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Genomes and Genes | Joel K GreensonSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Pathologic predictors of microsatellite instability in colorectal cancerJoel K Greenson
Department of Pathology, The University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
Am J Surg Pathol 33:126-33. 2009..Although this model is not perfect in predicting microsatellite instability, its use could improve the efficiency of expensive diagnostic testing...- Is it Crohn's disease? A severe systemic granulomatous reaction to sulfasalazine in patient with rheumatoid arthritisL G Quallich
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
BMC Gastroenterol 1:8. 2001..Although as many as 20% of treated patients may experience reversible, dose-dependent side effects, less frequent but potentially severe, systemic reactions have also been reported... 
Histopathology of interval (delayed) appendectomy specimens: strong association with granulomatous and xanthogranulomatous appendicitisGuangming Guo
Department of Pathology University of Michigan Helath System, Ann Arbor, MI 48109 0054, USA
Am J Surg Pathol 27:1147-51. 2003..Without the appropriate clinical history, these changes may be misinterpreted as Crohn disease...- Dysplasia in inflammatory bowel diseaseJoel K Greenson
Department of Pathology, University of Michigan Health System, Ann Arbor, 48109 0054, USA
Semin Diagn Pathol 19:31-7. 2002..All diagnoses of dysplasia should be confirmed, preferably by a pathologist experienced in interpreting gastrointestinal biopsies... - The clinical significance of focal active colitis in pediatric patientsWei Xin
Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0054, USA
Am J Surg Pathol 27:1134-8. 2003..Pediatric patients with focal active colitis have a much higher incidence of Crohn's disease than adults with same entity. Hence, it is important to document the presence of focal active colitis in pediatric patients... - Gastrointestinal stromal tumors and other mesenchymal lesions of the gutJoel K Greenson
Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0054, USA
Mod Pathol 16:366-75. 2003..This article reviews the histologic features of these tumors in the context of recent molecular genetic and immunohistochemical advances... - Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variantsJules Lin
Department of Surgery, Section of General Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
Clin Cancer Res 10:5708-16. 2004..In this study, expression of MAGE family A members was evaluated during the development of esophageal adenocarcinoma (EA) as potential targets for immunotherapy... 
Incidence of hepatocellular carcinoma and associated risk factors in hepatitis C-related advanced liver diseaseAnna S Lok
Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Gastroenterology 136:138-48. 2009..We evaluated the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) cohort for the incidence of HCC and associated risk factors...- Evolution of hepatic steatosis in patients with advanced hepatitis C: results from the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trialAnna S Lok
Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Hepatology 49:1828-37. 2009..Decreased alcohol intake and improved metabolic parameters are associated with a decline in steatosis and may modulate hepatitis C progression... - The molecular basis of pancreatic fibrosis: common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinomaCharles E Binkley
Department of Surgery, University of Michigan, Ann Arbor, MI, USA
Pancreas 29:254-63. 2004..CONCLUSIONS: These genes are likely important factors in epithelial-stromal signaling in pancreatic desmoplasia and may serve as diagnostic or therapeutic targets... - Serum fibrosis markers are associated with liver disease progression in non-responder patients with chronic hepatitis CRobert J Fontana
Department of Internal Medicine, University of Michigan, 3912 Taubman Center, Ann Arbor, Michigan, USA
Gut 59:1401-9. 2010..The aim of this study was to explore the association of serum fibrosis marker levels with the risk of clinical and histological disease progression in a large cohort of patients with chronic hepatitis C (CHC)... - Gemcitabine-based combination chemotherapy followed by radiation with capecitabine as adjuvant therapy for resected pancreas cancerSameer Desai
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0934, USA
Int J Radiat Oncol Biol Phys 75:1450-5. 2009..To report outcomes for patients with resected pancreas cancer treated with an adjuvant regimen consisting of gemcitabine-based combination chemotherapy followed by capecitabine and radiation... - An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancerSu Hyung Hong
Department of Pediatrics, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0656, USA
Cancer Res 64:5504-10. 2004..The detection of autoantibodies to calreticulin isoforms may have utility for the early diagnosis of pancreatic cancer... - Lifestyle, occupational, and reproductive factors and risk of colorectal cancerAn Chi Lo
