W S Griffin

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. ncbi request reprint Glial-neuronal interactions in Alzheimer's disease: the potential role of a 'cytokine cycle' in disease progression
    W S Griffin
    Department of Veterans Affairs Medical Center, Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Brain Pathol 8:65-72. 1998
  2. ncbi request reprint Senescence-accelerated overexpression of S100beta in brain of SAMP6 mice
    W S Griffin
    Department of Veterans Affairs Medical Center, and the Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Neurobiol Aging 19:71-6. 1998
  3. ncbi request reprint Life-long overexpression of S100beta in Down's syndrome: implications for Alzheimer pathogenesis
    W S Griffin
    Geriatric Research, Education, and Clinical Center of the Department of Veterans Affairs Medical Center, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Neurobiol Aging 19:401-5. 1998
  4. ncbi request reprint The pervasiveness of interleukin-1 in alzheimer pathogenesis: a role for specific polymorphisms in disease risk
    W S Griffin
    Departments of Geriatrics, Medicine, Psychiatry, and Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Exp Gerontol 35:481-7. 2000
  5. ncbi request reprint Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation
    J G Sheng
    The Donald W. Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, AR 72205, USA
    Neurochem Int 39:341-8. 2001
  6. ncbi request reprint Neuronal DNA damage correlates with overexpression of interleukin-1beta converting enzyme in APPV717F mice
    J G Sheng
    Donald W. Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Neurobiol Aging 22:895-902. 2001
  7. ncbi request reprint Interleukin-1, neuroinflammation, and Alzheimer's disease
    R E Mrak
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Neurobiol Aging 22:903-8. 2001
  8. ncbi request reprint Vitamin E suppression of microglial activation is neuroprotective
    Y Li
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Neurosci Res 66:163-70. 2001
  9. ncbi request reprint Overexpression of the neuritotrophic cytokine S100beta precedes the appearance of neuritic beta-amyloid plaques in APPV717F mice
    J G Sheng
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, USA
    J Neurochem 74:295-301. 2000
  10. ncbi request reprint Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease
    E R Peskind
    Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
    Neurochem Int 39:409-13. 2001

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Glial-neuronal interactions in Alzheimer's disease: the potential role of a 'cytokine cycle' in disease progression
    W S Griffin
    Department of Veterans Affairs Medical Center, Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Brain Pathol 8:65-72. 1998
    ..Chronic propagation of this cytokine cycle represents a possible mechanism for progression of neurodegenerative changes culminating in Alzheimer's disease...
  2. ncbi request reprint Senescence-accelerated overexpression of S100beta in brain of SAMP6 mice
    W S Griffin
    Department of Veterans Affairs Medical Center, and the Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Neurobiol Aging 19:71-6. 1998
    ....
  3. ncbi request reprint Life-long overexpression of S100beta in Down's syndrome: implications for Alzheimer pathogenesis
    W S Griffin
    Geriatric Research, Education, and Clinical Center of the Department of Veterans Affairs Medical Center, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Neurobiol Aging 19:401-5. 1998
    ..05). Our findings are consistent with the idea that conditions--including Down's syndrome--that promote chronic overexpression of S100beta may confer increased risk for later development of Alzheimer's disease...
  4. ncbi request reprint The pervasiveness of interleukin-1 in alzheimer pathogenesis: a role for specific polymorphisms in disease risk
    W S Griffin
    Departments of Geriatrics, Medicine, Psychiatry, and Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Exp Gerontol 35:481-7. 2000
    ..This increase is associated with earlier age of onset. Homozygosity for this polymorphism plus another in the IL-1B gene further increases risk...
  5. ncbi request reprint Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation
    J G Sheng
    The Donald W. Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, AR 72205, USA
    Neurochem Int 39:341-8. 2001
    ....
  6. ncbi request reprint Neuronal DNA damage correlates with overexpression of interleukin-1beta converting enzyme in APPV717F mice
    J G Sheng
    Donald W. Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Neurobiol Aging 22:895-902. 2001
    ..These findings are consistent with the idea that increases in ICE activity and expression contribute to neuronal injury in Alzheimer's disease...
  7. ncbi request reprint Interleukin-1, neuroinflammation, and Alzheimer's disease
    R E Mrak
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Neurobiol Aging 22:903-8. 2001
    ....
  8. ncbi request reprint Vitamin E suppression of microglial activation is neuroprotective
    Y Li
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Neurosci Res 66:163-70. 2001
    ....
  9. ncbi request reprint Overexpression of the neuritotrophic cytokine S100beta precedes the appearance of neuritic beta-amyloid plaques in APPV717F mice
    J G Sheng
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, USA
    J Neurochem 74:295-301. 2000
    ..Accelerated age-related overexpression of S100beta may interact with age-associated overexpression of mutant betaAPP in transgenic mice to promote development of Alzheimer-like neuropathological changes...
  10. ncbi request reprint Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease
    E R Peskind
    Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
    Neurochem Int 39:409-13. 2001
    ..These results suggest increased CNS expression of S100B in the earlier stages of AD, and are consistent with a role for S100B in the initiation and/or facilitation of neuritic plaque formation in AD brain...
  11. ncbi request reprint Phospholipid abnormalities in postmortem schizophrenic brains detected by 31P nuclear magnetic resonance spectroscopy: a preliminary study
    R A Komoroski
    Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Psychiatry Res 106:171-80. 2001
    ..Although these results are not in complete agreement with previous studies, they support the idea that PL abnormalities occur in the brain in schizophrenia and that fatty acid metabolism may be abnormal...