Joshua D Grill

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Choosing Alzheimer's disease prevention clinical trial populations
    Joshua D Grill
    Mary Easton Center for Alzheimer s Disease Research, Department of Neurology, UCLA, Los Angeles, CA, USA Electronic address
    Neurobiol Aging 35:466-71. 2014
  2. pmc Risk disclosure and preclinical Alzheimer's disease clinical trial enrollment
    Joshua D Grill
    Mary Easton Center for Alzheimer s Disease Research, UCLA, Los Angeles, CA, USA
    Alzheimers Dement 9:356-359.e1. 2013
  3. pmc Effect of study partner on the conduct of Alzheimer disease clinical trials
    Joshua D Grill
    Mary Easton Center for Alzheimer s Disease Research, University of California, Los Angeles, USA
    Neurology 80:282-8. 2013
  4. pmc Estimating sample sizes for predementia Alzheimer's trials based on the Alzheimer's Disease Neuroimaging Initiative
    Joshua D Grill
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Neurobiol Aging 34:62-72. 2013
  5. pmc Are patients whose study partners are spouses more likely to be eligible for Alzheimer's disease clinical trials?
    Joshua D Grill
    Mary Easton Center for Alzheimer s Disease Research, Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Dement Geriatr Cogn Disord 33:334-40. 2012
  6. doi request reprint Current therapeutic targets for the treatment of Alzheimer's disease
    Joshua D Grill
    Mary S Easton Center for Alzheimer s Disease Research, Deane F Johnson Center for Neurotherapeutics, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Expert Rev Neurother 10:711-28. 2010
  7. pmc Addressing the challenges to successful recruitment and retention in Alzheimer's disease clinical trials
    Joshua D Grill
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, University of California, Los Angeles, 10911 Weyburn Avenue, Suite 200, Los Angeles, CA 90095, USA
    Alzheimers Res Ther 2:34. 2010
  8. pmc Does study partner type impact the rate of Alzheimer's disease progression?
    Joshua D Grill
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Alzheimers Dis 38:507-14. 2014

Detail Information

Publications9

  1. pmc Choosing Alzheimer's disease prevention clinical trial populations
    Joshua D Grill
    Mary Easton Center for Alzheimer s Disease Research, Department of Neurology, UCLA, Los Angeles, CA, USA Electronic address
    Neurobiol Aging 35:466-71. 2014
    ..We conclude that Alzheimer's disease prevention trials can enroll elderly participants with minimal effect on trial retention and that enriching for older individuals with memory complaints might afford efficient trial designs. ..
  2. pmc Risk disclosure and preclinical Alzheimer's disease clinical trial enrollment
    Joshua D Grill
    Mary Easton Center for Alzheimer s Disease Research, UCLA, Los Angeles, CA, USA
    Alzheimers Dement 9:356-359.e1. 2013
    ..01) and less frequently cited time as a barrier to enrollment (P = .02). These results suggest potential challenges to preclinical AD clinical trial recruitment and that disclosing risk information may enhance enrollment...
  3. pmc Effect of study partner on the conduct of Alzheimer disease clinical trials
    Joshua D Grill
    Mary Easton Center for Alzheimer s Disease Research, University of California, Los Angeles, USA
    Neurology 80:282-8. 2013
    ..Alzheimer disease (AD) dementia clinical trials require 2 participants: a patient and a study partner. We assessed the prevalence of study partner types and how these types associate with patient-related outcome measures...
  4. pmc Estimating sample sizes for predementia Alzheimer's trials based on the Alzheimer's Disease Neuroimaging Initiative
    Joshua D Grill
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Neurobiol Aging 34:62-72. 2013
    ..For MCI, the Clinical Dementia Rating scale sum of boxes consistently required the smallest sample sizes. We conclude that predementia clinical trial conduct in Alzheimer's disease is enhanced by the use of biomarker inclusion criteria...
  5. pmc Are patients whose study partners are spouses more likely to be eligible for Alzheimer's disease clinical trials?
    Joshua D Grill
    Mary Easton Center for Alzheimer s Disease Research, Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Dement Geriatr Cogn Disord 33:334-40. 2012
    ..Alzheimer's disease (AD) clinical trials enroll two participants: a patient and a study partner. The primary caregiver most often fills the role of study partner and most trial study partners are spousal caregivers...
  6. doi request reprint Current therapeutic targets for the treatment of Alzheimer's disease
    Joshua D Grill
    Mary S Easton Center for Alzheimer s Disease Research, Deane F Johnson Center for Neurotherapeutics, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Expert Rev Neurother 10:711-28. 2010
    ..We provide a review of these targets for drug development...
  7. pmc Addressing the challenges to successful recruitment and retention in Alzheimer's disease clinical trials
    Joshua D Grill
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, University of California, Los Angeles, 10911 Weyburn Avenue, Suite 200, Los Angeles, CA 90095, USA
    Alzheimers Res Ther 2:34. 2010
    ..We review the challenges to recruitment and retention in Alzheimer's disease clinical trials and present a framework to address them...
  8. pmc Does study partner type impact the rate of Alzheimer's disease progression?
    Joshua D Grill
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Alzheimers Dis 38:507-14. 2014
    ..These results suggest that if investigators can improve in recruiting AD patients with adult child caregivers to research, the implications to study results may be minimal...