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
Dis Colon Rectum 53:830-7. 2010..Lifestyle factors and environmental exposures might help explain the risk of colorectal carcinoma in countries where the incidence is low, but unique patterns of young onset and a high proportion of rectal cancer exist... - A histologically defined subset of high-grade dysplasia in Barrett mucosa is predictive of associated carcinomaWeijian Zhu
Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
Am J Clin Pathol 132:94-100. 2009..Our findings highlight the evolution of diagnostic criteria for Barrett dysplasia... - Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagusMarie E Robert
Department of Pathology, Yale University, New Haven, CT 06520, USA
Am J Clin Pathol 124:519-27. 2005..Rab11a immunoreactivity did not enhance the diagnostic assessment of dysplasia in Barrett esophagus. The previously reported positive correlation of p53 immunoreactivity with the presence of dysplasia in Barrett esophagus was confirmed... - Phenotype of microsatellite unstable colorectal carcinomas: Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instabilityJoel K Greenson
Department of Pathology, Universit of Michigan Health System, Ann Arbor, 48109, USA
Am J Surg Pathol 27:563-70. 2003..The combination of >2 tumor infiltrating lymphocytes per high power field and/or any mucinous differentiation and/or the absence of dirty necrosis identified all MSI-H tumors in this study... - Phase I study of oxaliplatin, full-dose gemcitabine, and concurrent radiation therapy in pancreatic cancerSameer P Desai
Division of Hematology Oncology, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0934, USA
J Clin Oncol 25:4587-92. 2007..To determine a biweekly dose of oxaliplatin for combination with full-dose gemcitabine and concurrent radiation therapy (RT) in pancreatic cancer... - CDX2 polymorphisms, RNA expression, and risk of colorectal cancerLaura S Rozek
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
Cancer Res 65:5488-92. 2005.... - Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinomaJules Lin
Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Neoplasia 8:1062-71. 2006..02). EA-derived cells expressing UBE2C are sensitive to treatment with MG-262 and to silencing of UBE2C, suggesting that patients with EAs overexpressing UBE2C may benefit from agents targeting this ubiquitin-conjugating enzyme... - Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivationTakao Hinoi
Department of Internal Medicine, The Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 2200, USA
Cancer Res 67:9721-30. 2007.... - The association between selected risk factors for pancreatic cancer and the expression of p53 and K-ras codon 12 mutationsJon P Fryzek
Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109 2029, USA
Int J Gastrointest Cancer 37:139-45. 2006..Studies suggest that a few risk factors, including cigarette smoking, body mass index, having a relative with pancreatic cancer, and diabetes may be related to pancreatic cancer risk... - Sustained virologic response to therapy of recurrent hepatitis C after liver transplantation is related to early virologic response and dose adherencePratima Sharma
University of Michigan Health Systems, Division of Gastroenterology and Department of Pathology, Ann Arbor, MI 48109 0362, USA
Liver Transpl 13:1100-8. 2007..Similar to non-LT patients, those with lower pretreatment HCV RNA, a week 12 virological response, and pegylated IFN and RBV dose adherence were more likely to achieve SVR... - Occult and previous hepatitis B virus infection are not associated with hepatocellular carcinoma in United States patients with chronic hepatitis CAnna S Lok
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Hepatology 54:434-42. 2011..In the United States, neither previous nor occult HBV infection is an important factor in HCC development among patients with advanced chronic hepatitis C... - Genetic variation in 8q24 associated with risk of colorectal cancerStephen B Gruber
Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher, Ann Arbor, Michigan 48109, USA
Cancer Biol Ther 6:1143-7. 2007..2 (95% bootstrap CI = 1.16-17.8). Genetic variation at rs10505477 on 8q24 potentially accounts for 14% of CRC in this population and should be replicated in other studies... - Smoking, gender, and ethnicity predict somatic BRAF mutations in colorectal cancerLaura S Rozek
Environmental Health Sciences, School of Public Health, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
Cancer Epidemiol Biomarkers Prev 19:838-43. 2010..Epidemiologic studies of CRC should incorporate somatic characteristics to fully appreciate risk factors for this disease... - Human papillomavirus is not associated with colorectal cancer in a large international studyMichele C Gornick
Department of Human Genetics, School of Medicine, University of Michigan, 109 Zina Pitcher, Ann Arbor, MI 48109 2200, USA
