C C Gregorio

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality
    Kimberly L Fritz-Six
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Biol 163:1033-44. 2003
  2. pmc The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity
    C C Gregorio
    Departments of Cell Biology and Anatomy, and Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85724, USA
    J Cell Biol 143:1013-27. 1998
  3. ncbi request reprint Muscle assembly: a titanic achievement?
    C C Gregorio
    Departments of Cell Biology and Anatomy The University of Arizona 1501 North Campbell Avenue Tucson AZ 85724 5044 USA
    Curr Opin Cell Biol 11:18-25. 1999
  4. ncbi request reprint To the heart of myofibril assembly
    C C Gregorio
    Dept of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ, USA
    Trends Cell Biol 10:355-62. 2000
  5. ncbi request reprint Functional properties of the titin/connectin-associated proteins, the muscle-specific RING finger proteins (MURFs), in striated muscle
    Carol C Gregorio
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    J Muscle Res Cell Motil 26:389-400. 2005
  6. ncbi request reprint Assembly of thick, thin, and titin filaments in chick precardiac explants
    D E Rudy
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona, USA
    Dev Dyn 221:61-71. 2001
  7. pmc Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1
    Abigail S McElhinny
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    J Cell Biol 157:125-36. 2002
  8. ncbi request reprint Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development
    Abigail S McElhinny
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    J Cell Sci 117:3175-88. 2004
  9. ncbi request reprint The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments
    A S McElhinny
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona 85724, USA
    J Biol Chem 276:583-92. 2001
  10. pmc Nebulin regulates the assembly and lengths of the thin filaments in striated muscle
    Abigail S McElhinny
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    J Cell Biol 170:947-57. 2005

Collaborators

  • Siegfried Labeit
  • PARKER ANTIN
  • Henk Granzier
  • K Suzuki
  • Kathleen A Clark
  • Alla Kostyukova
  • Asako G Terasaki
  • Marie Louise Bang
  • Yasuko Ono
  • Michael Gotthardt
  • J H Omens
  • Huda Zoghbi
  • Kenneth R Chien
  • Masahiko Hoshijima
  • Andrew McCulloch
  • R S Fischer
  • Abigail S McElhinny
  • Christopher T Pappas
  • Melanie K Miller
  • Christian C Witt
  • Ryan E Mudry
  • Takehiro Tsukada
  • Paola Tonino
  • Steven T Kazmierski
  • Gloria M Conover
  • Paul A Krieg
  • Carlos M Moran
  • Anke Zieseniss
  • Igor I Adameyko
  • Cynthia N Perry
  • Dietmar Labeit
  • Kimberly L Fritz-Six
  • Hiroyuki Sorimachi
  • Velia M Fowler
  • Ralph Knoll
  • A S McElhinny
  • D E Rudy
  • Bryan D Hudson
  • Natalia Moroz
  • Syerra N Henderson
  • Ronald L Heimark
  • John A Cooper
  • Nandini Bhattacharya
  • Robert J Garriock
  • Sergei G Tevosian
  • Melinda Valichnac
  • Sarah Mount-Patrick
  • Nga Rewa M Houston-Cummings
  • Catherine Schwach
  • Alexander P Veselov
  • Stephanie H Witt
  • Elisabeth Ehler
  • Mark McNabb
  • Eva Puschmann
  • Markus Haak
  • Yiming Wu
  • Norbert Huebner
  • Meredith Richards
  • Charles Trombitas
  • Kaori Watanabe
  • Bisong Xu
  • Patrick R Cox
  • Jutta Schaper
  • Hideo Yasukawa
  • Veronika Person
  • Ilka Lorenzen-Schmidt
  • Takeharu Hayashi
  • William McKenna
  • Wolfgang Schaper
  • Wolfgang Poller
  • Kazumi Kakinuma
  • Hal M Hoffman
  • Heinz P Schultheiss
  • Mitsuhiro Yokoyama
  • Nobuyuki Shiga
  • Akinori Kimura
  • Nicholas J Schork
  • V M Fowler
  • B Kolmerer
  • T A Yatskievych

