J J Grantham

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. pmc Detected renal cysts are tips of the iceberg in adults with ADPKD
    Jared J Grantham
    Department of Internal Medicine, Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 7:1087-93. 2012
  2. ncbi request reprint Return of the secretory kidney
    Jared J Grantham
    Kidney Institute, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Physiol Renal Physiol 282:F1-9. 2002
  3. ncbi request reprint Volume progression in polycystic kidney disease
    Jared J Grantham
    Kidney Institute and the Department of Internal Medicine, Kansas University Medical Center, Kansas City, KS 66160, USA
    N Engl J Med 354:2122-30. 2006
  4. ncbi request reprint Does extended-release somatostatin slow the growth of renal cysts in autosomal-dominant polycystic kidney disease?
    Jared J Grantham
    Kansas University Medical Center, Kansas City, KS 66160, USA
    Nat Clin Pract Nephrol 2:66-7. 2006
  5. ncbi request reprint Volume progression in autosomal dominant polycystic kidney disease: the major factor determining clinical outcomes
    Jared J Grantham
    Kansas University Medical Center, Kansas City, Kansas, USA
    Clin J Am Soc Nephrol 1:148-57. 2006
  6. pmc The Jeremiah Metzger Lecture. Polycystic kidney disease: old disease in a new context
    Jared J Grantham
    Kidney Institute, Departments of Internal Medicine, Biochemistry and Molecular Biology, Kansas University Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Trans Am Clin Climatol Assoc 113:211-24; discussion 224-6. 2002
  7. pmc Determinants of renal volume in autosomal-dominant polycystic kidney disease
    J J Grantham
    Department of Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Kidney Int 73:108-16. 2008
  8. doi request reprint Clinical practice. Autosomal dominant polycystic kidney disease
    Jared J Grantham
    Kidney Institute and the Department of Internal Medicine, Kansas University Medical Center, Kansas City, KS 66160, USA
    N Engl J Med 359:1477-85. 2008
  9. pmc Evidence of extraordinary growth in the progressive enlargement of renal cysts
    Jared J Grantham
    Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 5:889-96. 2010
  10. ncbi request reprint Polycystic kidney disease: from the bedside to the gene and back
    J J Grantham
    Department of Internal Medicine, Biochemistry and Molecular Biology, Kidney Institute, Kansas University Medical Center, Kansas City, Kansas, USA
    Curr Opin Nephrol Hypertens 10:533-42. 2001