Cancer Causes Control 21:737-43. 2010..Recent publications have reported an association between colon cancer and human papillomaviruses (HPV), suggesting that HPV infection of the colonic mucosa may contribute to the development of colorectal cancer... - Lifestyle, occupational, and reproductive factors in relation to pancreatic cancer riskAn Chi Lo
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Pancreas 35:120-9. 2007..This study examined the epidemiology of pancreatic cancer in Egypt... - Histopathology of ulcerative colitis in initial rectal biopsy in childrenKay Washington
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Am J Surg Pathol 26:1441-9. 2002..This difference may be related to a shorter duration of symptoms before biopsy... - Molecular diagnosis of Campylobacter jejuni infection in cases of focal active colitisElizabeth N Schneider
Department of Pathology, Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, and Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA
Am J Surg Pathol 30:782-5. 2006..Furthermore, PCR analysis performed on fixed, routinely processed colon biopsies is an excellent diagnostic method for detection of this organism... - Adenoma-infiltrating lymphocytes (AILs) are a potential marker of hereditary nonpolyposis colorectal cancerAlexandros D Polydorides
Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
Am J Surg Pathol 32:1661-6. 2008..Therefore, increased numbers of AILs and decreased numbers of apoptoses in colorectal adenomas are simple and inexpensive markers that raise the possibility of HNPCC... - The yield of colonoscopy in patients with non-constipated irritable bowel syndrome: results from a prospective, controlled US trialWilliam D Chey
Divison of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan, USA
Am J Gastroenterol 105:859-65. 2010..This study compared the prevalence of structural colonic lesions in patients with suspected non-constipation-predominant IBS and healthy volunteers. We also determined the yield of rectosigmoid biopsies in patients with suspected IBS... - Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based frameworkKerby A Shedden
Department of Statistics, University of Michigan, Ann Arbor, MI 48109 1027, USA
Am J Pathol 163:1985-95. 2003..Our findings suggest that accurate and robust cancer diagnosis from gene expression profiles can be achieved by mimicking the classification strategies routinely used by surgical pathologists... - Metabolic syndrome is associated with greater histologic severity, higher carbohydrate, and lower fat diet in patients with NAFLDHellan Kang
Division of Gastroenterology, Department of Medicine, The University of Michigan, Ann Arbor, Michigan 48109-0362, USA
Am J Gastroenterol 101:2247-53. 2006..The role of a carbohydrate-restricted diet in decreasing the risk for metabolic syndrome and histologic severity should be assessed in patients with NAFLD... - Primary pulmonary adenocarcinoma with intestinal differentiation mimicking metastatic colorectal carcinoma: case report and review of literatureHong C Li
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
Am J Clin Pathol 131:129-33. 2009..This is the first description of pulmonary adenocarcinoma with intestinal differentiation with histopathologic and immunophenotypic findings indistinguishable from metastatic colorectal adenocarcinoma... - A phase II study of preoperative capecitabine and radiation therapy in patients with rectal cancerSameer P Desai
Division of Hematology Oncology, University of Michigan, Ann Arbor, MI 48109 0934, USA
Am J Clin Oncol 30:340-5. 2007..The purpose of this study was to evaluate the safety and efficacy of preoperative capecitabine and radiation therapy (RT) in patients with locally advanced rectal cancer (LARC)... - Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollutionAmr S Soliman
Department of Epidemiology, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109, USA
Carcinogenesis 28:1794-9. 2007..Variations in genetic mutations in pancreatic carcinoma between different geographical regions have not been studied extensively, especially in developing countries where pancreatic cancer is relatively rare... - Risk of colorectal cancer in self-reported inflammatory bowel disease and modification of risk by statin and NSAID useN Jewel Samadder
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
Cancer 117:1640-8. 2011..The objective of this study was to quantify the relative risk of inflammatory bowel disease (IBD) as a risk factor for CRC and to estimate whether this risk may be modified by long-term use of NSAIDs or statins... - The clinical significance of focally enhanced gastritis in childrenJonathan B McHugh
Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
Am J Surg Pathol 37:295-9. 2013..The presence of FEG is highly associated with IBD in pediatric patients. The presence of FEG does not reliably distinguish between patients with CD and those with UC... - Curcumin promotes apoptosis, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinomaWibisono Hartojo
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
Transl Oncol 3:99-108. 2010.... - Jumbo forceps are superior to standard large-capacity forceps in obtaining diagnostically adequate inflammatory bowel disease surveillance biopsy specimensB Joseph Elmunzer
