Susan Greenspan

..To determine the proportion of untreated women who reported receiving treatment after incident fracture and to identify factors that predict treatment across an international spectrum of individuals...

..Few data are available on the safety and efficacy of once-weekly oral bisphosphonate therapy in breast cancer survivors...

..Men should be evaluated for additional secondary causes of bone loss including vitamin D insufficiency. Guidelines are needed for androgen-induced bone loss screening and treatment...

..In addition to bone mineral density (BMD), trabecular microstructure contributes to skeletal strength. Our goal was to examine changes in trabecular microstructure in women on therapy...

..Our objective was to examine changes in bone density and turnover with sustained, discontinued, or delayed oral bisphosphonate therapy in men receiving ADT...

..Limited data are available on the efficacy of oral bisphosphonate therapy in breast cancer survivors. Our goal was to examine prevention of breast cancer-related bone loss in this cohort...

..Adequate intake for vitamin D (200 IU/day) was not met in 16/41 (39%); however, the dietary intake of vitamin D was not significantly different between the vitamin D insufficient and vitamin D sufficient groups...

..Serum 25-hydroxyvitamin D (25(OH)D) is low in obese adults...

..Androgen deprivation therapy (ADT) in men with prostate cancer is associated with bone loss and fractures...

..001). CONCLUSION: Alendronate increased BMD at both the spine and hip in elderly female residents of long-term care facilities...

..These findings have important clinical implications regarding the decision to treat prostate cancer patients with ADT...

..The effect of PTH therapy on serum and urinary calcium levels and the risk of hypercalcemia or hypercalciuria has not been formally evaluated...

..Recombinant human parathyroid hormone (1-84) (PTH) increases bone mass and strength and improves bone quality by stimulating new bone formation...

..We evaluated the association between a single nucleotide polymorphism in the farnesyl diphosphate synthase gene (FDPS), BMD and bone turnover markers...

..This study examined the prevalence of reduced bone mass in otherwise healthy children newly diagnosed with Crohn disease without previous corticosteroid exposure...

..In summary, within 3 to 9 months after LRGB, morbidly obese patients have an increase in bone resorption associated with a decrease in bone mass. Additional studies are needed to examine these findings over the longer term...

..CONCLUSION: In this 3-month study, the incidence of upper GI tract adverse events in patients treated with once-weekly alendronate, 70 mg, was comparable to that with placebo...

..Furthermore, they may be useful in monitoring disease activity, and serve as targets for biological therapy...

..We tested the hypothesis that men undergoing androgen deprivation therapy as treatment for prostate cancer are at greater risk for periodontitis and tooth loss...

..To investigate the influence of androgen deprivation therapy (ADT) in men with nonmetastatic prostate cancer...

..We conclude that short-term changes in biochemical markers of bone turnover at 6 months predict bone density changes at the spine and hip at 3 yr in elderly women on alendronate, hormone replacement therapy, or combination therapy...

..77 and 0.86 for lumbar and whole body z score cutoffs, respectively. Our data suggest that calcaneal BUA may serve as a reliable screening tool to detect reduced bone mass in pediatric patients with leukemia...

..The purpose of this study was to determine if vitamin D supplementation, 400-800 IU daily, could effectively treat vitamin D deficiency and insufficiency over 3 months...

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..These data provide additional information regarding potential mechanisms for fracture reduction with antiresorptive therapy...

..Changes in bone mineral density after discontinuation of therapy have not been compared directly...

..Although androgen deprivation therapy (ADT) for prostate cancer is associated with bone loss, little is known about when this bone loss occurs...

..Our aim was to determine the effect of hormone replacement on physical performance measures, functional ability, physical activity, falls, and cognitive function in elderly women...

..We compared body composition parameters in men with non-metastatic prostate cancer on or not on therapy with healthy, age-matched controls at baseline and monitored changes over a 2-year period...

..Further studies are needed to determine which factors are needed to target patients for appropriate diagnosis and treatment...

..However, they were not more likely to make significant health-related lifestyle changes after obtaining the results of their bone mass...

..Future studies are needed to determine whether bone quality, geometry, or turnover could account for these findings...

..Osteoporosis screening rates are low, and it is unclear which patient factors are associated with screening and physician recommendations for screening...

..Neither group displayed the expected strength losses with aging. Our subject cohorts, however, were not typical of those over age 65 years because individuals with existing health conditions were excluded from the study...

..Many older individuals would prefer the "best" test for osteoporosis screening, and may be willing to travel or pay more to obtain a better test...

..We review the sequence and turn of events pertaining to the discovery of vitamin D and the strategies for the eradication of the reemerging rickets problem...

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..We conducted a randomized, double-blind clinical study of parathyroid hormone and alendronate to test the hypothesis that the concurrent administration of the two agents would increase bone density more than the use of either one alone...

..The influence of these biochemical changes of type I collagen on bone fracture resistance remains to be studied...

..In the continuation of this trial, we asked whether antiresorptive therapy is required to maintain gains in bone mineral density after one year of therapy with parathyroid hormone (1-84)...

..We describe five common clinical scenarios encountered in the practice of osteoporosis medicine and various road maps that could lead to successful therapy...

..This study will examine the effectiveness and safety of a single dose intravenous therapy for osteoporosis in this frail, often neglected group. ..

b>Susan Greenspan, MD, Professor of Medicine at University of Pittsburgh, is applying for the K24 Midcareer Investigator Award in Patient-Oriented Research to advance her career in clinical investigations of osteoporosis in older men and ..

..This study will examine a preventive strategy, the potential mechanism of bone loss, the ability of biochemical marker to predict bone mass, and skeletal outcomes when antiresorptive therapy is withdrawn. ..

..This study will examine the effectiveness and safety of a single dose intravenous therapy for osteoporosis in this frail, often neglected group. ..