J R Graybill

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Treatment alternatives for Mycobacterium kansasii
    J R Graybill
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78284, USA
    J Antimicrob Chemother 47:417-20. 2001
  2. ncbi request reprint Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal meningitis. The NIAID Mycoses Study Group and AIDS Cooperative Treatment Groups
    J R Graybill
    Infectious Diseases Section, South Texas Veterans Health Care System, Audie L Murphy Memorial Veterans Hospital Division, San Antonio, TX 78284, USA
    Clin Infect Dis 30:47-54. 2000
  3. pmc Activities of sordarins in murine histoplasmosis
    J R Graybill
    University of Texas Health Science Center, San Antonio, Texas
    Antimicrob Agents Chemother 43:1716-8. 1999
  4. ncbi request reprint Voriconazole for candidosis: an important addition?
    John R Graybill
    Division of Infectious Diseases, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Lancet 366:1413-4. 2005
  5. ncbi request reprint SCH56592 treatment of murine invasive aspergillosis
    J R Graybill
    The University of Texas Health Science Center at San Antonio, 78284, USA
    J Antimicrob Chemother 42:539-42. 1998
  6. pmc Fluconazole versus Candida albicans: a complex relationship
    J R Graybill
    Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Antimicrob Agents Chemother 42:2938-42. 1998
  7. pmc Granulocyte colony-stimulating factor and azole antifungal therapy in murine aspergillosis: role of immune suppression
    J R Graybill
    University of Texas Health Science Center San Antonio, San Antonio, Texas 78284, USA
    Antimicrob Agents Chemother 42:2467-73. 1998
  8. pmc Treatment of histoplasmosis with MK-991 (L-743,872)
    J R Graybill
    The University of Texas Health Science Center at San Antonio, 78284, USA
    Antimicrob Agents Chemother 42:151-3. 1998
  9. pmc KY-62, a polyene analog of amphotericin B, for treatment of murine candidiasis
    J R Graybill
    University of Texas Health Science Center, San Antonio 78284, USA
    Antimicrob Agents Chemother 42:147-50. 1998
  10. pmc Treatment of murine disseminated candidiasis with L-743,872
    J R Graybill
    University of Texas Health Science Center at San Antonio and Audie Murphy Memorial Veterans Hospital, 78284, USA
    Antimicrob Agents Chemother 41:1775-7. 1997

Detail Information

Publications67

  1. ncbi request reprint Treatment alternatives for Mycobacterium kansasii
    J R Graybill
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78284, USA
    J Antimicrob Chemother 47:417-20. 2001
    ..All three drugs were highly active individually. Although there was no evidence of antagonism, combined therapy was not more effective than either component used alone...
  2. ncbi request reprint Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal meningitis. The NIAID Mycoses Study Group and AIDS Cooperative Treatment Groups
    J R Graybill
    Infectious Diseases Section, South Texas Veterans Health Care System, Audie L Murphy Memorial Veterans Hospital Division, San Antonio, TX 78284, USA
    Clin Infect Dis 30:47-54. 2000
    ..001). Patients with pretreatment opening pressure <250 mm H2O had increased short-term survival compared with those with higher pressure. We recommend that opening pressures >/=250 mm H2O be treated with large-volume CSF drainage...
  3. pmc Activities of sordarins in murine histoplasmosis
    J R Graybill
    University of Texas Health Science Center, San Antonio, Texas
    Antimicrob Agents Chemother 43:1716-8. 1999
    ..Sordarins were effective at doses as low as 2 mg/kg of body weight/day. This novel class of drugs compared favorably with amphotericin B and fluconazole for the treatment of histoplasmosis...
  4. ncbi request reprint Voriconazole for candidosis: an important addition?
