Research Topics
Genomes and Genes | William GrizzleSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Publications
Molecular characterization of colorectal neoplasia in translational researchW E Grizzle
Department of Pathology, Comprehensive Cancer Center, Bio Statistics Unit, University of Alabama at Birmingham, Birmingham, Ala 35233 0007, USA
Arch Pathol Lab Med 125:91-8. 2001..We also review the ways in which molecular markers may aid the early detection of colorectal neoplasia and promote our understanding of the earliest changes in colorectal neoplasia...- Avoiding biohazards in medical, veterinary and research laboratoriesW E Grizzle
Department of Pathology, University of Alabama at Birmingham, 35294, USA
Biotech Histochem 76:183-206. 2001..The issues discussed can be used to develop a general safety program as required by regulatory or accrediting agencies, including the Occupational Safety and Health Administration... - Serum protein expression profiling for cancer detection: validation of a SELDI-based approach for prostate cancerWilliam E Grizzle
University of Alabama at Birmingham, Birmingham, AL 35233 0007, USA
Dis Markers 19:185-95. 2003..At the end of this validation study, the usefulness of the general SELDI-TOF-MS approach to identifying patients with PCA will be demonstrated and how it compares with PCA diagnosis by measuring prostate specific antigen... - Molecular staging of colorectal cancer in African-American and Caucasian patients using phenotypic expression of p53, Bcl-2, MUC-1 AND p27(kip-1)William E Grizzle
Department of Pathology, UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35233 0007, USA
Int J Cancer 97:403-9. 2002..Nevertheless, nuclear accumulation of p53 (p53(nac)) and phenotypic expression of Bcl-2, MUC-1 and p27(kip-1) may be molecular markers approaching acceptance for use in molecular staging of specific subgroups of colorectal cancers... - Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancerAshka Y Pandya
Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
Clin Cancer Res 10:2709-19. 2004..Although KLF4 expression is increased in most cases of breast cancer, it was unknown whether these cases represent a distinct subtype with a different clinical outcome... - Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspiratesNirag Jhala
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Am J Clin Pathol 126:572-9. 2006..Clusterin-beta and MUC4 can help distinguish reactive ductal epithelial cells from the cells of pancreatic adenocarcinoma in FNA samples... 
Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducerJ Robert Newman
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, USA
Arch Otolaryngol Head Neck Surg 134:1218-24. 2008..Tumor cell-derived EMMPRIN is highly overexpressed in HNSCC and is thought to be induced by surrounding fibroblasts to stimulate matrix metalloproteases, which modulate tumor cell invasion, growth, and angiogenesis...- A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomesDongmei Sun
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Mol Ther 18:1606-14. 2010..The specificity of using exosomes as a drug carrier creates opportunities for treatments of many inflammation-related diseases without significant side effects due to innocent bystander or off-target effects... - KISS1 over-expression suppresses metastasis of pancreatic adenocarcinoma in a xenograft mouse modelLacey R McNally
Department of Radiation Oncology, University of Alabama at Birmingham, 35294 2182, USA
Clin Exp Metastasis 27:591-600. 2010..These data suggest induction of KISS1 expression has potential as an adjuvant treatment for pancreatic cancer... - TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growthLeo Christopher DeRosier
Departments of Surgery, University of Alabama at Birmingham, 1530 3rd Avenue South, Wallace Tumor Institute 674, Birmingham, AL 35294 6832, USA
Mol Cancer Ther 6:3198-207. 2007..To evaluate agonistic TRA-8 monoclonal antibody to human death receptor 5 (DR5) and gemcitabine in vitro and in an orthotopic pancreatic cancer model... - Gli1 promotes cell survival and is predictive of a poor outcome in ERalpha-negative breast cancerLusheng Xu
Department of Pathology, University of Alabama at Birmingham, Kaul 640B, 1530 Third Avenue South, Birmingham, AL 35294, USA
Breast Cancer Res Treat 123:59-71. 2010..005), but not ERalpha-positive cancers. In conclusion, we demonstrate a positive association between expression of Gli1 and ERalpha; however, our data indicate a greater functional effect of Gli1 in ERalpha-negative cancers... - Intravenous delivery of adenovirus-mediated soluble FLT-1 results in liver toxicityParameshwar J Mahasreshti
