Warner Greene

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Endogenous factors enhance HIV infection of tissue naive CD4 T cells by stimulating high molecular mass APOBEC3G complex formation
    Jason F Kreisberg
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA
    J Exp Med 203:865-70. 2006
  2. pmc The achilles heel of the trojan horse model of HIV-1 trans-infection
    Marielle Cavrois
    Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America
    PLoS Pathog 4:e1000051. 2008
  3. pmc Calcium/calcineurin synergizes with prostratin to promote NF-κB dependent activation of latent HIV
    Jonathan K Chan
    Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America
    PLoS ONE 8:e77749. 2013
  4. pmc A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirs
    Kara G Lassen
    Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America
    PLoS ONE 7:e30176. 2012
  5. pmc Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI
    Kyeong Ae Kim
    Institute of Molecular Virology, University Hospital Ulm, 89081 Ulm, Germany
    Retrovirology 7:55. 2010
  6. pmc Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression
    Christine Goffinet
    Department of Virology, University of Heidelberg, Heidelberg, Germany
    Retrovirology 4:53. 2007
  7. pmc Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo
    Nico Michel
    Department of Virology, University of Heidelberg, 69120 Heidelberg, Germany
    Retrovirology 6:2. 2009
  8. ncbi request reprint A history of AIDS: looking back to see ahead
    Warner C Greene
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
    Eur J Immunol 37:S94-102. 2007
  9. ncbi request reprint The brightening future of HIV therapeutics
    Warner C Greene
    Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, California 94141 9100, USA
    Nat Immunol 5:867-71. 2004
  10. ncbi request reprint Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy
    Warner C Greene
    Gladstone Institute of Virology and Immunology, Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    Nat Med 8:673-80. 2002

Research Grants

  1. Microglia and the Neuropathogenesis of HIV Disease
    Warner Greene; Fiscal Year: 2005
  2. Exploring How HTLV-1 Tax Induces T Cell Leukemia
    Warner Greene; Fiscal Year: 2004
  3. ANALYSIS OF THE ROLE OF VPR IN HIV PATHOGENESIS
    Warner Greene; Fiscal Year: 2004
  4. Exploring How HTLV-1 Tax Induces T Cell Leukemia
    Warner Greene; Fiscal Year: 2005
  5. Microglia and the Neuropathogenesis of HIV Disease
    Warner Greene; Fiscal Year: 2004
  6. Exploring How HTLV-1 Tax Induces T Cell Leukemia
    Warner Greene; Fiscal Year: 2003
  7. Signal Transduction by Cytokine Receptors in Vivo
    Warner Greene; Fiscal Year: 2003
  8. ANALYSIS OF THE ROLE OF VPR IN HIV PATHOGENESIS
    Warner Greene; Fiscal Year: 2003
  9. Regulation and Action of APOBEC3G
    Warner Greene; Fiscal Year: 2005
  10. Exploring How HTLV-1 Tax Induces T Cell Leukemia
    Warner Greene; Fiscal Year: 2002

Detail Information

Publications66

  1. pmc Endogenous factors enhance HIV infection of tissue naive CD4 T cells by stimulating high molecular mass APOBEC3G complex formation
    Jason F Kreisberg
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA
    J Exp Med 203:865-70. 2006
    ....
  2. pmc The achilles heel of the trojan horse model of HIV-1 trans-infection
    Marielle Cavrois
    Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America
    PLoS Pathog 4:e1000051. 2008
    ..This review traces the experimental lines of evidence that have contributed to what we view as the "rise and decline" of the Trojan horse model of HIV-1 trans-infection...
  3. pmc Calcium/calcineurin synergizes with prostratin to promote NF-κB dependent activation of latent HIV
    Jonathan K Chan
    Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America
    PLoS ONE 8:e77749. 2013
    ..Innovative approaches exploiting the synergistic actions of calcineurin and prostratin in the absence of generalized T-cell activation merit exploration as a means to attack the latent viral reservoir. ..
