Dennis Grayson

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. doi request reprint Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum
    A Zhubi
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Transl Psychiatry 4:e349. 2014
  2. pmc The dynamics of DNA methylation in schizophrenia and related psychiatric disorders
    Dennis R Grayson
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 38:138-66. 2013
  3. doi request reprint Laboratory of molecular neurobiology (1988-1994)
    Dennis R Grayson
    Molecular Neuroscience, The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois Chicago, 1601 W Taylor St, Chicago, IL 60612, United States
    Pharmacol Res 64:339-43. 2011
  4. doi request reprint Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders?
    Dennis R Grayson
    Department of Psychiatry, University of Illinois, Chicago, IL 60612, USA
    Mol Pharmacol 77:126-35. 2010
  5. ncbi request reprint The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia
    Dennis R Grayson
    Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago, 1601 W Taylor St, 60612, USA
    Pharmacol Ther 111:272-86. 2006
  6. pmc Reelin promoter hypermethylation in schizophrenia
    Dennis R Grayson
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:9341-6. 2005
  7. ncbi request reprint Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice
    Lucio Tremolizzo
    Department of Psychiatry, Psychiatric Institute, College of Medicine, University of Illinois at Chicago, Illinois 60612, USA
    Biol Psychiatry 57:500-9. 2005
  8. pmc DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures
    Jai Sung Noh
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:1749-54. 2005
  9. pmc The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes
    Marija Kundakovic
    Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Mol Pharmacol 75:342-54. 2009
  10. ncbi request reprint GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon
    Alessandro Guidotti
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 Taylor St, Chicago, IL 60612, USA
    Psychopharmacology (Berl) 180:191-205. 2005