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Clin Cancer Res 9:2701-10. 2003..Tumor-specific targeting of the vectors and tumor-specific expression strategies should be used to ensure a clinically useful antiangiogenesis gene therapy... - Recurrence and survival predictive value of phenotypic expression of Bcl-2 varies with tumor stage of colorectal adenocarcinomaChakrapani Chatla
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Cancer Biomark 1:241-50. 2005..These findings might be useful in identifying biologically aggressive phenotypes of Stage II CRCs, and may aid the oncologist in designing maximally appropriate therapeutic regimens... - Adenovirus-mediated FLT1-targeted proapoptotic gene therapy of human prostate cancerSergey A Kaliberov
Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Mol Ther 10:1059-70. 2004..Our results suggest that specific TRAIL delivery employing the FLT1 promoter can effectively inhibit tumor growth and demonstrate the advantage of combination radiotherapy and gene therapy for the treatment of prostate cancer... - Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer modelJ Michael Straughn
Division of Gynecologic Oncology, University of Alabama at Birmingham, 619 19th Street South, OHB Room 538, Birmingham, AL 35249, USA
Gynecol Oncol 101:46-54. 2006..We sought to determine the therapeutic potential of TRA-8 (anti-DR5 monoclonal antibody) in combination with chemotherapy and radiation therapy in a cervical cancer model... - p53 and erbB-2 are not associated in matched cases of primary and metastatic ovarian carcinomasCristina Rodriguez-Burford
Department of Pathology, The University of Alabama at Birmingham, AL 35294, USA
Dis Markers 19:11-7. 2003..Thus, the nuclear accumulation of p53 and immunostaining of p185erbB-2 in the cytoplasm or on the cellular membranes are independent... - Adenoviral vector-mediated augmentation of epidermal growth factor receptor (EGFr) enhances the radiosensitization properties of anti-EGFr treatment in prostate cancer cellsJames A Bonner
Department of Radiation Oncology, University of Alabama School of Medicine, Birmingham, Alabama, USA
Int J Radiat Oncol Biol Phys 58:950-8. 2004.... 
Effect of TRA-8 anti-death receptor 5 antibody in combination with chemotherapy in an ex vivo human ovarian cancer modelPeter J Frederick
Division of Gynecologic Oncology, Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL, USA
Int J Gynecol Cancer 19:814-9. 2009..To investigate the cytotoxicity of TRA-8, an antibody that specifically binds death receptor 5, alone and in combination with chemotherapy, using an ex vivo human ovarian cancer model...- A Phase I study of combined modality (90)Yttrium-CC49 intraperitoneal radioimmunotherapy for ovarian cancerRonald D Alvarez
Department of Obstetrics, University of Alabama at Birmingham Cancer Center, Birmingham, Alabama 35233, USA
Clin Cancer Res 8:2806-11. 2002..The purpose of this study was to determine the feasibility and maximum tolerated dose of (90)Yttrium-CC49 ((90)Y-CC49) as the radioimmunotherapy (RIT) component of an i.p. combined modality treatment for recurrent ovarian cancer... - Experimental cancer therapy using restoration of NAD+ -linked 15-hydroxyprostaglandin dehydrogenase expressionLyudmila N Kaliberova
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
Mol Cancer Ther 8:3130-9. 2009..These results suggest that 15-PGDH-mediated regulation of PGE(2) catabolism in the tumor microenvironment represents a novel approach for therapy of human breast and colon cancer... - Smad4 inhibits tumor growth by inducing apoptosis in estrogen receptor-alpha-positive breast cancer cellsQingnan Li
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
J Biol Chem 280:27022-8. 2005..Smad4-induced apoptosis in ERalpha-positive breast cancer cells may explain the invasive nature of ERalpha-negative breast tumors, thereby providing a potential target for breast cancer intervention... - Breast tumor xenografts: diffusion-weighted MR imaging to assess early therapy with novel apoptosis-inducing anti-DR5 antibodyHyunki Kim
Department of Radiology, University of Alabama at Birmingham, 1530 3rd Ave S, BDB 11, Birmingham, AL 35294, USA
