Susan Greenspan

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Predictors of treatment with osteoporosis medications after recent fragility fractures in a multinational cohort of postmenopausal women
    Susan L Greenspan
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 60:455-61. 2012
  2. ncbi request reprint Prevention of bone loss in survivors of breast cancer: A randomized, double-blind, placebo-controlled clinical trial
    Susan L Greenspan
    Department of Medicine, University of Pittsburgh, 3471 Fifth Avenue, Suite 1110, Pittsburgh, Pennsylvania 15213 3221, USA
    J Clin Endocrinol Metab 92:131-6. 2007
  3. pmc Approach to the prostate cancer patient with bone disease
    Susan L Greenspan
    University of Pittsburgh School of Medicine, Clinical and Translational Research Center, Osteoporosis Prevention and Treatment Center, 3471 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 93:2-7. 2008
  4. doi request reprint Changes in trabecular microarchitecture in postmenopausal women on bisphosphonate therapy
    Susan L Greenspan
    University of Pittsburgh, Department of Medicine, Pittsburgh, PA 15213, USA
    Bone 46:1006-10. 2010
  5. pmc Skeletal health after continuation, withdrawal, or delay of alendronate in men with prostate cancer undergoing androgen-deprivation therapy
    Susan L Greenspan
    Divisions of Geriatric Medicine and Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA 15213 3221, USA
    J Clin Oncol 26:4426-34. 2008
  6. doi request reprint Risedronate prevents bone loss in breast cancer survivors: a 2-year, randomized, double-blind, placebo-controlled clinical trial
    Susan L Greenspan
    Department of Medicine, University of Pittsburgh, 3471 Fifth Ave, Kaufmann Suite 1110, Pittsburgh, PA 15213, USA
    J Clin Oncol 26:2644-52. 2008
  7. ncbi request reprint Vitamin D insufficiency in preadolescent African-American children
    Kumaravel Rajakumar
    Department of Pediatrics, University of Pittsburgh School of Medicine, USA
    Clin Pediatr (Phila) 44:683-92. 2005
  8. doi request reprint Vitamin D status and response to Vitamin D(3) in obese vs. non-obese African American children
    Kumaravel Rajakumar
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 16:90-5. 2008
  9. ncbi request reprint Effect of once-weekly oral alendronate on bone loss in men receiving androgen deprivation therapy for prostate cancer: a randomized trial
    Susan L Greenspan
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Ann Intern Med 146:416-24. 2007
  10. ncbi request reprint Alendronate improves bone mineral density in elderly women with osteoporosis residing in long-term care facilities. A randomized, double-blind, placebo-controlled trial
    Susan L Greenspan
    University of Pittsburgh Osteoporosis Prevention and Treatment Center, 1110 Kaufmann Building, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Ann Intern Med 136:742-6. 2002

Research Grants

  1. Maintenance of Skeletal Integrity in Frail Elders
    Susan L Greenspan; Fiscal Year: 2010
  2. Osteoporosis in Older Men and Women
    Susan Greenspan; Fiscal Year: 2007
  3. Prevention of Osteoporosis in Men with Prostate Cancer
    Susan Greenspan; Fiscal Year: 2005
  4. Maintenance of Skeletal Integrity in Frail Elders
    Susan Greenspan; Fiscal Year: 2009

Detail Information

Publications42

  1. doi request reprint Predictors of treatment with osteoporosis medications after recent fragility fractures in a multinational cohort of postmenopausal women
    Susan L Greenspan
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 60:455-61. 2012
    ..To determine the proportion of untreated women who reported receiving treatment after incident fracture and to identify factors that predict treatment across an international spectrum of individuals...
  2. ncbi request reprint Prevention of bone loss in survivors of breast cancer: A randomized, double-blind, placebo-controlled clinical trial
    Susan L Greenspan
    Department of Medicine, University of Pittsburgh, 3471 Fifth Avenue, Suite 1110, Pittsburgh, Pennsylvania 15213 3221, USA
    J Clin Endocrinol Metab 92:131-6. 2007
    ..Few data are available on the safety and efficacy of once-weekly oral bisphosphonate therapy in breast cancer survivors...
