South, Birmingham, AL 35294 0007, USA
    Cancer 101:66-76. 2004
    ..In the current study, the authors evaluated the racial differences in survival based on tumor location and pathologic stage between African-American patients and Caucasian patients who underwent surgery alone for CRC...
  30. ncbi request reprint Smad4 as a transcription corepressor for estrogen receptor alpha
    Liyu Wu
    Department of Pathology, University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama 35294, USA
    J Biol Chem 278:15192-200. 2003
    ..Our findings represent a novel mechanism that TGF-beta may regulate cell fate through Smad4-mediated cross-talk with estrogen...
  31. ncbi request reprint Role of microvascular density in nonlocalizing parathyroid sestamibi scans
    Glenn Peters
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Laryngoscope 117:2163-8. 2007
    ..We hypothesize that an increase in microvascular density (MVD) within an adenoma will result in rapid tracer washout and a subsequent nonlocalizing scan. This study investigates the role of MVD in sestamibi localization...
  32. ncbi request reprint Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung
    Chandrika J Piyathilake
    Department Nutrition Sciences, Heidi Weiss Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Clin Cancer Res 8:734-44. 2002
    ....
  33. pmc DCE-MRI detects early vascular response in breast tumor xenografts following anti-DR5 therapy
    Hyunki Kim
    The Department of Radiology, University of Alabama at Birmingham, AL 35294, USA
    Mol Imaging Biol 13:94-103. 2011
    ..Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) measured the early vascular changes after administration of TRA-8, bevacizumab, or TRA-8 combined with bevacizumab in breast tumor xenografts...
  34. ncbi request reprint Oncolytic HSV-1 for the treatment of brain tumours
    James M Markert
    Division of Neurosurgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 3410, USA
    Herpes 13:66-71. 2006
    ..In this review, the background of this approach will be discussed, followed by a discussion of the clinical trials, as well as potential directions for future trials...
  35. ncbi request reprint A phase I trial of the single-chain immunotoxin SGN-10 (BR96 sFv-PE40) in patients with advanced solid tumors
    James A Posey
    Departments of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
    Clin Cancer Res 8:3092-9. 2002
    ..This antibody is specific for a Lewis(Y) (Le(Y))-related carbohydrate antigen expressed on multiple carcinomas...
  36. pmc Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R IRES
    Scott W Blume
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Exp Mol Pathol 88:341-52. 2010
    ....
  37. ncbi request reprint Hormone receptors and proliferation in breast carcinomas of equivalent histologic grades in pre- and postmenopausal women
    Lynya I Talley
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Int J Cancer 98:118-27. 2002
    ..Our data also suggest that some prognostic factors are not equally effective as predictors of survival in pre- and postmenopausal women...
  38. ncbi request reprint Anti-tumor activity of the TRA-8 anti-DR5 antibody in combination with cisplatin in an ex vivo human cervical cancer model
    James E Kendrick
    Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Gynecol Oncol 108:591-7. 2008
    ..To investigate the cytotoxicity of TRA-8, an antibody that specifically binds death receptor 5 (DR5), alone and in combination with cisplatin, using an ex vivo human cervical cancer model...
  39. ncbi request reprint Tumor exosomes inhibit differentiation of bone marrow dendritic cells
    Shaohua Yu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Immunol 178:6867-75. 2007
    ..These data suggest that tumor exosome-mediated induction of IL-6 plays a role in blocking BM DC differentiation...
  40. pmc Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity
    Huang Ge Zhang
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochim Biophys Acta 1773:1116-23. 2007
    ..These data suggest that partial reversal of tumor exosome-mediated inhibition of NK cell tumor cytotoxicity may account for the anti-cancer properties of curcumin...
  41. ncbi request reprint Phase I study of 90Y-CC49 monoclonal antibody therapy in patients with advanced non-small cell lung cancer: effect of chelating agents and paclitaxel co-administration
    Andres Forero
    Department of Medicine, Comprehensive Cancer Center, University of Alabama at Birmingham, 1824 Sixth Avenue South, Birmingham, AL 35294 3300, USA
    Cancer Biother Radiopharm 20:467-78. 2005
    ....