Radiology 248:844-51. 2008..To measure the early therapeutic response to a novel apoptosis-inducing antibody, TRA-8, by using diffusion-weighted magnetic resonance (MR) imaging in a mouse breast cancer model... - Postsurgical disparity in survival between African Americans and Caucasians with colonic adenocarcinomaDominik Alexander
Department of Epidemiology, University of Alabama-Birmingham, 19th Street South, Birmingham, AL 35294-0007, USA
Cancer 101:66-76. 2004.... - BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor modelWilliam E Grizzle
Department of Pathology, University of Alabama at Birmingham, AL 35294-0007, USA
Int J Cancer 101:270-9. 2002..The T-cell immune response minimized tumor development in types III and IV since T-cell depletion of the BXD RI mice resulted in aggressively growing tumors in these strains... - Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasiaKyoko Kojima
Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
Cancer Res 67:8121-30. 2007..This indicates that Smad4 is dispensable for normal pancreatic development but is critical for at least partial suppression of multiple Kras(G12D)-dependent disease-associated phenotypes... - Combination treatment with TRA-8 anti death receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of pancreatic cancerLeo Christopher DeRosier
Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 6832, USA
Clin Cancer Res 13:5535s-5543s. 2007..Evaluate the response of human pancreatic cancer cell lines and orthotopic tumors to TRA-8, an agonistic antibody to death receptor 5, in combination with irinotecan (CPT-11)... - Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptorGandham Mahendra
Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
Cancer Gene Ther 12:26-34. 2005..These studies indicate that rAAV-mediated sFlt-1 gene therapy may be a feasible approach for inhibiting tumor angiogenesis, particularly as an adjuvant/therapy... - Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblastsXinwen Yang
Department of Medicine, University of Alabama at Birmingham, and the Birmingham Veterans Administration Medical Center, Birmingham, AL 35294-0007, USA
Am J Pathol 167:705-19. 2005..Taken together, our findings suggest a unique role for caspase-4 in cleaving vimentin and releasing cytosolic p53 for nuclear translocation, events that may regulate the sensitivity of RASFs to receptor-mediated apoptosis... - Exosomes are endogenous nanoparticles that can deliver biological information between cellsDongmei Sun
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Adv Drug Deliv Rev 65:342-7. 2013..This review will focus on exosomes as a biological nanoparticle drug carrier with emphasis on their immune-regulatory activities... - Smad4 as a transcription corepressor for estrogen receptor alphaLiyu Wu
Department of Pathology, University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama 35294, USA
J Biol Chem 278:15192-200. 2003..Our findings represent a novel mechanism that TGF-beta may regulate cell fate through Smad4-mediated cross-talk with estrogen... - Role of microvascular density in nonlocalizing parathyroid sestamibi scansGlenn Peters
Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
Laryngoscope 117:2163-8. 2007..We hypothesize that an increase in microvascular density (MVD) within an adenoma will result in rapid tracer washout and a subsequent nonlocalizing scan. This study investigates the role of MVD in sestamibi localization... - Patterns of global DNA and histone methylation appear to be similar in normal, dysplastic and neoplastic oral epithelium of humansChandrika J Piyathilake
Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
Dis Markers 21:147-51. 2005..77, p< 0.001). Patterns of DNA and histone methylation are similar in tissues across the spectrum of oral carcinogenesis, and there is a significant positive association between these two epigenetic mechanisms... - Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R IRESScott W Blume
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Exp Mol Pathol 88:341-52. 2010.... - DCE-MRI detects early vascular response in breast tumor xenografts following anti-DR5 therapyHyunki Kim
The Department of Radiology, University of Alabama at Birmingham, AL 35294, USA
Mol Imaging Biol 13:94-103. 2011..Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) measured the early vascular changes after administration of TRA-8, bevacizumab, or TRA-8 combined with bevacizumab in breast tumor xenografts... - How to efficiently obtain human tissues to support specific biomedical research projectsWalter C Bell
University of Alabama at Birmingham, Alabama 35294 0007, USA
