J S Greenberger

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Modulation of in utero total body irradiation induced newborn mouse growth retardation by maternal manganese superoxide dismutase-plasmid liposome (MnSOD-PL) gene therapy
    M W Epperly
    Department of Radiation Oncology, UPCI Cancer Institute, Pittsburgh, PA 15232, USA
    Gene Ther 18:579-83. 2011
  2. pmc Strategies for discovery of small molecule radiation protectors and radiation mitigators
    Joel S Greenberger
    Radiation Oncology Department, University of Pittsburgh Cancer Institute Pittsburgh, PA, USA
    Front Oncol 1:59. 2011
  3. ncbi request reprint Differences in irradiated lung gene transcription between fibrosis-prone C57BL/6NHsd and fibrosis-resistant C3H/HeNHsd mice
    Ronny Kalash
    Professor and Chairman, Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Rm 533, Pittsburgh, P A 15232, U S A
    In Vivo 28:147-71. 2014
  4. ncbi request reprint Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU/min SRS beam
    Ronny Kalash
    Professor and Chairman, Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Rm 533, Pittsburgh, PA 15232, U S A
    In Vivo 28:1-12. 2014
  5. ncbi request reprint Radioresistance of bone marrow stromal and hematopoietic progenitor cell lines derived from Nrf2-/- homozygous deletion recombinant-negative mice
    Hebist Berhane
    University of Pittsburgh Cancer Institute, Department of Radiation Oncology, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
    In Vivo 27:571-82. 2013
  6. pmc Increased longevity of hematopoiesis in continuous marrow cultures and radiation resistance of marrow stromal and hematopoietic progenitor cells from caspase-1 homozygous recombinant-negative (knockout) mice
    Michael Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    In Vivo 27:419-30. 2013
  7. pmc Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice
    Ronny Kalash
    Professor and Chairman, Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Pittsburgh, PA 15232, U S A
    In Vivo 27:291-7. 2013
  8. pmc The zebrafish--Danio rerio--is a useful model for measuring the effects of small-molecule mitigators of late effects of ionizing irradiation
    Michael W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    In Vivo 26:889-97. 2012
  9. pmc Ionizing irradiation protection and mitigation of murine cells by carbamazepine is p53 and autophagy independent
    Hyun Kim
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, 5150 Centre Avenue, Pittsburgh, PA, USA
    In Vivo 26:341-54. 2012
  10. doi request reprint Bone marrow-derived stem cells and radiation response
    Joel S Greenberger
    Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Semin Radiat Oncol 19:133-9. 2009

