Affiliation: University of Texas Southwestern Medical Center
- Identification of the heart as the critical site of adenosine mediated embryo protectionChristopher C Wendler
Department of Pediatrics, Section of Developmental Endocrinology and Biology, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT 06520 USA
BMC Dev Biol 10:57. 2010....
- Adenosine: front and center in linking nutrition and metabolism to neuronal activityRobert W Greene
Department of Psychiatry, University of Texas Southwestern Medical Center and Dallas VA Medical Center, Dallas, Texas 75390, USA
J Clin Invest 121:2548-50. 2011..The authors' work serves to emphasize the importance of controlling Adk expression, not only as the mechanism of action of the ketogenic diet, but also as a potential target of future therapies...
- Slow wave activity during sleep: functional and therapeutic implicationsRobert W Greene
Department of Psychiatry, UTSW Medical Center, Dallas VA, Dallas, Texas 75390, USA
Neuroscientist 16:618-33. 2010..In this review, the authors discuss their current understanding of the neural mechanisms and possible functions of EEG SWA...
- Sleep: a functional enigmaRobert Greene
Department of Psychiatry, VAMC Dallas and UTSW, Dallas, TX, USA
Neuromolecular Med 5:59-68. 2004..Finally, evidence for a role of non-REM sleep in developmental central nervous system (CNS) plasticity, as well as learning and memory, is discussed...
- Essential role of brain-derived neurotrophic factor in adult hippocampal functionLisa M Monteggia
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Proc Natl Acad Sci U S A 101:10827-32. 2004..These results establish roles for BDNF in the adult, and demonstrate the strength of this inducible knockout system in studying gene function in the adult brain...
- Adenosine mediation of presynaptic feedback inhibition of glutamate releaseDario Brambilla
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Neuron 46:275-83. 2005..The time course of the adenosine response to an increase in glutamate release is slow (tau > 10 min), consistent with the role of adenosine as a fatigue factor that inhibits the activity of cholinergic arousal centers to reduce arousal...
- Control and function of the homeostatic sleep response by adenosine A1 receptorsTheresa E Bjorness
Department of Psychiatry, University of Texas Southwestern, Dallas, Texas 75390, USA
J Neurosci 29:1267-76. 2009..Thus, AdoA(1)R activation is needed for normal rebound SWA, and when the SWA rebound is reduced, there is a failure to maintain working memory function, suggesting a functional role for SWA homeostasis...
- Negative regulation of cyclin-dependent kinase 5 targets by protein kinase CBogachan Sahin
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, United States
Eur J Pharmacol 581:270-5. 2008..These results suggest that PKC exerts its effects on the phosphorylation state of Cdk5 substrates through an indirect mechanism that may involve the regulatory binding partners of Cdk5 other than its neuronal cofactors...
- Hippocampus, V: studying hippocampal behaviorsRobert W Greene
Am J Psychiatry 162:856. 2005
- Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vectorThomas E Scammell
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Neurosci 23:5762-70. 2003..This transduction knock-out technique holds enormous potential for dissecting the functions of different CNS pathways...
- High frequency EEG activity during sleep: characteristics in schizophrenia and depressionJanet L Tekell
VA Ann Arbor Healthcare System 116A, University of Michigan, 2215 Fuller Road, Ann Arbor, MI 48105, USA
Clin EEG Neurosci 36:25-35. 2005..It is not clear how HFA would change in relation to clinical improvement, and further study is needed to clarify the association of HFA to the state/trait characteristics of SZ and MDD...
- Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signalingBogachan Sahin
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Brain Res 1129:1-14. 2007..Finally, the phosphorylation state of these proteins was further assessed in vivo by systemic administration of caffeine...
- Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampusRichard Bergeron
Ottawa Health Research Institute, Department of Psychiatry, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
J Neurochem 100:346-57. 2007..All together, these results suggest that NAAG acts as an endogenous modulator of NMDARs in the CA1 area of the hippocampus...
- Zaprinast stimulates extracellular adenosine accumulation in rat pontine slicesMinou Le
Department of Neurology and Program in Neuroscience, Enders Research Building, Room 349, Children s Hospital and Harvard Medical School, Longwood Avenue, Boston, MA 02115, USA
Neurosci Lett 371:12-7. 2004....
- Transient 23-30 Hz oscillations in mouse hippocampus during exploration of novel environmentsJoshua D Berke
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48104, USA
Hippocampus 18:519-29. 2008..These findings suggest that beta2 oscillations indicate a hippocampal dynamic state that facilitates the formation of unique contextual representations...
- NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neuronsRichard Bergeron
Ottawa Health Research Institute, Ottawa, ON, Canada
Neuropsychopharmacology 30:7-16. 2005..Moreover, in dissociated pyramidal neurons of the CA1 region, NAAG also reduced the NMDA current and this effect was reversed by glycine. These results suggest that NAAG reduces the NMDA currents in hippocampal CA1 pyramidal neurons...
- Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylationBogachan Sahin
The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Eur J Biochem 271:3547-55. 2004..Further analysis revealed, however, that this PKC-dependent phosphorylation occurred at one or more serine residues associated with the N-terminal affinity tag used for protein purification...
- Adenosine induces inositol 1,4,5-trisphosphate receptor-mediated mobilization of intracellular calcium stores in basal forebrain cholinergic neuronsRadhika Basheer
Department of Psychiatry, Harvard Medical School, Veterans Affairs Medical Center, West Roxbury, Massachusetts 02132, USA
J Neurosci 22:7680-6. 2002..These data suggest a potential role for a calcium-signaling pathway in adenosine-induced long-term effects of sleep deprivation and a key role for cholinergic neurons in this process...
- The Role of Adenosine in Wake/Sleep TransitionRobert Greene; Fiscal Year: 2008..This may provide the requisite target cellular mechanism(s) for NMDA receptors and other potential modulators of extracellular AD. ..