  42. ncbi request reprint SIRT1 is significantly elevated in mouse and human prostate cancer
    Derek M Huffman
    Division of Physiology and Metabolism, Department of Nutrition Sciences, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
    Cancer Res 67:6612-8. 2007
    ..Because SIRT1 may function as a tumor promoter, these results suggest that SIRT1 should be considered as a potential therapeutic target for prostate cancer...
  43. ncbi request reprint Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in mice
    Kurt R Zinn
    Depts of Radiology, University of Alabama at Birmingham, Boshell Bldg, BDB 11, 1530 3rd Ave S, Birmingham, AL 35294 0012, USA
    Radiology 223:417-25. 2002
    ..To compare two systems for assessing gene transfer to cancer cells and xenograft tumors with noninvasive gamma camera imaging...
  44. pmc Prognostic significance of p53 codon 72 polymorphism differs with race in colorectal adenocarcinoma
    Venkat R Katkoori
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 7331, USA
    Clin Cancer Res 15:2406-16. 2009
    ..Therefore, this study assessed the prognostic value of this polymorphism in African American and Caucasian colorectal adenocarcinoma patients separately...
  45. pmc How to efficiently obtain human tissues to support specific biomedical research projects
    Walter C Bell
    University of Alabama at Birmingham, Alabama 35294 0007, USA
    Cancer Epidemiol Biomarkers Prev 18:1676-9. 2009
    ..This review is best accomplished by discussing their requests with the tissue resource and correcting specific limitations that block access to the tissues they need...
  46. pmc Mandatory fortification with folic acid in the United States is associated with increased expression of DNA methyltransferase-1 in the cervix
    Chandrika J Piyathilake
    Department of Nutrition Sciences, The University of Alabama at Birmingham, Alabama, USA
    Nutrition 24:94-9. 2008
    ....
  47. ncbi request reprint Quantitation of cytosine deaminase mRNA by real-time reverse transcription polymerase chain reaction: a sensitive method for assessing 5-fluorocytosine toxicity in vitro
    C Ryan Miller
    Department of Radiation Oncology, Comprehensive Cancer Center, Birmingham, Alabama 35294, USA
    Anal Biochem 301:189-99. 2002
    ....
  48. ncbi request reprint Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model
    Donald J Buchsbaum
    Departments of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Clin Cancer Res 9:3731-41. 2003
    ..Tumor size and regression rates were determined. In addition, a study was carried out with TRA-8 and Adriamycin in combination with 3 Gy (60)Co irradiation of 2LMP xenografts on days 9 and 17...
  49. ncbi request reprint Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinoma
    Eben L Rosenthal
    Division of Otolarynology Head and Neck Surgery, Comprehensive Cancer Center, University of Alabama at Birmingham, 35249, USA
    Laryngoscope 113:1406-10. 2003
    ..We hypothesize that EMMPRIN is overexpressed in laryngeal cancer...
  50. pmc Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host
    Cunren Liu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Alabama 35294 0007, USA
    Blood 109:4336-42. 2007
    ..Western blot analyses further suggests that MSCs suppress IL-2-mediated NK cell cytotoxicity by affecting the activity of Stat5...
  51. ncbi request reprint Prognostic significance of p27(kip-1) expression in colorectal adenocarcinomas is associated with tumor stage
    Upender Manne
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Clin Cancer Res 10:1743-52. 2004
    ..Therefore, in this study, we investigated whether the prognostic value of p27(kip-1) expression varies with the tumor site, tumor stage and patient ethnicity...
  52. ncbi request reprint Adeno-associated virus 2-mediated antiangiogenic cancer gene therapy: long-term efficacy of a vector encoding angiostatin and endostatin over vectors encoding a single factor
    Selvarangan Ponnazhagan
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer Res 64:1781-7. 2004
    ....
  53. ncbi request reprint The pattern of expression of Mn and Cu-Zn superoxide dismutase varies among squamous cell cancers of the lung, larynx, and oral cavity
    Chandrika J Piyathilake
    Division of Nutritional Biochemistry and Molecular Biology, University of Alabama at Birmingham, University Station, Birmingham, Alabama 35294, USA
    Head Neck 24:859-67. 2002
    ..Despite the importance of reactive oxygen species (ROS) in the development of smoking-related cancers, little is known about the pattern of expression of ROS scavengers in these cancers...
