J J Grantham

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. ncbi Detected renal cysts are tips of the iceberg in adults with ADPKD
    Jared J Grantham
    Department of Internal Medicine, Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 7:1087-93. 2012
  2. ncbi The Jeremiah Metzger Lecture. Polycystic kidney disease: old disease in a new context
    Jared J Grantham
    Kidney Institute, Departments of Internal Medicine, Biochemistry and Molecular Biology, Kansas University Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Trans Am Clin Climatol Assoc 113:211-24; discussion 224-6. 2002
  3. ncbi Does extended-release somatostatin slow the growth of renal cysts in autosomal-dominant polycystic kidney disease?
    Jared J Grantham
    Kansas University Medical Center, Kansas City, KS 66160, USA
    Nat Clin Pract Nephrol 2:66-7. 2006
  4. ncbi Volume progression in autosomal dominant polycystic kidney disease: the major factor determining clinical outcomes
    Jared J Grantham
    Kansas University Medical Center, Kansas City, Kansas, USA
    Clin J Am Soc Nephrol 1:148-57. 2006
  5. ncbi Determinants of renal volume in autosomal-dominant polycystic kidney disease
    J J Grantham
    Department of Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Kidney Int 73:108-16. 2008
  6. ncbi Lillian Jean Kaplan International Prize for advancement in the understanding of polycystic kidney disease. Understanding polycystic kidney disease: a systems biology approach
    Jared J Grantham
    Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Kidney Int 64:1157-62. 2003
  7. ncbi Clinical practice. Autosomal dominant polycystic kidney disease
    Jared J Grantham
    Kidney Institute and the Department of Internal Medicine, Kansas University Medical Center, Kansas City, KS 66160, USA
    N Engl J Med 359:1477-85. 2008
  8. ncbi Evidence of extraordinary growth in the progressive enlargement of renal cysts
    Jared J Grantham
    Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 5:889-96. 2010
  9. ncbi Volume progression in polycystic kidney disease
    Jared J Grantham
    Kidney Institute and the Department of Internal Medicine, Kansas University Medical Center, Kansas City, KS 66160, USA
    N Engl J Med 354:2122-30. 2006
  10. ncbi Why kidneys fail in autosomal dominant polycystic kidney disease
    Jared J Grantham
    The Kidney Institute, Department of Medicine, 3901 Rainbow Boulevard, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Nat Rev Nephrol 7:556-66. 2011

