Jolanta Grembecka

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
    Jolanta Grembecka
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Nat Chem Biol 8:277-84. 2012
  2. pmc Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias
    Jolanta Grembecka
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:40690-8. 2010
  3. pmc Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia
    Aibin Shi
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Blood 120:4461-9. 2012
  4. pmc Detection of disordered regions in globular proteins using ¹³C-detected NMR
    Felicia L V Gray
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Protein Sci 21:1954-60. 2012
  5. pmc High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction
    Shihan He
    Department of Pathology, University of Michigan, Ann Arbor, 1150 West Medical Center Drive, MSRBI, Room 4510D, Michigan, 48109, United States
    J Med Chem 57:1543-56. 2014
  6. ncbi request reprint Dysregulated hematopoiesis caused by mammary cancer is associated with epigenetic changes and hox gene expression in hematopoietic cells
    Alexander Sio
    Authors Affiliations Department of Microbiology and Immunology, I3 Research Group, Life Sciences Institute, University of British Columbia, Vancouver Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia, Canada and Department of Pathology, University of Michigan, Ann Arbor, Michigan
    Cancer Res 73:5892-904. 2013
  7. pmc Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
    Marcelo J Murai
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 286:31742-8. 2011
  8. ncbi request reprint Challenges and opportunities in targeting the menin-MLL interaction
    Tomasz Cierpicki
    Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA
    Future Med Chem 6:447-62. 2014
  9. pmc Cytokine induced phenotypic and epigenetic signatures are key to establishing specific macrophage phenotypes
    Nicolai A Kittan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e78045. 2013

Collaborators

  • Brad H Nelson
  • Shaun R Stauffer
  • Danielle L Krebs
  • William F Carson
  • Tomasz Cierpicki
  • Marcelo J Murai
  • Shihan He
  • Nicolai A Kittan
  • Trupta Purohit
  • Alexander Sio
  • Aibin Shi
  • Felicia L V Gray
  • Maksymilian Chruszcz
  • Gireesh Reddy
  • Jonathan Pollock
  • Timothy J Senter
  • Changho Han
  • Sunil Kumar Upadhyay
  • Craig W Lindsley
  • Rocco D Gogliotti
  • Gabor Jarai
  • Kenneth W Harder
  • Steven L Kunkel
  • Cory M Hogaboam
  • Morgan E Roberts
  • Karen A Cavassani
  • Matthew Schaller
  • John Westwick
  • Sumanta Mukherjee
  • Manreet K Chehal
  • Kevin Tsai
  • Abhay Dhaliwal
  • Ronald M Allen
  • Katherine A Gallagher
  • Xueling Fan
  • George Lund
  • Thomas Hartley

Detail Information

Publications9

  1. pmc Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
    Jolanta Grembecka
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Nat Chem Biol 8:277-84. 2012
    ..Our findings also highlight a new therapeutic strategy for aggressive leukemias with MLL rearrangements...
  2. pmc Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias
    Jolanta Grembecka
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:40690-8. 2010
    ....
  3. pmc Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia
    Aibin Shi
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Blood 120:4461-9. 2012
    ....
  4. pmc Detection of disordered regions in globular proteins using ¹³C-detected NMR
    Felicia L V Gray
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Protein Sci 21:1954-60. 2012
    ..Our work provides an efficient way to characterize disordered fragments in globular proteins for structural biology applications...
  5. pmc High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction
    Shihan He
    Department of Pathology, University of Michigan, Ann Arbor, 1150 West Medical Center Drive, MSRBI, Room 4510D, Michigan, 48109, United States
    J Med Chem 57:1543-56. 2014
    ..Our studies provide novel and attractive scaffold as a new potential therapeutic approach for MLL leukemias and demonstrate an example of PPI amenable to inhibition by small molecules. ..
  6. ncbi request reprint Dysregulated hematopoiesis caused by mammary cancer is associated with epigenetic changes and hox gene expression in hematopoietic cells
    Alexander Sio
    Authors Affiliations Department of Microbiology and Immunology, I3 Research Group, Life Sciences Institute, University of British Columbia, Vancouver Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia, Canada and Department of Pathology, University of Michigan, Ann Arbor, Michigan
    Cancer Res 73:5892-904. 2013
    ..Together, our results show that mammary tumor-secreted factors induce profound perturbations in hematopoiesis and expression of key hematopoietic regulatory genes...
  7. pmc Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
    Marcelo J Murai
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 286:31742-8. 2011
    ..It also provides essential structural information for development of inhibitors targeting the menin-MLL interaction as a novel therapeutic strategy in MLL-related leukemias...
  8. ncbi request reprint Challenges and opportunities in targeting the menin-MLL interaction
    Tomasz Cierpicki
    Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA
    Future Med Chem 6:447-62. 2014
    ..This review summarizes the most recent achievements in targeting the menin-MLL interaction as well as discusses potential benefits of blocking menin in cancer. ..
  9. pmc Cytokine induced phenotypic and epigenetic signatures are key to establishing specific macrophage phenotypes
    Nicolai A Kittan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e78045. 2013
    ..In addition, we describe a novel role for MLL as marker for classical activation. Our findings provide new insights into MΦ polarization that could be helpful to distinguish MΦ activation states...