Ralph Green

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi Anemias beyond B12 and iron deficiency: the buzz about other B's, elementary, and nonelementary problems
    Ralph Green
    University of California, Davis, Sacramento, CA 95817, USA
    Hematology Am Soc Hematol Educ Program 2012:492-8. 2012
  2. pmc Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies
    Ralph Green
    Department of Pathology, University of California, Davis, Sacramento, CA 95817, USA
    Am J Clin Nutr 94:666S-72S. 2011
  3. pmc Is it time for vitamin B-12 fortification? What are the questions?
    Ralph Green
    School of Medicine, Department of Medical Pathology and Laboratory Medicine, University of California, Davis, Davis, CA, USA
    Am J Clin Nutr 89:712S-6S. 2009
  4. ncbi Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on Aging
    Marisa I Ramos
    School of Medicine, Department of Medical Pathology, University of California, Davis, USA
    Am J Clin Nutr 82:1346-52. 2005
  5. ncbi Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification
    Marisa I Ramos
    Department of Pathology and Laboratory Medicine, University of California, Davis School of Medicine, Davis, USA
    Am J Clin Nutr 80:1024-8. 2004
  6. ncbi High prevalence of cobalamin deficiency in Guatemalan schoolchildren: associations with low plasma holotranscobalamin II and elevated serum methylmalonic acid and plasma homocysteine concentrations
    Lisa M Rogers
    Department of Nutrition, Program in International Nutrition, University of California, Davis, 95616 8669, USA
    Am J Clin Nutr 77:433-40. 2003
  7. pmc Fraction of total plasma vitamin B12 bound to transcobalamin correlates with cognitive function in elderly Latinos with depressive symptoms
    Marjorie G Garrod
    Department of Medical Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, CA, USA
    Clin Chem 54:1210-7. 2008
  8. ncbi Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency
    Joshua W Miller
    Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Clin Chem 52:278-85. 2006
  9. pmc Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate
    Joshua W Miller
    School of Medicine, Department of Medical Pathology and Laboratory Medicine, University of California, Davis, CA, USA
    Am J Clin Nutr 90:1586-92. 2009
  10. ncbi Indicators for assessing folate and vitamin B12 status and for monitoring the efficacy of intervention strategies
    Ralph Green
    Department of Medical Pathology and Laboratory Medicine, University of California, Davis, California, USA
    Food Nutr Bull 29:S52-63; discussion S64-6. 2008