Cancer Epidemiol Biomarkers Prev 18:1676-9. 2009..This review is best accomplished by discussing their requests with the tissue resource and correcting specific limitations that block access to the tissues they need... - Oncolytic HSV-1 for the treatment of brain tumoursJames M Markert
Division of Neurosurgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 3410, USA
Herpes 13:66-71. 2006..In this review, the background of this approach will be discussed, followed by a discussion of the clinical trials, as well as potential directions for future trials... - Prognostic significance of p53 codon 72 polymorphism differs with race in colorectal adenocarcinomaVenkat R Katkoori
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 7331, USA
Clin Cancer Res 15:2406-16. 2009..Therefore, this study assessed the prognostic value of this polymorphism in African American and Caucasian colorectal adenocarcinoma patients separately... - Tumor exosomes inhibit differentiation of bone marrow dendritic cellsShaohua Yu
Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Immunol 178:6867-75. 2007..These data suggest that tumor exosome-mediated induction of IL-6 plays a role in blocking BM DC differentiation... - Mandatory fortification with folic acid in the United States is associated with increased expression of DNA methyltransferase-1 in the cervixChandrika J Piyathilake
Department of Nutrition Sciences, The University of Alabama at Birmingham, Alabama, USA
Nutrition 24:94-9. 2008.... - SIRT1 is significantly elevated in mouse and human prostate cancerDerek M Huffman
Division of Physiology and Metabolism, Department of Nutrition Sciences, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
Cancer Res 67:6612-8. 2007..Because SIRT1 may function as a tumor promoter, these results suggest that SIRT1 should be considered as a potential therapeutic target for prostate cancer... - Anti-tumor activity of the TRA-8 anti-DR5 antibody in combination with cisplatin in an ex vivo human cervical cancer modelJames E Kendrick
Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Gynecol Oncol 108:591-7. 2008..To investigate the cytotoxicity of TRA-8, an antibody that specifically binds death receptor 5 (DR5), alone and in combination with cisplatin, using an ex vivo human cervical cancer model... - Mandatory fortification with folic acid in the United States is not associated with changes in the degree or the pattern of global DNA methylation in cells involved in cervical carcinogenesisChandrika J Piyathilake
Department of Nutrition Sciences, The University of Alabama at Birmingham, AL 35294, USA
Cancer Biomark 2:259-66. 2006..These results suggest that mandatory fortification with folic acid in the United States has not resulted in a change in the degree or the pattern of global DNA methylation in cells involved in cervical carcinogenesis... - Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicityHuang Ge Zhang
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Biochim Biophys Acta 1773:1116-23. 2007..These data suggest that partial reversal of tumor exosome-mediated inhibition of NK cell tumor cytotoxicity may account for the anti-cancer properties of curcumin... - Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing hostCunren Liu
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Alabama 35294 0007, USA
Blood 109:4336-42. 2007..Western blot analyses further suggests that MSCs suppress IL-2-mediated NK cell cytotoxicity by affecting the activity of Stat5... - Phase I study of 90Y-CC49 monoclonal antibody therapy in patients with advanced non-small cell lung cancer: effect of chelating agents and paclitaxel co-administrationAndres Forero
Department of Medicine, Comprehensive Cancer Center, University of Alabama at Birmingham, 1824 Sixth Avenue South, Birmingham, AL 35294 3300, USA
Cancer Biother Radiopharm 20:467-78. 2005.... - Expression of CEA, Tag-72, and Lewis-Y antigen in primary and metastatic lesions of ovarian carcinomaDavid C Chhieng
Department of Pathology, University of Alabama, Birmingham 35249-6823, USA
Hum Pathol 34:1016-21. 2003..CEA (Col-1), due to its low expression and variation in phenotypic expression between primary and metastatic lesions, should be evaluated carefully in metastatic lesions before targeting the CEA antigen with CEA (Col-1)-like antibodies... - Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer modelDonald J Buchsbaum