Research Grants

  1. Kansas Polycystic Kidney Imaging Program (CRISPII)
    Jared Grantham; Fiscal Year: 2007

Collaborators

Detail Information

Publications43

  1. ncbi Detected renal cysts are tips of the iceberg in adults with ADPKD
    Jared J Grantham
    Department of Internal Medicine, Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 7:1087-93. 2012
    ..The total cyst load and range of cyst diameters are unknown. The purpose of this study was to quantify the total number and range of diameters of individual cysts in adults with preserved GFR...
  2. ncbi The Jeremiah Metzger Lecture. Polycystic kidney disease: old disease in a new context
    Jared J Grantham
    Kidney Institute, Departments of Internal Medicine, Biochemistry and Molecular Biology, Kansas University Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Trans Am Clin Climatol Assoc 113:211-24; discussion 224-6. 2002
    ..The chromosomal location of the major ADPKD genotype, PKD1, was defined in 1985 (3), a date that marks the beginning of a remarkable period of discovery...
  3. ncbi Does extended-release somatostatin slow the growth of renal cysts in autosomal-dominant polycystic kidney disease?
    Jared J Grantham
    Kansas University Medical Center, Kansas City, KS 66160, USA
    Nat Clin Pract Nephrol 2:66-7. 2006
  4. ncbi Volume progression in autosomal dominant polycystic kidney disease: the major factor determining clinical outcomes
    Jared J Grantham
    Kansas University Medical Center, Kansas City, Kansas, USA
    Clin J Am Soc Nephrol 1:148-57. 2006
    ....
  5. ncbi Determinants of renal volume in autosomal-dominant polycystic kidney disease
    J J Grantham
    Department of Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Kidney Int 73:108-16. 2008
    ..The good fit between the exponential models and the extrapolated CRISP data indicates that the TCV growth rate is a defining trait for individual patients and may be used as a prognostic marker...
  6. ncbi Lillian Jean Kaplan International Prize for advancement in the understanding of polycystic kidney disease. Understanding polycystic kidney disease: a systems biology approach
    Jared J Grantham
    Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Kidney Int 64:1157-62. 2003
    ....
  7. ncbi Clinical practice. Autosomal dominant polycystic kidney disease
    Jared J Grantham
    Kidney Institute and the Department of Internal Medicine, Kansas University Medical Center, Kansas City, KS 66160, USA
    N Engl J Med 359:1477-85. 2008
  8. ncbi Evidence of extraordinary growth in the progressive enlargement of renal cysts
    Jared J Grantham
    Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 5:889-96. 2010
    ..In adults, the combined renal cyst component enlarges at approximately 12%/yr by growth of individual cysts. To explore this discrepancy, the growth rates of individual cysts were determined in adult polycystic kidneys...
  9. ncbi Volume progression in polycystic kidney disease
    Jared J Grantham
    Kidney Institute and the Department of Internal Medicine, Kansas University Medical Center, Kansas City, KS 66160, USA
    N Engl J Med 354:2122-30. 2006
    ..Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of cyst-filled kidneys...
  10. ncbi Why kidneys fail in autosomal dominant polycystic kidney disease
    Jared J Grantham
    The Kidney Institute, Department of Medicine, 3901 Rainbow Boulevard, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Nat Rev Nephrol 7:556-66. 2011
    ....
  11. ncbi Polycystic kidney disease: from the bedside to the gene and back
    J J Grantham
    Department of Internal Medicine, Biochemistry and Molecular Biology, Kidney Institute, Kansas University Medical Center, Kansas City, Kansas, USA
    Curr Opin Nephrol Hypertens 10:533-42. 2001
    ..Were I the editor, this entire celebratory volume would be used to extol the thrilling growth of knowledge during the tenure of this polycystic kidney disease watcher...
  12. ncbi Return of the secretory kidney
    Jared J Grantham
    Kidney Institute, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Physiol Renal Physiol 282:F1-9. 2002
    ....
  13. ncbi cAMP-dependent fluid secretion in rat inner medullary collecting ducts
    D P Wallace
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Physiol Renal Physiol 280:F1019-29. 2001
    ..We suggest that salt and fluid secretion by the terminal portions of the renal collecting system may have a role in modulating the composition and volume of the final urine...
  14. ncbi Autosomal recessive polycystic kidney disease in a murine model. A gross and microscopic description
    V H Gattone
    Department of Anatomy, University of Kansas Medical Center, Kansas City
    Lab Invest 59:231-8. 1988
    ..Therefore, the degree of cell proliferation necessary to allow the observed tubular enlargement appears to be minimal...
  15. ncbi Matrix metalloproteinases and TIMPS in cultured C57BL/6J-cpk kidney tubules
    C A Rankin
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, USA
    Kidney Int 50:835-44. 1996
    ..These data suggest that cystic kidney tubules synthesize and secrete high levels of MMPs which may then participate in the restructuring of the tubular basement membrane...
  16. ncbi Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype
    Tamio Yamaguchi
