Dale Greiner

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Humanized mice for the study of type 1 and type 2 diabetes
    Dale L Greiner
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Ann N Y Acad Sci 1245:55-8. 2011
  2. ncbi request reprint Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere
    D L Greiner
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Clin Immunol 100:134-43. 2001
  3. ncbi request reprint Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice
    Todd Pearson
    Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 171:185-95. 2003
  4. ncbi request reprint Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms
    Scott J Banuelos
    Department of Surgery, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Transplantation 78:660-7. 2004
  5. ncbi request reprint Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms
    Daron Forman
    Program in Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 168:6047-56. 2002
  6. ncbi request reprint Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance
    Nancy E Phillips
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:3015-23. 2003
  7. pmc TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts
    Thomas B Thornley
    Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 176:1561-70. 2006
  8. ncbi request reprint Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice
    Scott J Banuelos
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Clin Immunol 112:273-83. 2004
  9. pmc Creation of "humanized" mice to study human immunity
    Todd Pearson
    Diabetes Division, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Curr Protoc Immunol . 2008
  10. ncbi request reprint Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody
    Thomas G Markees
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Transplantation 78:1601-8. 2004

Research Grants

  1. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 2003
  2. GENETICS OF AUTOIMMUNITY IN BB RATS
    Dale Greiner; Fiscal Year: 2000
  3. HUMAN HEMOPOIESIS IN NEW SCID MOUSE MODELS
    Dale Greiner; Fiscal Year: 2001
  4. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 2001
  5. GENETICS OF AUTOIMMUNITY IN BB RATS
    Dale Greiner; Fiscal Year: 2001
  6. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 2002
  7. HUMAN HEMOPOIESIS IN NEW SCID MOUSE MODELS
    Dale Greiner; Fiscal Year: 2002
  8. GENETICS OF AUTOIMMUNITY IN BB RATS
    Dale Greiner; Fiscal Year: 2002
  9. HUMAN HEMOPOIESIS IN NEW SCID MOUSE MODELS
    Dale Greiner; Fiscal Year: 2003
  10. GENETICS OF AUTOIMMUNITY IN BB RATS
    Dale Greiner; Fiscal Year: 2003

Collaborators

Detail Information

Publications76

  1. pmc Humanized mice for the study of type 1 and type 2 diabetes
    Dale L Greiner
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Ann N Y Acad Sci 1245:55-8. 2011
    ..The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk...
  2. ncbi request reprint Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere
    D L Greiner
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Clin Immunol 100:134-43. 2001
    ..In this review we attempt to identify the most promising avenues of continuing research in these models and the most important issues that must be faced by the designers of human therapies based on the animal dataset...
  3. ncbi request reprint Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice
    Todd Pearson
    Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 171:185-95. 2003
    ..The outcomes of tolerance induction protocols tested in NOD mice may not accurately predict outcomes in human subjects...
  4. ncbi request reprint Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms
    Scott J Banuelos
    Department of Surgery, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Transplantation 78:660-7. 2004
    ..Induction of skin allograft survival requires the presence of CD4 cells and deletion of alloreactive CD8 cells. The specific roles of CD4 and CD4CD25 cells and the mechanism(s) by which they act are not fully understood...
  5. ncbi request reprint Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms
    Daron Forman
    Program in Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 168:6047-56. 2002
    ..Clinical application of stem cell transplantation protocols based on costimulation blockade and tolerance induction may require patient isolation to facilitate the procedure and to protect recipients...
  6. ncbi request reprint Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance
    Nancy E Phillips
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:3015-23. 2003
    ..We speculate that a requirement for regulatory CD4(+) T cells in skin allograft recipients could account for this differential response to tolerance induction...
  7. pmc TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts
    Thomas B Thornley
    Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 176:1561-70. 2006
    ..We conclude that TLR signaling abrogates the effects of costimulation blockade by preventing alloreactive CD8+ T cell apoptosis through a mechanism not dependent on TNFR2 or IL-12R signaling...
  8. ncbi request reprint Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice
    Scott J Banuelos
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Clin Immunol 112:273-83. 2004
    ..host disease (GVHD). We propose that diabetic NOD-RagI(null)Prf1(null) mice co-engrafted with HLA-A2 mouse transgenic islets and allogeneic human PBMC provide an effective in vivo model of human islet allograft rejection...
