Research Topics
Species | JESSE GREGORYSummaryAffiliation: University of Florida Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Folate biofortification in food plantsSamir Bekaert
Department of Molecular Genetics, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
Trends Plant Sci 13:28-35. 2008..Here, we review the current status of investigations in the field of folate enhancement on the eve of a new era in food fortification...
Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cellsMei Zhao
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611 0370, USA
Am J Physiol Endocrinol Metab 304:E342-51. 2013..These results and observations of changes in human plasma fatty acid profiles caused by vitamin B-6 restriction suggest a mechanism by which vitamin B-6 inadequacy influences the cardiovascular risk...- Primed, constant infusion with [2H3]serine allows in vivo kinetic measurement of serine turnover, homocysteine remethylation, and transsulfuration processes in human one-carbon metabolismJ F Gregory
Department of Nutritional Sciences, University of California Berkeley, Berkeley, CA, USA
Am J Clin Nutr 72:1535-41. 2000..One-carbon metabolism involves both mitochondrial and cytosolic forms of folate-dependent enzymes in mammalian cells, but few in vivo data exist to characterize the biochemical processes involved... - In vivo kinetics of folate metabolismJesse F Gregory
Food Science and Human Nutrition Department, University of Florida, P O Box 110370, Gainesville, Florida 32611 0370, USA
Annu Rev Nutr 22:199-220. 2002..This review considers the strengths and weaknesses of various approaches to the study of folate kinetics and resulting data, followed by a summary and interpretation of existing data... - Kinetics of folate turnover in pregnant women (second trimester) and nonpregnant controls during folic acid supplementation: stable-isotopic labeling of plasma folate, urinary folate and folate catabolites shows subtle effects of pregnancy on turnover of J F Gregory
Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611 0370, USA
J Nutr 131:1928-37. 2001.... - Case study: folate bioavailabilityJ F Gregory
Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611 0370, USA
J Nutr 131:1376S-82S. 2001.... - Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young womenSteven R Davis
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, College of Medicine, University of Florida, Gainesville 32611 0370, USA
J Nutr 135:1045-50. 2005..In conclusion, elevated homocysteine synthesis is a cause of mild hyperhomocysteinemia in women with marginal folate status, particularly those with the MTHFR 677 T/T genotype... - Methionine synthase reductase 66A->G polymorphism is associated with increased plasma homocysteine concentration when combined with the homozygous methylenetetrahydrofolate reductase 677C->T variantJaimie D Vaughn
Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
J Nutr 134:2985-90. 2004.... - The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in womenSteven R Davis
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, College of Medicine, University of Florida, Gainesville, FL 32611 0370, USA
J Nutr 135:1040-4. 2005.... - 5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leavesAymeric Goyer
Horticultural Sciences Department, University of Florida, Gainesville, Florida 32611, USA
J Biol Chem 280:26137-42. 2005..However, the near-normal growth of the mutant shows that even exceptionally high 5-CHO-THF levels do not much affect fluxes through SHMT or any other folate-dependent reaction, i.e. that 5-CHO-THF is well tolerated in plants... - Folate deprivation reduces homocysteine remethylation in a human intestinal epithelial cell culture model: role of serine in one-carbon donationJustin H Townsend
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611 0370, USA
Am J Physiol Gastrointest Liver Physiol 286:G588-95. 2004..Remethylation is reduced as a result of folate restriction in this mucosal cell model, and one-carbon sources other than the three carbon of serine contribute to remethylation under this condition... - Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donorSteven R Davis
Food Science and Human Nutrition Department, Institute of Food and Agricultural Science, University of Florida, Gainesville, Florida 32611-0370, USA
