HARVEY GRILL

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals
    Scott E Kanoski
    Dept of Psychology, School of Arts and Sciences, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 303:E496-503. 2012
  2. pmc TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin
    Andrea M Spaeth
    Dept of Psychology, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 302:E1252-60. 2012
  3. doi request reprint The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake
    H J Grill
    Psychology and Neuroscience, University of Pennsylvania, Philadelphia, PA, USA
    Int J Obes (Lond) 33:S11-5. 2009
  4. ncbi request reprint Imaging obesity: fMRI, food reward, and feeding
    Harvey J Grill
    Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 6:423-5. 2007
  5. ncbi request reprint Long-term effects on feeding and body weight after stimulation of forebrain or hindbrain CRH receptors with urocortin
    H J Grill
    Department of Psychology, Institute of Neurological Sciences, University of Pennsylvania, 3815 Walnut St, Philadelphia, PA 19143, USA
    Brain Res 867:19-28. 2000
  6. ncbi request reprint Distributed neural control of energy balance: contributions from hindbrain and hypothalamus
    Harvey J Grill
    Graduate Group of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Obesity (Silver Spring) 14:216S-221S. 2006
  7. ncbi request reprint Attenuation of lipopolysaccharide anorexia by antagonism of caudal brain stem but not forebrain GLP-1-R
    Harvey J Grill
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1190-3. 2004
  8. ncbi request reprint Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake
    Harvey J Grill
    Graduate Group of Psychology, Dept of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA
    Endocrinology 143:239-46. 2002
  9. pmc Leptin and the systems neuroscience of meal size control
    Harvey J Grill
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Front Neuroendocrinol 31:61-78. 2010
  10. pmc Energetic responses to cold temperatures in rats lacking forebrain-caudal brain stem connections
    Katherine M Nautiyal
    Graduate Groups of Psychology and Neuroscience, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Am J Physiol Regul Integr Comp Physiol 295:R789-98. 2008

