Joel K Greenson

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Pathologic predictors of microsatellite instability in colorectal cancer
    Joel K Greenson
    Department of Pathology, The University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 33:126-33. 2009
  2. pmc Is it Crohn's disease? A severe systemic granulomatous reaction to sulfasalazine in patient with rheumatoid arthritis
    L G Quallich
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    BMC Gastroenterol 1:8. 2001
  3. ncbi request reprint Dysplasia in inflammatory bowel disease
    Joel K Greenson
    Department of Pathology, University of Michigan Health System, Ann Arbor, 48109 0054, USA
    Semin Diagn Pathol 19:31-7. 2002
  4. ncbi request reprint Histopathology of interval (delayed) appendectomy specimens: strong association with granulomatous and xanthogranulomatous appendicitis
    Guangming Guo
    Department of Pathology University of Michigan Helath System, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 27:1147-51. 2003
  5. ncbi request reprint The clinical significance of focal active colitis in pediatric patients
    Wei Xin
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0054, USA
    Am J Surg Pathol 27:1134-8. 2003
  6. ncbi request reprint Gastrointestinal stromal tumors and other mesenchymal lesions of the gut
    Joel K Greenson
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0054, USA
    Mod Pathol 16:366-75. 2003
  7. ncbi request reprint Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants
    Jules Lin
    Department of Surgery, Section of General Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 10:5708-16. 2004
  8. pmc Incidence of hepatocellular carcinoma and associated risk factors in hepatitis C-related advanced liver disease
    Anna S Lok
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Gastroenterology 136:138-48. 2009
  9. pmc Evolution of hepatic steatosis in patients with advanced hepatitis C: results from the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trial
    Anna S Lok
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Hepatology 49:1828-37. 2009
  10. ncbi request reprint The molecular basis of pancreatic fibrosis: common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma
    Charles E Binkley
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Pancreas 29:254-63. 2004

Detail Information

Publications76

  1. pmc Pathologic predictors of microsatellite instability in colorectal cancer
    Joel K Greenson
    Department of Pathology, The University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 33:126-33. 2009
    ..Although this model is not perfect in predicting microsatellite instability, its use could improve the efficiency of expensive diagnostic testing...
  2. pmc Is it Crohn's disease? A severe systemic granulomatous reaction to sulfasalazine in patient with rheumatoid arthritis
    L G Quallich
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    BMC Gastroenterol 1:8. 2001
    ..Although as many as 20% of treated patients may experience reversible, dose-dependent side effects, less frequent but potentially severe, systemic reactions have also been reported...
  3. ncbi request reprint Dysplasia in inflammatory bowel disease
    Joel K Greenson
    Department of Pathology, University of Michigan Health System, Ann Arbor, 48109 0054, USA
    Semin Diagn Pathol 19:31-7. 2002
    ..All diagnoses of dysplasia should be confirmed, preferably by a pathologist experienced in interpreting gastrointestinal biopsies...
  4. ncbi request reprint Histopathology of interval (delayed) appendectomy specimens: strong association with granulomatous and xanthogranulomatous appendicitis
    Guangming Guo
    Department of Pathology University of Michigan Helath System, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 27:1147-51. 2003
    ..Without the appropriate clinical history, these changes may be misinterpreted as Crohn disease...
  5. ncbi request reprint The clinical significance of focal active colitis in pediatric patients
    Wei Xin
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0054, USA
    Am J Surg Pathol 27:1134-8. 2003
    ..Pediatric patients with focal active colitis have a much higher incidence of Crohn's disease than adults with same entity. Hence, it is important to document the presence of focal active colitis in pediatric patients...
  6. ncbi request reprint Gastrointestinal stromal tumors and other mesenchymal lesions of the gut
    Joel K Greenson
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0054, USA
    Mod Pathol 16:366-75. 2003
    ..This article reviews the histologic features of these tumors in the context of recent molecular genetic and immunohistochemical advances...