Am J Physiol Endocrinol Metab 286:E272-9. 2004..Our dual-tracer procedure is well suited to measure the effects of nutrient deficiencies, genetic polymorphisms, and other metabolic perturbations on homocysteine synthesis and total and folate-dependent homocysteine remethylation... - Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and menSteven R Davis
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville 32611-0370, USA
Am J Clin Nutr 81:648-55. 2005..CONCLUSIONS: Moderate vitamin B-6 deficiency does not significantly alter the rates of homocysteine remethylation or synthesis in healthy young adults in the absence of dietary methionine intake... - Folate catabolite excretion is responsive to changes in dietary folate intake in elderly womenJudith M Wolfe
Food Science and Human Nutrition Department, College of Agricultural and Life Sciences, University of Florida, Gainesville 32611, USA
Am J Clin Nutr 77:919-23. 2003..0002) after repletion with 400 microg folate/d. CONCLUSIONS: Total urinary pABG excretion reflects total body folate pool size and is a long-term indicator that parallels functional measures of folate status... - Synthesis and turnover of folates in plantsAndrew D Hanson
Horticultural Sciences Department, University of Florida, Gainesville, Florida 32611, USA
Curr Opin Plant Biol 5:244-9. 2002..Moreover, new analytical advances will help to elucidate plant folate turnover and transport, which are practically unexplored... - Characterization of the folate salvage enzyme p-aminobenzoylglutamate hydrolase in plantsGale G Bozzo
Horticultural Sciences Department, University of Florida, Gainesville, FL 32611, United States
Phytochemistry 69:29-37. 2008..The finding that Arabidopsis has folate-hydrolyzing activity points to an enzymatic component of folate degradation in plants... - Vitamin B-12 status is inversely associated with plasma homocysteine in young women with C677T and/or A1298C methylenetetrahydrofolate reductase polymorphismsLynn B Bailey
Food Science and Human Nutrition Department, and Department of Statistics, University of Florida, Gainesville 32611, USA
J Nutr 132:1872-8. 2002..These data suggest that enhancing vitamin B-12 status may significantly decrease homocysteine in young women with C677T and/or A1298C MTHFR polymorphisms, even when vitamin B-12 concentrations are within the normal range... - DNA methylation determination by liquid chromatography-tandem mass spectrometry using novel biosynthetic [U-15N]deoxycytidine and [U-15N]methyldeoxycytidine internal standardsEoin P Quinlivan
Biomedical Mass Spectrometry Laboratory, General Clinical Research Center and Food Science and Human Nutrition Department, University of Florida, Gainesville, FL, USA
Nucleic Acids Res 36:e119. 2008..Inter- and intraassay variation for the assay (%RSD, n = 6) was <2.5%... - DNA digestion to deoxyribonucleoside: a simplified one-step procedureEoin P Quinlivan
Biomedical Mass Spectrometry Laboratory, General Clinical Research Center, University of Florida, Gainesville, FL 32611, USA
Anal Biochem 373:383-5. 2008..The new protocol is fully compatible with LC-MS/MS and gives similar recoveries for all five major deoxyribonucleosides when compared to the older protocol... - Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosidesEoin P Quinlivan
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, College of Medicine, University of Florida, Gainesville, FL 32611, USA
J Nutr 135:389-96. 2005..These findings support the feasibility of further assessment of factors affecting deoxynucleotide synthesis and DNA methylation in human 1-carbon metabolism... - A nudix enzyme removes pyrophosphate from dihydroneopterin triphosphate in the folate synthesis pathway of bacteria and plantsSebastian M J Klaus
Horticultural Sciences Department, University of Florida, Gainesville, FL 32611, USA
J Biol Chem 280:5274-80. 2005..and Kraszewska, E. (2002) J. Biol. Chem. 277, 50482-50486). However, we found that this activity is negligible at physiological levels of Mn(2+) and that, with 1 mM Mg(2+), AtNUDT1 prefers DHNTP and (deoxy) nucleoside triphosphates... - Folate biofortification of tomato fruitRocio I Díaz De La Garza
Department of Horticultural Sciences, University of Florida, Gainesville, FL 32611, USA