    John R Graybill
    Division of Infectious Diseases, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Lancet 366:1413-4. 2005
  5. ncbi request reprint SCH56592 treatment of murine invasive aspergillosis
    J R Graybill
    The University of Texas Health Science Center at San Antonio, 78284, USA
    J Antimicrob Chemother 42:539-42. 1998
    ..SCH56592 prolonged survival and reduced lung tissue counts of A. fumigatus, while amphotericin B had marginal benefit. SCH56592 merits further development for treatment of aspergillosis...
  6. pmc Fluconazole versus Candida albicans: a complex relationship
    J R Graybill
    Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Antimicrob Agents Chemother 42:2938-42. 1998
    ..albicans isolates is associated with increasing fluconazole MICs in some cases but not in others and shows that these low-virulence strains may not consistently cause infection...
  7. pmc Granulocyte colony-stimulating factor and azole antifungal therapy in murine aspergillosis: role of immune suppression
    J R Graybill
    University of Texas Health Science Center San Antonio, San Antonio, Texas 78284, USA
    Antimicrob Agents Chemother 42:2467-73. 1998
    ..Host predisposing factors contribute in different ways to the outcome of growth factor therapy in aspergillosis...
  8. pmc Treatment of histoplasmosis with MK-991 (L-743,872)
    J R Graybill
    The University of Texas Health Science Center at San Antonio, 78284, USA
    Antimicrob Agents Chemother 42:151-3. 1998
    ..05 mg/kg of body weight/day. MK-991 was modestly effective in athymic mice at a higher dose, 5 mg/kg/day. These studies suggest that MK-991 may be appropriate for clinical development in histoplasmosis...
  9. pmc KY-62, a polyene analog of amphotericin B, for treatment of murine candidiasis
    J R Graybill
    University of Texas Health Science Center, San Antonio 78284, USA
    Antimicrob Agents Chemother 42:147-50. 1998
    ..KY-62 was less effective in mice rendered neutropenic with 5-fluorouracil. The addition of flucytosine had little effect. KY-62 may have potential for clinical development...
  10. pmc Treatment of murine disseminated candidiasis with L-743,872
    J R Graybill
    University of Texas Health Science Center at San Antonio and Audie Murphy Memorial Veterans Hospital, 78284, USA
    Antimicrob Agents Chemother 41:1775-7. 1997
    ..In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis...
  11. pmc SCH 56592, amphotericin B, or itraconazole therapy of experimental murine cerebral phaeohyphomycosis due to Ramichloridium obovoideum ("Ramichloridium mackenziei")
    H M Al-Abdely
    Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Antimicrob Agents Chemother 44:1159-62. 2000
    ..This study indicates a possible role of SCH 56592 in the treatment of the serious cerebral phaeohyphomycosis due to R. obovoideum...
  12. pmc Efficacies of KY62 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous leishmaniasis and visceral leishmaniasis
    H M Al-Abdely
    Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Antimicrob Agents Chemother 42:2542-8. 1998
    ..These studies indicate potent activity of KY62 against experimental cutaneous leishmaniasis caused by L. amazoniensis and against experimental visceral leishmaniasis caused by L. donovani...
  13. pmc Correlation between antifungal susceptibilities of Coccidioides immitis in vitro and antifungal treatment with caspofungin in a mouse model
    G M Gonzalez
    Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 45:1854-9. 2001
    ..A better in vitro-in vivo correlation was noted when we used the MEC instead of the MIC as the endpoint for antifungal susceptibility testing. Caspofungin may have a role in the treatment of coccidioidomycosis...
  14. doi request reprint Therapeutic and prophylactic efficacy of aminocandin (IP960) against disseminated candidiasis in mice
    L K Najvar
    Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Clin Microbiol Infect 14:595-600. 2008
    ..These results demonstrate that single doses of aminocandin are effective as treatment and prophylaxis, and suggest that extended interval dosing may be a useful strategy for treating invasive candidiasis...
  15. ncbi request reprint The echinocandins, first novel class of antifungals in two decades: will they live up to their promise?