  7. ncbi request reprint Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants
    Jules Lin
    Department of Surgery, Section of General Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 10:5708-16. 2004
    ..In this study, expression of MAGE family A members was evaluated during the development of esophageal adenocarcinoma (EA) as potential targets for immunotherapy...
  8. pmc Incidence of hepatocellular carcinoma and associated risk factors in hepatitis C-related advanced liver disease
    Anna S Lok
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Gastroenterology 136:138-48. 2009
    ..We evaluated the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) cohort for the incidence of HCC and associated risk factors...
  9. pmc Evolution of hepatic steatosis in patients with advanced hepatitis C: results from the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trial
    Anna S Lok
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Hepatology 49:1828-37. 2009
    ....
  10. ncbi request reprint The molecular basis of pancreatic fibrosis: common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma
    Charles E Binkley
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Pancreas 29:254-63. 2004
    ....
  11. pmc Serum fibrosis markers are associated with liver disease progression in non-responder patients with chronic hepatitis C
    Robert J Fontana
    Department of Internal Medicine, University of Michigan, 3912 Taubman Center, Ann Arbor, Michigan, USA
    Gut 59:1401-9. 2010
    ..The aim of this study was to explore the association of serum fibrosis marker levels with the risk of clinical and histological disease progression in a large cohort of patients with chronic hepatitis C (CHC)...
  12. doi request reprint Gemcitabine-based combination chemotherapy followed by radiation with capecitabine as adjuvant therapy for resected pancreas cancer
    Sameer Desai
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0934, USA
    Int J Radiat Oncol Biol Phys 75:1450-5. 2009
    ..To report outcomes for patients with resected pancreas cancer treated with an adjuvant regimen consisting of gemcitabine-based combination chemotherapy followed by capecitabine and radiation...
  13. doi request reprint A histologically defined subset of high-grade dysplasia in Barrett mucosa is predictive of associated carcinoma
    Weijian Zhu
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Am J Clin Pathol 132:94-100. 2009
    ..Our findings highlight the evolution of diagnostic criteria for Barrett dysplasia...
  14. pmc Lifestyle, occupational, and reproductive factors and risk of colorectal cancer
    An Chi Lo
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    Dis Colon Rectum 53:830-7. 2010
    ..Lifestyle factors and environmental exposures might help explain the risk of colorectal carcinoma in countries where the incidence is low, but unique patterns of young onset and a high proportion of rectal cancer exist...
  15. ncbi request reprint An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer
    Su Hyung Hong
    Department of Pediatrics, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0656, USA
    Cancer Res 64:5504-10. 2004
    ..The detection of autoantibodies to calreticulin isoforms may have utility for the early diagnosis of pancreatic cancer...
  16. pmc Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma
    Jules Lin
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 8:1062-71. 2006
    ..02). EA-derived cells expressing UBE2C are sensitive to treatment with MG-262 and to silencing of UBE2C, suggesting that patients with EAs overexpressing UBE2C may benefit from agents targeting this ubiquitin-conjugating enzyme...
  17. ncbi request reprint Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus
    Marie E Robert
    Department of Pathology, Yale University, New Haven, CT 06520, USA
    Am J Clin Pathol 124:519-27. 2005
    ..Rab11a immunoreactivity did not enhance the diagnostic assessment of dysplasia in Barrett esophagus. The previously reported positive correlation of p53 immunoreactivity with the presence of dysplasia in Barrett esophagus was confirmed...
  18. pmc Low Paneth cell numbers at onset of gastrointestinal graft-versus-host disease identify patients at high risk for nonrelapse mortality
    John E Levine
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Blood 122:1505-9. 2013
    ..004). We conclude that the enumeration of duodenal Paneth cells is a readily available index of disease severity that provides important information regarding GVHD prognosis. ..
