Harvey J Grill

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance
    Harvey J Grill
    Graduate Group of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 16:296-309. 2012
  2. pmc Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency
    Bart C De Jonghe
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia PA, USA
    Am J Physiol Endocrinol Metab 303:E644-51. 2012
  3. pmc The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1
    Matthew R Hayes
    Translational Neuroscience Program, Dept of Psychiatry, Perelman School of Medicine at the Univ of Pennsylvania, TRL Bldg, Office 2219, 125 South 31st St, Philadelphia, PA 19104, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1479-85. 2011
  4. pmc Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals
    Scott E Kanoski
    Dept of Psychology, School of Arts and Sciences, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 303:E496-503. 2012
  5. pmc Hindbrain cocaine- and amphetamine-regulated transcript induces hypothermia mediated by GLP-1 receptors
    Karolina P Skibicka
    Graduate Group of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 29:6973-81. 2009
  6. pmc Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure
    Bart C De Jonghe
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 300:E1002-11. 2011
  7. pmc Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation
    Matthew R Hayes
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Cell Metab 13:320-30. 2011
  8. pmc Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors
    Karolina P Skibicka
    Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:1705-11. 2009
  9. pmc Leptin and the systems neuroscience of meal size control
    Harvey J Grill
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Front Neuroendocrinol 31:61-78. 2010
  10. pmc Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4
    Scott E Kanoski
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 152:3103-12. 2011

