Almut Grenz

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. doi request reprint Hypoxia signaling during intestinal ischemia and inflammation
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Aurora, Colorado 80045, USA
    Curr Opin Crit Care 18:178-85. 2012
  2. pmc Partial netrin-1 deficiency aggravates acute kidney injury
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
    PLoS ONE 6:e14812. 2011
  3. pmc Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
    J Clin Invest 122:693-710. 2012
  4. pmc A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 118:3301-15. 2008
  5. pmc Protective role for netrin-1 during diabetic nephropathy
    Eunyoung Tak
    Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, 12700 E 19th Avenue, Mailstop B112, Research Complex 2, Room 7121, Aurora, CO, 80045, USA
    J Mol Med (Berl) 91:1071-80. 2013
  6. pmc Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-α release
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 189:4566-73. 2012
  7. doi request reprint Adenosine generation and signaling during acute kidney injury
    Jessica D Bauerle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, 12700 E 19 Avenue, Mailstop B112, Research Complex 2, Room 7124, Aurora, CO 80045, USA
    J Am Soc Nephrol 22:14-20. 2011
  8. pmc Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease
    Jens M Poth
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado School of Medicine, 12700 East 19th Avenue, Mailstop B112, Aurora, CO 80045, USA
    J Mol Med (Berl) 91:183-93. 2013
  9. pmc Signaling through hepatocellular A2B adenosine receptors dampens ischemia and reperfusion injury of the liver
    Michael A Zimmerman
    Division of Transplant Surgery, Department of Surgery, and Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 110:12012-7. 2013
  10. pmc Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemia
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA
    Antioxid Redox Signal 15:2221-34. 2011

Collaborators

Detail Information

Publications14

  1. doi request reprint Hypoxia signaling during intestinal ischemia and inflammation
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Aurora, Colorado 80045, USA
    Curr Opin Crit Care 18:178-85. 2012
    ..In many instances, HIF-dependent alterations of gene expression represent endogenous adaptive responses that dampen pathologic inflammation and could be targeted to treat intestinal injury...
  2. pmc Partial netrin-1 deficiency aggravates acute kidney injury
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
    PLoS ONE 6:e14812. 2011
    ..Finally, treatment of Ntn-1(+/-) mice with exogenous netrin-1 restored a normal phenotype during AKI. Taking together, these studies implicate endogenous netrin-1 in attenuating renal inflammation during AKI...
  3. pmc Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
    J Clin Invest 122:693-710. 2012
    ..These studies identify ENT1 and adenosine receptors as key to the process of reestablishing renal perfusion following ischemic AKI. If translatable from mice to humans, these data have important therapeutic implications...
  4. pmc A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 118:3301-15. 2008
    ..Taken together, these studies reveal a role for A2BAR signaling in attenuating VILI and implicate this receptor as a potential therapeutic target during acute lung injury...
  5. pmc Protective role for netrin-1 during diabetic nephropathy
    Eunyoung Tak
    Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, 12700 E 19th Avenue, Mailstop B112, Research Complex 2, Room 7121, Aurora, CO, 80045, USA
    J Mol Med (Berl) 91:1071-80. 2013
    ..Taken together, these studies demonstrate a functional role for endogenous netrin-1 in attenuating diabetic kidney disease. ..
  6. pmc Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-α release
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 189:4566-73. 2012
    ..In total, these data demonstrate a critical role of adenosine signaling in constraining neutrophil-dependent production of TNF-α and implicate therapies targeting TNF-α in the treatment of ischemic AKI...
  7. doi request reprint Adenosine generation and signaling during acute kidney injury
    Jessica D Bauerle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, 12700 E 19 Avenue, Mailstop B112, Research Complex 2, Room 7124, Aurora, CO 80045, USA
    J Am Soc Nephrol 22:14-20. 2011
    ..If these experimental strategies can be translated into a clinical setting, adenosine receptor therapeutics may become an integral part in the prevention or treatment of AKI from renal ischemia...
  8. pmc Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease
    Jens M Poth
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado School of Medicine, 12700 East 19th Avenue, Mailstop B112, Aurora, CO 80045, USA
    J Mol Med (Berl) 91:183-93. 2013
    ....
  9. pmc Signaling through hepatocellular A2B adenosine receptors dampens ischemia and reperfusion injury of the liver
    Michael A Zimmerman
    Division of Transplant Surgery, Department of Surgery, and Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 110:12012-7. 2013
    ..These studies provide a unique role for hepatocellular-specific Adora2b signaling in liver protection during ischemia and reperfusion injury...
  10. pmc Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemia
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA
    Antioxid Redox Signal 15:2221-34. 2011
    ....
  11. doi request reprint Usefulness of pressure-controlled ventilation at high inspiratory pressures to induce acute lung injury in mice
    Tobias Eckle
    University of Colorado Denver Dept of Anesthesiology and Perioperative Medicine, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 295:L718-24. 2008
    ..Together, these studies demonstrate feasibility of this model to induce murine ALI...
  12. pmc The reno-vascular A2B adenosine receptor protects the kidney from ischemia
    Almut Grenz
    Department of Pharmacology and Toxicology, Tubingen University Hospital, Tubingen, Germany Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 5:e137. 2008
    ..Here, we identified a novel pathway of renal protection from ischemia using ischemic preconditioning (IP)...
  13. doi request reprint Hyperhomocysteinemia is associated with decreased erythropoietin expression in rats
    Almut Grenz
    Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, USA
    Cell Physiol Biochem 26:449-56. 2010
    ....
  14. pmc Interleukin 37 expression protects mice from colitis
    Eoin N McNamee
    Department of Medicine, Section of Pediatric Gastroenterology, Digestive Health Institute, Children s Hospital Colorado, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 108:16711-6. 2011
    ..Thus, IL-37 emerges as key modulator of intestinal inflammation...