  19. ncbi request reprint Phenotype of microsatellite unstable colorectal carcinomas: Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability
    Joel K Greenson
    Department of Pathology, Universit of Michigan Health System, Ann Arbor, 48109, USA
    Am J Surg Pathol 27:563-70. 2003
    ..The combination of >2 tumor infiltrating lymphocytes per high power field and/or any mucinous differentiation and/or the absence of dirty necrosis identified all MSI-H tumors in this study...
  20. ncbi request reprint CDX2 polymorphisms, RNA expression, and risk of colorectal cancer
    Laura S Rozek
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
    Cancer Res 65:5488-92. 2005
    ....
  21. ncbi request reprint Phase I study of oxaliplatin, full-dose gemcitabine, and concurrent radiation therapy in pancreatic cancer
    Sameer P Desai
    Division of Hematology Oncology, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0934, USA
    J Clin Oncol 25:4587-92. 2007
    ..To determine a biweekly dose of oxaliplatin for combination with full-dose gemcitabine and concurrent radiation therapy (RT) in pancreatic cancer...
  22. doi request reprint A multi-institutional phase 2 study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer
    Edward J Kim
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer 119:2692-700. 2013
    ..The purpose of this study was to evaluate preoperative treatment with full-dose gemcitabine, oxaliplatin, and radiation therapy (RT) in patients with localized pancreatic cancer...
  23. ncbi request reprint Lifestyle, occupational, and reproductive factors in relation to pancreatic cancer risk
    An Chi Lo
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Pancreas 35:120-9. 2007
    ..This study examined the epidemiology of pancreatic cancer in Egypt...
  24. ncbi request reprint Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation
    Takao Hinoi
    Department of Internal Medicine, The Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 2200, USA
    Cancer Res 67:9721-30. 2007
    ....
  25. ncbi request reprint The association between selected risk factors for pancreatic cancer and the expression of p53 and K-ras codon 12 mutations
    Jon P Fryzek
    Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109 2029, USA
    Int J Gastrointest Cancer 37:139-45. 2006
    ..Studies suggest that a few risk factors, including cigarette smoking, body mass index, having a relative with pancreatic cancer, and diabetes may be related to pancreatic cancer risk...
  26. ncbi request reprint A phase II study of preoperative capecitabine and radiation therapy in patients with rectal cancer
    Sameer P Desai
    Division of Hematology Oncology, University of Michigan, Ann Arbor, MI 48109 0934, USA
    Am J Clin Oncol 30:340-5. 2007
    ..The purpose of this study was to evaluate the safety and efficacy of preoperative capecitabine and radiation therapy (RT) in patients with locally advanced rectal cancer (LARC)...
  27. ncbi request reprint Genetic variation in 8q24 associated with risk of colorectal cancer
    Stephen B Gruber
    Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher, Ann Arbor, Michigan 48109, USA
    Cancer Biol Ther 6:1143-7. 2007
    ..2 (95% bootstrap CI = 1.16-17.8). Genetic variation at rs10505477 on 8q24 potentially accounts for 14% of CRC in this population and should be replicated in other studies...
  28. pmc Smoking, gender, and ethnicity predict somatic BRAF mutations in colorectal cancer
    Laura S Rozek
    Environmental Health Sciences, School of Public Health, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Cancer Epidemiol Biomarkers Prev 19:838-43. 2010
    ..Epidemiologic studies of CRC should incorporate somatic characteristics to fully appreciate risk factors for this disease...
  29. ncbi request reprint Sustained virologic response to therapy of recurrent hepatitis C after liver transplantation is related to early virologic response and dose adherence
    Pratima Sharma
    University of Michigan Health Systems, Division of Gastroenterology and Department of Pathology, Ann Arbor, MI 48109 0362, USA
    Liver Transpl 13:1100-8. 2007
    ..Similar to non-LT patients, those with lower pretreatment HCV RNA, a week 12 virological response, and pegylated IFN and RBV dose adherence were more likely to achieve SVR...