Collaborators

Detail Information

Publications26

  1. doi request reprint Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance
    Harvey J Grill
    Graduate Group of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 16:296-309. 2012
    ..These hindbrain-mediated controls are neuroanatomically distributed; they involve endemic hindbrain neurons and circuits, hindbrain projections to peripheral circuits, and projections to and from midbrain and forebrain nuclei...
  2. pmc Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency
    Bart C De Jonghe
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia PA, USA
    Am J Physiol Endocrinol Metab 303:E644-51. 2012
    ..These studies are the first to show that hindbrain administration of leptin or a melanocortin receptor agonist alters energy balance in mice likely via participation of hindbrain POMC neurons...
  3. pmc The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1
    Matthew R Hayes
    Translational Neuroscience Program, Dept of Psychiatry, Perelman School of Medicine at the Univ of Pennsylvania, TRL Bldg, Office 2219, 125 South 31st St, Philadelphia, PA 19104, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1479-85. 2011
    ....
  4. pmc Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals
    Scott E Kanoski
    Dept of Psychology, School of Arts and Sciences, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 303:E496-503. 2012
    ..Overall, these findings deepen the understanding of the distributed neuronal systems and behavioral mechanisms that mediate the effects of leptin receptor signaling on the control of food intake...
  5. pmc Hindbrain cocaine- and amphetamine-regulated transcript induces hypothermia mediated by GLP-1 receptors
    Karolina P Skibicka
    Graduate Group of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 29:6973-81. 2009
    ..Data reveal a novel function of CART in temperature regulation and open possibilities for future studies on the clinical potential of the hypothermic effect...
  6. pmc Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure
    Bart C De Jonghe
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 300:E1002-11. 2011
    ..These data show that PTP1B in POMC neurons plays a role in short-term cold-induced reduction of SPA and may influence cold-induced thermogenesis via enhanced activation of the thyroid axis...
  7. pmc Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation
    Matthew R Hayes
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Cell Metab 13:320-30. 2011
    ..Pharmacotherapies targeting these signaling pathways, which mediate intake-suppressive effects of CNS GLP-1R activation, may prove efficacious in treating obesity...
  8. pmc Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors
    Karolina P Skibicka
    Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:1705-11. 2009
    ....
  9. pmc Leptin and the systems neuroscience of meal size control
    Harvey J Grill
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Front Neuroendocrinol 31:61-78. 2010
    ....
  10. pmc Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4
    Scott E Kanoski
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 152:3103-12. 2011
    ..Conclusion: Food intake suppression after peripheral administration of exendin-4 and liraglutide is mediated by activation of GLP-1R expressed on vagal afferents as well as direct CNS GLP-1R activation...
  11. pmc TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin
    Andrea M Spaeth
    Dept of Psychology, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 302:E1252-60. 2012
    ..Collectively, these results indicate that TrkB-mediated signaling in the mNTS negatively regulates food intake and, in part, the intake inhibitory effects of leptin administered into the NTS...
  12. pmc Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins
    Karolina P Skibicka
    Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:5351-61. 2009
    ..Data are consistent with the view that energetic and feeding responses are not controlled by regionally divergent MC3/4Rs and can be elicited from multiple, anatomically distributed MC3/4R populations...
  13. doi request reprint Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats
    Matthew R Hayes
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:1342-9. 2011
    ..i.d.) and liraglutide (q.d.), lead to comparable and pronounced suppression of food intake and body weight in DIO rats, suggesting a potential role for these drugs as a clinical tool for obesity treatment...
  14. pmc Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling
    Matthew R Hayes
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:2654-9. 2009
    ..We conclude that endogenous NTS GLP-1R activation driven by gastric satiation signals contributes to the control of normal feeding...
  15. pmc Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance
    Matthew R Hayes
    Graduate Group of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:2175-82. 2009
    ....
  16. pmc Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation
    Matthew R Hayes
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, 3720 Walnut Street, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 149:4059-68. 2008
    ..Contrary to the literature, hypothalamic/forebrain processing and forebrain-caudal brainstem communication is not required for the observed responses...
  17. pmc Energetic responses to cold temperatures in rats lacking forebrain-caudal brain stem connections
    Katherine M Nautiyal
    Graduate Groups of Psychology and Neuroscience, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Am J Physiol Regul Integr Comp Physiol 295:R789-98. 2008
    ....
  18. pmc Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation
    Matthew R Hayes
    University of Pennsylvania, Philadelphia, 19104, USA
    Cell Metab 11:77-83. 2010
    ..Overall these findings demonstrate that LepRs in mNTS and AP neurons are required for normal energy balance control...
  19. pmc Hippocampal leptin signaling reduces food intake and modulates food-related memory processing
    Scott E Kanoski
    Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 36:1859-70. 2011
    ..To conclude, the results support a role for hippocampal leptin signaling in the control of food intake and food-related memory processing...
  20. pmc Energetic responses are triggered by caudal brainstem melanocortin receptor stimulation and mediated by local sympathetic effector circuits
    Karolina P Skibicka
    Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    Endocrinology 149:3605-16. 2008
    ....
  21. pmc Caudal brainstem delivery of ghrelin induces fos expression in the nucleus of the solitary tract, but not in the arcuate or paraventricular nuclei of the hypothalamus
    Lucy F Faulconbridge
    Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Brain Res 1218:151-7. 2008
    ..These data support the NTS as a target of ghrelin action by building upon prior findings of increases in food intake in response to third- and fourth-ventricle ghrelin delivery...
  22. ncbi request reprint Imaging obesity: fMRI, food reward, and feeding
    Harvey J Grill
    Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 6:423-5. 2007
    ..Recent papers by Batterham et al. (2007) and Farooqi et al. (2007) link peptide YY(3-36) and leptin to the activation of nonhomeostatic brain regions...
  23. ncbi request reprint Distinct forebrain and caudal brainstem contributions to the neuropeptide Y mediation of ghrelin hyperphagia
    Lucy F Faulconbridge
    Department of Psychology, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Diabetes 54:1985-93. 2005
    ..These results demonstrate distinct mediating pathways (due to location and subtypes of relevant NPY receptor) for the hyperphagic response driven separately by forebrain and CBS ghrelin administration...
  24. pmc Ghrelin signaling in the ventral hippocampus stimulates learned and motivational aspects of feeding via PI3K-Akt signaling
    Scott E Kanoski
    Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Biol Psychiatry 73:915-23. 2013
    ....
  25. ncbi request reprint Distributed neural control of energy balance: contributions from hindbrain and hypothalamus
    Harvey J Grill
    Graduate Group of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Obesity (Silver Spring) 14:216S-221S. 2006
    ....
  26. ncbi request reprint Central structures necessary and sufficient for ingestive and glycemic responses to Urocortin I administration
    Derek Daniels
    Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:11457-62. 2004
    ....