Research Topics
Species | HARVEY GRILLSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signalsScott E Kanoski
Dept of Psychology, School of Arts and Sciences, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
Am J Physiol Endocrinol Metab 303:E496-503. 2012..Overall, these findings deepen the understanding of the distributed neuronal systems and behavioral mechanisms that mediate the effects of leptin receptor signaling on the control of food intake...- TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptinAndrea M Spaeth
Dept of Psychology, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
Am J Physiol Endocrinol Metab 302:E1252-60. 2012..Collectively, these results indicate that TrkB-mediated signaling in the mNTS negatively regulates food intake and, in part, the intake inhibitory effects of leptin administered into the NTS... 
The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intakeH J Grill
Psychology and Neuroscience, University of Pennsylvania, Philadelphia, PA, USA
Int J Obes (Lond) 33:S11-5. 2009..Overall, data support the view that the NTS and circuits within the hindbrain mediate the intake inhibition of GI signals, and that the effects of leptin on food intake result from the amplification of GI signal processing...
Imaging obesity: fMRI, food reward, and feedingHarvey J Grill
Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
Cell Metab 6:423-5. 2007..Recent papers by Batterham et al. (2007) and Farooqi et al. (2007) link peptide YY(3-36) and leptin to the activation of nonhomeostatic brain regions...- Long-term effects on feeding and body weight after stimulation of forebrain or hindbrain CRH receptors with urocortinH J Grill
Department of Psychology, Institute of Neurological Sciences, University of Pennsylvania, 3815 Walnut St, Philadelphia, PA 19143, USA
Brain Res 867:19-28. 2000.... - Distributed neural control of energy balance: contributions from hindbrain and hypothalamusHarvey J Grill
Graduate Group of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
Obesity (Silver Spring) 14:216S-221S. 2006.... - Attenuation of lipopolysaccharide anorexia by antagonism of caudal brain stem but not forebrain GLP-1-RHarvey J Grill
Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Physiol Regul Integr Comp Physiol 287:R1190-3. 2004..Exendin-(9-39) delivery thus limited to forebrain did not attenuate the anorexic response to LPS. These data suggest that LPS anorexia is mediated, in part, by release of the native peptide acting on GLP-1-R within the caudal brain stem... - Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intakeHarvey J Grill
Graduate Group of Psychology, Dept of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA
Endocrinology 143:239-46. 2002..The results indicate that the CBS contains neurons that are potentially direct targets for the action of leptin in the control of energy homeostasis... - Leptin and the systems neuroscience of meal size controlHarvey J Grill
Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
Front Neuroendocrinol 31:61-78. 2010.... - Energetic responses to cold temperatures in rats lacking forebrain-caudal brain stem connectionsKatherine M Nautiyal
Graduate Groups of Psychology and Neuroscience, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
Am J Physiol Regul Integr Comp Physiol 295:R789-98. 2008.... - Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulationMatthew R Hayes
Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, 3720 Walnut Street, Philadelphia, Pennsylvania 19104, USA
Endocrinology 149:4059-68. 2008..Contrary to the literature, hypothalamic/forebrain processing and forebrain-caudal brainstem communication is not required for the observed responses... - Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balanceMatthew R Hayes
Graduate Group of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, Pennsylvania 19104, USA
Endocrinology 150:2175-82. 2009.... - Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signalingMatthew R Hayes
Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Endocrinology 150:2654-9. 2009..We conclude that endogenous NTS GLP-1R activation driven by gastric satiation signals contributes to the control of normal feeding... - Energetic responses are triggered by caudal brainstem melanocortin receptor stimulation and mediated by local sympathetic effector circuitsKarolina P Skibicka
Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
Endocrinology 149:3605-16. 2008.... - Behavioral processes underlying the intake suppressive effects of melanocortin 3/4 receptor activation in the ratDiana L Williams
Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia 19104, USA
Psychopharmacology (Berl) 161:47-53. 2002..Central application of MTII, a melanocortin 3/4 receptor agonist, reduces food intake. The behavioral mechanisms underlying the anorexia, however, have not been evaluated... - The neuroanatomical axis for control of energy balanceHarvey J Grill
Graduate Group of Psychology, University of Pennsylvania, Philadelphia, 19104, USA
Front Neuroendocrinol 23:2-40. 2002.... - Meal-related ghrelin suppression requires postgastric feedbackDiana L Williams
Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA
Endocrinology 144:2765-7. 2003..We conclude that the meal-related suppression of plasma ghrelin requires postgastric (pre- or postabsorptive) stimulation... - Hindbrain cocaine- and amphetamine-regulated transcript induces hypothermia mediated by GLP-1 receptorsKarolina P Skibicka
Graduate Group of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 29:6973-81. 2009..Data reveal a novel function of CART in temperature regulation and open possibilities for future studies on the clinical potential of the hypothermic effect... - Hyperphagic effects of brainstem ghrelin administrationLucy F Faulconbridge
Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Diabetes 52:2260-5. 2003..Taken together, the results affirm a caudal brainstem site of action and recommend further investigation into multisite interactions underlying the modulation of ingestive behavior by ghrelin... - Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortinsKarolina P Skibicka
Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Endocrinology 150:5351-61. 2009..Data are consistent with the view that energetic and feeding responses are not controlled by regionally divergent MC3/4Rs and can be elicited from multiple, anatomically distributed MC3/4R populations... - Distinct forebrain and caudal brainstem contributions to the neuropeptide Y mediation of ghrelin hyperphagiaLucy F Faulconbridge
Department of Psychology, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
Diabetes 54:1985-93. 2005..These results demonstrate distinct mediating pathways (due to location and subtypes of relevant NPY receptor) for the hyperphagic response driven separately by forebrain and CBS ghrelin administration... - Central structures necessary and sufficient for ingestive and glycemic responses to Urocortin I administrationDerek Daniels
Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 24:11457-62. 2004.... - Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulationMatthew R Hayes
University of Pennsylvania, Philadelphia, 19104, USA
Cell Metab 11:77-83. 2010..Overall these findings demonstrate that LepRs in mNTS and AP neurons are required for normal energy balance control... - Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptorsKarolina P Skibicka
Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Endocrinology 150:1705-11. 2009.... - Food deprivation after treatment blocks the multiple-day hyperphagic response to SHU9119 administrationDiana L Williams
Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA
Brain Res 996:180-6. 2004..The results indicate an interaction between melanocortin receptor activity and the metabolic state of the animal, and constrain our thinking about the peripheral signals and central mechanisms that underlie this interaction... - Caudal brainstem delivery of ghrelin induces fos expression in the nucleus of the solitary tract, but not in the arcuate or paraventricular nuclei of the hypothalamusLucy F Faulconbridge
Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
Brain Res 1218:151-7. 2008..These data support the NTS as a target of ghrelin action by building upon prior findings of increases in food intake in response to third- and fourth-ventricle ghrelin delivery... - Leptin and the control of food intake: neurons in the nucleus of the solitary tract are activated by both gastric distension and leptinLihong Huo
Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Endocrinology 148:2189-97. 2007..These results are consistent with the hypothesis that leptin acts directly on neurons within the mNTS to reduce food intake through an interaction with GI signal processing... - Energy expenditure and body composition of chronically maintained decerebrate rats in the fed and fasted conditionRuth B S Harris
Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens, Georgia 30602, USA
Endocrinology 147:1365-76. 2006..In the absence of communication from the forebrain, the caudal brainstem is inadequate for maintenance of testosterone levels or lean tissue in fed or fasted animals... - Role of the duodenum and macronutrient type in ghrelin regulationJoost Overduin
Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, S 111 Endo, Seattle, Washington 98108, USA
Endocrinology 146:845-50. 2005..The relatively weak suppression of ghrelin by lipids compared with glucose or amino acids could represent one mechanism promoting high-fat dietary weight gain... - Vagotomy dissociates short- and long-term controls of circulating ghrelinDiana L Williams
Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Mail Stop 111 ENDO, Seattle, Washington 98108, USA
Endocrinology 144:5184-7. 2003..The dissociation between nutrient load- and deprivation-related ghrelin responses indicates that the regulation of circulating ghrelin levels involves separate mechanisms operating through anatomically distinct pathways... - Leptin responsiveness in chronically decerebrate ratsRuth B S Harris
Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens, GA 30602, USA
Endocrinology 148:4623-33. 2007.... - Divergent leptin signaling in proglucagon neurons of the nucleus of the solitary tract in mice and ratsLihong Huo
Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Endocrinology 149:492-7. 2008..These data, combined with previous results, suggest a different mechanism of interaction between leptin and NTS proglucagon neurons in mice and rats... - Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleusLihong Huo
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Diabetes 55:567-73. 2006..We conclude that POMC neurons in the NTS do not respond to leptin unlike ARC POMC neurons. POMC neurons in the hypothalamus may therefore mediate all of leptin's signaling via POMC-derived peptides in the central nervous system...
Research Grants
- NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIORHARVEY GRILL; Fiscal Year: 2003....
- NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIORHARVEY GRILL; Fiscal Year: 2007..abstract_text> ..
- NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIORHARVEY GRILL; Fiscal Year: 2009....
- NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIORHARVEY GRILL; Fiscal Year: 1993..Failures to uncover differences between decerebrate and intact rats will be dramatic and, as in the past, will stimulate investigations of the location, connectivity and physiology of the relevant CBS integrative circuits...
- NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIORHARVEY GRILL; Fiscal Year: 1990....
- NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIORHarvey J Grill; Fiscal Year: 2010....