Steven C Griffen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Administration of Lispro insulin with meals improves glycemic control, increases circulating leptin, and suppresses ghrelin, compared with regular/NPH insulin in female patients with type 1 diabetes
    Steven C Griffen
    Medical Center, Patient Support and Services Building Suite G 400, University of California Davis, 4150 V Street, Sacramento, CA 95817, USA
    J Clin Endocrinol Metab 91:485-91. 2006
  2. pmc Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: amelioration by the antioxidant, alpha-lipoic acid
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1343-50. 2010
  3. pmc Concomitant reduction of low-density lipoprotein-cholesterol and biomarkers of inflammation with low-dose simvastatin therapy in patients with type 1 diabetes
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 92:3136-40. 2007
  4. pmc Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 93:578-83. 2008
  5. pmc Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complications
    Sridevi Devaraj
    Department of Pathology, Laboratory for Atherosclerosis and Metabolic Research, UCDavis Medical Center, Sacramento, CA 95817, USA
    Diabetes 56:2790-6. 2007
  6. pmc Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women
    Michael M Swarbrick
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Br J Nutr 100:947-52. 2008
  7. pmc Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, Davis, CA 95616 8669, USA
    Am J Clin Nutr 87:1194-203. 2008
  8. ncbi request reprint Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells
    Shih Khoo
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 278:32969-77. 2003
  9. ncbi request reprint Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes
    Tessy Iype
    Department of Internal Medicine and the Diabetes Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 280:16798-807. 2005

Research Grants

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Administration of Lispro insulin with meals improves glycemic control, increases circulating leptin, and suppresses ghrelin, compared with regular/NPH insulin in female patients with type 1 diabetes
    Steven C Griffen
    Medical Center, Patient Support and Services Building Suite G 400, University of California Davis, 4150 V Street, Sacramento, CA 95817, USA
    J Clin Endocrinol Metab 91:485-91. 2006
    ..Exogenous insulin administration often poorly reproduces normal insulin patterns and may less effectively regulate leptin and ghrelin, two hormones involved in the control of appetite and adiposity...
  2. pmc Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: amelioration by the antioxidant, alpha-lipoic acid
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1343-50. 2010
    ..In conclusion, dietary fructose accelerates the onset of T2DM in UCD-T2DM rats, and LA ameliorates the effects of fructose by improving glucose homeostasis, possibly by preserving beta-cell function...
  3. pmc Concomitant reduction of low-density lipoprotein-cholesterol and biomarkers of inflammation with low-dose simvastatin therapy in patients with type 1 diabetes
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 92:3136-40. 2007
    ..TIDM is a proinflammatory state. Whereas there is consensus on lipid management in type 2 diabetes, there is a lack of data in type 1 diabetes. In addition to benefits on the lipid profile, statin therapy is antiinflammatory...
  4. pmc Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 93:578-83. 2008
    ..TLR2 and TLR4 are important in atherosclerosis. However, there is a paucity of data examining TLR2 and TLR4 expression in T1DM and examining its contribution to the proinflammatory state...
  5. pmc Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complications
    Sridevi Devaraj
    Department of Pathology, Laboratory for Atherosclerosis and Metabolic Research, UCDavis Medical Center, Sacramento, CA 95817, USA
    Diabetes 56:2790-6. 2007
    ....
  6. pmc Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women
    Michael M Swarbrick
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Br J Nutr 100:947-52. 2008
    ....
  7. pmc Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, Davis, CA 95616 8669, USA
    Am J Clin Nutr 87:1194-203. 2008
    ..However, pure fructose and glucose are not commonly used as sweeteners. High-fructose corn syrup (HFCS) has replaced sucrose as the predominant sweetener in beverages in the United States...
  8. ncbi request reprint Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells
    Shih Khoo
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 278:32969-77. 2003
    ..Phosphorylation increases their functional activity and results in a cumulative transactivation of the promoter. Thus, ERK1/2 act at multiple points to transduce a glucose signal to insulin gene transcription...
  9. ncbi request reprint Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes
    Tessy Iype
    Department of Internal Medicine and the Diabetes Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 280:16798-807. 2005
    ..This complex leads to enhancement of elongation by the basal transcriptional machinery...

Research Grants2

  1. IMPAIRED BETA CELL GENE EXPRESSION IN A MODEL OF NIDDM
    STEVEN GRIFFEN; Fiscal Year: 2003
    ..These studies will provide critical information regarding the interaction of the beta-cell and the insulin resistant state in the pathogenesis of DM-2, and identify candidates for human mutations causing type 2 diabetes mellitus. ..
  2. IMPAIRED BETA CELL GENE EXPRESSION IN A MODEL OF NIDDM
    STEVEN GRIFFEN; Fiscal Year: 2003
    ..These studies will define the beta-cell defect in the ZDF rat and may help give insight into the defects in insulin production and secretion seen in NIDDM. ..