Departments of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Clin Cancer Res 9:3731-41. 2003..Tumor size and regression rates were determined. In addition, a study was carried out with TRA-8 and Adriamycin in combination with 3 Gy (60)Co irradiation of 2LMP xenografts on days 9 and 17... - Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinomaEben L Rosenthal
Division of Otolarynology Head and Neck Surgery, Comprehensive Cancer Center, University of Alabama at Birmingham, 35249, USA
Laryngoscope 113:1406-10. 2003..We hypothesize that EMMPRIN is overexpressed in laryngeal cancer... - Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lungChandrika J Piyathilake
Department Nutrition Sciences, Heidi Weiss Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Clin Cancer Res 8:734-44. 2002.... - Inhibition of tumorigenicity by the 5'-untranslated RNA of the human c-myc P0 transcriptScott W Blume
Department of Medicine, University of Alabama at Birmingham, Tumor Institute, Room 508, 1824 6th Avenue South, Birmingham, AL 35294 3300, USA
Exp Cell Res 288:131-42. 2003.... - The pattern of expression of Mn and Cu-Zn superoxide dismutase varies among squamous cell cancers of the lung, larynx, and oral cavityChandrika J Piyathilake
Division of Nutritional Biochemistry and Molecular Biology, University of Alabama at Birmingham, University Station, Birmingham, Alabama 35294, USA
Head Neck 24:859-67. 2002..Despite the importance of reactive oxygen species (ROS) in the development of smoking-related cancers, little is known about the pattern of expression of ROS scavengers in these cancers... - Nuclear accumulation of p53 is a potential marker for the development of squamous cell lung cancer in smokersChandrika J Piyathilake
Department of Nutrition Sciences, The University of Alabama, Birmingham, AL 35294, USA
Chest 123:181-6. 2003.... - Effects of body weight gain reduction resulting from chemopreventive agent treatment on mammary gland morphologyCristina Rodriguez-Burford
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Nutr Cancer 43:67-75. 2002..It would appear that the observed decrease in mammary cancers observed with moderate reductions in body weight gain might be due to multiple related factors different from those related to 4-HPR treatment... - Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in miceKurt R Zinn
Depts of Radiology, University of Alabama at Birmingham, Boshell Bldg, BDB 11, 1530 3rd Ave S, Birmingham, AL 35294 0012, USA
Radiology 223:417-25. 2002..To compare two systems for assessing gene transfer to cancer cells and xenograft tumors with noninvasive gamma camera imaging... - Treatment of pancreatic cancer xenografts with Erbitux (IMC-C225) anti-EGFR antibody, gemcitabine, and radiationDonald J Buchsbaum
Department of Radiation Oncology, University of Alabama at Birmingham, Wallace Tumor Institute, Room 674, 1824 6th Avenue South, Birmingham, AL 35294, USA
Int J Radiat Oncol Biol Phys 54:1180-93. 2002..To investigate treatment of human pancreatic cancer cell lines and xenografts with combinations of Erbitux (IMC-C225) anti-epidermal growth factor receptor (EGFR) antibody, gemcitabine, and radiation... - A phase I trial of the single-chain immunotoxin SGN-10 (BR96 sFv-PE40) in patients with advanced solid tumorsJames A Posey
Departments of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
Clin Cancer Res 8:3092-9. 2002..024 to 0.962 mg/m(2), administered on days 1, 4, 8, and 11, followed by 2 weeks of rest and a second cycle of therapy. Pharmacokinetics and human antibody response to SGN-10 were also determined... - MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspirationDavid C Chhieng
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249 6823, USA
Cancer 99:365-71. 2003.... - High-grade tumor differentiation is an indicator of poor prognosis in African Americans with colonic adenocarcinomasDominik Alexander
Department of Epidemiology, University of Alabama-Birmingham, Birmingham, Alabama 35294-7331, USA
Cancer 103:2163-70. 2005.... - Pattern of nonspecific (or global) DNA methylation in oral carcinogenesisChandrika J Piyathilake
Department of Nutrition Sciences, Division of Nutritional Biochemistry and Molecular Biology, University of Alabama at Birmingham, University Station, Birmingham, AL 35294, USA
Head Neck 27:1061-7. 2005.... - Effects of nonsteroidal anti-inflammatory agents (NSAIDs) on ovarian carcinoma cell lines: preclinical evaluation of NSAIDs as chemopreventive agentsCristina Rodriguez-Burford
Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Biostatistics Unit, The University of Alabama at Birmingham, Birmingham, Alabama 35213, USA