  4. pmc A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirs
    Kara G Lassen
    Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America
    PLoS ONE 7:e30176. 2012
    ..These findings reveal potentially important biological differences within the latently infected pool of memory CD4 T cells and describe a flexible primary CD4 T-cell system to evaluate novel antagonists of HIV latency...
  5. pmc Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI
    Kyeong Ae Kim
    Institute of Molecular Virology, University Hospital Ulm, 89081 Ulm, Germany
    Retrovirology 7:55. 2010
    ..Despite its importance for the global spread of HIV-1, however, the effect of semen on virus infection is controversial...
  6. pmc Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression
    Christine Goffinet
    Department of Virology, University of Heidelberg, Heidelberg, Germany
    Retrovirology 4:53. 2007
    ....
  7. pmc Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo
    Nico Michel
    Department of Virology, University of Heidelberg, 69120 Heidelberg, Germany
    Retrovirology 6:2. 2009
    ..Rat primary CD4 T-cells, but not macrophages, display a profound transcriptional deficit that is ameliorated by transient trans-complementation with the human Tat-interacting protein Cyclin T1 (hCycT1)...
  8. ncbi request reprint A history of AIDS: looking back to see ahead
    Warner C Greene
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
    Eur J Immunol 37:S94-102. 2007
    ..With these sobering statistics as a backdrop, this feature traces the history of the devastating HIV/AIDS pandemic and offers a view for what the future may hold...
  9. ncbi request reprint The brightening future of HIV therapeutics
    Warner C Greene
    Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, California 94141 9100, USA
    Nat Immunol 5:867-71. 2004
  10. ncbi request reprint Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy
    Warner C Greene
    Gladstone Institute of Virology and Immunology, Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    Nat Med 8:673-80. 2002
    ..Understanding the dynamic interplay of host cell and virus is essential to the effort to eradicate HIV...
  11. ncbi request reprint Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells
    Ya Lin Chiu
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94143, USA
    Nature 435:108-14. 2005
    ..the reverse transcripts slowly formed in unstimulated CD4+ T cells reveals only low levels of dG dA hypermutation, raising the possibility that the APOBEC3G-restricting activity may not be strictly dependent on deoxycytidine deamination..
  12. pmc NF-kappaB RelA phosphorylation regulates RelA acetylation
    Lin Feng Chen
    Gladstone Institute of Virology and Immunology, 1650 Owens St, San Francisco, CA 94158, USA
    Mol Cell Biol 25:7966-75. 2005
    ..These findings indicate that the acetylation of RelA at lysine 310 is importantly regulated by prior phosphorylation of serines 276 and 536. Such phosphorylated and acetylated forms of RelA display enhanced transcriptional activity...
  13. ncbi request reprint A seminal finding for understanding HIV transmission
    Nadia R Roan
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
    Cell 131:1044-6. 2007
    ..As a potential explanation for this discrepancy, Münch et al. (2007) now identify and characterize a factor found in human semen that under certain conditions can enhance HIV infectivity by more than 100,000-fold...
  14. pmc Newly synthesized APOBEC3G is incorporated into HIV virions, inhibited by HIV RNA, and subsequently activated by RNase H
    Vanessa B Soros
    Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America
    PLoS Pathog 3:e15. 2007
    ..These findings highlight an unexpected interplay between host and virus where initiation of antiviral enzymatic activity is dependent on the action of an essential viral enzyme...
  15. ncbi request reprint Slipping through the door: HIV entry into the nucleus
    Michael P Sherman
    Gladstone Institute of Virology and Immunology, P O Box 419100, San Francisco, CA 94141 9100, USA
    Microbes Infect 4:67-73. 2002
    ..We discuss recent studies that have advanced our understanding of this key step in the HIV life cycle...
  16. ncbi request reprint HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability
    Kim Stopak
    Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Cell 12:591-601. 2003
    ....
  17. doi request reprint The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements
    Ya Lin Chiu
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    Annu Rev Immunol 26:317-53. 2008
    ....
