GRACE GRIESBACH

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Temperature and heart rate responses to exercise following mild traumatic brain injury
    Grace S Griesbach
    Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 7039, USA
    J Neurotrauma 30:281-91. 2013
  2. pmc Effects of acute restraint-induced stress on glucocorticoid receptors and brain-derived neurotrophic factor after mild traumatic brain injury
    G S Griesbach
    Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Neuroscience 210:393-402. 2012
  3. pmc Differential effects of voluntary and forced exercise on stress responses after traumatic brain injury
    Grace S Griesbach
    Department of Neurosurgery, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095 7039, USA
    J Neurotrauma 29:1426-33. 2012
  4. pmc Heightening of the stress response during the first weeks after a mild traumatic brain injury
    G S Griesbach
    Department of Neurosurgery, David Geffen School of Medicine at University of California Los Angeles, Box 957030, Los Angeles, CA 90095 7039, USA
    Neuroscience 178:147-58. 2011
  5. pmc Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation
    Grace Sophia Griesbach
    Department of Neurosurgery, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 7039, USA
    Brain Res 1288:105-15. 2009
  6. pmc Controlled contusion injury alters molecular systems associated with cognitive performance
    Grace Sophia Griesbach
    Department of Neurosurgery, University of California, Los Angeles, California 90024 7039, USA
    J Neurosci Res 87:795-805. 2009
  7. pmc Voluntary exercise or amphetamine treatment, but not the combination, increases hippocampal brain-derived neurotrophic factor and synapsin I following cortical contusion injury in rats
    G S Griesbach
    Division of Neurosurgery, Department of Surgery, David Geffen School of Medicine at UCLA, Box 957039, Los Angeles, CA 90095 7039, USA
    Neuroscience 154:530-40. 2008
  8. ncbi request reprint Time window for voluntary exercise-induced increases in hippocampal neuroplasticity molecules after traumatic brain injury is severity dependent
    Grace S Griesbach
    Division of Neurosurgery, University of California Los Angeles UCLA, Los Angeles, California, USA
    J Neurotrauma 24:1161-71. 2007
  9. ncbi request reprint The upregulation of plasticity-related proteins following TBI is disrupted with acute voluntary exercise
    Grace Sophia Griesbach
    Division of Neurosurgery, Department of Surgery, UCLA, Los Angeles, CA, USA
    Brain Res 1016:154-62. 2004
  10. ncbi request reprint Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function
    G S Griesbach
    David Geffen School of Medicine at UCLA, Division of Neurosurgery, Los Angeles, CA 90095 7039, USA
    Neuroscience 125:129-39. 2004