Research Grants

Collaborators

Detail Information

Publications45

  1. pmc Detected renal cysts are tips of the iceberg in adults with ADPKD
    Jared J Grantham
    Department of Internal Medicine, Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 7:1087-93. 2012
    ..The total cyst load and range of cyst diameters are unknown. The purpose of this study was to quantify the total number and range of diameters of individual cysts in adults with preserved GFR...
  2. ncbi request reprint Return of the secretory kidney
    Jared J Grantham
    Kidney Institute, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Physiol Renal Physiol 282:F1-9. 2002
    ....
  3. ncbi request reprint Volume progression in polycystic kidney disease
    Jared J Grantham
    Kidney Institute and the Department of Internal Medicine, Kansas University Medical Center, Kansas City, KS 66160, USA
    N Engl J Med 354:2122-30. 2006
    ..Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of cyst-filled kidneys...
  4. ncbi request reprint Does extended-release somatostatin slow the growth of renal cysts in autosomal-dominant polycystic kidney disease?
    Jared J Grantham
    Kansas University Medical Center, Kansas City, KS 66160, USA
    Nat Clin Pract Nephrol 2:66-7. 2006
  5. ncbi request reprint Volume progression in autosomal dominant polycystic kidney disease: the major factor determining clinical outcomes
    Jared J Grantham
    Kansas University Medical Center, Kansas City, Kansas, USA
    Clin J Am Soc Nephrol 1:148-57. 2006
    ....
  6. pmc The Jeremiah Metzger Lecture. Polycystic kidney disease: old disease in a new context
    Jared J Grantham
    Kidney Institute, Departments of Internal Medicine, Biochemistry and Molecular Biology, Kansas University Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Trans Am Clin Climatol Assoc 113:211-24; discussion 224-6. 2002
    ..The chromosomal location of the major ADPKD genotype, PKD1, was defined in 1985 (3), a date that marks the beginning of a remarkable period of discovery...
  7. pmc Determinants of renal volume in autosomal-dominant polycystic kidney disease
    J J Grantham
    Department of Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Kidney Int 73:108-16. 2008
    ..The good fit between the exponential models and the extrapolated CRISP data indicates that the TCV growth rate is a defining trait for individual patients and may be used as a prognostic marker...
  8. doi request reprint Clinical practice. Autosomal dominant polycystic kidney disease
    Jared J Grantham
    Kidney Institute and the Department of Internal Medicine, Kansas University Medical Center, Kansas City, KS 66160, USA
    N Engl J Med 359:1477-85. 2008
  9. pmc Evidence of extraordinary growth in the progressive enlargement of renal cysts
    Jared J Grantham
    Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 5:889-96. 2010
    ..In adults, the combined renal cyst component enlarges at approximately 12%/yr by growth of individual cysts. To explore this discrepancy, the growth rates of individual cysts were determined in adult polycystic kidneys...
  10. ncbi request reprint Polycystic kidney disease: from the bedside to the gene and back
    J J Grantham
    Department of Internal Medicine, Biochemistry and Molecular Biology, Kidney Institute, Kansas University Medical Center, Kansas City, Kansas, USA
    Curr Opin Nephrol Hypertens 10:533-42. 2001
    ..Were I the editor, this entire celebratory volume would be used to extol the thrilling growth of knowledge during the tenure of this polycystic kidney disease watcher...
  11. ncbi request reprint Lillian Jean Kaplan International Prize for advancement in the understanding of polycystic kidney disease. Understanding polycystic kidney disease: a systems biology approach
    Jared J Grantham
    Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Kidney Int 64:1157-62. 2003
    ....
  12. doi request reprint Why kidneys fail in autosomal dominant polycystic kidney disease
    Jared J Grantham
    The Kidney Institute, Department of Medicine, 3901 Rainbow Boulevard, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Nat Rev Nephrol 7:556-66. 2011
    ....
  13. ncbi request reprint cAMP-dependent fluid secretion in rat inner medullary collecting ducts
    D P Wallace
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Physiol Renal Physiol 280:F1019-29. 2001
    ..We suggest that salt and fluid secretion by the terminal portions of the renal collecting system may have a role in modulating the composition and volume of the final urine...
  14. ncbi request reprint Autosomal recessive polycystic kidney disease in a murine model. A gross and microscopic description
    V H Gattone
    Department of Anatomy, University of Kansas Medical Center, Kansas City
    Lab Invest 59:231-8. 1988
    ..Therefore, the degree of cell proliferation necessary to allow the observed tubular enlargement appears to be minimal...
  15. ncbi request reprint Sequential protooncogene expression in regenerating kidney following acute renal injury
    B D Cowley
    Department of Medicine, University of Kansas Medical Center, Kansas City 66103
    J Biol Chem 264:8389-93. 1989
    ..Further studies of the molecular correlates of acute renal injury may yield insight into the pathogenesis of this and other clinically important renal disorders...
  16. pmc Elevated c-myc protooncogene expression in autosomal recessive polycystic kidney disease
    B D Cowley
    Department of Medicine, University of Kansas Medical Center, Kansas City 66103
    Proc Natl Acad Sci U S A 84:8394-8. 1987