  9. pmc Creation of "humanized" mice to study human immunity
    Todd Pearson
    Diabetes Division, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Curr Protoc Immunol . 2008
    ....
  10. ncbi request reprint Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody
    Thomas G Markees
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Transplantation 78:1601-8. 2004
    ..It is unknown if other lymphohematopoietic cell populations can be used as a DST...
  11. pmc TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade
    David M Miller
    Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 182:5547-59. 2009
    ..These data suggest that distinct but overlapping cellular and molecular mechanisms control the ability of TLR agonists to block tolerance induction to hematopoietic and skin allografts in mice treated with costimulation blockade...
  12. pmc NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection
    Waldemar J Racki
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Transplantation 89:527-36. 2010
    ..In contrast, human skin graft integrity is excellent on CB17-scid bg (SCID.bg) mice, but they engraft poorly with human immune systems...
  13. pmc Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice
    Julie Mangada
    Program in Immunology and Virology, The University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Diabetes 58:165-73. 2009
    ..However, costimulation blockade-based tolerance protocols have failed in prolonging islet allograft survival in NOD mice...
  14. ncbi request reprint Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections
    Michael A Brehm
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:4077-86. 2003
    ..Mice previously infected with LCMV and harboring allo-specific memory T cells were refractory to the induction of tolerance to allogeneic skin grafts...
  15. ncbi request reprint NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction
    Todd Pearson
    Program in Immunology and Virology, University of Massachusetts Medical School, Worcester 01605, USA
    Diabetes 52:321-6. 2003
    ....
  16. ncbi request reprint Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3
    Todd Pearson
    The University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Diabetes 53:1972-8. 2004
    ....
  17. ncbi request reprint A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene
    Marie King
    Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01655, USA
    Clin Immunol 126:303-14. 2008
    ..These data suggest that humanized NOD-scid Il2rgamma(null) mice may represent an important surrogate for investigating in vivo mechanisms of human islet allograft rejection...
  18. pmc Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice
    Lisa J Giassi
    Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Exp Biol Med (Maywood) 233:997-1012. 2008
    ..Ex vivo expanded CD34(+) human UCB cells have the capacity to generate multiple hematopoietic lineages and a functional human immune system upon transplantation into TNFalpha-treated NOD-scid IL2rgamma(null) mice...
  19. ncbi request reprint Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity
    Marie King
    Diabetes Division, University of Massachusetts Medical School, 373 Plantation Street, Suite 218, Worcester, MA 01605, USA
    Ann N Y Acad Sci 1103:90-3. 2007
    ..Herein, we describe the challenges of recapitulating human immunity in humanized mice and features of NOD-scid Il2rgamma(null) mice that help overcome them...
  20. pmc Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat
    Prerna Chopra
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    In Vivo 23:195-201. 2009
    ..However, alpha-GalCer can activate or suppress immune responses, raising concern about its potential use in human diabetes...
  21. ncbi request reprint Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations
    Danny Zipris
    Program in Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:3592-602. 2003
    ....
  22. ncbi request reprint Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice
    Hideyuki Masaki
    Division of Diabetes, University of Massachusetts Medical School, Worcester, MA, USA
    Xenotransplantation 13:224-32. 2006
    ..The goal of this study was to determine if co-stimulation blockade would facilitate chimerism and xenograft tolerance in irradiation-conditioned concordant recipients...
  23. pmc Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes
    Anja Jaeschke
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 102:6931-5. 2005
    ..We conclude that JNK protein kinases may have important roles in diabetes, including functions of JNK1 in type 2 diabetes and JNK2 in type 1 diabetes...
  24. pmc Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance
    Thomas B Thornley
    Department of Medicine, Division of Diabetes, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 179:6620-9. 2007
    ..Blocking of type 1 IFN-dependent pathways in patients may improve allograft survival in the presence of exogenous TLR ligands...
  25. pmc Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease
    Steve Pino
    Department of Medicine, The University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 602:105-17. 2010
    ....
  26. ncbi request reprint Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice
    Ethel J Gordon
    University of Massachusetts Medical School, Diabetes Division, Department of Medicine, 373 Plantation St, Biotech 2, Suite 218, Worcester, MA 01605, USA
    Diabetes 54:107-15. 2005
    ..We conclude that the resistance of NOD mice to xenograft tolerance induction involves some mechanisms that also participate in the expression of autoimmunity and other mechanisms that are distinct...