  18. pmc Measuring HIV fusion mediated by envelopes from primary viral isolates
    Marielle Cavrois
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Methods 53:34-8. 2011
    ..Here, we describe a relatively simple strategy to clone primary envelopes into a provirus and increase the sensitivity of the virion-based fusion assay...
  19. pmc HIV is inactivated after transepithelial migration via adult oral epithelial cells but not fetal epithelial cells
    Sharof M Tugizov
    Department of Medicine, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0512, USA
    Virology 409:211-22. 2011
    ..Inactivation of innate proteins in adult oral keratinocytes restored HIV infectivity. These data suggest that high-level innate protein expression may contribute to the resistance of the adult oral epithelium to HIV transmission...
  20. ncbi request reprint p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1
    Jan Bohuslav
    Gladstone Institute of Virology and Immunology and the Department of Medicine, University of California, San Francisco, California 94143 1234, USA
    J Biol Chem 279:26115-25. 2004
    ..These findings highlight a rather unusual pathway of NF-kappaB activation, which is utilized by the p53 tumor suppressor...
  21. pmc Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection)
    Nadia R Roan
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94158, USA
    J Biol Chem 285:1861-9. 2010
    ..Because SEVI can increase HIV infectivity by several orders of magnitude, supplementing current HIV microbicide candidates with SEVI inhibitors, such as surfen, might greatly increase their potency...
  22. pmc NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation
    Samuel A Williams
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
    EMBO J 25:139-49. 2006
    ..The combination of HDAC inhibitors and Tat merits consideration as a new strategy for purging latent HIV proviruses from their cellular reservoirs...
  23. ncbi request reprint APOBEC3 cytidine deaminases: distinct antiviral actions along the retroviral life cycle
    Ya Lin Chiu
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141, USA
    J Biol Chem 281:8309-12. 2006
    ..Although scientifically fascinating, advances in APOBEC3 biology may lead to new antiviral drugs and improved lentiviral vectors for gene therapy...
  24. ncbi request reprint Shaping the nuclear action of NF-kappaB
    Lin Feng Chen
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141, USA
    Nat Rev Mol Cell Biol 5:392-401. 2004
  25. ncbi request reprint Multifaceted antiviral actions of APOBEC3 cytidine deaminases
    Ya Lin Chiu
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141 9100, USA
    Trends Immunol 27:291-7. 2006
    ....
  26. pmc High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition
    Ya Lin Chiu
    Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 103:15588-93. 2006
    ....
  27. ncbi request reprint Distinct patterns of cytokine regulation of APOBEC3G expression and activity in primary lymphocytes, macrophages, and dendritic cells
    Kim S Stopak
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94158, USA
    J Biol Chem 282:3539-46. 2007
    ..Together, these results highlight the distinct inductive effects of select cytokines on A3G gene expression and A3G complex assembly that occur in natural cellular targets of HIV infection...
  28. pmc APOBEC3G: an intracellular centurion
    Ya Lin Chiu
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Philos Trans R Soc Lond B Biol Sci 364:689-703. 2009
    ..LMM A3G opposes the external threat posed by exogenous retroviruses, while HMM A3G complexes oppose the internal threat posed by the retrotransposition of select types of retroelements...
  29. pmc The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection
    Nadia R Roan
    Gladstone Institute of Virology and Immunology, University of California, P O Box 419100, San Francisco, CA 94141 9100, USA
    J Virol 83:73-80. 2009
    ..Combinations of agents that neutrale SEVI action and produce HIV virucidal effects are an attractive future direction for microbicide development...
  30. doi request reprint Novel targets for HIV therapy
    Warner C Greene
    Gladstone Institute of Virology and Immunology, San Francisco, CA, USA
    Antiviral Res 80:251-65. 2008
    ....
  31. ncbi request reprint Assessing acetylation of NF-kappaB
    Lin Feng Chen
    Gladstone Institute of Virology and Immunology, University of California, San Francisco 94158, USA
    Methods 36:368-75. 2005
    ..Anti-RelA antibodies that selectively react with site-specific acetylated forms of RelA are a singularly powerful tool for the study of NF-kappaB acetylation both in vivo and in vitro...