    ..Thus, the level of c-myc expression in cystic kidneys appears to be out of proportion to the rate of cell division, suggesting that elevated and potentially abnormal c-myc expression may be involved in the pathogenesis of PKD...
  17. ncbi request reprint Matrix metalloproteinases and TIMPS in cultured C57BL/6J-cpk kidney tubules
    C A Rankin
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, USA
    Kidney Int 50:835-44. 1996
    ..These data suggest that cystic kidney tubules synthesize and secrete high levels of MMPs which may then participate in the restructuring of the tubular basement membrane...
  18. ncbi request reprint Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype
    Tamio Yamaguchi
    Department of Biochemistry, The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 279:40419-30. 2004
    ..We conclude that disruption of calcium mobilization in cells that are normally growth-inhibited by cAMP can derepress the B-Raf/ERK pathway, thus converting these cells to a phenotype that is growth-stimulated by cAMP...
  19. ncbi request reprint A synthetic channel-forming peptide induces Cl(-) secretion: modulation by Ca(2+)-dependent K(+) channels
    D P Wallace
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7401, USA
    Biochim Biophys Acta 1464:69-82. 2000
    ....
  20. ncbi request reprint The genetics and physiology of polycystic kidney disease
    J P Calvet
    Department of Biochemistry, Kidney Institute, University of Kansas Medical Center, Kansas City, KS, USA
    Semin Nephrol 21:107-23. 2001
    ..This knowledge should facilitate the discovery of inhibitors of signal transduction cascades that can be used in the treatment of ADPKD...
  21. ncbi request reprint Polycystin-1 transforms the cAMP growth-responsive phenotype of M-1 cells
    M Sutters
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160-7421, USA
    Kidney Int 60:484-94. 2001
    ..CONCLUSIONS: Expression of the polycystin-1 C-terminal tail disrupts normal cellular signaling and transforms the stably transfected M-1 cells to an abnormal PKD cell proliferation phenotype...
  22. ncbi request reprint The effect of caffeine on renal epithelial cells from patients with autosomal dominant polycystic kidney disease
    Franck A Belibi
    Kidney Institute, Department of Medicine, University of Kansas Medical Center, Kansas City 66160, USA
    J Am Soc Nephrol 13:2723-9. 2002
    ..Caffeine is, therefore, a risk factor for the promotion of cyst enlargement in patients with ADPKD...
  23. ncbi request reprint Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells
    Franck A Belibi
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160 7382, USA
    Kidney Int 66:964-73. 2004
    ..This study determined if common receptor-mediated agonists and an anonymous lipid stimulate the production of 3' 5'-cyclic monophosphate (cAMP) in mural epithelial cells from the two major types of human cystic diseases...
  24. ncbi request reprint Electrolyte and fluid secretion by cultured human inner medullary collecting duct cells
    Darren P Wallace
    Kidney Institute and Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Physiol Renal Physiol 283:F1337-50. 2002
    ..We suggest that salt secretion at specialized sites along human collecting ducts may be important in the formation of the final urine...
  25. pmc Water prescription in autosomal dominant polycystic kidney disease: a pilot study
    Connie J Wang
    Division of Nephrology and Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA
    Clin J Am Soc Nephrol 6:192-7. 2011
    ..In this study, a simple method to quantify the amount of water to achieve a specific mean urine osmolality target in patients with ADPKD was developed and tested...
  26. ncbi request reprint Sulfonylurea-sensitive K(+) transport is involved in Cl(-) secretion and cyst trowth by cultured ADPKD cells
    Lawrence P Sullivan
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City 66160, USA
    J Am Soc Nephrol 13:2619-27. 2002
    ..2, is expressed in cultured ADPKD cells and in normal human kidney. These results suggest that ATP-sensitive K(+) channel blockers should be investigated as possible therapeutic agents to inhibit cyst growth in ADPKD...
  27. ncbi request reprint CRISP: opening a new frontier in the diagnosis and treatment of PKD
    Jared J Grantham
    Kidney Institute and Department of Internal Medicine, Kansas University Medical Center, Kansas City, USA
    Nephrol News Issues 20:29-30. 2006
  28. ncbi request reprint Sonographic assessment of the severity and progression of autosomal dominant polycystic kidney disease: the Consortium of Renal Imaging Studies in Polycystic Kidney Disease (CRISP)
    W CHARLES O'NEILL
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Am J Kidney Dis 46:1058-64. 2005
    ..The accuracy and precision of ultrasonography (US) in assessing the severity of autosomal dominant polycystic kidney disease (ADPKD) is unknown...
  29. ncbi request reprint Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease
    Shizuko Nagao
    The Kidney Institute, Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Kidney Int 63:427-37. 2003
    ..To determine the extent to which this signaling pathway is involved in cyst pathogenesis in vivo, we measured the expression of select components of the MAP kinase cascade in Han:SPRD rats with ADPKD at an early stage of the disease...
  30. ncbi request reprint Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na(+),K(+),2Cl(-) Co-transporter-dependent cystic dilation
    Brenda S Magenheimer
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Am Soc Nephrol 17:3424-37. 2006
    ....
  31. ncbi request reprint Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys
    Tamio Yamaguchi
    Kidney Institute, Kansas University Medical Center, Kansas City, Kansas 66160 7382, USA
