W E Grizzle

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc The effect of antigen retrieval on cells fixed in 10% neutral buffered formalin followed by transfer to 70% ethanol
    Dennis Otali
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 8:e82405. 2013
  2. pmc Differential expression of breast cancer-associated genes between stage- and age-matched tumor specimens from African- and Caucasian-American Women diagnosed with breast cancer
    Jessica M Grunda
    Department of Medicine, Division of Endocrinology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    BMC Res Notes 5:248. 2012
  3. pmc CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion
    Erica L Johnson
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    World J Surg Oncol 8:62. 2010
  4. pmc Expression of LIM kinase 1 is associated with reversible G1/S phase arrest, chromosomal instability and prostate cancer
    Monica Davila
    Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, Florida, USA
    Mol Cancer 6:40. 2007
  5. pmc Dual effects of TGF-beta on ERalpha-mediated estrogenic transcriptional activity in breast cancer
    Yongsheng Ren
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249 USA
    Mol Cancer 8:111. 2009
  6. pmc CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion
    Erica L Johnson
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310, USA
    J Ovarian Res 3:15. 2010
  7. pmc Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer
    Chandrakumar Shanmugam
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Hematol Oncol 4:25. 2011
  8. pmc The deployment of a tissue request tracking system for the CHTN: a case study in managing change in informatics for biobanking operations
    Mary E Edgerton
    Section of Pathology Informatics, Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA
    BMC Med Inform Decis Mak 10:32. 2010
  9. pmc Special symposium: fixation and tissue processing models
    W E Grizzle
    Department of Pathology, University of Alabama at Birmingham, Zeigler Research Building, ZRB 408, 703 South 19th Street, Birmingham, AL 35294 0007, USA
    Biotech Histochem 84:185-93. 2009
  10. pmc Translational pathology of neoplasia
    William E Grizzle
    Department of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, AL, USA
    Cancer Biomark 9:7-20. 2010

Collaborators

Detail Information

Publications49

  1. pmc The effect of antigen retrieval on cells fixed in 10% neutral buffered formalin followed by transfer to 70% ethanol
    Dennis Otali
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 8:e82405. 2013
    ....
  2. pmc Differential expression of breast cancer-associated genes between stage- and age-matched tumor specimens from African- and Caucasian-American Women diagnosed with breast cancer
    Jessica M Grunda
    Department of Medicine, Division of Endocrinology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    BMC Res Notes 5:248. 2012
    ..The purpose of this study was to investigate gene expression differences between Caucasian-American women (CAW) and AAW that may contribute to this poorer prognosis...
  3. pmc CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion
    Erica L Johnson
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    World J Surg Oncol 8:62. 2010
    ..The current study shows OvCa tissue and cells significantly express CCR9, which interacts with CCL25 to support carcinoma cell migration and invasion...
  4. pmc Expression of LIM kinase 1 is associated with reversible G1/S phase arrest, chromosomal instability and prostate cancer
    Monica Davila
    Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, Florida, USA
    Mol Cancer 6:40. 2007
    ..In this study, we investigated the effects of ectopic expression of LIMK1 on cellular morphology, cell cycle progression and expression profile of LIMK1 in prostate tumors...
  5. pmc Dual effects of TGF-beta on ERalpha-mediated estrogenic transcriptional activity in breast cancer
    Yongsheng Ren
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249 USA
    Mol Cancer 8:111. 2009
    ..We investigated how TGF-beta regulates ERalpha-induced gene transcription and potential mechanisms of frequent TGF-beta resistance in breast cancer...
  6. pmc CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion
    Erica L Johnson
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310, USA
    J Ovarian Res 3:15. 2010
    ..In this study, we investigated the potential role and molecular mechanisms of CCR9-mediated inhibition of cisplatin-induced apoptosis in OvCa cells...
  7. pmc Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer
    Chandrakumar Shanmugam
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Hematol Oncol 4:25. 2011
    ..Although evaluation of at least 12 lymph nodes (LNs) is recommended as the minimum number of nodes required for accurate staging of colon cancer patients, there is disagreement on what constitutes an adequate identification of such LNs...
  8. pmc The deployment of a tissue request tracking system for the CHTN: a case study in managing change in informatics for biobanking operations
    Mary E Edgerton
    Section of Pathology Informatics, Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA
    BMC Med Inform Decis Mak 10:32. 2010
    ....