  32. ncbi request reprint Prostratin antagonizes HIV latency by activating NF-kappaB
    Samuel A Williams
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, California 94141, USA
    J Biol Chem 279:42008-17. 2004
    ..These findings provide new insights into the molecular pathway through which prostratin antagonizes HIV latency highlighting a central role for the action of NF-kappaB...
  33. ncbi request reprint Protecting APOBEC3G: a potential new target for HIV drug discovery
    Kimberly Stopak
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 9418, USA
    Curr Opin Investig Drugs 6:141-7. 2005
    ..The potent activity of APOBEC3G has led to considerable interest in the identification of small molecules that interrupt the Vif-induced degradative process...
  34. pmc Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB
    Lin Feng Chen
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
    EMBO J 21:6539-48. 2002
    ..Together, these findings highlight how site-specific acetylation of RelA differentially regulates distinct biological activities of the NF-kappaB transcription factor complex...
  35. ncbi request reprint Regulation of NF-kappaB action by reversible acetylation
    Warner C Greene
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94141, USA
    Novartis Found Symp 259:208-17; discussion 218-25. 2004
    ....
  36. ncbi request reprint Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement
    David Fenard
    Gladstone Institute of Virology and Immunology, University of California, 94158, USA
    J Immunol 175:6050-7. 2005
    ..g., activated p21-activated kinase-2) into the immunological synapse may underlie the increased frequency of cells expressing transcriptionally active forms of NF-kappaB and NFAT and the resultant changes in T cell activation...
  37. pmc Human immunodeficiency virus fusion to dendritic cells declines as cells mature
    Marielle Cavrois
    Gladstone Institute of Virology and Immunology, 1650 Owens St, San Francisco, CA 94158, USA
    J Virol 80:1992-9. 2006
    ..In conclusion, our results demonstrate that the defect in HIV replication observed in mature MDDCs stems at least in part from a decline in viral fusion...
  38. pmc Regulation of HIV-1 latency by T-cell activation
    Samuel A Williams
    Gladstone Institute of Virology and Immunology, University of California, 1650 Owens Street, San Francisco, CA 94158, USA
    Cytokine 39:63-74. 2007
    ....
  39. ncbi request reprint Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation
    Lin Feng Chen
    Gladstone Institute of Virology and Immunology, University of California, P O Box 419100, San Francisco, CA 94141 9100, USA
    J Mol Med (Berl) 81:549-57. 2003
    ..This readies the cell for the next NF-kappaB-inducing stimulus. Thus, reversible acetylation of RelA serves as an important intranuclear regulatory mechanism that further provides for dynamic control of NF-kappaB action...
  40. pmc Compensatory link between fusion and endocytosis of human immunodeficiency virus type 1 in human CD4 T lymphocytes
    Evelyne Schaeffer
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141, USA
    J Virol 78:1375-83. 2004
    ..In summary, our results reveal an unexpected, CD4-mediated reciprocal relationship between the pathways governing HIV virion fusion and endocytosis...
  41. pmc Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation
    Hye Sook Kwon
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
    Cell Host Microbe 3:158-67. 2008
    ..These events likely contribute to the state of immune cell hyperactivation found in HIV-infected individuals...
  42. ncbi request reprint Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65
    ALISON M O'MAHONY
    Gladstone Institute for Virology and Immunology, Department of Medicine, University of California, San Francisco, California 94141, USA
    J Biol Chem 279:18137-45. 2004
    ..IKK2 plays a dominant role in signaling for IkappaBalpha degradation, whereas IKK1 appears to play an important role in enhancing the transcriptional activity of NF-kappaB by promoting RelA/p65 phosphorylation...
