Jolanta Grembecka

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
    Jolanta Grembecka
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Nat Chem Biol 8:277-84. 2012
  2. pmc Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias
    Jolanta Grembecka
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:40690-8. 2010
  3. pmc Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia
    Aibin Shi
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Blood 120:4461-9. 2012
  4. pmc Detection of disordered regions in globular proteins using ¹³C-detected NMR
    Felicia L V Gray
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Protein Sci 21:1954-60. 2012
  5. pmc Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
    Marcelo J Murai
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 286:31742-8. 2011

Collaborators

  • Marcelo J Murai
  • Tomasz Cierpicki
  • Aibin Shi
  • Felicia L V Gray
  • Maksymilian Chruszcz
  • Gireesh Reddy
  • Trupta Purohit
  • Thomas Hartley
  • Shihan He
  • George Lund

Detail Information

Publications5

  1. pmc Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
    Jolanta Grembecka
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Nat Chem Biol 8:277-84. 2012
    ..Our findings also highlight a new therapeutic strategy for aggressive leukemias with MLL rearrangements...
  2. pmc Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias
    Jolanta Grembecka
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:40690-8. 2010
    ....
  3. pmc Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia
    Aibin Shi
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Blood 120:4461-9. 2012
    ....
  4. pmc Detection of disordered regions in globular proteins using ¹³C-detected NMR
    Felicia L V Gray
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Protein Sci 21:1954-60. 2012
    ..Our work provides an efficient way to characterize disordered fragments in globular proteins for structural biology applications...
  5. pmc Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
    Marcelo J Murai
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 286:31742-8. 2011
    ..It also provides essential structural information for development of inhibitors targeting the menin-MLL interaction as a novel therapeutic strategy in MLL-related leukemias...