  9. pmc Special symposium: fixation and tissue processing models
    W E Grizzle
    Department of Pathology, University of Alabama at Birmingham, Zeigler Research Building, ZRB 408, 703 South 19th Street, Birmingham, AL 35294 0007, USA
    Biotech Histochem 84:185-93. 2009
    ..This article is a brief review of issues attending the use of 10% NBF combined with tissue processing as an interrelated process to study biomarkers identified by immunohistochemistry...
  10. pmc Translational pathology of neoplasia
    William E Grizzle
    Department of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, AL, USA
    Cancer Biomark 9:7-20. 2010
    ..The goal of this manuscript is to introduce the reader to how biomarkers may be used and the limitations on the uses of biomarkers in translational research...
  11. pmc The biology of incipient, pre-invasive or intraepithelial neoplasia
    William E Grizzle
    Department of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, AL, USA
    Cancer Biomark 9:21-39. 2010
    ..With the development of more molecularly targeted therapy with fewer side effects, preventive therapies may be more successfully targeted to pre-invasive neoplastic lesions...
  12. pmc Issues in collecting, processing and storing human tissues and associated information to support biomedical research
    William E Grizzle
    Division of Anatomic Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA
    Cancer Biomark 9:531-49. 2010
    ..A MTA should address biohazards as well as indemnification. Thus, many issues must be considered and addressed in order to establish and operate successfully a biorepository...
  13. ncbi request reprint Altered global methylation of DNA: an epigenetic difference in susceptibility for lung cancer is associated with its progression
    C J Piyathilake
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Pathol 32:856-62. 2001
    ..If these results are confirmed, the status of DNA methylation in early lesions such as epithelial hyperplasia could be used to identify smokers who are at risk for the development of SCC...
  14. ncbi request reprint Fatty acid synthase: an early molecular marker of progression of prostatic adenocarcinoma to androgen independence
    R B Myers
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Urol 165:1027-32. 2001
    ..Furthermore, increased fatty acid synthase levels associated with androgen independent proliferation may represent an early event in the development of the androgen independent phenotype...
  15. pmc Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritis
    X Xu
    Department of Physiology and Physics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Scand J Immunol 70:309-16. 2009
    ....
  16. ncbi request reprint Genetic dissection of age-related changes of immune function in mice
    J D Mountz
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Scand J Immunol 54:10-20. 2001
    ..This review outlines ongoing and future strategies that will enable the mapping and identification of these genes...
  17. doi request reprint CRAdRGDflt-IL24 virotherapy in combination with chemotherapy of experimental glioma
    L N Kaliberova
    Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35294 6832, USA
    Cancer Gene Ther 16:794-805. 2009
    ..These data indicate that combined treatment with CRAdRGDflt-IL24-mediated oncolytic virotherapy and TMZ chemotherapy provides a promising approach for glioma therapy...
  18. ncbi request reprint Molecular characterization of colorectal neoplasia in translational research
    W E Grizzle
    Department of Pathology, Comprehensive Cancer Center, Bio Statistics Unit, University of Alabama at Birmingham, Birmingham, Ala 35233 0007, USA
    Arch Pathol Lab Med 125:91-8. 2001
    ..To present recent advances in the use of molecular markers in diagnosis, in prognosis, in early detection, in novel therapies, and in understanding the molecular pathogenesis of colorectal neoplasia...
  19. ncbi request reprint Immunohistochemical expression of molecular markers in an avian model: a potential model for preclinical evaluation of agents for ovarian cancer chemoprevention
    C Rodriguez-Burford
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Gynecol Oncol 81:373-9. 2001
    ..The purpose of this study was to evaluate the immunohistochemical expression of available antibodies that have been utilized in chemoprevention studies in this potential model of epithelial carcinoma...
  20. ncbi request reprint Methods of antigen recovery vary in their usefulness in unmasking specific antigens in immunohistochemistry
    A R Frost
    Department of Pathology, University of Alabama at Birmingham, 35294 0007, USA
    Appl Immunohistochem Mol Morphol 8:236-43. 2000
    ..MAR provided the most intense staining for Bcl-2 and PR, but this enhanced staining must be weighed against the greater tissue section loss from MAR. This study demonstrated that AR methods are not equally applicable to all antibodies...
  21. ncbi request reprint Bayesian monitoring of a phase 2 chemoprevention trial in high-risk cohorts for prostate cancer
    H L Weiss
    Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
    Urology 57:220-3. 2001
    ..This study demonstrates the potential utility of Bayesian methods in the decision-making process in the conduct of phase 2 chemoprevention trials...
  22. ncbi request reprint Selective induction of tumor-associated antigens in murine pulmonary vasculature using double-targeted adenoviral vectors
    M Everts
    Division of Human Gene Therapy, Department of Medicine, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
    Gene Ther 12:1042-8. 2005
    ....