  43. pmc Sustained induction of NF-kappa B is required for efficient expression of latent human immunodeficiency virus type 1
    Samuel A Williams
    Gladstone Institute of Virology and Immunology, University of California San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
    J Virol 81:6043-56. 2007
    ..Conversely, the action of this phosphatase is overcome in the presence of Tat, promoting very efficient RNA Pol II elongation...
  44. pmc Nuclear export of Vpr is required for efficient replication of human immunodeficiency virus type 1 in tissue macrophages
    Michael P Sherman
    Gladstone Institute of Virology and Immunology, San Francisco, California 94141, USA
    J Virol 77:7582-9. 2003
    ....
  45. pmc In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions
    Marielle Cavrois
    Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 3:e4. 2007
    ..Our findings suggest that attachment inhibitors could neutralize trans-infection of T cells by DCs in vivo...
  46. ncbi request reprint HIV-1 virion fusion assay: uncoating not required and no effect of Nef on fusion
    Marielle Cavrois
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141 9100, United States
    Virology 328:36-44. 2004
    ....
  47. pmc Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis
    Cheryl A Stoddart
    Gladstone Institute of Virology and Immunology Departments of Medicine Microbiology and Immunology, University of California, San Francisco, California 94141, USA
    J Virol 77:2124-33. 2003
    ..Nef-mediated CD4 downregulation merits consideration as a new target for the development of small-molecule inhibitors...
  48. ncbi request reprint Host factors regulating post-integration latency of HIV
    Samuel A F Williams
    Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, CA 94158, USA
    Trends Microbiol 13:137-9. 2005
    ..Understanding the molecular basis for viral latency is the key first step...
  49. pmc Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue
    Gilad Doitsh
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Cell 143:789-801. 2010
    ..While this response likely evolved to protect the host, it centrally contributes to the immunopathogenic effects of HIV...
  50. ncbi request reprint Insights into the biology of HIV-1 viral protein R
    Michael P Sherman
    Gladstone Institute of Virology and Immunology and Department of Medicine, University of California, San Francisco, California 94141 9100, USA
    DNA Cell Biol 21:679-88. 2002
    ..We review the biologic properties of Vpr, focusing on its mechanism of action, role in HIV replication, and significance for host pathogenesis...
  51. ncbi request reprint HIV-1 Vpr displays natural protein-transducing properties: implications for viral pathogenesis
    Michael P Sherman
    Gladstone Institute of Virology and Immunology, San Fransisco, California 94141, USA
    Virology 302:95-105. 2002
    ..Native Vpr may thus be optimized for protein transduction, a feature that might enhance and extend the pathological effects of HIV infection...
  52. pmc Identification of two APOBEC3F splice variants displaying HIV-1 antiviral activity and contrasting sensitivity to Vif
    Kara G Lassen
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    J Biol Chem 285:29326-35. 2010
    ..Thus, alternative splicing of A3F mRNA generates truncated antiviral proteins that differ sharply in their sensitivity to Vif...
  53. pmc Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection
    Mario L Santiago
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Science 321:1343-6. 2008
    ..The link between Apobec3 and neutralizing antibody responses highlights an Apobec3-dependent mechanism of host protection that might extend to HIV and other human retroviral infections...
  54. ncbi request reprint Fluorescence resonance energy transfer-based HIV-1 virion fusion assay
    Marielle Cavrois
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, USA
    Methods Mol Biol 263:333-44. 2004
    ..Finally, the assay can also be adapted to study fusion mediated by the envelope proteins from other viruses through the construction of HIV-1 pseudotypes...
  55. ncbi request reprint Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax
    Hakju Kwon
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    J Biol Chem 280:35713-22. 2005
    ..Of note, this skin disease completely resolved when Tax transgene expression was suppressed by administration of doxycycline, emphasizing the key role played by this viral oncoprotein in the observed pathology...
  56. ncbi request reprint A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes
    Marielle Cavrois
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141 9100, USA
    Nat Biotechnol 20:1151-4. 2002
    ..BlaM cleaves the beta-lactam ring in CCF2, changing its fluorescence emission spectrum from green (520 nm) to blue (447 nm) and thereby allowing fusion to be detected by fluorescence microscopy, flow cytometry, or UV photometry...