  3. pmc Approach to the prostate cancer patient with bone disease
    Susan L Greenspan
    University of Pittsburgh School of Medicine, Clinical and Translational Research Center, Osteoporosis Prevention and Treatment Center, 3471 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 93:2-7. 2008
    ..Men should be evaluated for additional secondary causes of bone loss including vitamin D insufficiency. Guidelines are needed for androgen-induced bone loss screening and treatment...
  4. doi request reprint Changes in trabecular microarchitecture in postmenopausal women on bisphosphonate therapy
    Susan L Greenspan
    University of Pittsburgh, Department of Medicine, Pittsburgh, PA 15213, USA
    Bone 46:1006-10. 2010
    ..In addition to bone mineral density (BMD), trabecular microstructure contributes to skeletal strength. Our goal was to examine changes in trabecular microstructure in women on therapy...
  5. pmc Skeletal health after continuation, withdrawal, or delay of alendronate in men with prostate cancer undergoing androgen-deprivation therapy
    Susan L Greenspan
    Divisions of Geriatric Medicine and Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA 15213 3221, USA
    J Clin Oncol 26:4426-34. 2008
    ..Our objective was to examine changes in bone density and turnover with sustained, discontinued, or delayed oral bisphosphonate therapy in men receiving ADT...
  6. doi request reprint Risedronate prevents bone loss in breast cancer survivors: a 2-year, randomized, double-blind, placebo-controlled clinical trial
    Susan L Greenspan
    Department of Medicine, University of Pittsburgh, 3471 Fifth Ave, Kaufmann Suite 1110, Pittsburgh, PA 15213, USA
    J Clin Oncol 26:2644-52. 2008
    ..Limited data are available on the efficacy of oral bisphosphonate therapy in breast cancer survivors. Our goal was to examine prevention of breast cancer-related bone loss in this cohort...
  7. ncbi request reprint Vitamin D insufficiency in preadolescent African-American children
    Kumaravel Rajakumar
    Department of Pediatrics, University of Pittsburgh School of Medicine, USA
    Clin Pediatr (Phila) 44:683-92. 2005
    ..Adequate intake for vitamin D (200 IU/day) was not met in 16/41 (39%); however, the dietary intake of vitamin D was not significantly different between the vitamin D insufficient and vitamin D sufficient groups...
  8. doi request reprint Vitamin D status and response to Vitamin D(3) in obese vs. non-obese African American children
    Kumaravel Rajakumar
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 16:90-5. 2008
    ..Serum 25-hydroxyvitamin D (25(OH)D) is low in obese adults...
  9. ncbi request reprint Effect of once-weekly oral alendronate on bone loss in men receiving androgen deprivation therapy for prostate cancer: a randomized trial
    Susan L Greenspan
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Ann Intern Med 146:416-24. 2007
    ..Androgen deprivation therapy (ADT) in men with prostate cancer is associated with bone loss and fractures...
  10. ncbi request reprint Alendronate improves bone mineral density in elderly women with osteoporosis residing in long-term care facilities. A randomized, double-blind, placebo-controlled trial
    Susan L Greenspan
    University of Pittsburgh Osteoporosis Prevention and Treatment Center, 1110 Kaufmann Building, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Ann Intern Med 136:742-6. 2002
    ..Many elderly female residents of long-term care facilities have osteoporosis and could benefit from intervention to increase bone density...
  11. ncbi request reprint Quality of life in prostate cancer patients taking androgen deprivation therapy
    Kirsten Dacal
    School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 54:85-90. 2006
    ....
  12. pmc Elevations in serum and urinary calcium with parathyroid hormone (1-84) with and without alendronate for osteoporosis
    Diana M Antoniucci
    Division of Endocrinology, Department of Medicine, University of California, San Francisco, California 94107, USA
    J Clin Endocrinol Metab 92:942-7. 2007
    ..The effect of PTH therapy on serum and urinary calcium levels and the risk of hypercalcemia or hypercalciuria has not been formally evaluated...