  30. pmc Occult and previous hepatitis B virus infection are not associated with hepatocellular carcinoma in United States patients with chronic hepatitis C
    Anna S Lok
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Hepatology 54:434-42. 2011
    ..7% of controls. HBV DNA was detected in the serum of only one control subject and no patients with HCC. HBV DNA (as a marker of occult HBV infection) was detected in the livers of 10.7% of HCC cases and 23.6% of controls (P=0.18)...
  31. doi request reprint Human papillomavirus is not associated with colorectal cancer in a large international study
    Michele C Gornick
    Department of Human Genetics, School of Medicine, University of Michigan, 109 Zina Pitcher, Ann Arbor, MI 48109 2200, USA
    Cancer Causes Control 21:737-43. 2010
    ..Recent publications have reported an association between colon cancer and human papillomaviruses (HPV), suggesting that HPV infection of the colonic mucosa may contribute to the development of colorectal cancer...
  32. ncbi request reprint Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution
    Amr S Soliman
    Department of Epidemiology, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109, USA
    Carcinogenesis 28:1794-9. 2007
    ..Variations in genetic mutations in pancreatic carcinoma between different geographical regions have not been studied extensively, especially in developing countries where pancreatic cancer is relatively rare...
  33. ncbi request reprint Histopathology of ulcerative colitis in initial rectal biopsy in children
    Kay Washington
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Am J Surg Pathol 26:1441-9. 2002
    ..This difference may be related to a shorter duration of symptoms before biopsy...
  34. ncbi request reprint Molecular diagnosis of Campylobacter jejuni infection in cases of focal active colitis
    Elizabeth N Schneider
    Department of Pathology, Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, and Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA
    Am J Surg Pathol 30:782-5. 2006
    ..Furthermore, PCR analysis performed on fixed, routinely processed colon biopsies is an excellent diagnostic method for detection of this organism...
  35. pmc The yield of colonoscopy in patients with non-constipated irritable bowel syndrome: results from a prospective, controlled US trial
    William D Chey
    Divison of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Am J Gastroenterol 105:859-65. 2010
    ..This study compared the prevalence of structural colonic lesions in patients with suspected non-constipation-predominant IBS and healthy volunteers. We also determined the yield of rectosigmoid biopsies in patients with suspected IBS...
  36. pmc Adenoma-infiltrating lymphocytes (AILs) are a potential marker of hereditary nonpolyposis colorectal cancer
    Alexandros D Polydorides
    Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 32:1661-6. 2008
    ..Therefore, increased numbers of AILs and decreased numbers of apoptoses in colorectal adenomas are simple and inexpensive markers that raise the possibility of HNPCC...
  37. ncbi request reprint Metabolic syndrome is associated with greater histologic severity, higher carbohydrate, and lower fat diet in patients with NAFLD
    Hellan Kang
    Division of Gastroenterology, Department of Medicine, The University of Michigan, Ann Arbor, Michigan 48109 0362, USA
    Am J Gastroenterol 101:2247-53. 2006
    ..Insulin resistance (IR) is a key component of metabolic syndrome. The aim was to determine the dietary composition, physical activity, and histologic severity between NAFLD patients with and without metabolic syndrome...
  38. pmc Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework
    Kerby A Shedden
    Department of Statistics, University of Michigan, Ann Arbor, MI 48109 1027, USA
    Am J Pathol 163:1985-95. 2003
    ..Our findings suggest that accurate and robust cancer diagnosis from gene expression profiles can be achieved by mimicking the classification strategies routinely used by surgical pathologists...
  39. doi request reprint Primary pulmonary adenocarcinoma with intestinal differentiation mimicking metastatic colorectal carcinoma: case report and review of literature
    Hong C Li
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Clin Pathol 131:129-33. 2009
    ..This is the first description of pulmonary adenocarcinoma with intestinal differentiation with histopathologic and immunophenotypic findings indistinguishable from metastatic colorectal adenocarcinoma...
