Frederick Grinnell

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts
    Sangmyung Rhee
    Department of Cell Biology, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
    J Cell Biol 172:423-32. 2006
  2. doi request reprint Research integrity and everyday practice of science
    Frederick Grinnell
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Sci Eng Ethics 19:685-701. 2013
  3. pmc The effect of growth factor environment on fibroblast morphological response to substrate stiffness
    Frederick Grinnell
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    Biomaterials 34:965-74. 2013
  4. ncbi request reprint Transforming growth factor beta stimulates fibroblast-collagen matrix contraction by different mechanisms in mechanically loaded and unloaded matrices
    Frederick Grinnell
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Exp Cell Res 273:248-55. 2002
  5. pmc Fibroblast mechanics in three-dimensional collagen matrices
    Frederick Grinnell
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390 9039, USA
    J Bodyw Mov Ther 12:191-3. 2008
  6. ncbi request reprint Intelligent design: fallacy recapitulates ontogeny
    Frederick Grinnell
    Department of Cell Biology, Ethics in Science and Medicine Program, University of Texas Southwestern Medical School, Dallas, Texas 75390 9039, USA
    FASEB J 20:410-1. 2006
  7. ncbi request reprint Bioethical pluralism and complementarity
    Frederick Grinnell
    Department of Cell Biology and Ethics in Science and Medicine Program, University of Texas Southwestern Medical Center, Dallas 75390 9039, USA
    Perspect Biol Med 45:338-49. 2002
  8. pmc Dendritic fibroblasts in three-dimensional collagen matrices
    Frederick Grinnell
    Department of Cell Biology, University of Texas Southwestern Medical School, Dallas 75390 9039, USA
    Mol Biol Cell 14:384-95. 2003
  9. ncbi request reprint Fibroblast biology in three-dimensional collagen matrices
    Frederick Grinnell
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Trends Cell Biol 13:264-9. 2003
  10. ncbi request reprint Nested collagen matrices: a new model to study migration of human fibroblast populations in three dimensions
    Frederick Grinnell
    Department of Cell Biology, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Exp Cell Res 312:86-94. 2006

Research Grants

  1. DEVELOPMENT OF AN IN VITRO WOUND HEALING MODEL
    Frederick Grinnell; Fiscal Year: 1993
  2. INTRACELLULAR TRAFFICKING OF TROPOELASTIN
    Frederick Grinnell; Fiscal Year: 2002
  3. DEVELOPMENT OF AN IN VITRO WOUND HEALING MODEL
    Frederick Grinnell; Fiscal Year: 2007
  4. DEVELOPMENT OF AN IN VITRO WOUND HEALING MODEL
    Frederick Grinnell; Fiscal Year: 2010
  5. DEVELOPMENT OF AN IN VITRO WOUND HEALING MODEL
    Frederick Grinnell; Fiscal Year: 1990
  6. DEVELOPMENT OF AN IN VITRO WOUND HEALING MODEL
    Frederick Grinnell; Fiscal Year: 2010