  57. pmc Studies of ebola virus glycoprotein-mediated entry and fusion by using pseudotyped human immunodeficiency virus type 1 virions: involvement of cytoskeletal proteins and enhancement by tumor necrosis factor alpha
    Akihito Yonezawa
    Gladstone Institute of Virology and Immunology, 1650 Owens St, San Francisco, CA 94158, USA
    J Virol 79:918-26. 2005
    ..Finally, these studies indicate that pseudotyping in the HIV-1 virion-based fusion assay may be a valuable approach to the study of entry and fusion properties mediated through the envelopes of other viral pathogens...
  58. doi request reprint HIV vaccine research: the way forward
    Anthony S Fauci
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA
    Science 321:530-2. 2008
    ..This article summarizes progress and challenges in HIV vaccine research, the priorities arising from a recent summit at NIAID, and the actions needed, some already under way, to address those priorities...
  59. ncbi request reprint A plea for justice for jailed medical workers
    Sunil K Ahuja
    Science 314:924-5. 2006
  60. ncbi request reprint Redistricting the retroviral restriction factors
    Warner C Greene
    Nat Med 10:778-80. 2004
  61. ncbi request reprint The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo
    Philip J Ellery
    AIDS Pathogenesis and Clinical Research Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    J Immunol 178:6581-9. 2007
    ..Collectively, these data show that CD16+ monocytes are preferentially susceptible to HIV-1 entry, more permissive for replication, and constitute a continuing source of viral persistence during HAART...
  62. ncbi request reprint How resting T cells deMURR HIV infection
    Warner C Greene
    Nat Immunol 5:18-9. 2004
  63. pmc Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo
    Erik S Zimmerman
    Division of Cellular Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Virol 80:10407-18. 2006
    ..We report that infected cells in vivo display an aberrant cell cycle profile whereby a majority of cells have a 4N DNA content, consistent with the onset of G2 arrest...
  64. pmc Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef
    Oliver T Keppler
    Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    J Virol 79:1655-65. 2005
    ....
  65. ncbi request reprint Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-kappaB- and AP-1-mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin
    Bysani Chandrasekar
    Department of Veterans Affairs South Texas Veterans Health Care System, San Antonio, Texas 78229 4404, USA
    J Biol Chem 281:15099-109. 2006
    ..Atorvastatin inhibits IL-18-mediated aortic SMC migration and has therapeutic potential for attenuating the progression of atherosclerosis and restenosis...
  66. ncbi request reprint Cyclophilin A interacts with HIV-1 Vpr and is required for its functional expression
    Kerstin Zander
    Heinrich Pette Institute of Experimental Virology and Immunology, University of Hamburg, D 20251 Hamburg, Germany
    J Biol Chem 278:43202-13. 2003
    ....

Research Grants24

  1. Microglia and the Neuropathogenesis of HIV Disease
    Warner Greene; Fiscal Year: 2005
    ..This work should both define the utility of this new experimental system for studying neuropathogenesis and provide new information about the pathologic events that may contribute to impairment of neurologic function in HIV disease. ..
  2. Exploring How HTLV-1 Tax Induces T Cell Leukemia
    Warner Greene; Fiscal Year: 2004
    ..Through these combined in vivo and in vitro experiments, we hope to gain key insights into the molecular events underlying HTLV-I Tax mediated leukemogenesis. ..
  3. ANALYSIS OF THE ROLE OF VPR IN HIV PATHOGENESIS
    Warner Greene; Fiscal Year: 2004
    ..abstract_text> ..
  4. Exploring How HTLV-1 Tax Induces T Cell Leukemia
    Warner Greene; Fiscal Year: 2005
    ..Through these combined in vivo and in vitro experiments, we hope to gain key insights into the molecular events underlying HTLV-I Tax mediated leukemogenesis. ..