  13. ncbi request reprint Effect of recombinant human parathyroid hormone (1-84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: a randomized trial
    Susan L Greenspan
    University of Pittsburgh, Osteoporosis Prevention and Treatment Center, Pittsburgh, Pennsylvania 15213, USA
    Ann Intern Med 146:326-39. 2007
    ..Recombinant human parathyroid hormone (1-84) (PTH) increases bone mass and strength and improves bone quality by stimulating new bone formation...
  14. pmc Farnesyl diphosphate synthase: a novel genotype association with bone mineral density in elderly women
    Matthew E Levy
    Division of Endocrinology and Metabolism and Division of Geriatrics, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States
    Maturitas 57:247-52. 2007
    ..We evaluated the association between a single nucleotide polymorphism in the farnesyl diphosphate synthase gene (FDPS), BMD and bone turnover markers...
  15. ncbi request reprint Altered bone mass in children at diagnosis of Crohn disease: a pilot study
    Manisha Harpavat
    Department of Pediatric Gastroenterology, Children s Hospital of Pittsburgh, University of Pittsburgh School of MedicinePittsburgh, PA 15213, USA
    J Pediatr Gastroenterol Nutr 40:295-300. 2005
    ..This study examined the prevalence of reduced bone mass in otherwise healthy children newly diagnosed with Crohn disease without previous corticosteroid exposure...
  16. ncbi request reprint Gastric bypass surgery for morbid obesity leads to an increase in bone turnover and a decrease in bone mass
    Penelope S Coates
    Osteoporosis Prevention and Treatment Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 89:1061-5. 2004
    ..In summary, within 3 to 9 months after LRGB, morbidly obese patients have an increase in bone resorption associated with a decrease in bone mass. Additional studies are needed to examine these findings over the longer term...
  17. ncbi request reprint Tolerability of once-weekly alendronate in patients with osteoporosis: a randomized, double-blind, placebo-controlled study
    Susan Greenspan
    Department of Medicine, University of Texas Southwestern Medical School, Dallas 75216, USA
    Mayo Clin Proc 77:1044-52. 2002
    ..To compare the upper gastrointestinal (GI) tract tolerability of once-weekly oral alendronate, 70 mg, and placebo...
  18. doi request reprint Plasma inflammatory mediators associated with bone metabolism in COPD
    Jessica M Bon
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    COPD 7:186-91. 2010
    ..Furthermore, they may be useful in monitoring disease activity, and serve as targets for biological therapy...
  19. pmc The effect of androgen deprivation therapy on periodontal disease in men with prostate cancer
    Pouran Famili
    Department of Periodontics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Urol 177:921-4. 2007
    ..We tested the hypothesis that men undergoing androgen deprivation therapy as treatment for prostate cancer are at greater risk for periodontitis and tooth loss...
  20. doi request reprint Physical function changes in prostate cancer patients on androgen deprivation therapy: a 2-year prospective study
    Matthew E Levy
    Division of Geriatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Urology 71:735-9. 2008
    ..To investigate the influence of androgen deprivation therapy (ADT) in men with nonmetastatic prostate cancer...
  21. ncbi request reprint Early changes in biochemical markers of bone turnover are associated with long-term changes in bone mineral density in elderly women on alendronate, hormone replacement therapy, or combination therapy: a three-year, double-blind, placebo-controlled, rando
    Susan L Greenspan
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pennsylvania 15213 3221, USA
    J Clin Endocrinol Metab 90:2762-7. 2005
    ..We conclude that short-term changes in biochemical markers of bone turnover at 6 months predict bone density changes at the spine and hip at 3 yr in elderly women on alendronate, hormone replacement therapy, or combination therapy...
  22. ncbi request reprint A pilot study of heel ultrasound to screen for low bone mass in children with leukemia
    Sanjay P Ahuja
    Division of Pediatric Hematology Oncology and Blood and Marrow Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Pediatr Hematol Oncol 28:427-32. 2006
    ..77 and 0.86 for lumbar and whole body z score cutoffs, respectively. Our data suggest that calcaneal BUA may serve as a reliable screening tool to detect reduced bone mass in pediatric patients with leukemia...