Research Grants

  1. Regulation of the Reelin Gene
    Dennis Grayson; Fiscal Year: 2006

Collaborators

Detail Information

Publications36

  1. doi request reprint Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum
    A Zhubi
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Transl Psychiatry 4:e349. 2014
    ..These data are consistent with the hypothesis that an increase of 5-hmC (relative to 5-mC) at specific gene domains enhances the binding of MeCP2 to 5-hmC and reduces expression of the corresponding target genes in ASD cerebella. ..
  2. pmc The dynamics of DNA methylation in schizophrenia and related psychiatric disorders
    Dennis R Grayson
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 38:138-66. 2013
    ....
  3. doi request reprint Laboratory of molecular neurobiology (1988-1994)
    Dennis R Grayson
    Molecular Neuroscience, The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois Chicago, 1601 W Taylor St, Chicago, IL 60612, United States
    Pharmacol Res 64:339-43. 2011
    ..How these processes are linked to changes in gene expression has been the focus of studies in the neurosciences for many years...
  4. doi request reprint Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders?
    Dennis R Grayson
    Department of Psychiatry, University of Illinois, Chicago, IL 60612, USA
    Mol Pharmacol 77:126-35. 2010
    ..Before we consider the clinical use of additional HDAC inhibitors to treat schizophrenia or unipolar depression, there are a number of key issues that need to be resolved...
  5. ncbi request reprint The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia
    Dennis R Grayson
    Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago, 1601 W Taylor St, 60612, USA
    Pharmacol Ther 111:272-86. 2006
    ....
  6. pmc Reelin promoter hypermethylation in schizophrenia
    Dennis R Grayson
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:9341-6. 2005
    ..Collectively, the data show that this promoter region has positive and negative properties and that the function of this complex cis element relates to its methylation status...
  7. ncbi request reprint Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice
    Lucio Tremolizzo
    Department of Psychiatry, Psychiatric Institute, College of Medicine, University of Illinois at Chicago, Illinois 60612, USA
    Biol Psychiatry 57:500-9. 2005
    ..We studied whether MET-induced epigenetic reelin promoter hypermethylation and the associated behavioral alterations can be reduced by valproate in doses that inhibit histone deacetylases (HDACs)...
  8. pmc DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures
    Jai Sung Noh
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:1749-54. 2005
    ..These data support the hypothesis that the reduced amounts of reelin and GAD67 mRNAs documented in postmortem schizophrenia brain may be the consequence of a Dnmt1-mediated hypermethylation of the corresponding promoters...
  9. pmc The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes
    Marija Kundakovic
    Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Mol Pharmacol 75:342-54. 2009
    ..These data provide a mechanistic rationale for the use of epigenetic drugs, individually or in combination, as a potential novel therapeutic strategy to alleviate deficits associated with schizophrenia...
  10. ncbi request reprint GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon
    Alessandro Guidotti
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 Taylor St, Chicago, IL 60612, USA
    Psychopharmacology (Berl) 180:191-205. 2005
    ..Indirectly, this GABAergic neuron downregulation may play a key role in the expression of positive and negative symptoms of SZ and BP disorders...
  11. pmc On the epigenetic regulation of the human reelin promoter
    Ying Chen
    Psychiatric Institute, Department of Psychiatry, 1601 West Taylor Street, M C 912, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Nucleic Acids Res 30:2930-9. 2002
    ..Our data also raise the interesting possibility that the down-regulation of reelin expression documented in psychiatric patients might be the consequence of inappropriate promoter hypermethylation...
  12. ncbi request reprint S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis
    Alessandro Guidotti
    Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, Illinois, USA
    Neuroreport 18:57-60. 2007
    ....
  13. ncbi request reprint DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes
    Marija Kundakovic
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 1601 W Taylor St, Chicago IL 60612, USA
    Mol Pharmacol 71:644-53. 2007
    ....
  14. ncbi request reprint Induction of the reelin promoter by retinoic acid is mediated by Sp1
    Ying Chen
    Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Psychiatric Institute, Chicago, Illinois 60612, USA
    J Neurochem 103:650-65. 2007
    ..The data suggest that while the Pax6 site plays a role in modulating reelin expression, it is not absolutely required for induction by RA...
  15. ncbi request reprint From trans-methylation to cytosine methylation: evolution of the methylation hypothesis of schizophrenia
    Dennis R Grayson
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois Chicago, Chicago, IL 60612, USA
    Epigenetics 4:144-9. 2009
    ..We suggest that to expand our knowledge of epigenetically-responsive promoters using MET might allow for a better appreciation of global methylation changes occurring in selected brain regions...
  16. ncbi request reprint Histone deacetylase inhibitors decrease reelin promoter methylation in vitro
    Colin P Mitchell
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Illinois 60612, USA
    J Neurochem 93:483-92. 2005
    ..Our data indicate that while TSA and VPA act to increase histone acetylation and reduce promoter methylation, AZA acts only to decrease the amount of reelin promoter methylation...
  17. ncbi request reprint Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: preliminary results from a clinical population
    Rajiv P Sharma
    The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Schizophr Res 88:227-31. 2006
    ..The authors consider these results in the context of future application of HDAC inhibitors to the treatment of psychiatric disorders...
  18. doi request reprint Valproate induces DNA demethylation in nuclear extracts from adult mouse brain