  40. pmc Risk of colorectal cancer in self-reported inflammatory bowel disease and modification of risk by statin and NSAID use
    N Jewel Samadder
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    Cancer 117:1640-8. 2011
    ..The objective of this study was to quantify the relative risk of inflammatory bowel disease (IBD) as a risk factor for CRC and to estimate whether this risk may be modified by long-term use of NSAIDs or statins...
  41. doi request reprint The clinical significance of focally enhanced gastritis in children
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 37:295-9. 2013
    ..The presence of FEG is highly associated with IBD in pediatric patients. The presence of FEG does not reliably distinguish between patients with CD and those with UC...
  42. ncbi request reprint Jumbo forceps are superior to standard large-capacity forceps in obtaining diagnostically adequate inflammatory bowel disease surveillance biopsy specimens
    B Joseph Elmunzer
    Division of Gastroenterology Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Gastrointest Endosc 68:273-8; quiz 334, 336. 2008
    ..In inflammatory bowel disease (IBD) surveillance colonoscopy, an increased number of biopsy specimens correlates with a higher dysplasia detection rate. Larger biopsy specimens may also increase the diagnostic yield...
  43. pmc L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett's adenocarcinoma
    Jules Lin
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 6:74-84. 2004
    ..LAT-1 expression is also retained in cell lines grown in nude mice providing a model to evaluate melphalan as a chemotherapeutic agent against esophageal adenocarcinomas expressing LAT-1...
  44. ncbi request reprint The clinical significance of focally enhanced gastritis
    Wei Xin
    Department of Pathology, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 28:1347-51. 2004
    ..An isolated biopsy diagnosis of FEG should not be interpreted as being suggestive of Crohn's disease...
  45. pmc Hepatocyte-derived Snail1 propagates liver fibrosis progression
    R Grant Rowe
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Cell Biol 31:2392-403. 2011
    ....
  46. pmc Curcumin promotes apoptosis, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinoma
    Wibisono Hartojo
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
    Transl Oncol 3:99-108. 2010
    ....
  47. ncbi request reprint Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas
    Scott R Owens
    The University of Michigan Medical Center, Ann Arbor, MI, USA
    Am J Surg Pathol 31:285-90. 2007
    ..It also stained the dysplastic epithelial cells in adjacent areas of anal intraepithelial neoplasia. We report that the p63 immunostain is a highly specific and useful tool in the diagnosis of carcinomas of the anal canal...
  48. doi request reprint The clinical significance of duodenal lymphocytosis with normal villus architecture
    Suntrea T G Hammer
    Department of Pathology, University of Michigan Health System, Ann Arbor, 48109, USA
    Arch Pathol Lab Med 137:1216-9. 2013
    ....
  49. pmc Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis
    Xiang Xue
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA
    Cancer Res 72:2285-93. 2012
    ..Together, our findings show that a chronic increase in HIF-2α in the colon initiates protumorigenic signaling, which may have important implications in developing preventive and therapeutic strategies for colon cancer...
  50. doi request reprint The differential diagnosis of colitis in endoscopic biopsy specimens: a review article
    Lisa A Cerilli
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 5602, USA
    Arch Pathol Lab Med 136:854-64. 2012
    ..A variety of inflammatory disorders may affect the colon, with widely differing clinical outcomes and management. These conditions encompass a spectrum of acute and chronic conditions...
  51. pmc Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease
    James L M Ferrara
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Blood 118:6702-8. 2011
    ..001). REG3α is a plasma biomarker of GI GVHD that can be combined with clinical stage and histologic grade to improve risk stratification of patients...
  52. ncbi request reprint Pathogenic Yersinia DNA is detected in bowel and mesenteric lymph nodes from patients with Crohn's disease
    Laura W Lamps
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock 72212, USA
    Am J Surg Pathol 27:220-7. 2003
    ..Like previous studies associating infectious organisms with CD, much work remains to elucidate whether the presence of DNA is an epiphenomenon or actually a factor in the pathogenesis of CD...