  27. ncbi request reprint Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice
    Nicole A Turgeon
    University of Massachusetts Medical School, Worcester, Massachussetts 01605, USA
    Exp Biol Med (Maywood) 228:1096-104. 2003
    ..It is proposed that Hu-PBL-NOD-scid B2mnull mice engrafted with human skin will provide a useful model for analysis of interventions designed to modulate human allograft rejection...
  28. pmc Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning
    Edward Seung
    Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Clin Invest 112:795-808. 2003
    ..We conclude that robust allogeneic hematopoietic chimerism and central tolerance can be established in the absence of host myeloablative conditioning using a peripheral transplantation tolerance protocol...
  29. pmc Unexpected side products in the conjugation of an amine-derivatized morpholino oligomer with p-isothiocyanate benzyl DTPA and their removal
    Guozheng Liu
    Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Nucl Med Biol 38:159-63. 2011
    ..Adding a postconjugation-prepurification heating step dissociated the side products, improved the label stability and lowered tissue backgrounds in mice...
  30. pmc Preparation of (111)In-DTPA morpholino oligomer for low abdominal accumulation
    Guozheng Liu
    Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655 0243, USA
    Appl Radiat Isot 68:1709-14. 2010
    ....
  31. ncbi request reprint Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research
    Leonard D Shultz
    Division of Diabetes, Department of Medicine, 373 Plantation Street, Biotech 2, Suite 218, Worcester, MA 01605, USA
    Ann N Y Acad Sci 1103:77-89. 2007
    ..Overall, development of these new generations of humanized mice should facilitate in vivo studies of the human immune system as well as permit the investigation of the pathogenesis and effector phases of human T1D...
  32. ncbi request reprint Diabetes research in jeopardy: the extinction of clinical diabetes researchers
    Aldo A Rossini
    Diabetes Division, University of Massachusetts Medical School, 373 Plantation Street, Suite 218, Worcester, MA 01605, USA
    Ann N Y Acad Sci 1103:33-44. 2007
    ..Additionally, this environment, can offer young scientists the resources that would otherwise be unavailable to them. This concept is fundamental to creating more experienced and prolific scientists in the field of diabetes...
  33. ncbi request reprint Induction of tolerance for islet transplantation for type 1 diabetes
    Edward Seung
    Diabetes Division, University of Massachusetts Medical School, Two Biotech, 373 Plantation Street, Suite 218, Worcester, MA 01605, USA
    Curr Diab Rep 3:329-35. 2003
    ..Studies of the underlying mechanisms have provided new insights into the nature of both tolerance and autoimmunity...
  34. ncbi request reprint Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody
    Michael C Appel
    Department of Medicine, Division of Diabetes, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Transplantation 77:1341-9. 2004
    ....
  35. pmc Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes
    Rita Bortell
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Ann N Y Acad Sci 1150:112-22. 2008
    ..These investigations may uncover new therapies and strategies to prevent type 1A diabetes...
  36. ncbi request reprint TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat
    Danny Zipris
    Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    J Immunol 178:693-701. 2007
    ..Our data implicate the TLR9-signaling pathway in KRV-induced innate immune activation and autoimmune diabetes in the BBDR rat...
  37. ncbi request reprint Costimulatory blockade induces hyporesponsiveness in T cells that recognize alloantigen via indirect antigen presentation
    Nancy E Phillips
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Transplantation 82:1085-92. 2006
    ..This effect is due in part to deletion of host CD8 and CD4 T cells that recognize alloantigen by direct presentation. The fate of host CD4 T cells that recognize alloantigen by indirect presentation, however, is unclear...
  38. pmc Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice
    Madelyn R Schmidt
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 3:e3192. 2008
    ..The data indicate that production of fully immunologically competent humanized mice from PBL can be markedly facilitated by providing human BLyS...
  39. pmc Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice
    Michael A Brehm
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Blood 109:819-26. 2007
    ..We conclude that rapid production of TNF-alpha can be used to quantify naive alloreactive T cells, that it is abrogated after the induction of tolerance, and that it is a potential tool to predict allograft rejection...