  23. pmc Molecular biomarkers for breast cancer prognosis: coexpression of c-erbB-2 and p53
    S W Beenken
    Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Ann Surg 233:630-8. 2001
    ..To assess the prognostic significance of molecular biomarkers, particularly c-erbB-2 and p53, through study of prospective clinical data and archival breast cancer tissues for women accrued to the Alabama Breast Cancer Project...
  24. ncbi request reprint Cell density influences the effect of celecoxib in two carcinoma cell lines
    V S Vital-reyes
    Department of Pathology, The University of Alabama at Birmingham, 35294, USA
    Biotech Histochem 81:51-4. 2006
    ..Our results suggest that the inhibitory effect of celecoxib may be affected by cell density. Therefore, careful attention must be paid to determining the appropriate cell density for cytotoxicity studies...
  25. ncbi request reprint Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo
    P N Reynolds
    Division of Human Gene Therapy, Departments of Medicine, Surgery and Pathology, and Gene Therapy Center, University of Alabama at Birmingham, USA
    Nat Biotechnol 19:838-42. 2001
    ..This combined approach should be useful for the design of other gene delivery systems...
  26. doi request reprint Immunohistochemical detection of EGFR, p185(erbB-2), Bcl-2 and p53 in breast carcinomas in pre-menopausal and post-menopausal women
    Li Talley
    Biostatistics Unit of the Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Biotech Histochem 83:5-14. 2008
    ..In addition, there were differences in the prognostic effectiveness of these biomarkers in pre- vs. post-menopausal women...
  27. ncbi request reprint The use of dimethylsulfoxide as a vehicle in cell culture experiments using ovarian carcinoma cell lines
    C Rodriguez-Burford
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35233 0007, USA
    Biotech Histochem 78:17-21. 2003
    ..Our observations are important to consider when selecting an appropriate solvent, especially for growth inhibition studies using Caov-3, OVCAR-3, and SK-OV-3 cell lines...
  28. ncbi request reprint Effects of acute and chronic body weight gain reductions in the evaluation of agents for efficacy in mammary cancer prevention
    C Rodriguez-Burford
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Oncol Rep 8:373-9. 2001
    ....
  29. ncbi request reprint Longitudinal analysis of mammary cancer multiplicity in chemoprevention studies
    H L Weiss
    Biostatistics Unit, University of Alabama at Birmingham 35294, USA
    Anticancer Res 20:2281-7. 2000
    ..The nature of data collected from chemoprevention studies may be analyzed by a longitudinal analysis of repeatedly measured cancer multiplicity data...
  30. ncbi request reprint Avoiding biohazards in medical, veterinary and research laboratories
    W E Grizzle
    Department of Pathology, University of Alabama at Birmingham, 35294, USA
    Biotech Histochem 76:183-206. 2001
    ..The issues discussed can be used to develop a general safety program as required by regulatory or accrediting agencies, including the Occupational Safety and Health Administration...
  31. ncbi request reprint Specific membrane receptor gene expression targeted with radiolabeled peptide employing the erbB-2 and DF3 promoter elements in adenoviral vectors
    M A Stackhouse
    Department of Radiation Oncology, Comprehensive Cancer Center, University of Alabama, Birmingham 35294, USA
    Cancer Gene Ther 6:209-19. 1999
    ..The use of such a transcriptional targeting approach may restrict gene expression to tumors and limit the radiation dose deposited in normal tissues in vivo...
  32. ncbi request reprint Altered subcellular localization of suppressin, a novel inhibitor of cell-cycle entry, is an independent prognostic factor in colorectal adenocarcinomas
    U Manne
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Clin Cancer Res 7:3495-503. 2001
    ..Therefore, we evaluated the status of spn and its prognostic value in human colorectal adenocarcinoma (CRC)...
  33. ncbi request reprint Immunohistochemical evaluation of global DNA methylation: comparison with in vitro radiolabeled methyl incorporation assay
    C J Piyathilake
    Department of Nutrition Sciences, The University of Alabama at Birmingham, 35294, USA
    Biotech Histochem 75:251-8. 2000
    ....
  34. ncbi request reprint Effects of time and temperature during attachment of sections to microscope slides on immunohistochemical detection of antigens
    W T Jones
    Department of Pathology, University of Alabama at Birmingham, 35294-0007, USA
    Biotech Histochem 76:55-8. 2001
    ....