  53. ncbi request reprint Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients
    Amr S Soliman
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Int J Cancer 119:1455-61. 2006
    ..Our study identifies that there are differences in the types of mutations found in tumors from pancreatic carcinoma patients in Egypt and the US, and suggests that environmental factors may explain these differences...
  54. ncbi request reprint Hepatic steatosis in hepatitis C: comparison of diabetic and nondiabetic patients in the hepatitis C antiviral long-term treatment against cirrhosis trial
    Anna S F Lok
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0362, USA
    Clin Gastroenterol Hepatol 5:245-54. 2007
    ....
  55. pmc Adrenocortical carcinoma is a lynch syndrome-associated cancer
    Victoria M Raymond
    University of Michigan, Ann Arbor, MI, USA
    J Clin Oncol 31:3012-8. 2013
    ..The association of adult-onset ACC with inherited cancer predisposition syndromes is poorly understood. Our study sought to define the prevalence of Lynch syndrome (LS) among patients with ACC...
  56. ncbi request reprint Hepatic fat fraction: MR imaging for quantitative measurement and display--early experience
    Hero K Hussain
    Department of Radiology MRI, University of Michigan Health System, 1500 E Medical Center Dr, MRI UHB2A209, Ann Arbor, MI 48109 0030, USA
    Radiology 237:1048-55. 2005
    ..3% +/- 2.8 [standard deviation] and 28.6% +/- 2.4, vs quantitative histopathologic analysis, 11.2% and 28.5%, respectively). Supplemental material: radiology.rsnajnls.org/cgi/content/full/2373041639/DC1..
  57. pmc Reduced severity of a mouse colitis model with angiotensin converting enzyme inhibition
    Ariel U Spencer
    Department of Surgery, Section of Pediatric Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Dig Dis Sci 52:1060-70. 2007
    ..We conclude that ACE-I reduces the severity of DSS-induced colitis and reduces epithelial cell apoptosis...
  58. doi request reprint Lynch syndrome-associated neoplasms: a discussion on histopathology and immunohistochemistry
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Fam Cancer 12:241-60. 2013
    ....
  59. pmc Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor MK8776
    Carl G Engelke
    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109 5637, USA
    Clin Cancer Res 19:4412-21. 2013
    ..To improve upon this regimen, we combined the selective Checkpoint kinase 1 (Chk1) inhibitor MK8776 with gemcitabine-based chemoradiation in preclinical pancreatic cancer models...
  60. ncbi request reprint BLM heterozygosity and the risk of colorectal cancer
    Stephen B Gruber
    Departments of Internal Medicine and Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA
    Science 297:2013. 2002
  61. ncbi request reprint Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer
    Craig D Logsdon
    Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 63:2649-57. 2003
    ..These data provide new insights into the molecular pathology of pancreatic cancer that may be useful for detection, diagnosis, and treatment...
  62. ncbi request reprint A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
    Chun Tao Wai
    Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Hepatology 38:518-26. 2003
    ..Application of this index may decrease the need for staging liver biopsy specimens among CHC patients...
  63. ncbi request reprint Acute liver failure due to amoxicillin and amoxicillin/clavulanate
    Robert J Fontana
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0362, USA
    Dig Dis Sci 50:1785-90. 2005
    ..Early transfer of patients with severe drug-induced hepatotoxicity (i.e., encephalopathy or coagulopathy) to a transplant center is recommended due to their poor likelihood of recovery...
  64. ncbi request reprint One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: a pilot study
    Mary Ann Huang
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Am J Gastroenterol 100:1072-81. 2005
    ..The aim of the article is to determine if dietary intervention is effective in improving histological features of steatohepatitis in patients with biopsy-proven NASH...
  65. ncbi request reprint Surgical resection following radiation therapy with concurrent gemcitabine in patients with previously unresectable adenocarcinoma of the pancreas
    John B Ammori
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Gastrointest Surg 7:766-72. 2003
    ..The use of Gem/RT in a neoadjuvant setting is currently being investigated in a multi-institutional phase II trial...