    J R Graybill
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
    Int J Clin Pract 55:633-8. 2001
    ..These drugs have the potential of being significant additions to the management of mycoses in the critically ill patient...
  16. ncbi request reprint Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study Group
    T F Patterson
    Division of Infectious Diseases, University of Texas Health Science Center, San Antonio 78284 7881, USA
    Medicine (Baltimore) 79:250-60. 2000
    ..New approaches and new therapies are needed to improve the outcome of invasive aspergillosis in high-risk patients...
  17. pmc Efficacy of the triazole SCH 56592 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous and visceral leishmaniases
    H M Al-Abdely
    Medical Service, Audie Murphy Veterans Administration Hospital, San Antonio, Texas 78284, USA
    Antimicrob Agents Chemother 43:2910-4. 1999
    ..These studies indicate very good activity of SCH 56592 against cutaneous leishmaniasis due to L. amazonensis infection and, to a lesser degree, against visceral leishmaniasis due to L. donovani infection in susceptible BALB/c mice...
  18. pmc Treatment of Mycobacterium haemophilum infection in a murine model with clarithromycin, rifabutin, and ciprofloxacin
    B A Atkinson
    Department of Medicine, University of Texas Health Science Center at San Antonio, USA
    Antimicrob Agents Chemother 39:2316-9. 1995
    ..Combined rifabutin and clarithromycin provide effective treatment for M. haemophilum in this model...
  19. ncbi request reprint Control of a Candida glabrata prosthetic endovascular infection with posaconazole
    G M Anstead
    Medical Service, Department of Veterans Affairs Medical Center, South Texas Veterans Heatlh Care System, San Antonio, USA
    Med Mycol 44:273-7. 2006
    ..glabrata infection. Posaconazole had controlled the infection for about 3 months prior to his death. In conclusion, posaconazole may be a useful option in the management of prosthetic endovascular infections caused by C. glabrata...
  20. ncbi request reprint A comparison of itraconazole versus fluconazole as maintenance therapy for AIDS-associated cryptococcal meningitis. National Institute of Allergy and Infectious Diseases Mycoses Study Group
    M S Saag
    Department of Medicine, Comprehensive Cancer Center, University of Alabama School of Medicine at Birmingham 35294 2050, USA
    Clin Infect Dis 28:291-6. 1999
    ..27-27.14; P = .04). Fluconazole remains the treatment of choice for maintenance therapy for AIDS-associated cryptococcal disease. Flucytosine may contribute to the prevention of relapse if used during the first 2 weeks of primary therapy...
  21. ncbi request reprint Experimental pulmonary histoplasmosis and emphysema
    J R Graybill
    Medical Service, Audie Murphy Memorial Veteran s Hospital, San Antonio, TX 78284
    Am Rev Respir Dis 137:1193-7. 1988
    ..Therefore, in this murine model, we could not substantiate an interaction of underlying emphysema with acute primary or rechallenge pulmonary histoplasmosis...
  22. ncbi request reprint Experimental murine model of disseminated Pseudallescheria infection
    G M Gonzalez
    The University of Texas Health Science Center at San Antonio, Department of Medicine, 78229 3900, USA
    Med Mycol 40:243-8. 2002
    ..In contrast, disseminated infection persisted in most organs in immunosuppressed animals (p < 0.0001). This model should be appropriate for in vivo evaluation of antifungal chemotherapy...
  23. ncbi request reprint Antifungal compounds: controversies, queries and conclusions
    J R Graybill
    University of Texas Health Science Center, San Antonio 78284, USA
    Med Mycol 38:323-33. 2000
    ..Due to the limitations of space, this paper presents the most relevant parts of each presentation. The large and up-to-date list of references should be useful to gain a better understanding of these subjects...