  23. ncbi request reprint Vitamin D supplementation in older women
    Susan L Greenspan
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 60:754-9. 2005
    ..The purpose of this study was to determine if vitamin D supplementation, 400-800 IU daily, could effectively treat vitamin D deficiency and insufficiency over 3 months...
  24. ncbi request reprint Combination therapy with hormone replacement and alendronate for prevention of bone loss in elderly women: a randomized controlled trial
    Susan L Greenspan
    Division of Endocrinology and Metabolism and Division of Geriatric Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    JAMA 289:2525-33. 2003
    ....
  25. ncbi request reprint Effect of hormone replacement, alendronate, or combination therapy on hip structural geometry: a 3-year, double-blind, placebo-controlled clinical trial
    Susan L Greenspan
    Osteoporosis Prevention and Treatment Center, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 3221, USA
    J Bone Miner Res 20:1525-32. 2005
    ..These data provide additional information regarding potential mechanisms for fracture reduction with antiresorptive therapy...
  26. ncbi request reprint Significant differential effects of alendronate, estrogen, or combination therapy on the rate of bone loss after discontinuation of treatment of postmenopausal osteoporosis. A randomized, double-blind, placebo-controlled trial
    Susan L Greenspan
    University of Pittsburgh, Osteoporosis Prevention and Treatment Center, Kaufmann Medical Building, Suite 1110, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Ann Intern Med 137:875-83. 2002
    ..Changes in bone mineral density after discontinuation of therapy have not been compared directly...
  27. ncbi request reprint Bone loss after initiation of androgen deprivation therapy in patients with prostate cancer
    Susan L Greenspan
    Osteoporosis Prevention and Treatment Center, University of Pittsburgh, Kaufmann Medical Building, Suite 1110, 3471 Fifth Avenue, Pittsburgh, Pennsylvania 15213 3221, USA
    J Clin Endocrinol Metab 90:6410-7. 2005
    ..Although androgen deprivation therapy (ADT) for prostate cancer is associated with bone loss, little is known about when this bone loss occurs...
  28. ncbi request reprint The effect of hormone replacement on physical performance in community-dwelling elderly women
    Susan L Greenspan
    Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 3221, USA
    Am J Med 118:1232-9. 2005
    ..Our aim was to determine the effect of hormone replacement on physical performance measures, functional ability, physical activity, falls, and cognitive function in elderly women...
  29. pmc Body composition changes during androgen deprivation therapy for prostate cancer: a 2-year prospective study
    Gijsberta J Van Londen
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States
    Crit Rev Oncol Hematol 68:172-7. 2008
    ..We compared body composition parameters in men with non-metastatic prostate cancer on or not on therapy with healthy, age-matched controls at baseline and monitored changes over a 2-year period...
  30. ncbi request reprint The management of osteoporosis following hip fracture: have we improved our care?
    Sachin Bahl
    Division of Endocrinology, Department of Medicine, University of Pittsburgh Medical Center, Shadyside Hospital, Pittsburgh, PA 15213, USA
    Osteoporos Int 14:884-8. 2003
    ..Further studies are needed to determine which factors are needed to target patients for appropriate diagnosis and treatment...
  31. ncbi request reprint Does bone mineral density and knowledge influence health-related behaviors of elderly men at risk for osteoporosis?
    Avni Patel
    Osteoporosis Prevention and Treatment Center, Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Clin Densitom 6:323-30. 2003
    ..However, they were not more likely to make significant health-related lifestyle changes after obtaining the results of their bone mass...
  32. ncbi request reprint Skeletal integrity in patients with nail patella syndrome
    Adele L Towers
    University of Pittsburgh, Osteoporosis Prevention and Treatment Center, Kaufmann Medical Building, Suite 1110, 3471 Fifth Avenue, Pittsburgh, Pennsylvania 15213 3221, USA
    J Clin Endocrinol Metab 90:1961-5. 2005
    ..Future studies are needed to determine whether bone quality, geometry, or turnover could account for these findings...