  5. Microglia and the Neuropathogenesis of HIV Disease
    Warner Greene; Fiscal Year: 2004
    ..This work should both define the utility of this new experimental system for studying neuropathogenesis and provide new information about the pathologic events that may contribute to impairment of neurologic function in HIV disease. ..
  6. Exploring How HTLV-1 Tax Induces T Cell Leukemia
    Warner Greene; Fiscal Year: 2003
    ..Through these combined in vivo and in vitro experiments, we hope to gain key insights into the molecular events underlying HTLV-I Tax mediated leukemogenesis. ..
  7. Signal Transduction by Cytokine Receptors in Vivo
    Warner Greene; Fiscal Year: 2003
    ..The findings should also point to new, rational therapeutic avenues for reversing these conditions in some settings. ..
  8. ANALYSIS OF THE ROLE OF VPR IN HIV PATHOGENESIS
    Warner Greene; Fiscal Year: 2003
    ..abstract_text> ..
  9. Regulation and Action of APOBEC3G
    Warner Greene; Fiscal Year: 2005
    ..With such understanding, new therapeutic strategies for inhibiting HIV growth could emerge. ..
  10. Exploring How HTLV-1 Tax Induces T Cell Leukemia
    Warner Greene; Fiscal Year: 2002
    ..Through these combined in vivo and in vitro experiments, we hope to gain key insights into the molecular events underlying HTLV-I Tax mediated leukemogenesis. ..
  11. Exploring How HTLV-1 Tax Induces T Cell Leukemia
    Warner Greene; Fiscal Year: 2006
    ..Through these combined in vivo and in vitro experiments, we hope to gain key insights into the molecular events underlying HTLV-I Tax mediated leukemogenesis. ..
  12. Regulation and Action of APOBEC3G
    Warner Greene; Fiscal Year: 2007
    ..With such understanding, new therapeutic strategies for inhibiting HIV growth could emerge. ..
  13. Microglia and the Neuropathogenesis of HIV Disease
    Warner Greene; Fiscal Year: 2006
    ..This work should both define the utility of this new experimental system for studying neuropathogenesis and provide new information about the pathologic events that may contribute to impairment of neurologic function in HIV disease. ..
  14. Regulation and Action of APOBEC3G
    Warner Greene; Fiscal Year: 2006
    ..With such understanding, new therapeutic strategies for inhibiting HIV growth could emerge. ..
  15. Regulation and Action of APOBEC3G
    Warner Greene; Fiscal Year: 2009
    ..With such understanding, new therapeutic strategies for inhibiting HIV growth could emerge. ..
  16. Signal Transduction by Cytokine Receptors in Vivo
    Warner Greene; Fiscal Year: 2004
    ..The findings should also point to new, rational therapeutic avenues for reversing these conditions in some settings. ..
  17. Microglia and the Neuropathogenesis of HIV Disease
    Warner Greene; Fiscal Year: 2003
    ..This work should both define the utility of this new experimental system for studying neuropathogenesis and provide new information about the pathologic events that may contribute to impairment of neurologic function in HIV disease. ..
  18. HIV FITNESS, VIRULENCE AND EVOLUTION
    Warner Greene; Fiscal Year: 2003
    ....
  19. Signal Transduction by Cytokine Receptors in Vivo
    Warner Greene; Fiscal Year: 2002
    ..The findings should also point to new, rational therapeutic avenues for reversing these conditions in some settings. ..
  20. ANALYSIS OF THE ROLE OF VPR IN HIV PATHOGENESIS
    Warner Greene; Fiscal Year: 2002
    ..abstract_text> ..
  21. HIV FITNESS, VIRULENCE AND EVOLUTION
    Warner Greene; Fiscal Year: 2001
    ....
  22. ANALYSIS OF THE ROLE OF VPR IN HIV PATHOGENESIS
    Warner Greene; Fiscal Year: 2001
    ..abstract_text> ..
  23. ANALYSIS OF THE ROLE OF VPR IN HIV PATHOGENESIS
    Warner Greene; Fiscal Year: 2000
    ..abstract_text> ..