Robert Greene

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Identification of the heart as the critical site of adenosine mediated embryo protection
    Christopher C Wendler
    Department of Pediatrics, Section of Developmental Endocrinology and Biology, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT 06520 USA
    BMC Dev Biol 10:57. 2010
  2. pmc Adenosine: front and center in linking nutrition and metabolism to neuronal activity
    Robert W Greene
    Department of Psychiatry, University of Texas Southwestern Medical Center and Dallas VA Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 121:2548-50. 2011
  3. doi request reprint Slow wave activity during sleep: functional and therapeutic implications
    Robert W Greene
    Department of Psychiatry, UTSW Medical Center, Dallas VA, Dallas, Texas 75390, USA
    Neuroscientist 16:618-33. 2010
  4. ncbi request reprint Sleep: a functional enigma
    Robert Greene
    Department of Psychiatry, VAMC Dallas and UTSW, Dallas, TX, USA
    Neuromolecular Med 5:59-68. 2004
  5. pmc Essential role of brain-derived neurotrophic factor in adult hippocampal function
    Lisa M Monteggia
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 101:10827-32. 2004
  6. ncbi request reprint Adenosine mediation of presynaptic feedback inhibition of glutamate release
    Dario Brambilla
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 46:275-83. 2005
  7. pmc Control and function of the homeostatic sleep response by adenosine A1 receptors
    Theresa E Bjorness
    Department of Psychiatry, University of Texas Southwestern, Dallas, Texas 75390, USA
    J Neurosci 29:1267-76. 2009
  8. pmc Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C
    Bogachan Sahin
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, United States
    Eur J Pharmacol 581:270-5. 2008
  9. ncbi request reprint Hippocampus, V: studying hippocampal behaviors
    Robert W Greene
    Am J Psychiatry 162:856. 2005
  10. ncbi request reprint Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 23:5762-70. 2003