Clin Cancer Res 8:202-9. 2002..The purpose of this study was to investigate the cellular effects of acetylsalicylic acid (ASA), acetaminophen, and a COX-2 inhibitor (NS-398) on the growth of cell lines of human ovarian cancer in vitro... - Quantitation of cytosine deaminase mRNA by real-time reverse transcription polymerase chain reaction: a sensitive method for assessing 5-fluorocytosine toxicity in vitroC Ryan Miller
Department of Radiation Oncology, Comprehensive Cancer Center, Birmingham, Alabama 35294, USA
Anal Biochem 301:189-99. 2002.... - Hormone receptors and proliferation in breast carcinomas of equivalent histologic grades in pre- and postmenopausal womenLynya I Talley
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
Int J Cancer 98:118-27. 2002..Our data also suggest that some prognostic factors are not equally effective as predictors of survival in pre- and postmenopausal women... - Prognostic significance of p27(kip-1) expression in colorectal adenocarcinomas is associated with tumor stageUpender Manne
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
Clin Cancer Res 10:1743-52. 2004..Therefore, in this study, we investigated whether the prognostic value of p27(kip-1) expression varies with the tumor site, tumor stage and patient ethnicity... - Adeno-associated virus 2-mediated antiangiogenic cancer gene therapy: long-term efficacy of a vector encoding angiostatin and endostatin over vectors encoding a single factorSelvarangan Ponnazhagan
Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Cancer Res 64:1781-7. 2004.... - Suppression by L-methionine of cell cycle progression in LNCaP and MCF-7 cells but not benign cellsMaximo A Benavides
Department of Pathology, University of Illinois at Chicago, College of Medicine, 840 South Wood Street, Chicago, Illinois 60612, USA
Anticancer Res 30:1881-5. 2010..Methionine inhibits proliferation of breast and prostate cancer cells. This study aimed to determine cell cycle effects of methionine and selectivity for cancer cells... - Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell functionCunren Liu
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
J Immunol 176:1375-85. 2006..We propose that tumor exosomes contribute to the growth of tumors by blocking IL-2-mediated activation of NK cells and their cytotoxic response to tumor cells... - Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM)Jessica M Grunda
Departments of Pharmacology and Toxicology, Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA
J Neurooncol 80:261-74. 2006.... - Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancerKang Liu
Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
Mol Cell Biol 29:2673-93. 2009..Thus, a physiological level of TopBP1 is essential for normal G(1)/S transition, but a pathological level of TopBP1 in cancer may perturb p53 function and contribute to an aggressive tumor behavior... - Cancer incidence among triazine herbicide manufacturing workersPaul A MacLennan
Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama
J Occup Environ Med 44:1048-58. 2002..There is no epidemiologic or other information that clearly supports a causal relation between atrazine and prostate cancer... - Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cellsYuelong Liu
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Am J Pathol 176:2490-9. 2010..Together these data demonstrate a pivotal role for MyD88 in tumor exosome-mediated expansion of MDSCs and tumor metastasis... - Dual effects of TGF-beta on ERalpha-mediated estrogenic transcriptional activity in breast cancerYongsheng Ren
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249 USA
Mol Cancer 8:111. 2009..We investigated how TGF-beta regulates ERalpha-induced gene transcription and potential mechanisms of frequent TGF-beta resistance in breast cancer... - Anosmin-1 involved in neuronal cell migration is hypoxia inducible and cancer regulatedBixi Jian
Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA
Cell Cycle 8:3770-6. 2009..Our results suggest that KAL1 gene expression plays an important role in cancer metastasis and protection from apoptosis... - A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell deathHuang Ge Zhang
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, 35294, USA
J Immunol 176:7385-93. 2006..Neutralization of exosomal membrane TNF-alpha by sTNFbp partially reversed this resistance, suggesting that not only TNF-alpha but also additional exosomal proteins may contribute to the development of apoptosis resistance... - Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancerLiza D Robles