  54. ncbi request reprint Inhibition of tumorigenicity by the 5'-untranslated RNA of the human c-myc P0 transcript
    Scott W Blume
    Department of Medicine, University of Alabama at Birmingham, Tumor Institute, Room 508, 1824 6th Avenue South, Birmingham, AL 35294 3300, USA
    Exp Cell Res 288:131-42. 2003
    ....
  55. ncbi request reprint MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration
    David C Chhieng
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249 6823, USA
    Cancer 99:365-71. 2003
    ....
  56. ncbi request reprint Expression of CEA, Tag-72, and Lewis-Y antigen in primary and metastatic lesions of ovarian carcinoma
    David C Chhieng
    Department of Pathology, University of Alabama, Birmingham 35249 6823, USA
    Hum Pathol 34:1016-21. 2003
    ..CEA (Col-1), due to its low expression and variation in phenotypic expression between primary and metastatic lesions, should be evaluated carefully in metastatic lesions before targeting the CEA antigen with CEA (Col-1)-like antibodies...
  57. ncbi request reprint Effects of nonsteroidal anti-inflammatory agents (NSAIDs) on ovarian carcinoma cell lines: preclinical evaluation of NSAIDs as chemopreventive agents
    Cristina Rodriguez-Burford
    Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Biostatistics Unit, The University of Alabama at Birmingham, Birmingham, Alabama 35213, USA
    Clin Cancer Res 8:202-9. 2002
    ..The purpose of this study was to investigate the cellular effects of acetylsalicylic acid (ASA), acetaminophen, and a COX-2 inhibitor (NS-398) on the growth of cell lines of human ovarian cancer in vitro...
  58. ncbi request reprint Nuclear accumulation of p53 is a potential marker for the development of squamous cell lung cancer in smokers
    Chandrika J Piyathilake
    Department of Nutrition Sciences, The University of Alabama, Birmingham, AL 35294, USA
    Chest 123:181-6. 2003
    ..To determine whether the nuclear accumulation of p53 in patients with early bronchial neoplasia represents an altered susceptibility for the development of lung cancer...
  59. pmc High-grade tumor differentiation is an indicator of poor prognosis in African Americans with colonic adenocarcinomas
    Dominik Alexander
    Department of Epidemiology, University of Alabama Birmingham, Birmingham, Alabama 35294 7331, USA
    Cancer 103:2163-70. 2005
    ..To identify the factors that contribute to poorer colon carcinoma survival rates for African Americans compared with Caucasians, the authors evaluated survival differences based on the histologic grade (differentiation) of the tumor...
  60. ncbi request reprint Effects of body weight gain reduction resulting from chemopreventive agent treatment on mammary gland morphology
    Cristina Rodriguez-Burford
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Nutr Cancer 43:67-75. 2002
    ..It would appear that the observed decrease in mammary cancers observed with moderate reductions in body weight gain might be due to multiple related factors different from those related to 4-HPR treatment...
  61. ncbi request reprint Mandatory fortification with folic acid in the United States is not associated with changes in the degree or the pattern of global DNA methylation in cells involved in cervical carcinogenesis
    Chandrika J Piyathilake
    Department of Nutrition Sciences, The University of Alabama at Birmingham, AL 35294, USA
    Cancer Biomark 2:259-66. 2006
    ..These results suggest that mandatory fortification with folic acid in the United States has not resulted in a change in the degree or the pattern of global DNA methylation in cells involved in cervical carcinogenesis...
  62. pmc Pattern of nonspecific (or global) DNA methylation in oral carcinogenesis
    Chandrika J Piyathilake
    Department of Nutrition Sciences, Division of Nutritional Biochemistry and Molecular Biology, University of Alabama at Birmingham, University Station, Birmingham, AL 35294, USA
    Head Neck 27:1061-7. 2005
    ....
  63. pmc Patterns of global DNA and histone methylation appear to be similar in normal, dysplastic and neoplastic oral epithelium of humans
    Chandrika J Piyathilake
    Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
    Dis Markers 21:147-51. 2005
    ..77, p< 0.001). Patterns of DNA and histone methylation are similar in tissues across the spectrum of oral carcinogenesis, and there is a significant positive association between these two epigenetic mechanisms...