Research Grants

Collaborators

Detail Information

Publications18

  1. pmc Identification of the heart as the critical site of adenosine mediated embryo protection
    Christopher C Wendler
    Department of Pediatrics, Section of Developmental Endocrinology and Biology, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT 06520 USA
    BMC Dev Biol 10:57. 2010
    ....
  2. pmc Adenosine: front and center in linking nutrition and metabolism to neuronal activity
    Robert W Greene
    Department of Psychiatry, University of Texas Southwestern Medical Center and Dallas VA Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 121:2548-50. 2011
    ..The authors' work serves to emphasize the importance of controlling Adk expression, not only as the mechanism of action of the ketogenic diet, but also as a potential target of future therapies...
  3. doi request reprint Slow wave activity during sleep: functional and therapeutic implications
    Robert W Greene
    Department of Psychiatry, UTSW Medical Center, Dallas VA, Dallas, Texas 75390, USA
    Neuroscientist 16:618-33. 2010
    ..In this review, the authors discuss their current understanding of the neural mechanisms and possible functions of EEG SWA...
  4. ncbi request reprint Sleep: a functional enigma
    Robert Greene
    Department of Psychiatry, VAMC Dallas and UTSW, Dallas, TX, USA
    Neuromolecular Med 5:59-68. 2004
    ..Finally, evidence for a role of non-REM sleep in developmental central nervous system (CNS) plasticity, as well as learning and memory, is discussed...
  5. pmc Essential role of brain-derived neurotrophic factor in adult hippocampal function
    Lisa M Monteggia
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 101:10827-32. 2004
    ..These results establish roles for BDNF in the adult, and demonstrate the strength of this inducible knockout system in studying gene function in the adult brain...
  6. ncbi request reprint Adenosine mediation of presynaptic feedback inhibition of glutamate release
    Dario Brambilla
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 46:275-83. 2005
    ..The time course of the adenosine response to an increase in glutamate release is slow (tau > 10 min), consistent with the role of adenosine as a fatigue factor that inhibits the activity of cholinergic arousal centers to reduce arousal...
  7. pmc Control and function of the homeostatic sleep response by adenosine A1 receptors
    Theresa E Bjorness
    Department of Psychiatry, University of Texas Southwestern, Dallas, Texas 75390, USA
    J Neurosci 29:1267-76. 2009
    ..Thus, AdoA(1)R activation is needed for normal rebound SWA, and when the SWA rebound is reduced, there is a failure to maintain working memory function, suggesting a functional role for SWA homeostasis...
  8. pmc Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C
    Bogachan Sahin
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, United States
    Eur J Pharmacol 581:270-5. 2008
    ..These results suggest that PKC exerts its effects on the phosphorylation state of Cdk5 substrates through an indirect mechanism that may involve the regulatory binding partners of Cdk5 other than its neuronal cofactors...
  9. ncbi request reprint Hippocampus, V: studying hippocampal behaviors
    Robert W Greene
    Am J Psychiatry 162:856. 2005
  10. ncbi request reprint Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 23:5762-70. 2003
    ..This transduction knock-out technique holds enormous potential for dissecting the functions of different CNS pathways...
  11. ncbi request reprint High frequency EEG activity during sleep: characteristics in schizophrenia and depression
    Janet L Tekell
    VA Ann Arbor Healthcare System 116A, University of Michigan, 2215 Fuller Road, Ann Arbor, MI 48105, USA
    Clin EEG Neurosci 36:25-35. 2005
    ..It is not clear how HFA would change in relation to clinical improvement, and further study is needed to clarify the association of HFA to the state/trait characteristics of SZ and MDD...
  12. pmc Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signaling
    Bogachan Sahin
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Brain Res 1129:1-14. 2007
    ..Finally, the phosphorylation state of these proteins was further assessed in vivo by systemic administration of caffeine...
  13. ncbi request reprint Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus
    Richard Bergeron
    Ottawa Health Research Institute, Department of Psychiatry, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Neurochem 100:346-57. 2007
    ..All together, these results suggest that NAAG acts as an endogenous modulator of NMDARs in the CA1 area of the hippocampus...
  14. ncbi request reprint Zaprinast stimulates extracellular adenosine accumulation in rat pontine slices
    Minou Le
    Department of Neurology and Program in Neuroscience, Enders Research Building, Room 349, Children s Hospital and Harvard Medical School, Longwood Avenue, Boston, MA 02115, USA
    Neurosci Lett 371:12-7. 2004
    ....
  15. doi request reprint Transient 23-30 Hz oscillations in mouse hippocampus during exploration of novel environments
    Joshua D Berke
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48104, USA
    Hippocampus 18:519-29. 2008
    ..These findings suggest that beta2 oscillations indicate a hippocampal dynamic state that facilitates the formation of unique contextual representations...
  16. ncbi request reprint NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neurons
    Richard Bergeron
    Ottawa Health Research Institute, Ottawa, ON, Canada
    Neuropsychopharmacology 30:7-16. 2005
    ..Moreover, in dissociated pyramidal neurons of the CA1 region, NAAG also reduced the NMDA current and this effect was reversed by glycine. These results suggest that NAAG reduces the NMDA currents in hippocampal CA1 pyramidal neurons...
  17. ncbi request reprint Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation
    Bogachan Sahin
    The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Eur J Biochem 271:3547-55. 2004
    ..Further analysis revealed, however, that this PKC-dependent phosphorylation occurred at one or more serine residues associated with the N-terminal affinity tag used for protein purification...
  18. ncbi request reprint Adenosine induces inositol 1,4,5-trisphosphate receptor-mediated mobilization of intracellular calcium stores in basal forebrain cholinergic neurons
    Radhika Basheer
    Department of Psychiatry, Harvard Medical School, Veterans Affairs Medical Center, West Roxbury, Massachusetts 02132, USA
    J Neurosci 22:7680-6. 2002
    ..These data suggest a potential role for a calcium-signaling pathway in adenosine-induced long-term effects of sleep deprivation and a key role for cholinergic neurons in this process...

Research Grants9

  1. The Role of Adenosine in Wake/Sleep Transition
    Robert Greene; Fiscal Year: 2007
    ..This may provide the requisite target cellular mechanism(s) for NMDA receptors and other potential modulators of extracellular AD. ..
  2. Dopamine Modulation of NMDA Receptor Synaptic Responses
    Robert W Greene; Fiscal Year: 2010
    ....
  3. Dopamine Modulation of NMDA Receptor Synaptic Responses
    Robert W Greene; Fiscal Year: 2011
    ....