Collaborators

Detail Information

Publications33

  1. pmc Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals
    Scott E Kanoski
    Dept of Psychology, School of Arts and Sciences, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 303:E496-503. 2012
    ..Overall, these findings deepen the understanding of the distributed neuronal systems and behavioral mechanisms that mediate the effects of leptin receptor signaling on the control of food intake...
  2. pmc TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin
    Andrea M Spaeth
    Dept of Psychology, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 302:E1252-60. 2012
    ..Collectively, these results indicate that TrkB-mediated signaling in the mNTS negatively regulates food intake and, in part, the intake inhibitory effects of leptin administered into the NTS...
  3. doi request reprint The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake
    H J Grill
    Psychology and Neuroscience, University of Pennsylvania, Philadelphia, PA, USA
    Int J Obes (Lond) 33:S11-5. 2009
    ..Overall, data support the view that the NTS and circuits within the hindbrain mediate the intake inhibition of GI signals, and that the effects of leptin on food intake result from the amplification of GI signal processing...
  4. ncbi request reprint Imaging obesity: fMRI, food reward, and feeding
    Harvey J Grill
    Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 6:423-5. 2007
    ..Recent papers by Batterham et al. (2007) and Farooqi et al. (2007) link peptide YY(3-36) and leptin to the activation of nonhomeostatic brain regions...
  5. ncbi request reprint Long-term effects on feeding and body weight after stimulation of forebrain or hindbrain CRH receptors with urocortin
    H J Grill
    Department of Psychology, Institute of Neurological Sciences, University of Pennsylvania, 3815 Walnut St, Philadelphia, PA 19143, USA
    Brain Res 867:19-28. 2000
    ....
  6. ncbi request reprint Distributed neural control of energy balance: contributions from hindbrain and hypothalamus
    Harvey J Grill
    Graduate Group of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Obesity (Silver Spring) 14:216S-221S. 2006
    ....
  7. ncbi request reprint Attenuation of lipopolysaccharide anorexia by antagonism of caudal brain stem but not forebrain GLP-1-R
    Harvey J Grill
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1190-3. 2004
    ..Exendin-(9-39) delivery thus limited to forebrain did not attenuate the anorexic response to LPS. These data suggest that LPS anorexia is mediated, in part, by release of the native peptide acting on GLP-1-R within the caudal brain stem...
  8. ncbi request reprint Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake
    Harvey J Grill
    Graduate Group of Psychology, Dept of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA
    Endocrinology 143:239-46. 2002
    ..The results indicate that the CBS contains neurons that are potentially direct targets for the action of leptin in the control of energy homeostasis...
  9. pmc Leptin and the systems neuroscience of meal size control
    Harvey J Grill
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Front Neuroendocrinol 31:61-78. 2010
    ....
  10. pmc Energetic responses to cold temperatures in rats lacking forebrain-caudal brain stem connections
    Katherine M Nautiyal
    Graduate Groups of Psychology and Neuroscience, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Am J Physiol Regul Integr Comp Physiol 295:R789-98. 2008
    ....
  11. pmc Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation
    Matthew R Hayes
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, 3720 Walnut Street, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 149:4059-68. 2008
    ..Contrary to the literature, hypothalamic/forebrain processing and forebrain-caudal brainstem communication is not required for the observed responses...
  12. pmc Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance
    Matthew R Hayes
    Graduate Group of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:2175-82. 2009
    ....
  13. pmc Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling
    Matthew R Hayes
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:2654-9. 2009
    ..We conclude that endogenous NTS GLP-1R activation driven by gastric satiation signals contributes to the control of normal feeding...
  14. pmc Energetic responses are triggered by caudal brainstem melanocortin receptor stimulation and mediated by local sympathetic effector circuits
    Karolina P Skibicka
    Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    Endocrinology 149:3605-16. 2008
    ....
  15. ncbi request reprint Behavioral processes underlying the intake suppressive effects of melanocortin 3/4 receptor activation in the rat
    Diana L Williams
    Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia 19104, USA
    Psychopharmacology (Berl) 161:47-53. 2002
    ..Central application of MTII, a melanocortin 3/4 receptor agonist, reduces food intake. The behavioral mechanisms underlying the anorexia, however, have not been evaluated...
  16. ncbi request reprint The neuroanatomical axis for control of energy balance
    Harvey J Grill
    Graduate Group of Psychology, University of Pennsylvania, Philadelphia, 19104, USA
    Front Neuroendocrinol 23:2-40. 2002
    ....
  17. ncbi request reprint Meal-related ghrelin suppression requires postgastric feedback
    Diana L Williams
    Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA
    Endocrinology 144:2765-7. 2003
    ..We conclude that the meal-related suppression of plasma ghrelin requires postgastric (pre- or postabsorptive) stimulation...
  18. pmc Hindbrain cocaine- and amphetamine-regulated transcript induces hypothermia mediated by GLP-1 receptors
    Karolina P Skibicka
    Graduate Group of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 29:6973-81. 2009
    ..Data reveal a novel function of CART in temperature regulation and open possibilities for future studies on the clinical potential of the hypothermic effect...
  19. ncbi request reprint Hyperphagic effects of brainstem ghrelin administration
    Lucy F Faulconbridge
    Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Diabetes 52:2260-5. 2003