  40. pmc Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice
    Michael A Brehm
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Diabetes 59:2265-70. 2010
    ..To create an immunodeficient mouse model that spontaneously develops hyperglycemia to serve as a diabetic host for human islets and stem cell-derived beta-cells in the absence or presence of a functional human immune system...
  41. pmc TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance
    David M Miller
    Department of Medicine, Division of Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Ann N Y Acad Sci 1150:149-51. 2008
    ....
  42. pmc Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation
    Michael A Brehm
    Diabetes Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Clin Immunol 135:84-98. 2010
    ..Our data define key parameters for establishing humanized mouse models to study human immunity...
  43. pmc Humanized mice for the study of type 1 diabetes and beta cell function
    Marie King
    Department of Medicine, Division of Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Ann N Y Acad Sci 1150:46-53. 2008
    ..These humanized mouse models provide an important preclinical bridge between in vitro studies and rodent models and the translation of discoveries in these model systems to the clinic...
  44. ncbi request reprint Role of innate immunity in transplantation tolerance
    David M Miller
    Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Crit Rev Immunol 28:403-39. 2008
    ..In this review, we discuss how the activation of TLRs can affect the induction and maintenance of transplantation tolerance...
  45. pmc The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats
    John P Mordes
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Diabetes 51:3254-62. 2002
    ..These characteristics suggest that iddm4 is one of the most powerful non-major histocompatibility complex determinants of susceptibility to autoimmune diabetes described to date...
  46. ncbi request reprint Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
    Todd Pearson
    Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Ann N Y Acad Sci 1005:148-56. 2003
    ..We believe that the recent discoveries we describe will have important implications for the development of tolerance-based transplantation therapies and their translation from the laboratory to the clinic...
  47. pmc CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells
    Steven C Pino
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 4:e5468. 2009
    ..These findings indicate a direct relationship between Gimap5 and the maintenance of ER homeostasis in the survival of T cells...
  48. pmc Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice
    Smita Jaiswal
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 4:e7251. 2009
    ..The lack of a suitable animal model to study viral and immunological mechanisms of human dengue disease has been a deterrent to dengue research...
  49. pmc Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism
    Kenneth D Bishop
    University of Massachusetts Medical School, Worcester, 01655, USA
    Cell Immunol 256:86-91. 2009
    ..We have also shown that the neutralization of IL-2 during restimulation abrogates the effect of PD-1 depletion, suggesting that tolerance mediated by PD-1 is wholly IL-2 dependent, and likewise intrinsic to the tolerized cells...
  50. ncbi request reprint Type 1 cytokines polarize thymocytes during T cell development in adult thymus organ cultures
    Barbara J Whalen
    Department of Medicine, University of Massachusetts Medical School, Biotech II, Suite 218, 373 Plantation Street, Worcester, MA 01605, USA
    J Autoimmun 20:27-42. 2003
    ..These data demonstrate that exposure to type 1 cytokines during intrathymic development can polarize differentiating T cells, and suggest a mechanism by which intrathymic exposure to type 1 cytokines may modulate T cell development...
  51. pmc Infection with viruses from several families triggers autoimmune diabetes in LEW*1WR1 rats: prevention of diabetes by maternal immunization
    Rebecca S Tirabassi
    BioMedical Research Models, Worcester, Massachusetts, USA
    Diabetes 59:110-8. 2010
    ....
  52. doi request reprint Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats
    Annie J Kruger
    Diabetes Division, University of Massachusetts, Worcester, MA 01605, USA
    Exp Biol Med (Maywood) 235:1328-37. 2010
    ....
  53. pmc Viral infection: a potent barrier to transplantation tolerance
    David M Miller
    Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Clin Dev Immunol 2008:742810. 2008
    ..In this review, we discuss how viruses modulate the induction and maintenance of transplantation tolerance...
  54. pmc Humanized mouse models to study human diseases
    Michael A Brehm
    Diabetes Division, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Curr Opin Endocrinol Diabetes Obes 17:120-5. 2010
    ..Update on humanized mouse models and their use in biomedical research...
  55. ncbi request reprint Rat models of type 1 diabetes: genetics, environment, and autoimmunity
    John P Mordes
    Department of Medicine, University of Massachusetts, Medical School, Worcester, MA, USA
    ILAR J 45:278-91. 2004
    ..Finally, data generated in the rat have correctly predicted the outcome of several human diabetes prevention trials, notably the failure of nicotinamide and low dose parenteral and oral insulin therapies...
