Thomas C Greenough

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usage
    Thomas C Greenough
    Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 5:e12926. 2010
  2. ncbi Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy
    Thomas C Greenough
    Pediatrics and Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Vaccine 26:6883-93. 2008
  3. ncbi Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus
    Thomas C Greenough
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Am J Pathol 167:455-63. 2005
  4. ncbi Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice
    Thomas C Greenough
    Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 02130, USA
    J Infect Dis 191:507-14. 2005
  5. ncbi Enhanced culture method for detection of replication-competent virus in peripheral blood mononuclear cells of HIV type 1-infected individuals
    John P Haran
    Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605
    AIDS Res Hum Retroviruses 18:577-83. 2002
  6. ncbi Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2
    Michael J Moore
    Partners AIDS Research Center, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, MA, USA
    J Virol 78:10628-35. 2004
  7. ncbi Nuclear localization of HIV type 1 Vif isolated from a long-term asymptomatic individual and potential role in virus attenuation
    Melissa A Farrow
    Program in Molecular Medicine and Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    AIDS Res Hum Retroviruses 21:565-74. 2005
  8. ncbi Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters
    Anjeanette Roberts
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 193:685-92. 2006
  9. ncbi Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2
    Wenhui Li
    Partners AIDS Research Center, 65 Landsdowne St, Cambridge, MA 02139, USA
    J Virol 78:11429-33. 2004
  10. ncbi Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
    Wenhui Li
    Partners AIDS Research Center, Brigham and Women s Hospital, Department of Medicine Microbiology and Molecular Genetics, Boston, Massachusetts 02115, USA
    Nature 426:450-4. 2003

Research Grants

  1. HIV 1 Gene Polymorphisms Associated with Non Progression
    Thomas Greenough; Fiscal Year: 2002

Collaborators

Detail Information

Publications10

  1. ncbi Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usage
    Thomas C Greenough
    Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 5:e12926. 2010
    ..To better understand the role of PD-1 in antiviral immunity we examined the expression of PD-1 on Epstein-Barr virus (EBV) epitope-specific CD8+ T cells during acute infectious mononucleosis (AIM) and convalescence...
  2. ncbi Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy
    Thomas C Greenough
    Pediatrics and Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Vaccine 26:6883-93. 2008
    ..Plasma HIV-1-specific antibody levels and neutralizing activity were unchanged following vaccination. Poxvirus-based vaccines may merit further study in therapeutic vaccine protocols...
  3. ncbi Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus
    Thomas C Greenough
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Am J Pathol 167:455-63. 2005
    ..These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis...
  4. ncbi Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice
    Thomas C Greenough
    Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 02130, USA
    J Infect Dis 191:507-14. 2005
    ..Antibodies to both epitopes protected mice against SARS-CoV challenge. Clinical trials are planned to test MAb 201, a fully human MAb specific for the epitope within the receptor-binding region...
  5. ncbi Enhanced culture method for detection of replication-competent virus in peripheral blood mononuclear cells of HIV type 1-infected individuals
    John P Haran
    Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605
    AIDS Res Hum Retroviruses 18:577-83. 2002
    ..This will be a useful technique by which to study viral latency and HIV-1 pathogenesis in adult and pediatric populations...
  6. ncbi Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2
    Michael J Moore
    Partners AIDS Research Center, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, MA, USA
    J Virol 78:10628-35. 2004
    ..These results permit studies of SARS-CoV entry inhibitors without the use of live virus and suggest a candidate therapy for SARS...
  7. ncbi Nuclear localization of HIV type 1 Vif isolated from a long-term asymptomatic individual and potential role in virus attenuation
    Melissa A Farrow
    Program in Molecular Medicine and Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    AIDS Res Hum Retroviruses 21:565-74. 2005
    ..Our data highlight the importance of Vif in HIV-1 pathogenesis and also provide a unique tool to investigate the interaction of Vif and Apobec3G...
  8. ncbi Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters
    Anjeanette Roberts
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 193:685-92. 2006
    ....
  9. ncbi Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2
    Wenhui Li
    Partners AIDS Research Center, 65 Landsdowne St, Cambridge, MA 02139, USA
    J Virol 78:11429-33. 2004
    ..These data imply that a mouse transgenically expressing human ACE2 may be a useful animal model of SARS...
  10. ncbi Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
    Wenhui Li
    Partners AIDS Research Center, Brigham and Women s Hospital, Department of Medicine Microbiology and Molecular Genetics, Boston, Massachusetts 02115, USA
    Nature 426:450-4. 2003
    ..Finally, anti-ACE2 but not anti-ACE1 antibody blocked viral replication on Vero E6 cells. Together our data indicate that ACE2 is a functional receptor for SARS-CoV...

Research Grants1

  1. HIV 1 Gene Polymorphisms Associated with Non Progression
    Thomas Greenough; Fiscal Year: 2002
    ....