  66. doi request reprint Life-long learning and self-assessment
    Jeffrey L Myers
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 5054, USA
    Arch Pathol Lab Med 136:851-3. 2012
    ....
  67. ncbi request reprint Are ulcers a marker for invasive carcinoma in Barrett's esophagus? Data from a diagnostic variability study with clinical follow-up
    Elizabeth Montgomery
    Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Gastroenterol 97:27-31. 2002
    ..We correlated follow-up information from 138 patients with Barrett's esophagus and varying degrees of dysplasia with the presence of ulcers...
  68. ncbi request reprint Percutaneous radiofrequency thermal ablation of hepatocellular carcinoma: a safe and effective bridge to liver transplantation
    Robert J Fontana
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
    Liver Transpl 8:1165-74. 2002
    ....
  69. ncbi request reprint Expression of hexokinase II and Glut-1 in untreated human breast cancer
    Raya S Brown
    Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical Center, Ann Arbor, MI, USA
    Nucl Med Biol 29:443-53. 2002
    ..6).FDG uptake in breast cancer tissue appears to be associated with the extent of immunodetectable expression of Glut-1, but not that of HKII, and FDG uptake may differ between individual tumors depending on tumor stage and histology...
  70. ncbi request reprint Colorectal polyps in carriers of the APC I1307K polymorphism
    Gad Rennert
    Department of Community Medicine and Epidemiology, CHS National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
    Dis Colon Rectum 48:2317-21. 2005
    ..The prevalence of polyps and adenomas in specimens of colorectal cancer who are carriers and noncarriers of the APC I1307K polymorphism is compared...
  71. ncbi request reprint Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours
    Tzafra Cohen
    Department of Pathology, Carmel Medical Center and Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel
    J Pathol 198:77-82. 2002
    ..In conclusion, the vast majority of EPTs examined expressed NP-2, suggesting its utility as a diagnostic marker for these tumours. The function of NP-2 in islet cell biology or tumourigenesis remains to be elucidated...
  72. ncbi request reprint The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer
    Steven M Lipkin
    Division of Oncology, Department of Medicine, University of California, Irvine, Irvine, California 92697, USA
    Nat Genet 36:694-9. 2004
    ..These studies suggest that variants of mismatch repair proteins with attenuated function may account for a higher proportion of susceptibility to sporadic microsatellite-stable CRC than previously assumed...
  73. ncbi request reprint Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor, ADMR
    Vijaya Ramachandran
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:2666-75. 2007
    ..These data indicate that adrenomedullin acting via ADMR increases the aggressiveness of pancreatic cancer cells and suggests that these molecules may be useful therapeutic targets...
  74. ncbi request reprint Analysis of protein expression and gene mutation of c-kit in colorectal neuroendocrine carcinomas
    Olaronke Akintola-Ogunremi
    Lauren V Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Surg Pathol 27:1551-8. 2003
    ..More importantly, our observations may have potential therapeutic implications since specific tyrosine kinase inhibitors have shown promise in the management of patients with kit-expressing malignancies...
  75. ncbi request reprint The association of body mass index and pancreatic cancer in residents of southeastern Michigan, 1996-1999
    Jon P Fryzek
    International Epidemiology Institute, Rockville, MD 20850, USA
    Am J Epidemiol 162:222-8. 2005
    ..In addition, body mass index may play a role in the etiology of pancreatic cancer even in the absence of diabetes...
  76. ncbi request reprint Statins and the risk of colorectal cancer
    Jenny N Poynter
    Department of Epidemiology, University of Michigan, Ann Arbor 48109 0638, USA
    N Engl J Med 352:2184-92. 2005
    ..Statins inhibit the growth of colon-cancer cell lines, and secondary analyses of some, but not all, clinical trials suggest that they reduce the risk of colorectal cancer...