  33. pmc Factors associated with osteoporosis screening and recommendations for osteoporosis screening in older adults
    Smita Nayak
    School of Medicine, Department of Medicine, Division of General Internal Medicine, Section of Decision Sciences and Clinical Systems Modeling, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Gen Intern Med 24:585-91. 2009
    ..Osteoporosis screening rates are low, and it is unclear which patient factors are associated with screening and physician recommendations for screening...
  34. ncbi request reprint Thigh muscle strength in senior athletes and healthy controls
    Jean L McCrory
    Department of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Strength Cond Res 23:2430-6. 2009
    ..Neither group displayed the expected strength losses with aging. Our subject cohorts, however, were not typical of those over age 65 years because individuals with existing health conditions were excluded from the study...
  35. pmc Osteoporosis screening preferences of older adults
    Smita Nayak
    Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Clin Densitom 12:279-86. 2009
    ..Many older individuals would prefer the "best" test for osteoporosis screening, and may be willing to travel or pay more to obtain a better test...
  36. pmc SOLAR ultraviolet radiation and vitamin D: a historical perspective
    Kumaravel Rajakumar
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Public Health 97:1746-54. 2007
    ..We review the sequence and turn of events pertaining to the discovery of vitamin D and the strategies for the eradication of the reemerging rickets problem...
  37. ncbi request reprint Physical function in men with prostate cancer on androgen deprivation therapy
    Cheryl A Clay
    Akron Children s Hospital, Akron, Ohio, USA
    Phys Ther 87:1325-33. 2007
    ....
  38. ncbi request reprint The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
    N Engl J Med 349:1207-15. 2003
    ..We conducted a randomized, double-blind clinical study of parathyroid hormone and alendronate to test the hypothesis that the concurrent administration of the two agents would increase bone density more than the use of either one alone...
  39. pmc Effects of PTH and alendronate on type I collagen isomerization in postmenopausal women with osteoporosis: the PaTH study
    Patrick Garnero
    INSERM Research Unit 664, Lyon, France
    J Bone Miner Res 23:1442-8. 2008
    ..The influence of these biochemical changes of type I collagen on bone fracture resistance remains to be studied...
  40. ncbi request reprint One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94105, USA
    N Engl J Med 353:555-65. 2005
    ..In the continuation of this trial, we asked whether antiresorptive therapy is required to maintain gains in bone mineral density after one year of therapy with parathyroid hormone (1-84)...
  41. ncbi request reprint Vignettes in osteoporosis: a road map to successful therapeutics
    Clifford J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, Maine 04401, USA
    J Bone Miner Res 19:3-10. 2004
    ..We describe five common clinical scenarios encountered in the practice of osteoporosis medicine and various road maps that could lead to successful therapy...
  42. ncbi request reprint Bisphosphonates and osteonecrosis of the jaw
    Nelson B Watts
    Ann Intern Med 145:791-2; author reply 792. 2006

Research Grants13

  1. Maintenance of Skeletal Integrity in Frail Elders
    Susan L Greenspan; Fiscal Year: 2010
    ..This study will examine the effectiveness and safety of a single dose intravenous therapy for osteoporosis in this frail, often neglected group. ..
  2. Osteoporosis in Older Men and Women
    Susan Greenspan; Fiscal Year: 2007
    b>Susan Greenspan, MD, Professor of Medicine at University of Pittsburgh, is applying for the K24 Midcareer Investigator Award in Patient-Oriented Research to advance her career in clinical investigations of osteoporosis in older men and ..
  3. Prevention of Osteoporosis in Men with Prostate Cancer
    Susan Greenspan; Fiscal Year: 2005
    ..This study will examine a preventive strategy, the potential mechanism of bone loss, the ability of biochemical marker to predict bone mass, and skeletal outcomes when antiresorptive therapy is withdrawn. ..
  4. Maintenance of Skeletal Integrity in Frail Elders
    Susan Greenspan; Fiscal Year: 2009
    ..This study will examine the effectiveness and safety of a single dose intravenous therapy for osteoporosis in this frail, often neglected group. ..