    Erbo Dong
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL, USA
    Epigenetics 5:730-5. 2010
    ....
  19. pmc CpG methylation in neurons: message, memory, or mask?
    Rajiv P Sharma
    The Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago, USA
    Neuropsychopharmacology 35:2009-20. 2010
    ..These include the regulation in post-mitotic neurons of the executor proteins, such as the DNA methyltransferases, the elusive and putative demethylases, and the interactions with histone modifying enzymes...
  20. pmc Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures
    David P Gavin
    The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL, USA
    J Psychiatry Neurosci 34:232-7. 2009
    ....
  21. ncbi request reprint Neonatal lesions of the ventral hippocampal formation alter GABA-A receptor subunit mRNA expression in adult rat frontal pole
    Colin P Mitchell
    Psychiatric Institute, University of Illinois at Chicago in affiliation with University of Chicago, 1601 W Taylor, Chicago, IL 60612, USA
    Biol Psychiatry 57:49-55. 2005
    ....
  22. doi request reprint Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling
    Alessandro Guidotti
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 Taylor Street, Chicago, IL 60612, USA
    Trends Pharmacol Sci 30:55-60. 2009
    ..This remodeling might contribute to reelin- and GAD(67)-promoter demethylation and might reverse the GABAergic-gene-expression downregulation associated with SZ morbidity...
  23. doi request reprint GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability
    Erminio Costa
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 Taylor, Chicago, IL 60612, USA
    Expert Rev Neurother 9:87-98. 2009
    ....
  24. pmc A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes
    Erbo Dong
    Psychiatric Institute, Department of Psychiatry, University of Illinois, College of Medicine, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 100:5479-84. 2003
    ..We conclude that reelin binds with high affinity to integrin receptors expressed in SNSs and thereby activates Arc protein synthesis...
  25. ncbi request reprint Depolarization induces downregulation of DNMT1 and DNMT3a in primary cortical cultures
    Rajiv P Sharma
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Epigenetics 3:74-80. 2008
    ..Our results support the idea that a reduction in DNA methyltransferase activity in the activated and depolarized neuron could contribute to the enhanced intensity and multiplicity of gene expression frequently reported...
  26. pmc Chromatin, DNA methylation and neuron gene regulation--the purpose of the package
    Rajiv P Sharma
    The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Psychiatry Neurosci 30:257-63. 2005
    ..Because chromatin structure can be modified by conventional pharmacologic therapy, a novel approach to the regulation of neuronal gene expression in clinical populations is possible...
  27. ncbi request reprint Epigenetic downregulation of GABAergic function in schizophrenia: potential for pharmacological intervention?
    Erminio Costa
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
    Mol Interv 3:220-9. 2003
  28. ncbi request reprint Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability
    Erminio Costa
    University of Illinois, Department of Psychiatry, Chicago, Illinois 60612, USA
    Epigenetics 2:29-36. 2007
    ..The results encourage the view that promoter hypermethylation in GABAergic neurons that occurs in SZ represents a testable target for novel therapeutic strategies to treat this disorder...
  29. pmc Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection
    Rajiv P Sharma
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, College of Medicine, 912 S Wood St, Chicago, IL 60612, United States
    Schizophr Res 98:111-7. 2008
    ..These findings provide additional support for the proposal that epigenetic factors are operative in the brain pathology of patients with schizophrenia...
  30. pmc Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation
    Graziano Pinna
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 103:4275-80. 2006
    ..Benzodiazepine response mediated by alpha1-containing GABA(A)-Rs is expected to be silent or reduced...
  31. ncbi request reprint GABAergic cortical neuron chromatin as a putative target to treat schizophrenia vulnerability
    Erminio Costa
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Crit Rev Neurobiol 15:121-42. 2003
    ....
  32. pmc Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects
    David P Gavin
    Schizophr Res 103:330-2. 2008
  33. pmc Expression of GABA A receptor alpha1 subunit mRNA and protein in rat neocortex following photothrombotic infarction
    Elena A Kharlamov
    Department of Neurology, Center for Neuroscience Research, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA
    Brain Res 1210:29-38. 2008
    ....
  34. ncbi request reprint Quantitative reverse transcription-polymerase chain reaction of GABA(A) alpha1, beta1 and gamma2S subunits in epileptic rats following photothrombotic infarction of neocortex
    Jiangping Liu
    Department of Neurology, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212 4772, USA
    Epilepsy Res 52:85-95. 2002
    ..0462). These findings suggest that large photothrombotic infarcts of the neocortex can result in a long-lasting differential expression of GABA(A) receptor subunit mRNAs in ipsilateral cortex variably associated with the epileptic state...
  35. ncbi request reprint Differential effects of prenatal cocaine exposure on selected subunit mRNAs of the GABA(A) receptor in rabbit anterior cingulate cortex
    Jed S Shumsky
    Department of Neurobiology and Anatomy, MCP Hahnemann University, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Chem Neuroanat 24:243-55. 2002
    ....
  36. ncbi request reprint Characterization of wild-type (R100R) and mutated (Q100Q) GABAA alpha 6 subunit in Sardinian alcohol non-preferring rats (sNP)
    Angela Sanna
    C N R Institute of Neurogenetic and Neuropharmacology, Cagliari, Italy
    Brain Res 967:98-105. 2003
    ..These data contribute to the characterization of the function of GABA(A) alpha(6) subunit and its involvement in determining alcohol related behavior...

Research Grants5

  1. Regulation of the Reelin Gene
    Dennis Grayson; Fiscal Year: 2006
    ....