Proc Natl Acad Sci U S A 104:4218-22. 2007..The folate levels we achieved provide the complete adult daily requirement in less than one standard serving... - Evidence for folate-salvage reactions in plantsGiuseppe Orsomando
Horticultural Sciences Department, University of Florida, Gainesville, FL 32611, USA
Plant J 46:426-35. 2006..We conclude that plants are excellent organisms in which to explore the biochemistry of folate salvage... - Methylenetetrahydrofolate reductase 677C-->T polymorphism affects DNA methylation in response to controlled folate intake in young womenKarla P Shelnutt
Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611, USA
J Nutr Biochem 15:554-60. 2004..The response to folate repletion suggests that following folate depletion women with the MTHFR 677 TT genotype have a greater increase in DNA methylation with folate repletion than women with the CC genotype... - Plant gamma-glutamyl hydrolases and folate polyglutamates: characterization, compartmentation, and co-occurrence in vacuolesGiuseppe Orsomando
Horticultural Sciences and Food Science Department, University of Florida, Gainesville, FL 32611, USA
J Biol Chem 280:28877-84. 2005..These data point to a hitherto unsuspected role for vacuoles in folate storage. Furthermore, the paradoxical co-occurrence of GGH and folylpolyglutamates in vacuoles implies that the polyglutamates are somehow protected from GGH attack... - Folate status response to controlled folate intake is affected by the methylenetetrahydrofolate reductase 677C-->T polymorphism in young womenKarla P Shelnutt
Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
J Nutr 133:4107-11. 2003..These results may be important when evaluating the impact of the MTHFR 677C-->T polymorphism in countries in which low folate diets are chronically consumed... - Metabolism of the folate precursor p-aminobenzoate in plants: glucose ester formation and vacuolar storageAymerick Eudes
Departments of Horticultural Sciences and Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611, USA
J Biol Chem 283:15451-9. 2008..In total, these data and the fact that isolated mitochondria did not take up [(3)H]pABA-Glc, suggest that the glucose ester represents a storage form of pABA that does not contribute directly to folate synthesis... - Pterin and folate salvage. Plants and Escherichia coli lack capacity to reduce oxidized pterinsAlexandre Noiriel
Horticultural Sciences Department, University of Florida, Gainesville, Florida 32611, USA
Plant Physiol 143:1101-9. 2007..If it is lacking, folate precursors or breakdown products that become oxidized will permanently exit the metabolically active pterin pool... - Higher plant plastids and cyanobacteria have folate carriers related to those of trypanosomatidsSebastian M J Klaus
Horticultural Sciences, University of Florida, Gainesville, Florida 32611, USA
J Biol Chem 280:38457-63. 2005..These findings establish conservation of function among folate and biopterin transporter family proteins from three kingdoms of life... - Hydrolytic activity toward pyridoxine-5'-beta-D-glucoside in rat intestinal mucosa is not increased by vitamin B-6 deficiency: effect of basal diet composition and pyridoxine intakeAmy D Mackey
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA
J Nutr 133:1362-7. 2003..In contrast to previous results from this laboratory, intestinal hydrolytic activity toward PNG did not increase in vitamin B-6-deficient rats... - Identification of transport-critical residues in a folate transporter from the folate-biopterin transporter (FBT) familyAymerick Eudes
Horticultural Sciences, Human Nutrition Department, University of Florida, Gainesville, Florida 32611, USA
J Biol Chem 285:2867-75. 2010..coli. Such negative data could reflect roles in transport of other substrates. These studies provide the first insights into the native structure and catalytic mechanism of FBT family carriers... - Uptake, hydrolysis, and metabolism of pyridoxine-5'-beta-D-glucoside in Caco-2 cellsAmy D Mackey
Food Science and Human Nutrition Department, University of Florida, Gainesville, FL, USA
J Nutr 134:842-6. 2004..The presence of lactose in this in vitro model of intestinal uptake reduced the enzymatic hydrolysis of PNG by lactase... - The folate precursor p-aminobenzoate is reversibly converted to its glucose ester in the plant cytosolEoin P Quinlivan
Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611, USA
J Biol Chem 278:20731-7. 2003..Esterification of pABA may eliminate such errant behavior and provide a readily reclaimable storage form of pABA as well as a substrate for membrane transporters... - Folate synthesis in plants: the last step of the p-aminobenzoate branch is catalyzed by a plastidial aminodeoxychorismate lyaseGilles J C Basset
Horticultural Sciences Department, University of Florida, Gainesville, FL 32611, USA
Plant J 40:453-61. 2004..As shown previously for the ADC synthase transcript, the level of ADC lyase mRNA in the pericarp of tomato fruit falls sharply as ripening advances, suggesting that the expression of these two enzymes is coregulated... - Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase IGilles Basset
Horticultural Sciences Department and Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
Proc Natl Acad Sci U S A 99:12489-94. 2002..As ripening advances, GCHI expression declines sharply, and folate content drops, suggesting that folate synthesis fails to keep pace with turnover... - Folate synthesis in plants: the p-aminobenzoate branch is initiated by a bifunctional PabA-PabB protein that is targeted to plastidsGilles J C Basset
Department of Horticultural Sciences, University of Florida, Gainesville, FL 32611, USA
Proc Natl Acad Sci U S A 101:1496-501. 2004..In the pericarp of tomato fruit, the PabA-PabB mRNA level fell drastically as ripening advanced, but there was no fall in total PABA content, which stayed between 0.7 and 2.3 nmol.g(-1) fresh weight... - Effect of food fortification on folic acid intake in the United StatesEoin P Quinlivan
Food Science and Human Nutrition Department, University of Florida, Gainesville, USA
Am J Clin Nutr 77:221-5. 2003..The effect of this much higher level of fortification must be carefully assessed, especially before calls for higher levels of fortification are considered... - Glycine turnover and decarboxylation rate quantified in healthy men and women using primed, constant infusions of [1,2-(13)C2]glycine and [(2)H3]leucineYvonne Lamers
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611 0370, USA
J Nutr 137:2647-52. 2007..GCS is responsible for a substantial proportion of whole body glycine flux and constitutes a major route for the generation of 1-carbon units... - Enzymatic hydrolysis of pyridoxine-5'-beta-D-glucoside is catalyzed by intestinal lactase-phlorizin hydrolaseAmy D Mackey
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611, USA
J Biol Chem 277:26858-64. 2002..These results indicate that LPH may play an important role in the bioavailability of PNG, but further characterization is needed to assess its physiological function... - Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and womenYvonne Lamers
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611, USA
J Nutr 139:452-60. 2009..We conclude that the in vivo GCS and SHMT reactions are quite resilient to the effects of marginal vitamin B-6 deficiency, presumably through a compensatory effect of increasing substrate concentration... - A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of lifeJeffrey C Waller
Horticultural Sciences, Food Science and Human Nutrition, Microbiology and Cell Science Departments, and Department of Biochemistry and Molecular Biology and National High Magnetic Field Laboratory, and McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA
Proc Natl Acad Sci U S A 107:10412-7. 2010..Thus COG0354 proteins have an ancient, conserved, folate-dependent function in the activity of certain Fe/S cluster enzymes... - Folate salvage in plants: pterin aldehyde reduction is mediated by multiple non-specific aldehyde reductasesAlexandre Noiriel
Horticultural Sciences Department, University of Florida, Gainesville, FL 32611, USA
Plant J 51:378-89. 2007..We conclude that pterin aldehyde salvage in plants involves multiple, generalist NADPH-linked reductases, and that the At1g10310 enzyme is typical of these and hence suitable for use in engineering studies of folate turnover... - Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G dietsCarolina P Lima
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA
J Nutr 136:2141-7. 2006..In spite of these effects, hepatic glutathione concentration increased in vitamin B-6 deficiency. These results suggest that vitamin B-6-dependent changes in transsulfuration do not limit hepatic glutathione production... - Folate biofortification in tomatoes by engineering the pteridine branch of folate synthesisRocio Diaz De La Garza
Department of Horticultural Sciences, University of Florida, Gainesville, FL 32611, USA
Proc Natl Acad Sci U S A 101:13720-5. 2004..These results demonstrate that engineering a moderate increase in pteridine production can significantly enhance the folate content in food plants and that boosting the PABA supply can produce further gains... - The analysis of folate and its metabolic precursors in biological samplesEoin P Quinlivan
Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611, USA
Anal Biochem 348:163-84. 2006 - Pharmacological biotin supplementation maintains biotin status and function in rats administered dietary carbamazepineSara C Rathman
Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611, USA
J Nutr 133:2857-62. 2003..These results support the use of biotin supplementation as a concurrent strategy during CBZ administration to help maintain biotin status, function of biotin-dependent enzymes and decrease CBZ-induced lactate accumulation... - Capillary electrophoresis and high-performance liquid chromatography determination of polyglutamyl 5-methyltetrahydrofolate forms in citrus productsNorman J Matella
Food Science and Human Nutrition Department, University of Florida, IFAS, Citrus Research and Education Center, 700 Experiment Station Road, Lake Alfred, Florida 33850, USA
J Agric Food Chem 53:2268-74. 2005..e., 93 degrees C for 5 s, 88 degrees C for 15 s, and 82 degrees C for 30 s). Both methods were precise, reproducible, and potentially faster than traditional analytical procedures requiring enzymatic deconjugation and microbial assays... - Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and womenYvonne Lamers
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611 0370, USA
Am J Clin Nutr 90:336-43. 2009..Despite this obligatory role of PLP, previous studies from this laboratory showed that vitamin B-6 deficiency caused elevated glutathione concentrations in rat liver and human plasma... - Reassessing folic acid consumption patterns in the United States (1999 2004): potential effect on neural tube defects and overexposure to folateEoin P Quinlivan
Biomedical Mass Spectrometry Laboratory, General Clinical Research Center, University of Florida, Gainesville, FL 32611 0370, USA
Am J Clin Nutr 86:1773-9. 2007..However, blood folate concentrations have decreased from their postfortification high as a result, in part, of decreasing food fortification concentrations and the popularity of low-carbohydrate weight-loss diets... - Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary vitamin B-6 restriction in young men and womenSteven R Davis
Food Science andHuman Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611-0370, USA
J Nutr 136:373-8. 2006..These data indicate that glutathione homeostasis is altered by dietary vitamin B-6 deficiency and appears to be unrelated to cysteine flux under conditions of minimal amino acid intake as evaluated in this study... - Improved methods for the preparation of [3H]folate polyglutamates: biosynthesis with Lactobacillus casei and enzymatic synthesis with Escherichia coli folylpolyglutamate synthetaseValeria Naponelli
Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611, USA
Anal Biochem 371:127-34. 2007..This enzymatic synthesis yielded predominantly tri-, tetra-, and pentaglutamyl species for the [(3)H]folate substrate... - FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosaAnne Pribat
University of Florida, Horticultural Sciences Department, Gainesville, FL 32611, USA
J Bacteriol 192:475-82. 2010.... - Intestinal brush border membrane catalyzes hydrolysis of pyridoxine-5'-beta-D-glucoside and exhibits parallel developmental changes of hydrolytic activities toward pyridoxine-5'-beta-D-glucoside and lactose in ratsLinda J Armada
Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
J Nutr 132:2695-9. 2002..84; P < 0.0001). These findings suggest that the hydrolysis of PNG is catalyzed at least partially at the brush border and that the bioavailability of PNG may be influenced by the residual LPH activity in children and adults... 