Detail Information

Publications27

  1. pmc Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality
    Kimberly L Fritz-Six
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Biol 163:1033-44. 2003
    ..We conclude that Tmod1 is required for regulation of actin filament lengths and myofibril maturation; this is critical for heart morphogenesis during embryonic development...
  2. pmc The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity
    C C Gregorio
    Departments of Cell Biology and Anatomy, and Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85724, USA
    J Cell Biol 143:1013-27. 1998
    ....
  3. ncbi request reprint Muscle assembly: a titanic achievement?
    C C Gregorio
    Departments of Cell Biology and Anatomy The University of Arizona 1501 North Campbell Avenue Tucson AZ 85724 5044 USA
    Curr Opin Cell Biol 11:18-25. 1999
    ....
  4. ncbi request reprint To the heart of myofibril assembly
    C C Gregorio
    Dept of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ, USA
    Trends Cell Biol 10:355-62. 2000
    ..As a consequence of this precise assembly, many different classes of proteins function together to convert the molecular interactions of actin and myosin efficiently into the macroscopic movements of contractile activity...
  5. ncbi request reprint Functional properties of the titin/connectin-associated proteins, the muscle-specific RING finger proteins (MURFs), in striated muscle
    Carol C Gregorio
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    J Muscle Res Cell Motil 26:389-400. 2005
    ....
  6. ncbi request reprint Assembly of thick, thin, and titin filaments in chick precardiac explants
    D E Rudy
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona, USA
    Dev Dyn 221:61-71. 2001
    ..Based on these findings, we conclude that the use of the avian precardiac explant system accurately allows for direct investigation of the mechanisms regulating de novo cardiac myofibrillogenesis...
  7. pmc Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1
    Abigail S McElhinny
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    J Cell Biol 157:125-36. 2002
    ..The dual interactions of MURF-1 with titin and GMEB-1 may link myofibril signaling pathways (perhaps including titin's kinase domain) with muscle gene expression...
  8. ncbi request reprint Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development
    Abigail S McElhinny
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    J Cell Sci 117:3175-88. 2004
    ..Furthermore, contractile activity was also affected. We speculate that some of the roles of MURF-2 are modulated via titin-based mechanisms...
  9. ncbi request reprint The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments
    A S McElhinny
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona 85724, USA
    J Biol Chem 276:583-92. 2001
    ..These data provide evidence that Tmod and nebulin may work together as a linked mechanism to control thin filament lengths in skeletal muscle...
  10. pmc Nebulin regulates the assembly and lengths of the thin filaments in striated muscle
    Abigail S McElhinny
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    J Cell Biol 170:947-57. 2005
    ..These data are consistent with nebulin functioning as a thin filament ruler and provide insight into mechanisms dictating macromolecular assembly...
  11. pmc A myopathy-linked desmin mutation perturbs striated muscle actin filament architecture
    Gloria M Conover
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    Mol Biol Cell 20:834-45. 2009
    ....
  12. ncbi request reprint Lasp-2 expression, localization, and ligand interactions: a new Z-disc scaffolding protein
    Anke Zieseniss
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona 85724, USA
    Cell Motil Cytoskeleton 65:59-72. 2008
    ..These results are consistent with a function of lasp-2 as a scaffolding and actin filament organizing protein within striated muscle Z-discs...
  13. ncbi request reprint The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules
    Melanie K Miller
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    J Mol Biol 333:951-64. 2003
    ..We speculate that the myofibrillar MARPs are regulated by stretch, and that this links titin-N2A-based myofibrillar stress/strain signals to a MARP-based regulation of muscle gene expression...
  14. ncbi request reprint Striated muscle cytoarchitecture: an intricate web of form and function
    Kathleen A Clark
    Department of Cell Biology, University of Arizona, Tucson 85724, USA
    Annu Rev Cell Dev Biol 18:637-706. 2002
    ..The exciting conclusion is that the striated muscle cytoskeleton, an exquisitely tuned, dynamic molecular machine, is capable of responding to subtle changes in cellular physiology...
  15. pmc Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal muscle