Collaborators

Detail Information

Publications30

  1. doi Anemias beyond B12 and iron deficiency: the buzz about other B's, elementary, and nonelementary problems
    Ralph Green
    University of California, Davis, Sacramento, CA 95817, USA
    Hematology Am Soc Hematol Educ Program 2012:492-8. 2012
    ..These "pearls" represent but 3 examples of the many varieties of problems in anemia diagnosis and are used to illustrate potential pitfalls and how to avoid them...
  2. pmc Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies
    Ralph Green
    Department of Pathology, University of California, Davis, Sacramento, CA 95817, USA
    Am J Clin Nutr 94:666S-72S. 2011
    ..The general methods as well as their uses, indications, and limitations are presented...
  3. pmc Is it time for vitamin B-12 fortification? What are the questions?
    Ralph Green
    School of Medicine, Department of Medical Pathology and Laboratory Medicine, University of California, Davis, Davis, CA, USA
    Am J Clin Nutr 89:712S-6S. 2009
    ..This analysis focuses on the research questions that are pertinent to the consideration of whether or not to introduce mandatory vitamin B-12 fortification in the United States...
  4. ncbi Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on Aging
    Marisa I Ramos
    School of Medicine, Department of Medical Pathology, University of California, Davis, USA
    Am J Clin Nutr 82:1346-52. 2005
    ..Since 1998, grain products in the United States have been fortified with folic acid, which has reduced the prevalence of folate deficiency and hyperhomocysteinemia...
  5. ncbi Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification
    Marisa I Ramos
    Department of Pathology and Laboratory Medicine, University of California, Davis School of Medicine, Davis, USA
    Am J Clin Nutr 80:1024-8. 2004
    ..A relation between low folate status and depression has been recognized since the 1960s. Since 1998, flour in the United States has been fortified with folic acid, and the prevalence of folate deficiency has decreased dramatically...
  6. ncbi High prevalence of cobalamin deficiency in Guatemalan schoolchildren: associations with low plasma holotranscobalamin II and elevated serum methylmalonic acid and plasma homocysteine concentrations
    Lisa M Rogers
    Department of Nutrition, Program in International Nutrition, University of California, Davis, 95616 8669, USA
    Am J Clin Nutr 77:433-40. 2003
    ..It is not known whether these low cobalamin concentrations are accompanied by altered metabolic functions...
  7. pmc Fraction of total plasma vitamin B12 bound to transcobalamin correlates with cognitive function in elderly Latinos with depressive symptoms
    Marjorie G Garrod
    Department of Medical Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, CA, USA
    Clin Chem 54:1210-7. 2008
    ..The fraction of total plasma vitamin B(12) bound to transcobalamin (holoTC/B12 ratio) may reflect tissue levels of the vitamin, but its clinical relevance is unclear...
  8. ncbi Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency
    Joshua W Miller
    Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Clin Chem 52:278-85. 2006
    ..Plasma vitamin B12 bound to transcobalamin (holoTC) is the fraction of total vitamin B12 available for tissue uptake and therefore has been proposed as a potentially useful alternative indicator of vitamin B12 status...
  9. pmc Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate
    Joshua W Miller
    School of Medicine, Department of Medical Pathology and Laboratory Medicine, University of California, Davis, CA, USA
    Am J Clin Nutr 90:1586-92. 2009
    ..These findings await confirmation in other populations...
  10. ncbi Indicators for assessing folate and vitamin B12 status and for monitoring the efficacy of intervention strategies
    Ralph Green
    Department of Medical Pathology and Laboratory Medicine, University of California, Davis, California, USA
    Food Nutr Bull 29:S52-63; discussion S64-6. 2008
    ..The general methods as well as their uses, indications, and limitations are presented...
  11. ncbi Plasma vitamin B-12 concentrations in an elderly latino population are predicted by serum gastrin concentrations and crystalline vitamin B-12 intake
    Alison K Campbell
    Department of Nutrition, Program in International Nutrition, University of California, Davis, CA, USA
    J Nutr 133:2770-6. 2003
    ..Crystalline vitamin B-12 intake predicted p-B12 in individuals with elevated serum gastrin, supporting IOM recommendations to increase consumption of crystalline vitamin B-12...
  12. ncbi Homocysteine and cognitive function in the Sacramento Area Latino Study on Aging
    Joshua W Miller
    Department of Medical Pathology, School of Medicine, University of California, Davis, USA
    Am J Clin Nutr 78:441-7. 2003
    ....
  13. ncbi Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population
    Ralph Green
    Department of Medical Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Clin Chem Lab Med 43:1048-51. 2005
    ..Steps to either reduce the prevalence of vitamin B12 deficiency or to identify and treat individuals with vitamin B12 deficiency could further reduce the prevalence of hyperhomocysteinemia...
  14. pmc Exchange transfusion therapy and its effects on real-time microcirculation in pediatric sickle cell anemia patients: an intravital microscopy study
    Anthony T W Cheung
    Department of Medical Pathology, University of California, Davis, CA, USA
    J Pediatr Hematol Oncol 34:169-74. 2012
    ..This paradoxical result warrants further investigation on the effects of transfusion volume and viscosity in the exchange transfusion process...
  15. ncbi Predictors of cobalamin deficiency in Guatemalan school children: diet, Helicobacter pylori, or bacterial overgrowth?
    Lisa M Rogers
    Department of Nutrition, Program in International Nutrition, University of California, Davis, California 95616 8669, USA
    J Pediatr Gastroenterol Nutr 36:27-36. 2003
    ..The authors investigated whether low vitamin B12 intake, impaired gastric function, infection, and bacterial overgrowth were risk factors for the high prevalence of cobalamin deficiency observed in Guatemalan children...
  16. pmc Homocysteine, cysteine, and risk of incident colorectal cancer in the Women's Health Initiative observational cohort
    Joshua W Miller
    Department of Medical Pathology and Laboratory Medicine, University of California, Davis, Davis, CA 95817, USA
    Am J Clin Nutr 97:827-34. 2013
    ..Hyperhomocysteinemia is associated with inflammation and may be a risk marker for CRC. Cysteine is a metabolic product of homocysteine and a precursor of the antioxidant glutathione. It is unknown whether cysteine is associated with CRC...