Collaborators

Detail Information

Publications26

  1. pmc P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts
    Sangmyung Rhee
    Department of Cell Biology, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
    J Cell Biol 172:423-32. 2006
    ..These findings establish a unified framework for understanding the cell signaling pathways involved in fibroblast contraction of floating collagen matrices...
  2. doi request reprint Research integrity and everyday practice of science
    Frederick Grinnell
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Sci Eng Ethics 19:685-701. 2013
    ....
  3. pmc The effect of growth factor environment on fibroblast morphological response to substrate stiffness
    Frederick Grinnell
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    Biomaterials 34:965-74. 2013
    ..Under growth factor conditions that stimulate global cell protrusion (PDGF), such resistance is not required...
  4. ncbi request reprint Transforming growth factor beta stimulates fibroblast-collagen matrix contraction by different mechanisms in mechanically loaded and unloaded matrices
    Frederick Grinnell
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Exp Cell Res 273:248-55. 2002
    ....
  5. pmc Fibroblast mechanics in three-dimensional collagen matrices
    Frederick Grinnell
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390 9039, USA
    J Bodyw Mov Ther 12:191-3. 2008
    ..Research on fibroblasts interacting with collagen matrices provides new insights regarding how cell-matrix tension state and growth factor specificity regulate cell migration and matrix remodeling...
  6. ncbi request reprint Intelligent design: fallacy recapitulates ontogeny
    Frederick Grinnell
    Department of Cell Biology, Ethics in Science and Medicine Program, University of Texas Southwestern Medical School, Dallas, Texas 75390 9039, USA
    FASEB J 20:410-1. 2006
  7. ncbi request reprint Bioethical pluralism and complementarity
    Frederick Grinnell
    Department of Cell Biology and Ethics in Science and Medicine Program, University of Texas Southwestern Medical Center, Dallas 75390 9039, USA
    Perspect Biol Med 45:338-49. 2002
    ..As a result, complementarity results in a state of holistic, dynamic tension, rather than one that yields singular or final moral judgments...
  8. pmc Dendritic fibroblasts in three-dimensional collagen matrices
    Frederick Grinnell
    Department of Cell Biology, University of Texas Southwestern Medical School, Dallas 75390 9039, USA
    Mol Biol Cell 14:384-95. 2003
    ..The dendritic network also supported metabolic coupling between cells. We suggest that the dendritic network provides a mechanism by which fibroblasts explore and become interconnected to each other in three-dimensional space...
  9. ncbi request reprint Fibroblast biology in three-dimensional collagen matrices
    Frederick Grinnell
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Trends Cell Biol 13:264-9. 2003
    ....
  10. ncbi request reprint Nested collagen matrices: a new model to study migration of human fibroblast populations in three dimensions
    Frederick Grinnell
    Department of Cell Biology, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Exp Cell Res 312:86-94. 2006
    ..Our studies using this model demonstrate important differences between regulation of fibroblast migration and remodeling in collagen matrices...
  11. doi request reprint Distinguishing fibroblast promigratory and procontractile growth factor environments in 3-D collagen matrices
    Hongmei Jiang
    Department of Cell Biology, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    FASEB J 22:2151-60. 2008
    ..Our findings suggest that different sets of growth factors generate promigratory and procontractile tissue environments for fibroblasts and that the balance between PDGF and S1P is a key determinant of fibroblast promigratory activity...
  12. ncbi request reprint Different molecular motors mediate platelet-derived growth factor and lysophosphatidic acid-stimulated floating collagen matrix contraction
    Masatoshi Abe
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    J Biol Chem 278:47707-12. 2003
    ..LPA-dependent, Rho kinase-independent force generation also was detected during fibroblast spreading on collagen-coated coverslips...
  13. pmc Microtubule function in fibroblast spreading is modulated according to the tension state of cell-matrix interactions
    Sangmyung Rhee
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    Proc Natl Acad Sci U S A 104:5425-30. 2007
    ....
  14. ncbi request reprint LPA-stimulated fibroblast contraction of floating collagen matrices does not require Rho kinase activity or retraction of fibroblast extensions
    David J Lee
    Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9039, USA
    Exp Cell Res 289:86-94. 2003
    ..Modulation was specific for LPA since fibroblast-collagen matrix contraction stimulated by platelet-derived growth factor was Rho kinase dependent before or after mechanical loading developed...
  15. pmc Fibroblast cluster formation on 3D collagen matrices requires cell contraction dependent fibronectin matrix organization
    Bruno da Rocha-Azevedo
    Department of Cell Biology, UT Southwestern Medical Center 5323, Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Exp Cell Res 319:546-55. 2013
    ....
  16. pmc The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices
    Miguel Miron-Mendoza
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd Dallas, TX 75390 9039, USA
    Biomaterials 31:6425-35. 2010
    ..Collagen translocation appeared to depend primarily on matrix stiffness, whereas cell spreading and migration were less dependent on matrix stiffness and more dependent on collagen matrix porosity...
  17. pmc Modulation of fibroblast morphology and adhesion during collagen matrix remodeling
    Elisa Tamariz
    Department of Cell Biology, University of Texas Southwestern Medical School, Dallas, Texas 75235 9039, USA
    Mol Biol Cell 13:3915-29. 2002
    ..Rho kinase activity is required for maturation of fibroblast morphology and formation of focal adhesions but not for translocation of collagen fibrils...
  18. pmc Fibroblast morphogenesis on 3D collagen matrices: the balance between cell clustering and cell migration
    Bruno da Rocha-Azevedo
    Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9039, USA
    Exp Cell Res 319:2440-6. 2013
    ..Binding of fibroblasts to a shared fibronectin fibrillar matrix stabilizes clusters, and fragmentation of the fibrillar matrix occurs when growth factor conditions are switched to promote cell dispersal...
  19. pmc Fibroblast mechanics in 3D collagen matrices
    Sangmyung Rhee
    Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd Dallas, Texas 75390 9039, USA
    Adv Drug Deliv Rev 59:1299-305. 2007
    ....
  20. ncbi request reprint Fibroblast quiescence in floating collagen matrices: decrease in serum activation of MEK and Raf but not Ras
    Jeanne Fringer
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    J Biol Chem 278:20612-7. 2003
    ..The findings suggest that quiescence of fibroblasts in floating collagen matrices may result from a defect in Ras coupling to its downstream effectors...
  21. pmc Cell-matrix entanglement and mechanical anchorage of fibroblasts in three-dimensional collagen matrices
    Hongmei Jiang
    Department of Cell Biology, University of Texas Southwestern Medical School, Dallas, TX 75390 9039, USA
    Mol Biol Cell 16:5070-6. 2005
    ..We suggest that cell-matrix entanglement represents a novel mechanism of cell anchorage that uniquely depends on the three-dimensional character of the matrix...
  22. pmc Collagen fibril flow and tissue translocation coupled to fibroblast migration in 3D collagen matrices
    Miguel Miron-Mendoza
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    Mol Biol Cell 19:2051-8. 2008
    ..Our findings demonstrate that when fibroblasts interact with collagen matrices, tractional force exerted by the cells can couple to matrix translocation as well as to cell migration...
  23. doi request reprint Cell motility and mechanics in three-dimensional collagen matrices
    Frederick Grinnell
    Departments of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Annu Rev Cell Dev Biol 26:335-61. 2010
    ..Finally, we review the significance of these concepts for the physiology of wound repair...
  24. ncbi request reprint Subject vulnerability: the precautionary principle of human research
    Frederick Grinnell
    UT Southwestern Medical Center, USA
    Am J Bioeth 4:72-4; discussion W32. 2004
  25. pmc Oncogenic Ras-transformed human fibroblasts exhibit differential changes in contraction and migration in 3D collagen matrices
    Gustavo C Menezes
    Universidade Federal do Rio de Janeiro, Instituto de Biofisica Carlos Chagas Filho, Rio de Janeiro, Brazil
    Exp Cell Res 314:3081-91. 2008
    ..These findings demonstrate differential regulation of collagen matrix contraction and cell migration in 3D collagen matrices...
  26. ncbi request reprint Human embryo research: from moral uncertainty to death
    Frederick Grinnell
    UT Southwestern Medical Center
    Am J Bioeth 4:12-3. 2004