Division of Gastroenterology Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
Gastrointest Endosc 68:273-8; quiz 334, 336. 2008..In inflammatory bowel disease (IBD) surveillance colonoscopy, an increased number of biopsy specimens correlates with a higher dysplasia detection rate. Larger biopsy specimens may also increase the diagnostic yield... - The clinical significance of focally enhanced gastritisWei Xin
Department of Pathology, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0054, USA
Am J Surg Pathol 28:1347-51. 2004..An isolated biopsy diagnosis of FEG should not be interpreted as being suggestive of Crohn's disease... - Hepatocyte-derived Snail1 propagates liver fibrosis progressionR Grant Rowe
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
Mol Cell Biol 31:2392-403. 2011.... - L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett's adenocarcinomaJules Lin
Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Neoplasia 6:74-84. 2004..LAT-1 expression is also retained in cell lines grown in nude mice providing a model to evaluate melphalan as a chemotherapeutic agent against esophageal adenocarcinomas expressing LAT-1... - Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomasScott R Owens
The University of Michigan Medical Center, Ann Arbor, MI, USA
Am J Surg Pathol 31:285-90. 2007..It also stained the dysplastic epithelial cells in adjacent areas of anal intraepithelial neoplasia. We report that the p63 immunostain is a highly specific and useful tool in the diagnosis of carcinomas of the anal canal... - Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasisXiang Xue
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA
Cancer Res 72:2285-93. 2012..Together, our findings show that a chronic increase in HIF-2α in the colon initiates protumorigenic signaling, which may have important implications in developing preventive and therapeutic strategies for colon cancer... - The differential diagnosis of colitis in endoscopic biopsy specimens: a review articleLisa A Cerilli
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 5602, USA
Arch Pathol Lab Med 136:854-64. 2012..A variety of inflammatory disorders may affect the colon, with widely differing clinical outcomes and management. These conditions encompass a spectrum of acute and chronic conditions... - Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host diseaseJames L M Ferrara
Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
Blood 118:6702-8. 2011..001). REG3α is a plasma biomarker of GI GVHD that can be combined with clinical stage and histologic grade to improve risk stratification of patients... - Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patientsAmr S Soliman
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Int J Cancer 119:1455-61. 2006..Our study identifies that there are differences in the types of mutations found in tumors from pancreatic carcinoma patients in Egypt and the US, and suggests that environmental factors may explain these differences... - Pathogenic Yersinia DNA is detected in bowel and mesenteric lymph nodes from patients with Crohn's diseaseLaura W Lamps
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock 72212, USA
Am J Surg Pathol 27:220-7. 2003..Like previous studies associating infectious organisms with CD, much work remains to elucidate whether the presence of DNA is an epiphenomenon or actually a factor in the pathogenesis of CD... - Hepatic fat fraction: MR imaging for quantitative measurement and display--early experienceHero K Hussain
Department of Radiology/MRI, University of Michigan Health System, 1500 E Medical Center Dr, MRI UHB2A209, Ann Arbor, MI 48109-0030, USA
Radiology 237:1048-55. 2005..3% +/- 2.8 [standard deviation] and 28.6% +/- 2.4, vs quantitative histopathologic analysis, 11.2% and 28.5%, respectively). Supplemental material: radiology.rsnajnls.org/cgi/content/full/2373041639/DC1.. - Reduced severity of a mouse colitis model with angiotensin converting enzyme inhibitionAriel U Spencer
Department of Surgery, Section of Pediatric Surgery, University of Michigan, Ann Arbor, MI 48109, USA
Dig Dis Sci 52:1060-70. 2007..We conclude that ACE-I reduces the severity of DSS-induced colitis and reduces epithelial cell apoptosis... - One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: a pilot studyMary Ann Huang
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA
Am J Gastroenterol 100:1072-81. 2005..This pilot study suggests that dietary intervention can be effective in improving histology in patients with biopsy-proven NASH... - Hepatic steatosis in hepatitis C: comparison of diabetic and nondiabetic patients in the hepatitis C antiviral long-term treatment against cirrhosis trialAnna S F Lok
Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0362, USA
Clin Gastroenterol Hepatol 5:245-54. 2007.... - Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancerCraig D Logsdon
Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