  24. ncbi request reprint Cryptococcus neoformans var. grubii isolates recovered from persons with AIDS demonstrate a wide range of virulence during murine meningoencephalitis that correlates with the expression of certain virulence factors
    Cornelius J Clancy
    Department of Medicine, Division of Infectious Diseases, University of Florida College of Medicine, FL, USA
    Microbiology 152:2247-55. 2006
    ..The virulence of a given isolate reflects a composite of factors rather than the contribution of a dominant factor. Growth at 37 degrees C and capsule size in vivo make particularly important contributions...
  25. ncbi request reprint Salvage treatment of histoplasmosis with posaconazole
    Angela Restrepo
    Corporacion para Investigaciones Biologicas, Carrera, Medellin, Colombia
    J Infect 54:319-27. 2007
    ....
  26. pmc Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production
    Robert A Cramer
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 5:972-80. 2006
    ..This result suggests that gliotoxin is not required for virulence in an immunosuppressed host with an invasive pulmonary infection...
  27. ncbi request reprint Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infections
    Issam I Raad
    The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Clin Infect Dis 42:1726-34. 2006
    ..Antifungal therapy is often required for long periods. Safety data from the clinical development program of the triazole antifungal agent, posaconazole, were analyzed...
  28. ncbi request reprint Retinal function assessed by ERG before and after induction of ocular aspergillosis and treatment by the anti-fungal, micafungin, in rabbits
    Joseph M Harrison
    Department of Ophthalmology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, Texas 78229 3900, USA
    Doc Ophthalmol 110:37-55. 2005
    ..Amphotericin B, but neither micafungin nor voriconazole produced significant reduction of the b-wave amplitude in the left eyes...
  29. ncbi request reprint Posaconazole as salvage treatment for invasive fusariosis in patients with underlying hematologic malignancy and other conditions
    Issam I Raad
    The M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
    Clin Infect Dis 42:1398-403. 2006
    ..Posaconazole is a broad-spectrum antifungal agent with in vitro and in vivo activity against Fusarium species...
  30. pmc In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis
    Barbara J Hoeben
    University of Texas Health at Austin College of Pharmacy, TX, USA
    Antimicrob Agents Chemother 50:1552-4. 2006
    ..Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure...
  31. pmc Caspofungin and liposomal amphotericin B therapy of experimental murine scedosporiosis
    Rosie Bocanegra
    The University of Texas Health Science Center at San Antonio, Department of Medicine Division of Infectious Diseases MC 7881, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 49:5139-41. 2005
    ..Amphotericin B and caspofungin were each effective, but combined therapy did not appear to offer advantages over liposomal amphotericin B alone...
  32. doi request reprint Posaconazole as salvage therapy in patients with invasive fungal infections after solid organ transplant
    Barbara D Alexander
    Division of Infectious Diseases and International Health, Box 3035, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 86:791-6. 2008
    ..In this post hoc analysis of a large, open-label, multicenter study, we evaluated efficacy and safety of posaconazole, a new extended-spectrum triazole, as salvage therapy for IFIs in SOT recipients...
  33. ncbi request reprint Coccidioidomycosis
    Gregory M Anstead
    Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, TX 78229, USA
    Infect Dis Clin North Am 20:621-43. 2006
    ..Additional resources are needed to conduct randomised, controlled clinical trials for the treatment of this disease...
  34. pmc Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative culture
    Ana C Vallor
    The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229 3900, USA
    Antimicrob Agents Chemother 52:2593-8. 2008
    ..02). Confirmation of fungal tissue burden by two or more methods should provide a more precise account of the burden, allowing improved assessment of diagnostic and therapeutic strategies in invasive pulmonary aspergillosis...
  35. doi request reprint Fungicidal versus Fungistatic: what's in a word?
    James S Lewis
    University Health System, Department of Pharmacy, 4502 Medical Drive, San Antonio, TX 78229, USA
    Expert Opin Pharmacother 9:927-35. 2008
    ..However, data to support the belief that the preferential use of a 'cidal' agent results in better patient outcomes has been lacking...