    Paola Tonino
    Department of Physiology, University of Arizona, Tucson, Arizona 85724 5217, USA
    J Cell Sci 123:384-91. 2010
    ..Thus the functional roles of nebulin extend beyond thin filament length regulation and include roles in maintaining physiological Z-disk widths and myofibrillar connectivity...
  16. ncbi request reprint Nebulin: the nebulous, multifunctional giant of striated muscle
    Abigail S McElhinny
    Department of Cell Biology and Anatomy, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    Trends Cardiovasc Med 13:195-201. 2003
    ....
  17. pmc Nebulin interacts with CapZ and regulates thin filament architecture within the Z-disc
    Christopher T Pappas
    Departments of Cell Biology and Anatomy and Molecular and Cellular Biology, The University of Arizona, Tucson, AZ 85721 0106, USA
    Mol Biol Cell 19:1837-47. 2008
    ..We propose a novel molecular model of Z-disc architecture in which nebulin interacts with CapZ from a thin filament of an adjacent sarcomere, thus providing a structural link between sarcomeres...
  18. pmc Nebulin regulates actin filament lengths by a stabilization mechanism
    Christopher T Pappas
    Department of Cell Biology and Anatomy and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson, AZ 85724, USA
    J Cell Biol 189:859-70. 2010
    ..e., recovered loss of endogenous nebulin). Thus, nebulin regulates thin filament architecture by a mechanism that includes stabilizing the filaments and preventing actin depolymerization...
  19. ncbi request reprint The complete mouse nebulin gene sequence and the identification of cardiac nebulin
    Steven T Kazmierski
    Department of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ 85724, USA
    J Mol Biol 328:835-46. 2003
    ....
  20. ncbi request reprint The sensitive giant: the role of titin-based stretch sensing complexes in the heart
    Melanie K Miller
    Department of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ 85724, USA
    Trends Cell Biol 14:119-26. 2004
    ..This new evidence suggests that complexes associated with the giant, myofibrillar protein titin sense myocyte stretch. Here, we discuss evidence supporting titin being an ideal biomechanical sensor...
  21. pmc Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle
    Takehiro Tsukada
    Department of Cell Biology and Anatomy, and Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724, USA
    J Cell Sci 123:3136-45. 2010
    ..Thus, Lmod2 antagonizes the function of Tmod1, and together, these molecules might fine-tune thin filament lengths...
  22. pmc The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytes
    Ryan E Mudry
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    J Cell Biol 162:1057-68. 2003
    ....
  23. ncbi request reprint Disruption in the tropomodulin1 (Tmod1) gene compromises cardiomyocyte development in murine embryonic stem cells by arresting myofibril maturation
    Yasuko Ono
    Department of Cell Biology and Anatomy, University of Arizona, 1501 N Campbell Avenue LSN 455, Tucson, AZ 85724, USA
    Dev Biol 282:336-48. 2005
    ....
  24. pmc Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle
    Carlos M Moran
    Department of Cell Biology and Anatomy, Molecular Cardiovascular Research Program, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    Cell Motil Cytoskeleton 65:652-61. 2008
    ..These observations raise the possibility that troponins play a role in regulation of smooth muscle function...
  25. ncbi request reprint The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy
    Ralph Knoll
    Institute of Molecular Medicine, Department of Medicine, University of California at San Diego, La Jolla 92093, USA
    Cell 111:943-55. 2002
    ..We propose that a Z disc MLP/T-cap complex is a key component of the in vivo cardiomyocyte stretch sensor machinery, and that defects in the complex can lead to human DCM and associated heart failure...
  26. ncbi request reprint Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling
    Christian C Witt
    Institut fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum Mannheim, Mannheim 68167, Germany
    J Mol Biol 336:145-54. 2004
    ..skeletal and cardiac muscle from heterozygous mdm/+ animals, and (3). dystrophic muscles from MDX mice. Thus, the altered composition of the titin N2A complex is specific for the titin-based skeletal muscular dystrophy in MDM...
  27. ncbi request reprint Expression and regulation of mouse SERDIN1, a highly conserved cardiac-specific leucine-rich repeat protein
    Igor I Adameyko
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Dev Dyn 233:540-52. 2005
    ..Cardiac specificity and localization patterns suggest that SERDIN1 is intimately integrated with the molecular pathways controlling cardiogenesis in vertebrates...