  35. ncbi request reprint Intraperitoneal radioimmunochemotherapy of ovarian cancer: a phase I study
    R F Meredith
    Department of Radiation Oncology, University of Alabama at Birmingham, Comprehensive Cancer Center, Wallace Tumor Institute 117, 1530 3rd Avenue South, Birmingham, AL 35294 6832, USA
    Cancer Biother Radiopharm 16:305-15. 2001
    ..The combination of intraperitoneal Taxol chemotherapy (100 mg/m2) with RIT using 177Lu-CC49 and interferon was well tolerated, with bone marrow suppression as the dose-limiting toxicity...
  36. ncbi request reprint Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of mice
    J D Mountz
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, AL 35294, USA
    Scand J Immunol 61:128-38. 2005
    ....
  37. doi request reprint Selective COX-2 inhibitor (celecoxib) decreases cellular growth in prostate cancer cell lines independent of p53
    V R Katkoori
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biotech Histochem 88:38-46. 2013
    ..Celecoxib reduces the growth of prostate cancer cell lines in part by decreasing proliferation, which suggests that the inhibition of growth of LNCaP cells by celecoxib is independent of normal levels of native p53...
  38. ncbi request reprint Intratumor heterogeneity of biomarker expression in breast carcinomas
    D C Chhieng
    Department of Anatomy, University of Alabama at Birmingham, 35294 6823, USA
    Biotech Histochem 79:25-36. 2004
    ..Minor regional variations were observed for EGFR and p53 in IDC. Similarly, no significant regional variation in the expression of markers was observed in DCIS except for PCNA...
  39. ncbi request reprint Cellular mechanism of thymic involution
    L Li
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Scand J Immunol 57:410-22. 2003
    ..These results suggest that, in D2 mice, both the thymocytes and stromal cells exhibit age-related defects, and that the genetic background of mice plays an important role in determining age-related alterations in thymic involution...
  40. ncbi request reprint Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands
    M D Gibbons
    Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, 1501 Fifth Avenue South, Birmingham, AL 35249-6889
    Laryngoscope 111:1373-8. 2001
    ..Conversely, erbB-2, erbB-3, EGFR, and TGF-alpha may have a role in the development and progression of MEC. These results have therapeutic implications for MEC of the major salivary glands...
  41. pmc The efficient operation of the surgical pathology gross room
    W C Bell
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Biotech Histochem 83:71-82. 2008
    ..We review here the basic function and management of the gross room including a brief discussion of common specimen types, biohazard exposure and safety, and collection of tissue for research...
  42. ncbi request reprint The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma
    S Ren
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Oncogene 19:1419-27. 2000
    ..The results demonstrate segmental copy number gains within chromosome 3p in cutaneous malignant melanoma and suggest that deregulation of a proteasome regulatory particle subunit may contribute to the malignant phenotype...
  43. pmc Combined effects of formalin fixation and tissue processing on immunorecognition
    D Otali
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Biotech Histochem 84:223-47. 2009
    ..The cellular variations that were observed indicate that the effects of fixation and other steps of tissue processing may depend on how antigens are packaged by specific cells...
  44. ncbi request reprint Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers
    M Yamamoto
    Division of Human Gene Therapy, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Ther 3:385-94. 2001
    ..The cox-2 promoter successfully mitigated the adverse effects of adenoviral suicide gene therapy by minimizing transgene expression in the liver...
  45. ncbi request reprint The response of extracellular signal-regulated kinase (ERK) to androgen-induced proliferation in the androgen-sensitive prostate cancer cell line, LNCaP
    W C Bell
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Biotech Histochem 78:11-6. 2003
    ....
  46. ncbi request reprint Race- and age-dependent alterations in global methylation of DNA in squamous cell carcinoma of the lung (United States)
    C J Piyathilake
    Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
    Cancer Causes Control 14:37-42. 2003
    ..The current study investigated the race- and age-dependent alterations in global DNA methylation on the development and progression of squamous cell carcinomas (SCCs) of the lung...
  47. pmc Immunohistochemical expression of rabphilin-3A-like (Noc2) in normal and tumor tissues of human endocrine pancreas
    C Shanmugam
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 7331, USA
    Biotech Histochem 84:39-45. 2009
    ..The concomitant expression of Noc2 with these molecules suggests that Noc2 may serve as an effector for Rab3A and Rab27A and that it is involved in the regulation of exocytosis of the endocrine pancreas in humans...
  48. ncbi request reprint Dissociation of cyclic inositol phosphohydrolase activity from annexin III
    M C Sekar
    Department of Pathology, University of Alabama at Birmingham, 35294, USA
    J Biol Chem 271:8295-9. 1996
    ..Our studies clearly show that cyclic inositol phosphohydrolase and annexin III are two different proteins...