    Kidney Int 63:1983-94. 2003
    ..In the current study, we examined the signaling pathway between PKA and MEK in ADPKD and HKC cells...
  32. ncbi request reprint Localization of overexpressed c-myc mRNA in polycystic kidneys of the cpk mouse
    M A Harding
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City
    Kidney Int 41:317-25. 1992
    ....
  33. ncbi request reprint Identification of a forskolin-like molecule in human renal cysts
    William C Putnam
    Midwest Research Institute, Kansas City, Missouri, USA
    J Am Soc Nephrol 18:934-43. 2007
    ..It is concluded that forskolin may have a role in promoting the enlargement of cysts in autosomal dominant PKD and recommended that patients avoid oral and parenteral preparations that contain this compound...
  34. ncbi request reprint Urinary excretion of monocyte chemoattractant protein-1 in autosomal dominant polycystic kidney disease
    Danxia Zheng
    Kidney Institute, Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Am Soc Nephrol 14:2588-95. 2003
    ..It is reasonable to include urine MCP-1 excretion among candidate surrogate markers in controlled, longitudinal studies of ADPKD...
  35. pmc Characterization of large rearrangements in autosomal dominant polycystic kidney disease and the PKD1/TSC2 contiguous gene syndrome
    Mark B Consugar
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 74:1468-79. 2008
    ..Our assay improves detection levels and the reliability of molecular testing of patients with ADPKD...
  36. ncbi request reprint Therapy for polycystic kidney disease? It's water, stupid!
    Jared J Grantham
    J Am Soc Nephrol 19:1-7. 2008
  37. ncbi request reprint Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys
    Erik M Schwiebert
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Renal Physiol 282:F763-75. 2002
    ..Therefore, we hypothesize that autocrine purinergic signaling may augment detrimentally cyst volume expansion in ADPKD or tubule dilation in ARPKD, accelerating disease progression...
  38. ncbi request reprint Magnetic resonance measurements of renal blood flow and disease progression in autosomal dominant polycystic kidney disease
    Vicente E Torres
    Mayo Clinic College of Medicine, Rochester, MN 55901, USA
    Clin J Am Soc Nephrol 2:112-20. 2007
    ..TKV and RBF were independent predictors of GFR decline (functional disease progression). In ADPKD, RBF reduction (1) parallels TKV increase, (2) precedes GFR decline, and (3) predicts structural and functional disease progression...
  39. ncbi request reprint Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort
    Arlene B Chapman
    Department of Medicine Renal Division, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Kidney Int 64:1035-45. 2003
    ....
  40. ncbi request reprint Comparison of methods for determining renal function decline in early autosomal dominant polycystic kidney disease: the consortium of radiologic imaging studies of polycystic kidney disease cohort
    Andrew D Rule
    Division of Nephrology, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, and University of Alabama, Birmingham, USA
    J Am Soc Nephrol 17:854-62. 2006
    ..Misclassification from changes in non-GFR factors (e.g., creatinine production, tubular secretion) conservatively biased associations with eGFR. Misclassification from method imprecision attenuated associations with creatinine clearance...
  41. ncbi request reprint Magnetic resonance measurements of renal blood flow as a marker of disease severity in autosomal-dominant polycystic kidney disease
    Bernard F King
    Department of Medicine Renal Division, University of Alabama, Birmingham, Alabama, USA
    Kidney Int 64:2214-21. 2003
    ..Despite evidence for the importance of nephroangiosclerosis in the progression of renal insufficiency in ADPKD, evaluation of renal blood flow (RBF) as a surrogate marker of disease severity has received little attention...
  42. ncbi request reprint Comprehensive molecular diagnostics in autosomal dominant polycystic kidney disease
    Sandro Rossetti
    Division of Nephrology, Mayo Clinic, Rochester, MN 55905, USA
    J Am Soc Nephrol 18:2143-60. 2007
    ..Although nondefinite mutation data must be treated with care in the clinical setting, this study shows the potential for molecular diagnostics in ADPKD that is likely to become increasingly important as therapies become available...
  43. ncbi request reprint Cyst number but not the rate of cystic growth is associated with the mutated gene in autosomal dominant polycystic kidney disease
    Peter C Harris
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Am Soc Nephrol 17:3013-9. 2006
    ..These insights will inform the development of targeted therapies in autosomal dominant PKD...
  44. ncbi request reprint Secretion of cytokines and growth factors into autosomal dominant polycystic kidney disease liver cyst fluid
    Matthew T Nichols
    Division of Gastroenterology, University of Colorado Health Sciences Center, Denver, CO, USA
    Hepatology 40:836-46. 2004
    ..Interruption of these signaling pathways may provide therapeutic targets for inhibiting liver cyst expansion...
  45. ncbi request reprint Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort
    Kyongtae T Bae
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin J Am Soc Nephrol 1:64-9. 2006
    ..Hepatic cysts are more prevalent and larger in total cyst volume in women than in men. Hepatic cyst prevalence and aggregate total hepatic cyst volume increased with age...

Research Grants2

  1. Kansas Polycystic Kidney Imaging Program (CRISPII)
    Jared Grantham; Fiscal Year: 2007
    ....