Genomes and Genes
Siri Atma W Greeley
Affiliation: University of Chicago
- Neonatal diabetes mellitus: a model for personalized medicineSiri Atma W Greeley
Department of Pediatrics, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, University of Chicago Pritzker School of Medicine, 5841 S Maryland Ave, MC 1027, Chicago, IL 60637, USA
Trends Endocrinol Metab 21:464-72. 2010..It remains to be determined what is the most appropriate treatment of other causes. The diagnosis and treatment of neonatal diabetes, therefore, represents a model for personalized medicine...
- Creation of the Web-based University of Chicago Monogenic Diabetes Registry: using technology to facilitate longitudinal study of rare subtypes of diabetesSiri Atma W Greeley
Department of Pediatrics, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago, Chicago, Illinois 60637, USA
J Diabetes Sci Technol 5:879-86. 2011..kovlerdiabetescenter.org/registry/) for individuals with either neonatal diabetes diagnosed before 1 year of age or with a phenotype suggestive of maturity-onset diabetes of the young...
- Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatmentSiri Atma W Greeley
Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Kovler Diabetes Center, The University of Chicago, Chicago, IL 60637, USA
Curr Diab Rep 11:519-32. 2011..This compelling example of personalized genetic medicine leading to improved glucose regulation and quality of life may-with continued research-be repeated for other forms of neonatal diabetes in the future...
- Diagnosis and treatment of neonatal diabetes: a United States experienceJulie Støy
Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
Pediatr Diabetes 9:450-9. 2008..The aim of this study was to identify the genetic cause of diabetes in 77 consecutive patients referred to the University of Chicago with diabetes diagnosed before 1 yr of age...
- Update in neonatal diabetesSiri Atma W Greeley
Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
Curr Opin Endocrinol Diabetes Obes 17:13-9. 2010..Identification of these mutations allows patients treated with insulin to be transferred to sulfonylureas, but associated conditions and other causes must be considered...
- Visuomotor performance in KCNJ11-related neonatal diabetes is impaired in children with DEND-associated mutations and may be improved by early treatment with sulfonylureasReshma P Shah
Section of Developmental and Behavioral Pediatrics and John P Kennedy Jr Intellectual and Developmental Disabilities Research Center, Department of Pediatrics, Comer Children s Hospital and Pritzer School of Medicine, The University of Chicago, Chicago, Illinois, USA
Diabetes Care 35:2086-8. 2012..To assess performance on an age-standardized neuromotor coordination task among sulfonylurea-treated KCNJ11-related neonatal diabetic patients...
- The cost-effectiveness of personalized genetic medicine: the case of genetic testing in neonatal diabetesSiri Atma W Greeley
Department of Pediatrics, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, University of Chicago, Chicago, Illinois, USA
Diabetes Care 34:622-7. 2011..Although treatment conversion has dramatic benefits, the cost-effectiveness of routine genetic testing is unknown...
- HLA-DQ haplotypes differ by ethnicity in patients with childhood-onset diabetesRebecca B Lipton
Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
Pediatr Diabetes 12:388-95. 2011..To understand the etiology of childhood-onset diabetes, we examined genetic risk markers, autoantibodies, and β-cell function in a mixed race group of young patients...
- Insulin gene mutations as a cause of permanent neonatal diabetesJulie Støy
Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 104:15040-4. 2007..One of the human mutations we report here is identical to that in the Akita mouse. The identification of insulin mutations as a cause of neonatal diabetes will facilitate the diagnosis and possibly, in time, treatment of this disorder...