  64. ncbi request reprint Treatment of pancreatic cancer xenografts with Erbitux (IMC-C225) anti-EGFR antibody, gemcitabine, and radiation
    Donald J Buchsbaum
    Department of Radiation Oncology, University of Alabama at Birmingham, Wallace Tumor Institute, Room 674, 1824 6th Avenue South, Birmingham, AL 35294, USA
    Int J Radiat Oncol Biol Phys 54:1180-93. 2002
    ..To investigate treatment of human pancreatic cancer cell lines and xenografts with combinations of Erbitux (IMC-C225) anti-epidermal growth factor receptor (EGFR) antibody, gemcitabine, and radiation...
  65. ncbi request reprint Suppression by L-methionine of cell cycle progression in LNCaP and MCF-7 cells but not benign cells
    Maximo A Benavides
    Department of Pathology, University of Illinois at Chicago, College of Medicine, 840 South Wood Street, Chicago, Illinois 60612, USA
    Anticancer Res 30:1881-5. 2010
    ..Methionine inhibits proliferation of breast and prostate cancer cells. This study aimed to determine cell cycle effects of methionine and selectivity for cancer cells...
  66. ncbi request reprint Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM)
    Jessica M Grunda
    Departments of Pharmacology and Toxicology, Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA
    J Neurooncol 80:261-74. 2006
    ....
  67. ncbi request reprint Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function
    Cunren Liu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
    J Immunol 176:1375-85. 2006
    ..We propose that tumor exosomes contribute to the growth of tumors by blocking IL-2-mediated activation of NK cells and their cytotoxic response to tumor cells...
  68. pmc Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer
    Kang Liu
    Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    Mol Cell Biol 29:2673-93. 2009
    ..Thus, a physiological level of TopBP1 is essential for normal G(1)/S transition, but a pathological level of TopBP1 in cancer may perturb p53 function and contribute to an aggressive tumor behavior...
  69. ncbi request reprint Cancer incidence among triazine herbicide manufacturing workers
    Paul A MacLennan
    Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama
    J Occup Environ Med 44:1048-58. 2002
    ..There is no epidemiologic or other information that clearly supports a causal relation between atrazine and prostate cancer...
  70. pmc Predictors of long-term outcome from intraperitoneal radioimmunotherapy for ovarian cancer
    Ruby Meredith
    Departments of Radiation Oncology, Medicine, Pathology and Gynecology, University of Alabama Comprehensive Cancer Center, Birmingham, Alabama, USA
    Cancer Biother Radiopharm 27:36-40. 2012
    ..Dose escalation of radionuclide did not change risk of progression; thus, this therapy may have therapeutic efficacy at modest dose levels...
  71. ncbi request reprint Ovarian biopsy in infertile patients with ovarian dysfunction
    Victor Vital-Reyes
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Int J Gynecol Pathol 25:90-4. 2006
    ..Therefore, its use cannot be generalized in the study of infertile patients with ovarian dysfunction. In contrast, ovarian biopsies may be useful to identify patients with POF when the ovarian reserve is likely altered...
  72. pmc Dual effects of TGF-beta on ERalpha-mediated estrogenic transcriptional activity in breast cancer
    Yongsheng Ren
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249 USA
    Mol Cancer 8:111. 2009
    ..We investigated how TGF-beta regulates ERalpha-induced gene transcription and potential mechanisms of frequent TGF-beta resistance in breast cancer...
  73. pmc Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells
    Yuelong Liu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Pathol 176:2490-9. 2010
    ..Together these data demonstrate a pivotal role for MyD88 in tumor exosome-mediated expansion of MDSCs and tumor metastasis...
  74. ncbi request reprint Anosmin-1 involved in neuronal cell migration is hypoxia inducible and cancer regulated
    Bixi Jian
    Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA
    Cell Cycle 8:3770-6. 2009
    ..Our results suggest that KAL1 gene expression plays an important role in cancer metastasis and protection from apoptosis...
  75. ncbi request reprint A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death
    Huang Ge Zhang
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, 35294, USA
    J Immunol 176:7385-93. 2006
    ..Neutralization of exosomal membrane TNF-alpha by sTNFbp partially reversed this resistance, suggesting that not only TNF-alpha but also additional exosomal proteins may contribute to the development of apoptosis resistance...
  76. ncbi request reprint Promoter hypermethylation profile of kidney cancer
    Essel Dulaimi
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 10:3972-9. 2004
    ..To gain insight into the role of epigenetic silencing of tumor suppressor and cancer genes in kidney tumorigenesis, we determined a hypermethylation profile of kidney cancer...