Research Grants22

  1. DEVELOPMENT OF AN IN VITRO WOUND HEALING MODEL
    Frederick Grinnell; Fiscal Year: 1993
    ..The distribution of adhesion proteins in the various wound fluids and proteolysis of fibronectin in the wounds will be analyzed...
  2. INTRACELLULAR TRAFFICKING OF TROPOELASTIN
    Frederick Grinnell; Fiscal Year: 2002
    ....
  3. DEVELOPMENT OF AN IN VITRO WOUND HEALING MODEL
    Frederick Grinnell; Fiscal Year: 2007
    ..Specific Aim #3 focuses on the factors that contribute to apoptosis of cells undergoing stressed matrix contraction. ..
  4. DEVELOPMENT OF AN IN VITRO WOUND HEALING MODEL
    Frederick Grinnell; Fiscal Year: 2010
    ..Indeed, the general usefulness of 3D matrix models to accelerate a wide range of translational research work increasingly has been recognized. ..
  5. DEVELOPMENT OF AN IN VITRO WOUND HEALING MODEL
    Frederick Grinnell; Fiscal Year: 1990
    ....
  6. DEVELOPMENT OF AN IN VITRO WOUND HEALING MODEL
    Frederick Grinnell; Fiscal Year: 2010
    ..Indeed, the general usefulness of 3D matrix models to accelerate a wide range of translational research work increasingly has been recognized. ..