Research Topics
Genomes and Genes | C C GregorioSummaryAffiliation: University of Arizona Country: USA Publications
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Detail Information
Publications
Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethalityKimberly L Fritz-Six
Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
J Cell Biol 163:1033-44. 2003..We conclude that Tmod1 is required for regulation of actin filament lengths and myofibril maturation; this is critical for heart morphogenesis during embryonic development...- The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrityC C Gregorio
Departments of Cell Biology and Anatomy, and Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85724, USA
J Cell Biol 143:1013-27. 1998.... 
Muscle assembly: a titanic achievement?C C Gregorio
Departments of Cell Biology and Anatomy The University of Arizona 1501 North Campbell Avenue Tucson AZ 85724 5044 USA
Curr Opin Cell Biol 11:18-25. 1999....- To the heart of myofibril assemblyC C Gregorio
Dept of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ, USA
Trends Cell Biol 10:355-62. 2000..As a consequence of this precise assembly, many different classes of proteins function together to convert the molecular interactions of actin and myosin efficiently into the macroscopic movements of contractile activity... - Functional properties of the titin/connectin-associated proteins, the muscle-specific RING finger proteins (MURFs), in striated muscleCarol C Gregorio
Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
J Muscle Res Cell Motil 26:389-400. 2005.... - Assembly of thick, thin, and titin filaments in chick precardiac explantsD E Rudy
Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona, USA
Dev Dyn 221:61-71. 2001..Based on these findings, we conclude that the use of the avian precardiac explant system accurately allows for direct investigation of the mechanisms regulating de novo cardiac myofibrillogenesis... - Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1Abigail S McElhinny
Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
J Cell Biol 157:125-36. 2002..The dual interactions of MURF-1 with titin and GMEB-1 may link myofibril signaling pathways (perhaps including titin's kinase domain) with muscle gene expression... - Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle developmentAbigail S McElhinny
Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
J Cell Sci 117:3175-88. 2004..Furthermore, contractile activity was also affected. We speculate that some of the roles of MURF-2 are modulated via titin-based mechanisms... - The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filamentsA S McElhinny
Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona 85724, USA
J Biol Chem 276:583-92. 2001..These data provide evidence that Tmod and nebulin may work together as a linked mechanism to control thin filament lengths in skeletal muscle... - Nebulin regulates the assembly and lengths of the thin filaments in striated muscleAbigail S McElhinny
Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
J Cell Biol 170:947-57. 2005..These data are consistent with nebulin functioning as a thin filament ruler and provide insight into mechanisms dictating macromolecular assembly... - A myopathy-linked desmin mutation perturbs striated muscle actin filament architectureGloria M Conover
Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
Mol Biol Cell 20:834-45. 2009.... - Lasp-2 expression, localization, and ligand interactions: a new Z-disc scaffolding proteinAnke Zieseniss
Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona 85724, USA
Cell Motil Cytoskeleton 65:59-72. 2008..These results are consistent with a function of lasp-2 as a scaffolding and actin filament organizing protein within striated muscle Z-discs... - The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response moleculesMelanie K Miller
Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
J Mol Biol 333:951-64. 2003..We speculate that the myofibrillar MARPs are regulated by stretch, and that this links titin-N2A-based myofibrillar stress/strain signals to a MARP-based regulation of muscle gene expression... - Striated muscle cytoarchitecture: an intricate web of form and functionKathleen A Clark
Department of Cell Biology, University of Arizona, Tucson 85724, USA
Annu Rev Cell Dev Biol 18:637-706. 2002..The exciting conclusion is that the striated muscle cytoskeleton, an exquisitely tuned, dynamic molecular machine, is capable of responding to subtle changes in cellular physiology... - Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal musclePaola Tonino
Department of Physiology, University of Arizona, Tucson, Arizona 85724 5217, USA
J Cell Sci 123:384-91. 2010..Thus the functional roles of nebulin extend beyond thin filament length regulation and include roles in maintaining physiological Z-disk widths and myofibrillar connectivity... - Nebulin: the nebulous, multifunctional giant of striated muscleAbigail S McElhinny
Department of Cell Biology and Anatomy, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
Trends Cardiovasc Med 13:195-201. 2003.... - Nebulin interacts with CapZ and regulates thin filament architecture within the Z-discChristopher T Pappas
Departments of Cell Biology and Anatomy and Molecular and Cellular Biology, The University of Arizona, Tucson, AZ 85721 0106, USA
Mol Biol Cell 19:1837-47. 2008..We propose a novel molecular model of Z-disc architecture in which nebulin interacts with CapZ from a thin filament of an adjacent sarcomere, thus providing a structural link between sarcomeres... - Nebulin regulates actin filament lengths by a stabilization mechanismChristopher T Pappas
Department of Cell Biology and Anatomy and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson, AZ 85724, USA
J Cell Biol 189:859-70. 2010..e., recovered loss of endogenous nebulin). Thus, nebulin regulates thin filament architecture by a mechanism that includes stabilizing the filaments and preventing actin depolymerization... - The complete mouse nebulin gene sequence and the identification of cardiac nebulinSteven T Kazmierski
Department of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ 85724, USA
J Mol Biol 328:835-46. 2003.... - The sensitive giant: the role of titin-based stretch sensing complexes in the heartMelanie K Miller
Department of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ 85724, USA
Trends Cell Biol 14:119-26. 2004..This new evidence suggests that complexes associated with the giant, myofibrillar protein titin sense myocyte stretch. Here, we discuss evidence supporting titin being an ideal biomechanical sensor... - Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscleTakehiro Tsukada
Department of Cell Biology and Anatomy, and Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724, USA
J Cell Sci 123:3136-45. 2010..Thus, Lmod2 antagonizes the function of Tmod1, and together, these molecules might fine-tune thin filament lengths... - The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytesRyan E Mudry
Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
J Cell Biol 162:1057-68. 2003.... - Disruption in the tropomodulin1 (Tmod1) gene compromises cardiomyocyte development in murine embryonic stem cells by arresting myofibril maturationYasuko Ono
Department of Cell Biology and Anatomy, University of Arizona, 1501 N Campbell Avenue LSN 455, Tucson, AZ 85724, USA
Dev Biol 282:336-48. 2005.... - Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscleCarlos M Moran
Department of Cell Biology and Anatomy, Molecular Cardiovascular Research Program, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
Cell Motil Cytoskeleton 65:652-61. 2008..These observations raise the possibility that troponins play a role in regulation of smooth muscle function... - The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathyRalph Knoll
Institute of Molecular Medicine, Department of Medicine, University of California at San Diego, La Jolla 92093, USA
Cell 111:943-55. 2002..We propose that a Z disc MLP/T-cap complex is a key component of the in vivo cardiomyocyte stretch sensor machinery, and that defects in the complex can lead to human DCM and associated heart failure... - Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signalingChristian C Witt
Institut fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum Mannheim, Mannheim 68167, Germany
J Mol Biol 336:145-54. 2004..skeletal and cardiac muscle from heterozygous mdm/+ animals, and (3). dystrophic muscles from MDX mice. Thus, the altered composition of the titin N2A complex is specific for the titin-based skeletal muscular dystrophy in MDM... - Expression and regulation of mouse SERDIN1, a highly conserved cardiac-specific leucine-rich repeat proteinIgor I Adameyko
Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Dev Dyn 233:540-52. 2005..Cardiac specificity and localization patterns suggest that SERDIN1 is intimately integrated with the molecular pathways controlling cardiogenesis in vertebrates...