  77. ncbi request reprint CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion
    Shailesh Singh
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    Lab Invest 84:1666-76. 2004
    ..These studies reveal important cellular and molecular mechanisms of CXCR4/CXCL12-mediated prostate cancer cell migration and invasion...
  78. ncbi request reprint Expression and functional role of CCR9 in prostate cancer cell migration and invasion
    Shailesh Singh
    Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Clin Cancer Res 10:8743-50. 2004
    ..The current study evaluates the molecular mechanisms of CCL25 and CCR9 in prostate cancer cell migration and invasion...
  79. ncbi request reprint A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers
    Carol J Fabian
    University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Clin Cancer Res 8:3105-17. 2002
    ..DFMO is an irreversible inhibitor of ornithine decarboxylase, the limiting enzyme of polyamine synthesis that is often up-regulated in breast cancer...
  80. pmc Receiver operating characteristic (ROC) to determine cut-off points of biomarkers in lung cancer patients
    Heidi L Weiss
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Dis Markers 19:273-8. 2003
    ....
  81. ncbi request reprint LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancer
    Monica Davila
    Department of Molecular Biology and Microbiology University of Central Florida, Orlando, Florida 32826, USA
    J Biol Chem 278:36868-75. 2003
    ..Our study correlates with the recent observations showing a metastasis-associated chromosomal gain on 7q11.2 in prostate cancer, suggesting a possible gain in LIMK1 DNA (7q11.23)...
  82. pmc Expression of LIM kinase 1 is associated with reversible G1/S phase arrest, chromosomal instability and prostate cancer
    Monica Davila
    Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, Florida, USA
    Mol Cancer 6:40. 2007
    ..In this study, we investigated the effects of ectopic expression of LIMK1 on cellular morphology, cell cycle progression and expression profile of LIMK1 in prostate tumors...
  83. ncbi request reprint SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer
    Dale McLerran
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Clin Chem 54:53-60. 2008
    ..This report is the 2nd of 2 companion articles describing a validation study of a SELDI-TOF MS approach with IMAC surface sample processing to identify prostatic adenocarcinoma...
  84. pmc p53 Nuclear accumulation and Bcl-2 expression in contiguous adenomatous components of colorectal adenocarcinomas predict aggressive tumor behavior
    Chandrakumar Shanmugam
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Histochem Cytochem 56:305-12. 2008
    ..77 months). These findings suggest that in those adenomas that demonstrate p53(nac) but lack Bcl-2 expression, their contiguous CRCs are more likely to be aggressive as they progress...
  85. pmc Early therapy evaluation of combined anti-death receptor 5 antibody and gemcitabine in orthotopic pancreatic tumor xenografts by diffusion-weighted magnetic resonance imaging
    Hyunki Kim
    Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Cancer Res 68:8369-76. 2008
    ..This study supports the clinical use of DWI for pancreatic tumor patients for early assessment of drug efficacy...
  86. ncbi request reprint Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer
    Liza D Robles
    Department of Molecular Biology and Microbiology, University of Central Florida, Orlando 32826 2362, USA
    J Biol Chem 277:25431-8. 2002
    ..Our study suggests a potential use of the lack of CDC6 expression as an index of prostate cancer development...

Research Grants8

  1. Confocal DNA Cytometry Prostate Cancer- Age & Ethnicity
    William Grizzle; Fiscal Year: 2002
    ..We will test the negative hypothesis that age and ethnic groups, with all other prognostic variables being equal, will have no correlation with tumor aggressiveness. ..
  2. Confocal DNA Cytometry Prostate Cancer- Age & Ethnicity
    William Grizzle; Fiscal Year: 2003
    ..We will test the negative hypothesis that age and ethnic groups, with all other prognostic variables being equal, will have no correlation with tumor aggressiveness. ..
  3. Biomarker Reference Laboratory, EDRN
    William Grizzle; Fiscal Year: 2005
    ....
  4. Biomarker Reference Laboratory, EDRN
    William Grizzle; Fiscal Year: 2007
    ....
  5. COOPERATIVE HUMAN TISSUE NETWORK
    William Grizzle; Fiscal Year: 2007
    ..In the next funding cycle,\par consortium agreements with participating institutions will provide access to tissues from more than\par 150,000 surgical procedures with a goal of supplying 50,000 samples.\fs20\par \par } ..