Thomas C Greenough
Affiliation: University of Massachusetts Medical School
- Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usageThomas C Greenough
Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS ONE 5:e12926. 2010..To better understand the role of PD-1 in antiviral immunity we examined the expression of PD-1 on Epstein-Barr virus (EBV) epitope-specific CD8+ T cells during acute infectious mononucleosis (AIM) and convalescence...
- Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapyThomas C Greenough
Pediatrics and Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Vaccine 26:6883-93. 2008..Plasma HIV-1-specific antibody levels and neutralizing activity were unchanged following vaccination. Poxvirus-based vaccines may merit further study in therapeutic vaccine protocols...
- Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirusThomas C Greenough
Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
Am J Pathol 167:455-63. 2005..These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis...
- Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in miceThomas C Greenough
Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 02130, USA
J Infect Dis 191:507-14. 2005..Antibodies to both epitopes protected mice against SARS-CoV challenge. Clinical trials are planned to test MAb 201, a fully human MAb specific for the epitope within the receptor-binding region...
- Enhanced culture method for detection of replication-competent virus in peripheral blood mononuclear cells of HIV type 1-infected individualsJohn P Haran
Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605
AIDS Res Hum Retroviruses 18:577-83. 2002..This will be a useful technique by which to study viral latency and HIV-1 pathogenesis in adult and pediatric populations...
- Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2Michael J Moore
Partners AIDS Research Center, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, MA, USA
J Virol 78:10628-35. 2004..These results permit studies of SARS-CoV entry inhibitors without the use of live virus and suggest a candidate therapy for SARS...
- Nuclear localization of HIV type 1 Vif isolated from a long-term asymptomatic individual and potential role in virus attenuationMelissa A Farrow
Program in Molecular Medicine and Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
AIDS Res Hum Retroviruses 21:565-74. 2005..Our data highlight the importance of Vif in HIV-1 pathogenesis and also provide a unique tool to investigate the interaction of Vif and Apobec3G...
- Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamstersAnjeanette Roberts
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 193:685-92. 2006....
- Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2Wenhui Li
Partners AIDS Research Center, 65 Landsdowne St, Cambridge, MA 02139, USA
J Virol 78:11429-33. 2004..These data imply that a mouse transgenically expressing human ACE2 may be a useful animal model of SARS...
- Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirusWenhui Li
Partners AIDS Research Center, Brigham and Women s Hospital, Department of Medicine Microbiology and Molecular Genetics, Boston, Massachusetts 02115, USA
Nature 426:450-4. 2003..Finally, anti-ACE2 but not anti-ACE1 antibody blocked viral replication on Vero E6 cells. Together our data indicate that ACE2 is a functional receptor for SARS-CoV...
- HIV 1 Gene Polymorphisms Associated with Non ProgressionThomas Greenough; Fiscal Year: 2002....