Research Topics
| Henry Randall GriffithSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
| Collaborators
|
Detail Information
Publications
The safety and tolerability of galantamine in patients with epilepsy and memory difficultiesH Randall Griffith
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
Epilepsy Behav 13:376-80. 2008..Galantamine appears to be safe and tolerable in patients with epilepsy. Further studies with larger samples and comparison with other cholinesterase inhibitors should be considered...
Reduced brain glutamate in patients with Parkinson's diseaseH Randall Griffith
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA
NMR Biomed 21:381-7. 2008..1)H MRS at 3 T should be investigated in future studies as a means of tracking the course of metabolic brain changes in association with progression of disease in patients with PD...- Executive function is associated with brain proton magnetic resonance spectroscopy in amnestic mild cognitive impairmentH Randall Griffith
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA
J Clin Exp Neuropsychol 29:599-609. 2007..This finding suggests a role for the posterior cingulate in executive function in MCI. Proton MRS may offer a means to track neurometabolic changes associated with cognitive impairment in MCI... - Cognitive functioning over 3 years in community dwelling older adults with chronic partial epilepsyH Randall Griffith
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35233, United States
Epilepsy Res 74:91-6. 2007..A failure to benefit from repeat exposure to a Delayed Recall task could indicate learning deficits. These patients may also progressively lose executive control, possibly as a result of accelerated aging... - Elevated brain scyllo-inositol concentrations in patients with Alzheimer's diseaseH Randall Griffith
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA
NMR Biomed 20:709-16. 2007..Further research on the mechanisms of sI increase in AD is needed. Future studies on the longitudinal course of sI/Cr in MCI and AD appear warranted... 
Brain metabolism differs in Alzheimer's disease and Parkinson's disease dementiaH Randall Griffith
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA
Alzheimers Dement 4:421-7. 2008..We compared brain metabolic abnormalities in Alzheimer's disease (AD) and in Parkinson's disease with dementia (PDD) as measured by proton magnetic resonance spectroscopy (MRS)...- Brain N-acetylaspartate is reduced in Parkinson disease with dementiaHenry Randall Griffith
Department of Neurology, Alzheimer s Disease Research Center, University of Alabama at Birmingham, Birmingham, AL, USA
Alzheimer Dis Assoc Disord 22:54-60. 2008..Future studies investigating the utility of brain MRS as a predictor of dementia in PD and comparing brain metabolism in PDD with other dementias seem warranted... - Older adults with epilepsy demonstrate cognitive impairments compared with patients with amnestic mild cognitive impairmentH Randall Griffith
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Epilepsy Behav 8:161-8. 2006..This study emphasizes the clinical importance of cognitive impairment in seniors with epilepsy and highlights the need for future studies addressing causes and treatment of cognitive impairment... - Memory for famous faces and the temporal pole: functional imaging findings in temporal lobe epilepsyH Randall Griffith
Department of Neurology, University of Alabama at Birmingham, AL, USA
Epilepsy Behav 9:173-80. 2006..Further study appears warranted to elucidate the networks involved in semantic knowledge for famous faces... - Amnestic mild cognitive impairment: diagnostic outcomes and clinical prediction over a two-year time periodH Randall Griffith
Department of Neurology, University of Alabama at Birmingham, 1216 Jefferson Tower, 625 19th Street South, Birmingham, AL, USA
J Int Neuropsychol Soc 12:166-75. 2006..Such methods could aid in identifying MCI patients who might benefit from early treatment, in providing prognostic information to patients, and identifying potential clinical trial participants... - Brain metabolic correlates of decision making in amnestic mild cognitive impairmentH Randall Griffith
Departments of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 17:492-504. 2010..46, p < .05). The relationship of NAA/Cr with decision-making suggests a role for posterior cortical neuronal functioning in performance of complex IADLs in MCI... - Memory relationships between MRI volumes and resting PET metabolism of medial temporal lobe structuresH Randall Griffith
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Epilepsy Behav 5:669-76. 2004..Multiple regression revealed that hippocampal volumes, but not PHG volumes or PET, significantly predicted PA and LM retention scores. These findings suggest that hippocampal volumes provide unique information regarding memory... - Magnetic resonance imaging volume of the angular gyri predicts financial skill deficits in people with amnestic mild cognitive impairmentH Randall Griffith
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Am Geriatr Soc 58:265-74. 2010..To better understand how brain atrophy in amnestic mild cognitive impairment (MCI) as measured using magnetic resonance imaging (MRI) volumetrics could affect instrumental activities of daily living (IADLs) such as financial abilities... - Neurocognitive predictors of financial capacity across the dementia spectrum: Normal aging, mild cognitive impairment, and Alzheimer's diseaseMegan G Sherod
Department of Neurology, University of Alabama at Birmingham, 35294 0017, USA
J Int Neuropsychol Soc 15:258-67. 2009..Executive function and verbal memory were secondary model predictors. The results offer insight into the cognitive basis of financial capacity across the dementia spectrum of cognitive aging, MCI, and AD... - Awareness of deficits in financial abilities in patients with mild cognitive impairment: going beyond self-informant discrepancyOzioma C Okonkwo
Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
Am J Geriatr Psychiatry 16:650-9. 2008..In this study, the authors used three different approaches to examine accuracy of self-report of financial abilities among patients with MCI... - The contribution of executive control on verbal-learning impairment in patients with Parkinson's disease with dementia and Alzheimer's diseaseTimothy J O'Brien
Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA
Arch Clin Neuropsychol 24:237-44. 2009..These findings suggest that deficits in executive functions play a vital role in learning impairments in patients with PDD; however, for AD patients, learning difficulties appear relatively independent of executive dysfunction... - Clinical interview assessment of financial capacity in older adults with mild cognitive impairment and Alzheimer's diseaseDaniel C Marson
Department of Neurology, SC 650, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Am Geriatr Soc 57:806-14. 2009..To investigate financial capacity in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) using a clinician interview approach... - Cognitive correlates of financial abilities in mild cognitive impairmentOzioma C Okonkwo
Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Am Geriatr Soc 54:1745-50. 2006..To investigate the cognitive correlates of financial abilities in mild cognitive impairment (MCI)... - Cognitive functioning in community dwelling older adults with chronic partial epilepsyRoy C Martin
Department of Neurology, UAB Epilepsy Center Birmingham, Birmingham, Alabama 35294 0021, USA
Epilepsia 46:298-303. 2005..To examine cognitive functioning in community-dwelling older adults with chronic partial epilepsy and demographically matched healthy older adults... - A controlled quantitative MRI volumetric investigation of hippocampal contributions to immediate and delayed memory performanceH Randall Griffith
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35233 6890, USA
J Clin Exp Neuropsychol 25:1117-27. 2003..The findings point to a consistent relationship of dominant hippocampal volumes to delayed verbal recall but no involvement of the temporal lobe or nondominant hippocampus in memory... - Declining medical decision-making capacity in mild AD: a two-year longitudinal studyJustin S Huthwaite
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35233-7340, USA
Behav Sci Law 24:453-63. 2006..Capacity outcome data reflect similar declines over time for these four consent standards. The findings suggest the value of early assessment and regular monitoring at two-year intervals of MDC in patients with mild AD... - Cerebrospinal fluid abnormalities and rate of decline in everyday function across the dementia spectrum: normal aging, mild cognitive impairment, and Alzheimer diseaseOzioma C Okonkwo
Department of Neurology, Johns Hopkins School of Medicine, 1620 McElderry St, Reed Hall East 2, Baltimore, MD 21205, USA
Arch Neurol 67:688-96. 2010..To investigate the effect of cerebrospinal fluid (CSF) abnormalities on the rate of decline in everyday function in normal aging, mild cognitive impairment (MCI), and mild Alzheimer disease (AD)... - Medical decision-making abilities in older adults with chronic partial epilepsyJennifer K Bambara
Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Epilepsy Behav 10:63-8. 2007..Physicians should consider the decisional abilities of their older adult patients with epilepsy when presenting treatment options... - Structural and functional neuroimaging correlates of depression in temporal lobe epilepsyElizabeth J Richardson
Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA
Epilepsy Behav 10:242-9. 2007..Future studies examining the potential role of extended neural regions may clarify the observed structural relationship between depressive symptoms and the amygdala... - Medical decision-making capacity in cognitively impaired Parkinson's disease patients without dementiaRoy C Martin
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
Mov Disord 23:1867-74. 2008..Clinicians and researchers should carefully assess decisional capacity in all patients with PD with cognitive impairment... - Determining empirically based self-reported cognitive change: development of reliable change indices and standardized regression-based change norms for the multiple abilities self-report questionnaire in an epilepsy sampleRoy Martin
Department of Neurology and UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USA
Epilepsy Behav 8:239-45. 2006.... - Contributions of volumetrics of the hippocampus and thalamus to verbal memory in temporal lobe epilepsy patientsChristopher C Stewart
Department of Psychology, University of Alabama at Birmingham, Birmingham, USA
Brain Cogn 69:65-72. 2009..They are also consistent with theories proposing that the hippocampus supports long-term memory encoding and storage, whereas the thalamus is implicated in the executive aspects of episodic memory... - Declining financial capacity in patients with mild Alzheimer disease: a one-year longitudinal studyRoy Martin
Department of Neurology and Alzheimer s Disease Research Center, University of Alabama at Birmingham, and VA Medical Center, Birmingham, AL 35294 0017, USA
Am J Geriatr Psychiatry 16:209-19. 2008..The objective of this study was to investigate change over time in financial abilities in patients with mild Alzheimer disease (AD)... - Proton magnetic resonance spectroscopy in dementias and mild cognitive impairmentH Randall Griffith
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Int Rev Neurobiol 84:105-31. 2009..Such developments will hopefully benefit the search for effective treatments of dementias in the twenty-first century...