  36. pmc Assessment of serum (1->3)-beta-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis
    Nathan P Wiederhold
    The University of Texas at Austin College of Pharmacy, Austin, Texas, USA
    Antimicrob Agents Chemother 52:1176-8. 2008
    ..Serum (1-->3)-beta-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents...
  37. ncbi request reprint Therapeutic efficacy of caspofungin alone and in combination with amphotericin B deoxycholate for coccidioidomycosis in a mouse model
    Gloria M Gonzalez
    Departamento de Microbiologia, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon 64460, Mexico
    J Antimicrob Chemother 60:1341-6. 2007
    ..The therapeutic efficacy of caspofungin alone and in combination with amphotericin B deoxycholate was evaluated in treatment of murine coccidioidomycosis...
  38. pmc New guinea pig model of Cryptococcal meningitis
    William R Kirkpatrick
    The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, San Antonio, TX 78229 3900, USA
    Antimicrob Agents Chemother 51:3011-3. 2007
    ..Disease was monitored by serial cerebrospinal fluid (CSF) cultures and quantitative organ cultures. Our model produces disseminating central nervous system disease and responds to antifungal therapy...
  39. ncbi request reprint Aerosolized nanostructured itraconazole as prophylaxis against invasive pulmonary aspergillosis
    Carlos A Alvarez
    The University of Texas at Austin College of Pharmacy, 1 University Station, A1900, Austin, TX 78712, USA
    J Infect 55:68-74. 2007
    ..We evaluated the effectiveness of an aerosolized nanostructured formulation of itraconazole produced by spray freezing into liquid (SFL) as prophylaxis against invasive pulmonary aspergillosis caused by A. fumigatus...
  40. pmc In vivo efficacy of anidulafungin and caspofungin against Candida glabrata and association with in vitro potency in the presence of sera
    Nathan P Wiederhold
    UTHSCSA, PERC, MSC 6220, San Antonio, TX 78229, USA
    Antimicrob Agents Chemother 51:1616-20. 2007
    ..The superior in vitro activity of anidulafungin did not confer enhanced in vivo efficacy against C. glabrata...
  41. ncbi request reprint Posaconazole for the treatment of azole-refractory oropharyngeal and esophageal candidiasis in subjects with HIV infection
    Daniel J Skiest
    University of Texas Southwestern Medical Center, Dallas, Texas
    Clin Infect Dis 44:607-14. 2007
    ....
  42. pmc Standardization of an experimental murine model of invasive pulmonary aspergillosis
    Donald C Sheppard
    McGill University, Department of Microbiology and Immunology, Montreal, Quebec, Canada
    Antimicrob Agents Chemother 50:3501-3. 2006
    ....
  43. pmc In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility
    Jason Cota
    University of Texas at Austin College of Pharmacy, UTHSCSA, Clinical Pharmacy, MSC 6220, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Antimicrob Agents Chemother 50:3926-8. 2006
    ..Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs...
  44. pmc Detection of Cryptococcus neoformans DNA in tissue samples by nested and real-time PCR assays
    Ralf Bialek
    Institute for Tropical Medicine, University Hospital Tubingen, Germany
    Clin Diagn Lab Immunol 9:461-9. 2002
    ..The sensitive and specific nested PCR assay as well as the rapid and quantitative LightCycler PCR assay might be useful for the diagnosis and monitoring of human cryptococcal infections...
  45. ncbi request reprint Comparison of staining methods and a nested PCR assay to detect Histoplasma capsulatum in tissue sections
    Ralf Bialek
    Institute for Tropical Medicine, University Hospital Tubingen, Germany
    Am J Clin Pathol 117:597-603. 2002
    ..The Grocott and fluorochrome stains did not differ significantly in detecting fungal elements. The PCR assay unambiguously identified H. capsulatum in tissue sections...
  46. ncbi request reprint Improving the mouse model for studying the efficacy of voriconazole
    John R Graybill
    The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases 7881, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Antimicrob Chemother 51:1373-6. 2003
    ..The mechanism may be inhibition of gut mucosal cytochrome enzymes that rapidly degrade voriconazole in the mouse. These murine studies support expansion of voriconazole therapy in other highly resistant systemic mycoses...