  17. ncbi Issues and challenges of non-tenure-track research faculty: the UC Davis School of Medicine experience
    Lydia Pleotis Howell
    University of California, Davis, School of Medicine, Sacramento, CA, USA
    Acad Med 85:1041-7. 2010
    ..Challenges in addressing these issues include limited availability of tenure-track positions, financial resources, adequate communication regarding change, and compliance with existing faculty search policies...
  18. pmc C-reactive protein is related to memory and medial temporal brain volume in older adults
    Brianne Magouirk Bettcher
    Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA
    Brain Behav Immun 26:103-8. 2012
    ..These findings underscore a potential role for inflammation in cognitive aging as a modifiable risk factor...
  19. pmc Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled (14)C-cobalamin
    Colleen Carkeet
    Department of Nutrition and Molecular Biosciences, University of California, Davis, CA 95616 5270, USA
    Proc Natl Acad Sci U S A 103:5694-9. 2006
    ..2 kBq/59 nCi) of purified (14)C-B(12) was administered and showed plasma appearance and clearance curves consistent with the predicted behavior of the pure vitamin. This method opens new avenues for study of B(12) assimilation...
  20. ncbi A mission-based reporting system applied to an academic pathology department
    Lydia Pleotis Howell
    Department of Pathology and Psychiatry, University of California Davis School of Medicine, Davis, CA 95616, USA
    Hum Pathol 34:437-43. 2003
    ..In a more general sense, these profiles allow appropriate monitoring of the workforce, funds flow analysis, allocation of resources, and strategic planning in an academic medical center...
  21. doi Structured illumination-based super-resolution optical microscopy for hemato- and cyto-pathology applications
    Tieqiao Zhang
    Center for Biophotonics, Science and Technology, University of California Davis, Sacramento, CA, USA
    Anal Cell Pathol (Amst) 36:27-35. 2013
    ..This research illustrates the potential of this technique to be used in hematology and cyto-pathology studies aimed at identifying nanometer-sized features that cannot be distinguished otherwise with conventional optical microscopy...
  22. doi Eculizumab therapy results in rapid and sustained decreases in markers of thrombin generation and inflammation in patients with PNH independent of its effects on hemolysis and microparticle formation
    Ilene C Weitz
    Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles 90033, CA, USA
    Thromb Res 130:361-8. 2012
    ....
  23. pmc Hematological disorders following gastric bypass surgery: emerging concepts of the interplay between nutritional deficiency and inflammation
    Mingyi Chen
    Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Biomed Res Int 2013:205467. 2013
    ..In this paper, the clinical characteristics and differential diagnosis of the hematological disorders associated with gastric bypass surgery are reviewed, and the underlying molecular mechanisms are discussed. ..
  24. pmc Comparison of real-time microvascular abnormalities in pediatric and adult sickle cell anemia patients
    Anthony T W Cheung
    Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, CA, USA
    Am J Hematol 85:899-901. 2010
    ..Intervention and effective treatment/management modalities should target pediatric patients to ameliorate, slow down, or prevent progressive microvascular deterioration...
  25. ncbi Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults
    Joshua W Miller
    Department of Medical Pathology, School of Medicine, University of California, Davis, CA 95817, USA
    Blood 100:718-20. 2002
    ..02). The PP genotype may be more efficient in delivering B12 to tissues, resulting in enhanced B12 functional status. TCII genotype may thus influence susceptibility to B12 deficiency...
  26. ncbi Methyl deficiency causes reduction of the methyl-CpG-binding protein, MeCP2, in rat liver
    Farah Esfandiari
    University of California Davis, School of Medicine, Department of Medical Pathology, Research 3, Room 3200A, 4645 Second Avenue, Sacramento, CA 95817, USA
    Carcinogenesis 24:1935-40. 2003
    ..Reduction of MeCP2 protein expression may influence the initiation and/or progression of hepatic cancer induced by methyl deficiency and may provide a useful marker of pre-neoplastic change...
  27. ncbi Relation of plasma homocysteine to plasma amyloid beta levels
    Jose A Luchsinger
    Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Neurochem Res 32:775-81. 2007
    ..Elevated plasma homocysteine and amyloid beta (Abeta) have been associated with Alzheimer's disease (AD). We investigated the cross-sectional association between these biomarkers...
  28. ncbi A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease
    Paul S Aisen
    Department of Neurology, Georgetown University Medical Center, Washington, DC 20007, USA
    Am J Geriatr Psychiatry 11:246-9. 2003
    ..Authors determined the impact of high-dose vitamin supplements on plasma homocysteine levels in patients with Alzheimer disease (AD)...
  29. pmc Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging
    Mary N Haan
    Epidemiology Program, School of Public Health, University of Michigan, Ann Arbor, MI 48104, USA
    Am J Clin Nutr 85:511-7. 2007
    ..High concentrations of homocysteine have been linked to a greater risk of Alzheimer disease, dementia, and cognitive decline...
  30. ncbi Prevalence of vitamin B12 deficiency in patients with plasma cell dyscrasias: a retrospective review
    Rachid Baz
    Internal Medicine Residency Program, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer 101:790-5. 2004
    ..Identifying this vitamin deficiency in such patients could help improve their anemia and increase their tolerance to potentially neurotoxic agents...

Research Grants4

  1. Vitamin B6, Vascular Dysfunction and Adhesion Molecules in Sickle Cell Disease
    Ralph Green; Fiscal Year: 2007
    ..The positive health impact of vitamin supplementation that could ameliorate the high morbidity and mortality associated with this disorder has the potential for high benefit with minimal cost and risk. ..
  2. Vitamin B6, Vascular Dysfunction and Adhesion Molecules in Sickle Cell Disease
    Ralph Green; Fiscal Year: 2009
    ..The positive health impact of vitamin supplementation that could ameliorate the high morbidity and mortality associated with this disorder has the potential for high benefit with minimal cost and risk. ..
  3. Vitamin B6, Vascular Dysfunction and Adhesion Molecules in Sickle Cell Disease
    Ralph Green; Fiscal Year: 2010
    ..The positive health impact of vitamin supplementation that could ameliorate the high morbidity and mortality associated with this disorder has the potential for high benefit with minimal cost and risk. ..