Collaborators

Detail Information

Publications38

  1. pmc Modulation of in utero total body irradiation induced newborn mouse growth retardation by maternal manganese superoxide dismutase-plasmid liposome (MnSOD-PL) gene therapy
    M W Epperly
    Department of Radiation Oncology, UPCI Cancer Institute, Pittsburgh, PA 15232, USA
    Gene Ther 18:579-83. 2011
    ....
  2. pmc Strategies for discovery of small molecule radiation protectors and radiation mitigators
    Joel S Greenberger
    Radiation Oncology Department, University of Pittsburgh Cancer Institute Pittsburgh, PA, USA
    Front Oncol 1:59. 2011
    ....
  3. ncbi request reprint Differences in irradiated lung gene transcription between fibrosis-prone C57BL/6NHsd and fibrosis-resistant C3H/HeNHsd mice
    Ronny Kalash
    Professor and Chairman, Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Rm 533, Pittsburgh, P A 15232, U S A
    In Vivo 28:147-71. 2014
    ..Background/Aim: We compared pulmonary irradiation-induced whole-lung, gene transcripts over 200 days after 20 Gy thoracic irradiation in female fibrosis-prone C57BL/6NHsd mice with fibrosis-resistant C3H/HeNHsd mice...
  4. ncbi request reprint Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU/min SRS beam
    Ronny Kalash
    Professor and Chairman, Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Rm 533, Pittsburgh, PA 15232, U S A
    In Vivo 28:1-12. 2014
    ..We evaluated the radiobiological effects of stereotactic radiosurgery (SRS) photon beams on survival of C57BL/6NTac mice following total body irradiation...
  5. ncbi request reprint Radioresistance of bone marrow stromal and hematopoietic progenitor cell lines derived from Nrf2-/- homozygous deletion recombinant-negative mice
    Hebist Berhane
    University of Pittsburgh Cancer Institute, Department of Radiation Oncology, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
    In Vivo 27:571-82. 2013
    ....
  6. pmc Increased longevity of hematopoiesis in continuous marrow cultures and radiation resistance of marrow stromal and hematopoietic progenitor cells from caspase-1 homozygous recombinant-negative (knockout) mice
    Michael Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    In Vivo 27:419-30. 2013
    ..We determined whether absence of caspase-1 altered the stress response of hematopoietic and bone marrow stromal cells in vitro...
  7. pmc Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice
    Ronny Kalash
    Professor and Chairman, Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Pittsburgh, PA 15232, U S A
    In Vivo 27:291-7. 2013
    ..Thoracic irradiation results in an acute inflammatory response, latent period, and late fibrosis. Little is known about the mechanisms involved in triggering late radiation fibrosis...
  8. pmc The zebrafish--Danio rerio--is a useful model for measuring the effects of small-molecule mitigators of late effects of ionizing irradiation
    Michael W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    In Vivo 26:889-97. 2012
    ..Use of zebrafish models may decrease the cost of screening new irradiation protectors and mitigators...
  9. pmc Ionizing irradiation protection and mitigation of murine cells by carbamazepine is p53 and autophagy independent
    Hyun Kim
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, 5150 Centre Avenue, Pittsburgh, PA, USA
    In Vivo 26:341-54. 2012
    ..Carbamazepine, a sodium channel blocker and pro-autophagy agent used in the treatment of epilepsy and trigeminal neuralgia, is also an ionizing radiation mitigator and protector...
  10. doi request reprint Bone marrow-derived stem cells and radiation response
    Joel S Greenberger
    Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Semin Radiat Oncol 19:133-9. 2009
    ..This review defines the status of research in the areas of stem cell quiescence, niche contact, and migratory responses to ionizing irradiation...
  11. pmc Radioprotection
    Joel S Greenberger
    Department of Radiation Oncology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    In Vivo 23:323-36. 2009
    ....
  12. pmc Irradiated esophageal cells are protected from radiation-induced recombination by MnSOD gene therapy
    Yunyun Niu
    Departments of Radiation Oncology and Surgery, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Radiat Res 173:453-61. 2010
    ..These results demonstrate the efficacy of MnSOD-PL for suppressing radiation-induced HR in vivo...
  13. pmc Repopulation of the irradiation damaged lung with bone marrow-derived cells
    Mark E Bernard
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
    In Vivo 26:9-18. 2012
    ..The effect of lung irradiation on reduction of lung stem cells and repopulation with bone marrow-derived cells was measured...
  14. ncbi request reprint Gene therapy approaches for stem cell protection
    J S Greenberger
    Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2532, USA
    Gene Ther 15:100-8. 2008
    ..Incorporating this knowledge into designs of novel approaches for stem cell protection is addressed in the present review...
  15. ncbi request reprint Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by manganese superoxide dismutase-plasmid/liposome (SOD2-PL) gene therapy
    M W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    Radiat Res 155:2-14. 2001
    ....
  16. ncbi request reprint Modulation of redox signal transduction pathways in the treatment of cancer
    J S Greenberger
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, PA 15213, USA
    Antioxid Redox Signal 3:347-59. 2001
    ..Reducing tissue-damaging effects of ROS may have relevance to cancer patients by ameliorating normal tissue damage from ionizing irradiation therapy, photodynamic therapy, and cancer chemotherapy...
  17. ncbi request reprint Intraesophageal MnSOD-plasmid liposome enhances engraftment and self-renewal of bone marrow derived progenitors of esophageal squamous epithelium
    Y Niu
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Gene Ther 15:347-56. 2008
    ..6+/-5.4 NSP-derived) compared to irradiation controls (23.4+/-1.8 SP, 6.0+/-3.0 NSP), P<0.0001. Thus, intraesophageal MnSOD-PL administration enhances engraftment of marrow-derived progenitors...
  18. ncbi request reprint Inhalation delivery of manganese superoxide dismutase-plasmid/liposomes protects the murine lung from irradiation damage
    M Carpenter
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Gene Ther 12:685-93. 2005
    ..Thus, inhalation radioprotective gene therapy using MnSOD-PL provides a practical and effective method for delivery of lung-specific radioprotection during fractionated radiotherapy protocols in a mouse model...
  19. ncbi request reprint Radioprotective gene therapy
    J S Greenberger
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Department of Environmental Health Science, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA
    Curr Gene Ther 3:183-95. 2003
    ..Encouraging results in pre-clinical models suggest that radioprotective gene therapy may facilitate dose escalation protocols to allow increases in the therapeutic ratio of cancer radiotherapy...
  20. ncbi request reprint Overexpression of manganese superoxide dismutase (MnSOD) in whole lung or alveolar type II cells of MnSOD transgenic mice does not provide intrinsic lung irradiation protection
    M W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Int J Cancer 96:11-21. 2001
    ..The overexpression of SOD2 in the SP1-SOD2 mice may have made the mice more sensitive to irradiation...
  21. ncbi request reprint Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation
    M W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Int J Cancer 96:221-31. 2001
    ..These studies provide further support for translation of MnSOD-PL treatment into human esophageal radiation protection...
  22. ncbi request reprint Bone marrow as a potential source of hepatic oval cells
    B E Petersen
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Science 284:1168-70. 1999
    ..From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability...
  23. ncbi request reprint Endothelial cell dysfunction in response to intracellular overexpression of amyloid precursor protein
    N Jahroudi
    Department of Radiation Oncology, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    J Neurosci Res 54:828-39. 1998
    ..Our results demonstrate that endothelial cells are specifically susceptible to intracellular overexpression of APP and free radical generation is the likely mechanism of cell damage due to APP overexpression...
  24. ncbi request reprint Identification of respiratory complexes I and III as mitochondrial sites of damage following exposure to ionizing radiation and nitric oxide
    L L Pearce
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Nitric Oxide 5:128-36. 2001
    ....
  25. ncbi request reprint Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase-plasmid/liposomes (MnSOD-PL) during lung radioprotective gene therapy
    M W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, 200 Lothrop Street, Pittsburgh, PA, USA
    Gene Ther 10:163-71. 2003
    ..The data provide a rationale for every second-day administration of intrapulmonary MnSOD-PL in clinical trials of radioprotective gene therapy. This should be sufficient to provide radioprotection during radiation treatments...
  26. ncbi request reprint Effect of the irradiated microenvironment on the expression and retrotransposition of intracisternal type A particles in hematopoietic cells
    K L Pogue-Geile
    Department of Radiation Oncology and Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Exp Hematol 28:680-9. 2000
    ..This model is to be distinguished from an active role in which the irradiated microenvironment would synthesize or activate a factor(s) that promotes retrotransposition...
  27. ncbi request reprint Inhibition of G1-phase arrest induced by ionizing radiation in hematopoietic cells by overexpression of genes involved in the G1/S-phase transition
    M Epperly
    Department of Radiation Oncology, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Radiat Res 143:245-54. 1995
    ....
  28. ncbi request reprint Results of multifield conformal radiation therapy of nonsmall-cell lung carcinoma using multileaf collimation beams
    S Bahri
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pennsylvania, USA
    Radiat Oncol Investig 7:297-308. 1999
    ..Our five-field conformal 3-DRTP technique, which incorporates treatment planning by dose/volume histogram (DVH) was associated with minimal toxicity and may facilitate dose escalation to the gross tumor...
  29. doi request reprint The impact of ionizing radiation on placental trophoblasts
    D J Kanter
    Magee Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA
    Placenta 35:85-91. 2014
    ..We hypothesized that radiation causes trophoblast injury, and alters the expression of injury-related transcripts in vitro or in vivo, thus affecting fetal growth...
  30. ncbi request reprint Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria
    H Bayir
    Center for Free Radical and Antioxidant Health, Pittsburgh, PA 15219, USA
    Biochim Biophys Acta 1757:648-59. 2006
    ..This review is focused on newly discovered redox mechanisms of complexes of cyt c with anionic phospholipids and their role in apoptotic pathways in health and disease...
  31. ncbi request reprint Mechanisms of muscle stem cell expansion with cytokines
    B M Deasy
    Bioengineering Department, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Stem Cells 20:50-60. 2002
    ....
  32. pmc Amelioration of radiation esophagitis by orally administered p53/Mdm2/Mdm4 inhibitor (BEB55) or GS-nitroxide
    Hyun Kim
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
    In Vivo 25:841-8. 2011
    ..Esophagitis is a significant toxicity of radiation therapy for lung cancer. In this study, reduction of irradiation esophagitis in mice, by orally administered p53/Mdm2/Mdm4 inhibitor, BEB55, or the GS-nitroxide, JP4-039, was evaluated...
  33. pmc Intraesophageal administration of GS-nitroxide (JP4-039) protects against ionizing irradiation-induced esophagitis
    Michael W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, U S A
    In Vivo 24:811-9. 2010
    ..this study evaluated esophageal radioprotection by the Gramicidin S (GS) derived-nitroxide, JP4-039, a mitochondrial targeting peptide-isostere covalently-linked to 4-amino-Tempo, delivered in a novel swallowed oil-based (F15) formulation...
  34. pmc Role of the esophageal vagus neural pathway in ionizing irradiation-induced seizures in nitric oxide synthase-1 homologous recombinant negative NOS1-/- mice
    Mark E Bernard
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
    In Vivo 25:861-9. 2011
    ..We sought to define the mechanism of total body irradiation (TBI)-induced seizures in NOS1(-/-) mice and amelioration by intra-esophageal manganese superoxide dismutase-plasmid liposomes (MnSOD-PL)...
  35. pmc Radiobiologic effects of GS-nitroxide (JP4-039) on the hematopoietic syndrome
    Julie P Goff
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    In Vivo 25:315-23. 2011
    ..Radiation mitigators must be safe for individuals likely to recover spontaneously...
  36. ncbi request reprint Modeling stem cell population growth: incorporating terms for proliferative heterogeneity
    B M Deasy
    Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Stem Cells 21:536-45. 2003
    ..Further, it is expected that the models will prove useful in establishing standardization of cell culture conditions and scalable systems and will be required to develop clinical protocols for stem cell therapeutics...
  37. ncbi request reprint Could gene therapy prevent the effects of irradiation exposure?
    J S Greenberger
    Pharmacogenomics 7:1141-5. 2006