  47. pmc Activity of posaconazole against Pseudallescheria boydii: in vitro and in vivo assays
    Gloria M Gonzalez
    Division of Infectious Diseases 7881, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Antimicrob Agents Chemother 47:1436-8. 2003
    ..Posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the CFU of P. boydii from tissues...
  48. pmc In vitro activity of caspofungin against Candida albicans biofilms
    Stefano P Bachmann
    Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Antimicrob Agents Chemother 46:3591-6. 2002
    ..albicans. Together these findings indicate that caspofungin displays potent activity against C. albicans biofilms in vitro and merits further investigation for the treatment of biofilm-associated infections...
  49. ncbi request reprint Determination of voriconazole in aqueous humor by liquid chromatography-electrospray ionization-mass spectrometry
    Lei Zhou
    Singapore Eye Research Institute, Singapore National Eye Center, Singapore 168751, Singapore
    J Chromatogr B Analyt Technol Biomed Life Sci 776:213-20. 2002
    ..i.d. The lower dosage produced an aqueous humor concentration of 7.29+/-5.84 microg/ml, while the higher dosage produced a concentration of 14.56+/-12.90 microg/ml...
  50. pmc In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model
    Qiu N Sun
    Division of Infectious Disease, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 46:2310-2. 2002
    ..25 to 8 microg/ml, respectively. The in vitro MIC range for amphotericin B is 0.125 to 0.25 microg/ml. At twice-daily doses of >or=15 mg/kg of body weight, posaconazole prolonged the survival of the mice and reduced tissue burden...
  51. pmc In vitro activities of free and lipid formulations of amphotericin B and nystatin against clinical isolates of Coccidioides immitis at various saprobic stages
    Gloria M Gonzalez
    Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 46:1583-5. 2002
    ..These results suggest that either inocula could be used for in vitro susceptibility studies with C. immitis...
  52. pmc In vitro activities of posaconazole, itraconazole, voriconazole, amphotericin B, and fluconazole against 37 clinical isolates of zygomycetes
    Qiu N Sun
    Division of Infectious Diseases 7811, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Antimicrob Agents Chemother 46:1581-2. 2002
    ..25 and 4 microg/ml, respectively. POS was significantly more active than VRC and FLC and slightly more active than ITC. The results suggest that POS has significant potential for clinical development against the zygomycetes...
  53. ncbi request reprint Polymerase chain reaction detection of aspergillus DNA in experimental models of invasive aspergillosis
    Juergen Loeffler
    Medizinische Klinik Abteilung II, University of Tuebingen, Otfried Mueller Strasse 10, 72076 Tuebingen, Germany
    J Infect Dis 185:1203-6. 2002
    ..Quantitative PCR analysis of blood samples showed a fungus load of 10(1)-10(2) cfu/mL of blood. The data confirm the superior sensitivity of PCR for the diagnosis of experimental Aspergillus infections...
  54. pmc Addition of caspofungin to fluconazole does not improve outcome in murine candidiasis
    John R Graybill
    The University of Texas Health Science Center at San Antonio, Department of Medicine, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 47:2373-5. 2003
    ..However, caspofungin is not 100% curative in candidiasis. Therefore, we evaluated combinations of fluconazole with caspofungin for murine candidemia. We could not show any benefit of combined therapy over individual antifungal drugs...
  55. ncbi request reprint Combination antifungal therapy of murine aspergillosis: liposomal amphotericin B and micafungin
    John R Graybill
    The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases 7881, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Antimicrob Chemother 52:656-62. 2003
    ..AmBisome and micafungin were used alone and in combination in a series of studies designed to identify any additive or antagonistic effects of combination antifungal therapy...