  56. pmc LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation
    John P Mordes
    BioMedical Research Models, 67 Millbrook St, Suite 422, Worcester, MA 01606, USA
    Diabetes 54:2727-33. 2005
    ..The LEW.1WR1 rat provides a new model for studying autoimmune diabetes and arthritis in an animal with a genetic predisposition to both disorders that can be amplified by environmental perturbation...
  57. ncbi request reprint Deficiencies in gut NK cell number and function precede diabetes onset in BB rats
    Derrick J Todd
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 172:5356-62. 2004
    ..Defects in IENK cell number and function may contribute to the pathogenesis of autoimmune diseases including type 1 diabetes...
  58. ncbi request reprint TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats
    Danny Zipris
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 174:131-42. 2005
    ..Our results suggest that the degree to which the innate immune system is activated by TLRs is important for expression of virus-induced diabetes in genetically susceptible hosts...
  59. ncbi request reprint Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice
    Todd Pearson
    Program in Immunology and Virology, at The University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Rev Endocr Metab Disord 4:255-61. 2003
  60. pmc Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice
    Jinhee Lee
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    BMC Immunol 14:53. 2013
    ..1 (NSG-A2) to generate NSG-A2-BLT mice and characterized their human immune response to Mycobacterium bovis bacillus Calmette-Guerin (BCG) infection to assess the utility of this model for investigating human TB...
  61. ncbi request reprint Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells
    John E Harris
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 173:7331-8. 2004
    ..These data indicate that sustained Egr-2 expression is necessary to induce a full anergic state through the actions of genes regulated by this transcription factor...
  62. pmc Ian4 is required for mitochondrial integrity and T cell survival
    Malini Pandarpurkar
    Department of Medicine and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Suite 218, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 100:10382-7. 2003
    ..The findings establish Ian4 as a tissue-specific regulator of mitochondrial integrity...
  63. pmc Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response
    Steven C Pino
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Stress Chaperones 13:421-34. 2008
    ..Collectively, these data suggest that induction of the ER stress response through PKC signaling is an important component for the preparation of a T cell response to antigen...
  64. ncbi request reprint ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose)
    Alan R Morrison
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 281:33363-72. 2006
    ..The data suggest that capability of polymerizing ADP-ribose may not be unique to PARPs and that poly(ADP-ribosylation), an established nuclear activity, may occur extracellularly and modulate cell function...
  65. ncbi request reprint A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3
    Jan Luuk Hillebrands
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 177:7820-32. 2006
    ..We conclude that CD4+CD25+ cells in the BBDR rat act in vitro and in vivo as natural Tregs. In addition, another population that is CD4+CD45RC-CD25- also participates in the regulation of autoimmune diabetes...
  66. pmc Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus
    John P Mordes
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, 01655, USA
    Mamm Genome 20:162-9. 2009
    ....
  67. ncbi request reprint T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7
    Sherri W Christianson
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    J Autoimmun 18:119-30. 2002
    ..We conclude that abnormal T cell development in me(v)/ me(v) mice may in part be due to defects in the ability of bone marrow-derived accessory cells to provide bioavailable IL-7 to developing thymocytes...
  68. ncbi request reprint Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells
    Leonard D Shultz
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 174:6477-89. 2005
    ..Thus, NOD-scid IL2Rgamma(null) mice engrafted with human mobilized blood stem cells provide a new in vivo long-lived model of robust multilineage human HSC engraftment...
  69. pmc T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice
    Priti Kumar
    Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Cell 134:577-86. 2008
    ..Moreover, scFvCD7-9R could deliver antiviral siRNAs to naive T cells in Hu-HSC mice and effectively suppress viremia in infected mice. Thus, siRNA therapy for HIV infection appears to be feasible in a preclinical animal model...
  70. ncbi request reprint Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells
    Leonard D Shultz
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Exp Hematol 31:551-8. 2003
    ..The objective of these studies was to deplete NK cells both by genetic manipulation of the hosts and by antibody depletion of cell populations that may regulate engraftment with human STRC...
  71. ncbi request reprint NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment
    Leonard D Shultz
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Transplantation 76:1036-42. 2003
    ....
  72. ncbi request reprint Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression
    David V Serreze
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 177:6675-84. 2006
    ....