Cancer Res 63:2649-57. 2003..These data provide new insights into the molecular pathology of pancreatic cancer that may be useful for detection, diagnosis, and treatment... - Acute liver failure due to amoxicillin and amoxicillin/clavulanateRobert J Fontana
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0362, USA
Dig Dis Sci 50:1785-90. 2005..Early transfer of patients with severe drug-induced hepatotoxicity (i.e., encephalopathy or coagulopathy) to a transplant center is recommended due to their poor likelihood of recovery... - A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis CChun-Tao Wai
Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Hepatology 38:518-26. 2003..Application of this index may decrease the need for staging liver biopsy specimens among CHC patients... - Surgical resection following radiation therapy with concurrent gemcitabine in patients with previously unresectable adenocarcinoma of the pancreasJohn B Ammori
Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
J Gastrointest Surg 7:766-72. 2003..The use of Gem/RT in a neoadjuvant setting is currently being investigated in a multi-institutional phase II trial... - Life-long learning and self-assessmentJeffrey L Myers
Department of Pathology, University of Michigan, Ann Arbor, MI 48109 5054, USA
Arch Pathol Lab Med 136:851-3. 2012.... - Are ulcers a marker for invasive carcinoma in Barrett's esophagus? Data from a diagnostic variability study with clinical follow-upElizabeth Montgomery
Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
Am J Gastroenterol 97:27-31. 2002..We correlated follow-up information from 138 patients with Barrett's esophagus and varying degrees of dysplasia with the presence of ulcers... - Percutaneous radiofrequency thermal ablation of hepatocellular carcinoma: a safe and effective bridge to liver transplantationRobert J Fontana
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
Liver Transpl 8:1165-74. 2002.... - Expression of hexokinase II and Glut-1 in untreated human breast cancerRaya S Brown
Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical Center, Ann Arbor, MI, USA
Nucl Med Biol 29:443-53. 2002..6).FDG uptake in breast cancer tissue appears to be associated with the extent of immunodetectable expression of Glut-1, but not that of HKII, and FDG uptake may differ between individual tumors depending on tumor stage and histology... - BLM heterozygosity and the risk of colorectal cancerStephen B Gruber
Departments of Internal Medicine and Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA
Science 297:2013. 2002 - Colorectal polyps in carriers of the APC I1307K polymorphismGad Rennert
Department of Community Medicine and Epidemiology, CHS National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
Dis Colon Rectum 48:2317-21. 2005..The prevalence of polyps and adenomas in specimens of colorectal cancer who are carriers and noncarriers of the APC I1307K polymorphism is compared... - The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancerSteven M Lipkin
Division of Oncology, Department of Medicine, University of California, Irvine, Irvine, California 92697, USA
Nat Genet 36:694-9. 2004..These studies suggest that variants of mismatch repair proteins with attenuated function may account for a higher proportion of susceptibility to sporadic microsatellite-stable CRC than previously assumed... - Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumoursTzafra Cohen
Department of Pathology, Carmel Medical Center and Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel
J Pathol 198:77-82. 2002..In conclusion, the vast majority of EPTs examined expressed NP-2, suggesting its utility as a diagnostic marker for these tumours. The function of NP-2 in islet cell biology or tumourigenesis remains to be elucidated... - Statins and the risk of colorectal cancerJenny N Poynter
Department of Epidemiology, University of Michigan, Ann Arbor 48109-0638, USA
N Engl J Med 352:2184-92. 2005..Because the absolute risk reduction is likely low, further investigation of the overall benefits of statins in preventing colorectal cancer is warranted... - Analysis of protein expression and gene mutation of c-kit in colorectal neuroendocrine carcinomasOlaronke Akintola-Ogunremi
Lauren V Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Surg Pathol 27:1551-8. 2003..More importantly, our observations may have potential therapeutic implications since specific tyrosine kinase inhibitors have shown promise in the management of patients with kit-expressing malignancies... - The association of body mass index and pancreatic cancer in residents of southeastern Michigan, 1996-1999Jon P Fryzek
International Epidemiology Institute, Rockville, MD 20850, USA
Am J Epidemiol 162:222-8. 2005..In addition, body mass index may play a role in the etiology of pancreatic cancer even in the absence of diabetes... - Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor, ADMRVijaya Ramachandran
Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 67:2666-75. 2007..These data indicate that adrenomedullin acting via ADMR increases the aggressiveness of pancreatic cancer cells and suggests that these molecules may be useful therapeutic targets...