Developmental and feedforward control of the expression of folate biosynthesis genes in tomato fruitJeffrey C Waller
Horticultural Sciences Department, University of Florida, Gainesville, FL 32611, USA
Mol Plant 3:66-77. 2010..Microarray analysis showed that only 14 other transcripts (of 11 000 surveyed) increased in abundance by two-fold or more in high-folate fruit, demonstrating that the induction of folate pathway genes is relatively specific...- Activities of hepatic cytosolic and mitochondrial forms of serine hydroxymethyltransferase and hepatic glycine concentration are affected by vitamin B-6 intake in ratsJennifer B Scheer
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611, USA
J Nutr 135:233-8. 2005..05), which suggests a functional effect of altered SHMT activity. Overall these results demonstrate the potential for disruption of SHMT-mediated one-carbon metabolism by inadequate vitamin B-6 intake... - A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolismMichael C Reed
Department of Mathematics, Duke University, Durham, NC 27708, USA
J Nutr 136:2653-61. 2006..These mathematical simulations of folate-mediated 1-carbon metabolism provide a cost-efficient approach to in silico experimentation that can complement and help guide laboratory studies... - In silico experimentation with a model of hepatic mitochondrial folate metabolismH Frederik Nijhout
Department of Biology, Duke University, Durham, NC 27708, USA
Theor Biol Med Model 3:40. 2006.... - Folic acid and the prevention of neural-tube defectsEoin P Quinlivan
N Engl J Med 350:2209-11; author reply 2209-11. 2004 - Homocysteine, B vitamins, and cardiovascular diseaseEoin P Quinlivan
N Engl J Med 355:206; author reply 209-11. 2006 - The impact of food fortification on folic acid intake in CanadaEoin P Quinlivan
Can J Public Health 94:154. 2003 - Consumption of the folate breakdown product para-aminobenzoylglutamate contributes minimally to urinary folate catabolite excretion in humans: investigation using [(13)C(5)]para-aminobenzoylglutamateMarie A Caudill
Human Nutrition and Food Science Department, Cal Poly Pomona University, Pomona, CA 91768, USA
J Nutr 132:2613-6. 2002..Overall, these results suggest that the contribution of dietary pABG to the urinary excretion of pABG and apABG is small... - Differential kinetic behavior and distribution for pteroylglutamic acid and reduced folates: a revised hypothesis of the primary site of PteGlu metabolism in humansAnthony J A Wright
Nutrition Department, Institute of Food Research, Norwich NR4 7UA, United Kingdom
J Nutr 135:619-23. 2005....
Research Grants
- NUTRITIONAL PROPERTIES OF PYRIDOXINE-BETA-GLUCOSIDEJESSE GREGORY; Fiscal Year: 2001..These studies will provide new insight into the regulation of PNG hydrolase that is the rate-limiting enzyme for the utilization of glycosylated B6 in human diets. ..
- GENETIC EFFECTS-FOLATE-DEPENDENT ONE-CARBON METABOLISMJESSE GREGORY; Fiscal Year: 2004..In total, these studies will yield new functional data regarding the effects of folate deficiency, and the influence of common polymorphism of MTHFR. ..
- Vitamin B6 Effects on One-Carbon MetabolismJESSE GREGORY; Fiscal Year: 2007..These studies will expand our understanding of the functional impact of vitamin B6 inadequacy and will yield new information regarding nutritional dependence of human 1C metabolism. ..
- NUTRITIONAL PROPERTIES OF PYRIDOXINE-BETA-GLUCOSIDEJESSE GREGORY; Fiscal Year: 1993....
- NUTRITIONAL PROPERTIES OF PYRIDOXINE-BETA-GLUCOSIDEJESSE GREGORY; Fiscal Year: 1990....
- Vitamin B6 Effects on One-Carbon MetabolismJesse F Gregory; Fiscal Year: 2010..These studies will expand our understanding of the functional impact of vitamin B6 inadequacy in OC users and will provide a metabolically validated supplementation strategy to alleviate low B6 status and promote health in OC users. ..