  73. ncbi request reprint A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo
    Atsushi Izawa
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:786-96. 2007
    ..These results describe a novel allospecific regulatory CD8(+)PD1(+) T cell induced by ICOS-B7h blockade in vivo...
  74. ncbi request reprint Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene
    Elizabeth P Blankenhorn
    Department of Microbiology and Immunology, Center for Immunogenetics and Inflammatory Diseases, Drexel University College of Medicine, Philadelphia, PA, USA
    Ann N Y Acad Sci 1103:128-31. 2007
    ..We conclude that Iddm4-mediated diabetes resistance in rats may be due to a recessive protective mutation in TCRVbeta4...
  75. pmc The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection
    Elizabeth P Blankenhorn
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 54:1233-7. 2005
    ....
  76. ncbi request reprint Humanized mice in translational biomedical research
    Leonard D Shultz
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Immunol 7:118-30. 2007
    ....

Research Grants30

  1. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 2003
    ....
  2. GENETICS OF AUTOIMMUNITY IN BB RATS
    Dale Greiner; Fiscal Year: 2000
    ..Our belief and ultimate hope is that understanding the genetics of IDDM in BB rats will lead to the identification of analogous loci and genes relevant to the pathogenesis and prevention of human IDDM. ..
  3. HUMAN HEMOPOIESIS IN NEW SCID MOUSE MODELS
    Dale Greiner; Fiscal Year: 2001
    ..abstract_text> ..
  4. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 2001
    ....
  5. GENETICS OF AUTOIMMUNITY IN BB RATS
    Dale Greiner; Fiscal Year: 2001
    ..Our belief and ultimate hope is that understanding the genetics of IDDM in BB rats will lead to the identification of analogous loci and genes relevant to the pathogenesis and prevention of human IDDM. ..
  6. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 2002
    ....
  7. HUMAN HEMOPOIESIS IN NEW SCID MOUSE MODELS
    Dale Greiner; Fiscal Year: 2002
    ..abstract_text> ..
  8. GENETICS OF AUTOIMMUNITY IN BB RATS
    Dale Greiner; Fiscal Year: 2002
    ..Our belief and ultimate hope is that understanding the genetics of IDDM in BB rats will lead to the identification of analogous loci and genes relevant to the pathogenesis and prevention of human IDDM. ..
  9. HUMAN HEMOPOIESIS IN NEW SCID MOUSE MODELS
    Dale Greiner; Fiscal Year: 2003
    ..abstract_text> ..
  10. GENETICS OF AUTOIMMUNITY IN BB RATS
    Dale Greiner; Fiscal Year: 2003
    ..The work we propose in the BB rat has the potential to contribute to that national goal. ..
  11. GENETICS OF AUTOIMMUNITY IN BB RATS
    Dale Greiner; Fiscal Year: 2004
    ..The work we propose in the BB rat has the potential to contribute to that national goal. ..
  12. GENETICS OF AUTOIMMUNITY IN BB RATS
    Dale Greiner; Fiscal Year: 2005
    ..The work we propose in the BB rat has the potential to contribute to that national goal. ..
  13. GENETICS OF AUTOIMMUNITY IN BB RATS
    Dale Greiner; Fiscal Year: 2006
    ..The work we propose in the BB rat has the potential to contribute to that national goal. ..
  14. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 2000
    ....
  15. HUMAN HEMOPOIESIS IN NEW SCID MOUSE MODELS
    Dale Greiner; Fiscal Year: 2000
    ..abstract_text> ..
  16. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 1999
    ....
  17. GENETICS OF AUTOIMMUNITY IN BB RATS
    Dale Greiner; Fiscal Year: 1999
    ..Our belief and ultimate hope is that understanding the genetics of IDDM in BB rats will lead to the identification of analogous loci and genes relevant to the pathogenesis and prevention of human IDDM. ..
  18. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 1992
    ..These experiments should allow us to test our hypothesis, and to formulate possible therapeutic modalities for the treatment of human IDDM...
  19. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 1993
    ..These experiments should allow us to test our hypothesis, and to formulate possible therapeutic modalities for the treatment of human IDDM...
  20. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 1991
    ..These experiments should allow us to test our hypothesis, and to formulate possible therapeutic modalities for the treatment of human IDDM...