  56. ncbi request reprint Refractory coccidioidomycosis treated with posaconazole
    Gregory M Anstead
    University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Clin Infect Dis 40:1770-6. 2005
    ..Drug-associated toxicities also may limit the clinical utility of the standard antifungal drugs. In addition, relapses in patients with disseminated coccidioidomycosis are common, making long-term management of this disease challenging...
  57. pmc Antifungal therapy of experimental cerebral phaeohyphomycosis due to Cladophialophora bantiana
    Hail M Al-Abdely
    Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio, Texas, USA
    Antimicrob Agents Chemother 49:1701-7. 2005
    ..We concluded that posaconazole shows promise for the treatment of C. bantiana brain infections...
  58. pmc Antifungal therapy of murine Aspergillus terreus infection
    John R Graybill
    The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases mail code 7881, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Antimicrob Agents Chemother 48:3715-9. 2004
    ..Caspofungin and posaconazole both appeared beneficial and may be reasonable treatment alternatives for infection with A. terreus...
  59. ncbi request reprint Alternatives to amphotericin B for Candida rugosa infection
    Steve Hernandez
    Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Antimicrob Chemother 54:477-80. 2004
    ..We evaluated amphotericin B, fluconazole, posaconazole and voriconazole as alternative treatments against infection in mice with two isolates of C. rugosa...
  60. pmc Posaconazole therapy of disseminated phaeohyphomycosis in a murine model
    John R Graybill
    Department of Medicine, Division of Infectious Diseases, Medicine ID Mail Code 7881, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Antimicrob Agents Chemother 48:2288-91. 2004
    ..Posaconazole reduced the counts in tissues and prolonged survival. Of particular interest, posaconazole reduced the counts of this neurotropic pathogen in the brain...
  61. pmc Efficacies of amphotericin B (AMB) lipid complex, AMB colloidal dispersion, liposomal AMB, and conventional AMB in treatment of murine coccidioidomycosis
    Gloria M Gonzalez
    Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Antimicrob Agents Chemother 48:2140-3. 2004
    ..003 to 0.0002), the lipid preparations could be administered at higher doses, sterilizing liver and spleen tissues. The efficacies of the lipid preparations were similar in this murine model of coccidioidomycosis...
  62. pmc Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis
    Steve Hernandez
    Department of Medicine, Division Infectious Diseases 7881, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 48:1382-3. 2004
    ..We concluded that there is a correlation between in vivo failure and rising in vitro caspofungin MICs...
  63. pmc Activity of posaconazole combined with amphotericin B against Aspergillus flavus infection in mice: comparative studies in two laboratories
    Laura K Najvar
    Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 48:758-64. 2004
    ..These studies do not confirm the antagonistic interaction of triazoles and polyenes reported by others...
  64. pmc In vitro and in vivo activities of posaconazole against Coccidioides immitis
    Gloria M Gonzalez
    Department of Medicine, Division of Infectious Diseases 7881, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 46:1352-6. 2002
    ..No sterilization of whole spleens and livers from mice treated with ITRA was seen. POSA displayed potent in vivo activity against the two strains of C. immitis tested...
  65. ncbi request reprint Subcutaneous mycoses
    Flavio Queiroz-Telles
    Hospital de Clinicas, Universidade Federal do Parana, Curitiba, PR, Brazil
    Infect Dis Clin North Am 17:59-85, viii. 2003
    ..Diagnosis rests on clinical presentation, histopathology, and culture of the etiologic agents. This article considers sporotrichosis, chromoblastomycosis, and mycetoma...
  66. ncbi request reprint Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt
    Elias J Anaissie
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Clin Infect Dis 43:1031-9. 2006
  67. ncbi request reprint Activity of posaconazole in the treatment of central nervous system fungal infections
    Punnee Pitisuttithum
    Vaccine Trial Centre, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    J Antimicrob Chemother 56:745-55. 2005
    ..In this subanalysis, we report on those subjects in this trial who had a fungal infection that involved the CNS...