Department of Molecular Biology and Microbiology, University of Central Florida, Orlando 32826 2362, USA
J Biol Chem 277:25431-8. 2002..Our study suggests a potential use of the lack of CDC6 expression as an index of prostate cancer development... - A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkersCarol J Fabian
University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Clin Cancer Res 8:3105-17. 2002..Subjects were randomized to 6 months of oral DFMO (0.5 g/m(2)/day) or placebo, followed by repeat fine-needle aspiration and biomarker assessment. The main study end point was an improvement in cytologic pattern... - Expression and functional role of CCR9 in prostate cancer cell migration and invasionShailesh Singh
Morehouse School of Medicine, Atlanta, Georgia 30310, USA
Clin Cancer Res 10:8743-50. 2004..The current study evaluates the molecular mechanisms of CCL25 and CCR9 in prostate cancer cell migration and invasion... - CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasionShailesh Singh
Morehouse School of Medicine, Atlanta, GA 30310, USA
Lab Invest 84:1666-76. 2004..These studies reveal important cellular and molecular mechanisms of CXCR4/CXCL12-mediated prostate cancer cell migration and invasion... - Receiver operating characteristic (ROC) to determine cut-off points of biomarkers in lung cancer patientsHeidi L Weiss
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Dis Markers 19:273-8. 2003.... - Promoter hypermethylation profile of kidney cancerEssel Dulaimi
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Clin Cancer Res 10:3972-9. 2004..To gain insight into the role of epigenetic silencing of tumor suppressor and cancer genes in kidney tumorigenesis, we determined a hypermethylation profile of kidney cancer... - Expression of LIM kinase 1 is associated with reversible G1/S phase arrest, chromosomal instability and prostate cancerMonica Davila
Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, Florida, USA
Mol Cancer 6:40. 2007..In this study, we investigated the effects of ectopic expression of LIMK1 on cellular morphology, cell cycle progression and expression profile of LIMK1 in prostate tumors... - SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancerDale McLerran
Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Clin Chem 54:53-60. 2008..This report is the 2nd of 2 companion articles describing a validation study of a SELDI-TOF MS approach with IMAC surface sample processing to identify prostatic adenocarcinoma... - LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancerMonica Davila
Department of Molecular Biology and Microbiology University of Central Florida, Orlando, Florida 32826, USA
J Biol Chem 278:36868-75. 2003..Our study correlates with the recent observations showing a metastasis-associated chromosomal gain on 7q11.2 in prostate cancer, suggesting a possible gain in LIMK1 DNA (7q11.23)... - Early therapy evaluation of combined anti-death receptor 5 antibody and gemcitabine in orthotopic pancreatic tumor xenografts by diffusion-weighted magnetic resonance imagingHyunki Kim
Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
Cancer Res 68:8369-76. 2008..This study supports the clinical use of DWI for pancreatic tumor patients for early assessment of drug efficacy... - p53 Nuclear accumulation and Bcl-2 expression in contiguous adenomatous components of colorectal adenocarcinomas predict aggressive tumor behaviorChandrakumar Shanmugam
Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
J Histochem Cytochem 56:305-12. 2008..77 months). These findings suggest that in those adenomas that demonstrate p53(nac) but lack Bcl-2 expression, their contiguous CRCs are more likely to be aggressive as they progress...
Research Grants
- Confocal DNA Cytometry Prostate Cancer- Age & EthnicityWilliam Grizzle; Fiscal Year: 2003..We will test the negative hypothesis that age and ethnic groups, with all other prognostic variables being equal, will have no correlation with tumor aggressiveness. ..
- Biomarker Reference Laboratory, EDRNWilliam Grizzle; Fiscal Year: 2007....
- COOPERATIVE HUMAN TISSUE NETWORKWilliam Grizzle; Fiscal Year: 2007..In the next funding cycle,\par consortium agreements with participating institutions will provide access to tissues from more than\par 150,000 surgical procedures with a goal of supplying 50,000 samples.\fs20\par \par } ..