Affiliation: University of Massachusetts Medical School
Gravallese E, Schett G. Effects of the IL-23-IL-17 pathway on bone in spondyloarthritis. Nat Rev Rheumatol. 2018;14:631-640 pubmed publisher
..However, the effects of these cytokines on bone cells are complex, and controversy remains regarding their exact roles in the specific bone microenvironments relevant to PsA and AS. ..
Baum R, Gravallese E. Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts. Clin Rev Allergy Immunol. 2016;51:1-15 pubmed publisher
..These pathways provide potential novel approaches for therapeutic intervention in diseases in which inflammation impacts bone. ..
Shaw A, Gravallese E. Mediators of inflammation and bone remodeling in rheumatic disease. Semin Cell Dev Biol. 2016;49:2-10 pubmed publisher
Shaw A, Maeda Y, Gravallese E. IL-17A deficiency promotes periosteal bone formation in a model of inflammatory arthritis. Arthritis Res Ther. 2016;18:104 pubmed publisher
..These results demonstrate that additional studies focusing on the role of IL-17A in bone formation in spondyloarthritis are indicated. ..
Stavre Z, Upchurch K, Kay J, Gravallese E. Differential Effects of Inflammation on Bone and Response to Biologics in Rheumatoid Arthritis and Spondyloarthritis. Curr Rheumatol Rep. 2016;18:72 pubmed publisher
..Here, we discuss the similarities and differences among biologic therapies as they pertain to radiographic progression. ..
Baum R, Sharma S, Carpenter S, Li Q, Busto P, Fitzgerald K, et al
. Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice. J Immunol. 2015;194:873-7 pubmed publisher
..Collectively, these data support distinct roles for cytosolic and endosomal nucleic acid-sensing pathways in disease manifestations. ..
Shim J, Stavre Z, Gravallese E. Bone Loss in Rheumatoid Arthritis: Basic Mechanisms and Clinical Implications. Calcif Tissue Int. 2018;102:533-546 pubmed publisher
..As new agents are introduced to control inflammation in RA, and novel mechanisms to target synovitis are identified, it may be possible in the future to fully repair damaged bone. ..