Detail Information

Publications13

  1. pmc Temperature and heart rate responses to exercise following mild traumatic brain injury
    Grace S Griesbach
    Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 7039, USA
    J Neurotrauma 30:281-91. 2013
    ..Here we show that cardiac and temperature autonomic function are compromised during the subacute period following a mild TBI...
  2. pmc Effects of acute restraint-induced stress on glucocorticoid receptors and brain-derived neurotrophic factor after mild traumatic brain injury
    G S Griesbach
    Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Neuroscience 210:393-402. 2012
    ..These findings suggest that the increased sensitivity to stressful events during the first post-injury weeks, after a mild FPI, has an impact on hippocampal neuroplasticity...
  3. pmc Differential effects of voluntary and forced exercise on stress responses after traumatic brain injury
    Grace S Griesbach
    Department of Neurosurgery, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095 7039, USA
    J Neurotrauma 29:1426-33. 2012
    ..It did, however, decrease hippocampal glucocorticoid receptors in the control group. The results suggest that exercise regimens with strong stress responses may not be beneficial during the early post-injury period...
  4. pmc Heightening of the stress response during the first weeks after a mild traumatic brain injury
    G S Griesbach
    Department of Neurosurgery, David Geffen School of Medicine at University of California Los Angeles, Box 957030, Los Angeles, CA 90095 7039, USA
    Neuroscience 178:147-58. 2011
    ..The increased sensitivity to stressful events in the first two post-injury weeks after a mild FPI may have a negative impact on early rehabilitative therapies...
  5. pmc Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation
    Grace Sophia Griesbach
    Department of Neurosurgery, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 7039, USA
    Brain Res 1288:105-15. 2009
    ..These studies provide evidence that BDNF has a major role in exercise's cognitive effects in traumatically injured brain...
  6. pmc Controlled contusion injury alters molecular systems associated with cognitive performance
    Grace Sophia Griesbach
    Department of Neurosurgery, University of California, Los Angeles, California 90024 7039, USA
    J Neurosci Res 87:795-805. 2009
    ..In addition, the delayed increase in the expression of BDNF and synapsin I within the cortex contralateral to CCI may reflect restorative processes in areas homotypical to the injury...
  7. pmc Voluntary exercise or amphetamine treatment, but not the combination, increases hippocampal brain-derived neurotrophic factor and synapsin I following cortical contusion injury in rats
    G S Griesbach
    Division of Neurosurgery, Department of Surgery, David Geffen School of Medicine at UCLA, Box 957039, Los Angeles, CA 90095 7039, USA
    Neuroscience 154:530-40. 2008
    ..These results indicate that, whereas exercise or AMPH treatment alone may induce plasticity and reduce oxidative stress after TBI, combining these treatments may cancel each other's therapeutic effects...
  8. ncbi request reprint Time window for voluntary exercise-induced increases in hippocampal neuroplasticity molecules after traumatic brain injury is severity dependent
    Grace S Griesbach
    Division of Neurosurgery, University of California Los Angeles UCLA, Los Angeles, California, USA
    J Neurotrauma 24:1161-71. 2007
    ..These results indicate that the time window for exercise-induced increases in BDNF, synapsin I, and CREB is dependent on injury severity...
  9. ncbi request reprint The upregulation of plasticity-related proteins following TBI is disrupted with acute voluntary exercise
    Grace Sophia Griesbach
    Division of Neurosurgery, Department of Surgery, UCLA, Los Angeles, CA, USA
    Brain Res 1016:154-62. 2004
    ..These results indicate that intracellular signaling proteins are increased during the first week following FPI and that premature voluntary exercise may compromise plasticity...
  10. ncbi request reprint Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function
    G S Griesbach
    David Geffen School of Medicine at UCLA, Division of Neurosurgery, Los Angeles, CA 90095 7039, USA
    Neuroscience 125:129-39. 2004
    ..However, when exercise is administered to soon after TBI, the molecular response to exercise is disrupted and recovery may be delayed...
  11. ncbi request reprint Alterations in BDNF and synapsin I within the occipital cortex and hippocampus after mild traumatic brain injury in the developing rat: reflections of injury-induced neuroplasticity
    Grace Sophia Griesbach
    Division of Neurosurgery, Department of Surgery, UCLA School of Medicine, Los Angeles, California 90024 7039, USA
    J Neurotrauma 19:803-14. 2002
    ....
  12. ncbi request reprint Experience-dependent behavioral plasticity is disturbed following traumatic injury to the immature brain
    Christopher C Giza
    Division of Neurosurgery, Department of Surgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Room 18 228 NPI, Mail Code 703919, Los Angeles, CA 90095, USA
    Behav Brain Res 157:11-22. 2005
    ..In addition, the ability to benefit from environmental stimulation following TBI is dependent upon time after injury...
  13. ncbi request reprint Effects of enriched environment and fluid percussion injury on dendritic arborization within the cerebral cortex of the developing rat
    Emily Yu Yen Ip
    UCLA School of Medicine, Division of Neurosurgery, Los Angeles, California 90025 7039, USA
    J Neurotrauma 19:573-85. 2002
    ..These results suggest that dendritic changes mediate the anatomical and behavioral changes characteristic of impaired developmental plasticity following FPI, and that these changes are dependent on location within the cerebral cortex...

Research Grants5

  1. Voluntary Exercise Therapy after Traumatic Brain Injury
    GRACE GRIESBACH; Fiscal Year: 2006
    ..In order to address these specific aims, I will utilize the lateral fluid-percussion injury model in rats and voluntary running wheel exposure. Protein, gene, histological and behavioral studies will be conducted. ..
  2. The role of traumatic brain injury stress response on exercise therapy
    Grace Sophia Griesbach; Fiscal Year: 2010
    ..This proposal will provide mechanistically based information that will aid in developing an optimal exercise regimen after TBI. ..
  3. The role of traumatic brain injury stress response on exercise therapy
    GRACE GRIESBACH; Fiscal Year: 2009
    ..This proposal will provide mechanistically based information that will aid in developing an optimal exercise regimen after TBI. ..