    ..Taken together, the results affirm a caudal brainstem site of action and recommend further investigation into multisite interactions underlying the modulation of ingestive behavior by ghrelin...
  20. pmc Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins
    Karolina P Skibicka
    Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:5351-61. 2009
    ..Data are consistent with the view that energetic and feeding responses are not controlled by regionally divergent MC3/4Rs and can be elicited from multiple, anatomically distributed MC3/4R populations...
  21. ncbi request reprint Distinct forebrain and caudal brainstem contributions to the neuropeptide Y mediation of ghrelin hyperphagia
    Lucy F Faulconbridge
    Department of Psychology, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Diabetes 54:1985-93. 2005
    ..These results demonstrate distinct mediating pathways (due to location and subtypes of relevant NPY receptor) for the hyperphagic response driven separately by forebrain and CBS ghrelin administration...
  22. ncbi request reprint Central structures necessary and sufficient for ingestive and glycemic responses to Urocortin I administration
    Derek Daniels
    Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:11457-62. 2004
    ....
  23. pmc Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation
    Matthew R Hayes
    University of Pennsylvania, Philadelphia, 19104, USA
    Cell Metab 11:77-83. 2010
    ..Overall these findings demonstrate that LepRs in mNTS and AP neurons are required for normal energy balance control...
  24. pmc Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors
    Karolina P Skibicka
    Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:1705-11. 2009
    ....
  25. ncbi request reprint Food deprivation after treatment blocks the multiple-day hyperphagic response to SHU9119 administration
    Diana L Williams
    Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA
    Brain Res 996:180-6. 2004
    ..The results indicate an interaction between melanocortin receptor activity and the metabolic state of the animal, and constrain our thinking about the peripheral signals and central mechanisms that underlie this interaction...
  26. pmc Caudal brainstem delivery of ghrelin induces fos expression in the nucleus of the solitary tract, but not in the arcuate or paraventricular nuclei of the hypothalamus
    Lucy F Faulconbridge
    Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Brain Res 1218:151-7. 2008
    ..These data support the NTS as a target of ghrelin action by building upon prior findings of increases in food intake in response to third- and fourth-ventricle ghrelin delivery...
  27. ncbi request reprint Leptin and the control of food intake: neurons in the nucleus of the solitary tract are activated by both gastric distension and leptin
    Lihong Huo
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 148:2189-97. 2007
    ..These results are consistent with the hypothesis that leptin acts directly on neurons within the mNTS to reduce food intake through an interaction with GI signal processing...
  28. ncbi request reprint Energy expenditure and body composition of chronically maintained decerebrate rats in the fed and fasted condition
    Ruth B S Harris
    Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens, Georgia 30602, USA
    Endocrinology 147:1365-76. 2006
    ..In the absence of communication from the forebrain, the caudal brainstem is inadequate for maintenance of testosterone levels or lean tissue in fed or fasted animals...
  29. ncbi request reprint Role of the duodenum and macronutrient type in ghrelin regulation
    Joost Overduin
    Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, S 111 Endo, Seattle, Washington 98108, USA
    Endocrinology 146:845-50. 2005
    ..The relatively weak suppression of ghrelin by lipids compared with glucose or amino acids could represent one mechanism promoting high-fat dietary weight gain...
  30. ncbi request reprint Vagotomy dissociates short- and long-term controls of circulating ghrelin
    Diana L Williams
    Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Mail Stop 111 ENDO, Seattle, Washington 98108, USA
    Endocrinology 144:5184-7. 2003
    ..The dissociation between nutrient load- and deprivation-related ghrelin responses indicates that the regulation of circulating ghrelin levels involves separate mechanisms operating through anatomically distinct pathways...
  31. ncbi request reprint Leptin responsiveness in chronically decerebrate rats
    Ruth B S Harris
    Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens, GA 30602, USA
    Endocrinology 148:4623-33. 2007
    ....
  32. pmc Divergent leptin signaling in proglucagon neurons of the nucleus of the solitary tract in mice and rats
    Lihong Huo
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Endocrinology 149:492-7. 2008
    ..These data, combined with previous results, suggest a different mechanism of interaction between leptin and NTS proglucagon neurons in mice and rats...
  33. ncbi request reprint Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus
    Lihong Huo
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Diabetes 55:567-73. 2006
    ..We conclude that POMC neurons in the NTS do not respond to leptin unlike ARC POMC neurons. POMC neurons in the hypothalamus may therefore mediate all of leptin's signaling via POMC-derived peptides in the central nervous system...

Research Grants28

  1. NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIOR
    HARVEY GRILL; Fiscal Year: 2003
    ....
  2. NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIOR
    HARVEY GRILL; Fiscal Year: 2007
    ..abstract_text> ..
  3. NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIOR
    HARVEY GRILL; Fiscal Year: 2009
    ....
  4. NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIOR
    HARVEY GRILL; Fiscal Year: 1993
    ..Failures to uncover differences between decerebrate and intact rats will be dramatic and, as in the past, will stimulate investigations of the location, connectivity and physiology of the relevant CBS integrative circuits...
  5. NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIOR
    HARVEY GRILL; Fiscal Year: 1990
    ....
  6. NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIOR
    Harvey J Grill; Fiscal Year: 2010
    ....