    Department of Biochemistry, The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 279:40419-30. 2004
    ..We conclude that disruption of calcium mobilization in cells that are normally growth-inhibited by cAMP can derepress the B-Raf/ERK pathway, thus converting these cells to a phenotype that is growth-stimulated by cAMP...
  17. ncbi Polycystin-1 transforms the cAMP growth-responsive phenotype of M-1 cells
    M Sutters
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160-7421, USA
    Kidney Int 60:484-94. 2001
    ..CONCLUSIONS: Expression of the polycystin-1 C-terminal tail disrupts normal cellular signaling and transforms the stably transfected M-1 cells to an abnormal PKD cell proliferation phenotype...
  18. ncbi The genetics and physiology of polycystic kidney disease
    J P Calvet
    Department of Biochemistry, Kidney Institute, University of Kansas Medical Center, Kansas City, KS, USA
    Semin Nephrol 21:107-23. 2001
    ..This knowledge should facilitate the discovery of inhibitors of signal transduction cascades that can be used in the treatment of ADPKD...
  19. ncbi A synthetic channel-forming peptide induces Cl(-) secretion: modulation by Ca(2+)-dependent K(+) channels
    D P Wallace
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7401, USA
    Biochim Biophys Acta 1464:69-82. 2000
    ....
  20. ncbi The effect of caffeine on renal epithelial cells from patients with autosomal dominant polycystic kidney disease
    Franck A Belibi
    Kidney Institute, Department of Medicine, University of Kansas Medical Center, Kansas City 66160, USA
    J Am Soc Nephrol 13:2723-9. 2002
    ..Caffeine is, therefore, a risk factor for the promotion of cyst enlargement in patients with ADPKD...
  21. ncbi Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells
    Franck A Belibi
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160-7382, USA
    Kidney Int 66:964-73. 2004
    ..We suggest that increased levels of cAMP may accelerate cyst growth and overall renal enlargement in patients with PKD...
  22. ncbi Water prescription in autosomal dominant polycystic kidney disease: a pilot study
    Connie J Wang
    Division of Nephrology and Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA
    Clin J Am Soc Nephrol 6:192-7. 2011
    ..In this study, a simple method to quantify the amount of water to achieve a specific mean urine osmolality target in patients with ADPKD was developed and tested...
  23. ncbi Electrolyte and fluid secretion by cultured human inner medullary collecting duct cells
    Darren P Wallace
    Kidney Institute and Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Physiol Renal Physiol 283:F1337-50. 2002
    ..We suggest that salt secretion at specialized sites along human collecting ducts may be important in the formation of the final urine...
  24. ncbi Sulfonylurea-sensitive K(+) transport is involved in Cl(-) secretion and cyst trowth by cultured ADPKD cells
    Lawrence P Sullivan
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City 66160, USA
    J Am Soc Nephrol 13:2619-27. 2002
    ..2, is expressed in cultured ADPKD cells and in normal human kidney. These results suggest that ATP-sensitive K(+) channel blockers should be investigated as possible therapeutic agents to inhibit cyst growth in ADPKD...
  25. ncbi Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na(+),K(+),2Cl(-) Co-transporter-dependent cystic dilation
    Brenda S Magenheimer
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Am Soc Nephrol 17:3424-37. 2006
    ....
  26. ncbi CRISP: opening a new frontier in the diagnosis and treatment of PKD
    Jared J Grantham
    Kidney Institute and Department of Internal Medicine, Kansas University Medical Center, Kansas City, USA
    Nephrol News Issues 20:29-30. 2006
  27. ncbi Sonographic assessment of the severity and progression of autosomal dominant polycystic kidney disease: the Consortium of Renal Imaging Studies in Polycystic Kidney Disease (CRISP)
    W CHARLES O'NEILL
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Am J Kidney Dis 46:1058-64. 2005
    ..The accuracy and precision of ultrasonography (US) in assessing the severity of autosomal dominant polycystic kidney disease (ADPKD) is unknown...
  28. ncbi Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease
    Shizuko Nagao
    The Kidney Institute, Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Kidney Int 63:427-37. 2003
    ..We suggest that cAMP, acting through PKA, Rap-1 and B-Raf, may contribute to the activation of ERK in a way that complements receptor tyrosine kinase-mediated agonists in the promotion of cyst enlargement...
  29. ncbi Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys
    Tamio Yamaguchi
    Kidney Institute, Kansas University Medical Center, Kansas City, Kansas 66160 7382, USA
    Kidney Int 63:1983-94. 2003
    ..In the current study, we examined the signaling pathway between PKA and MEK in ADPKD and HKC cells...
  30. ncbi Localization of overexpressed c-myc mRNA in polycystic kidneys of the cpk mouse
    M A Harding
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City
    Kidney Int 41:317-25. 1992
    ....
  31. ncbi Urinary excretion of monocyte chemoattractant protein-1 in autosomal dominant polycystic kidney disease
    Danxia Zheng
    Kidney Institute, Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Am Soc Nephrol 14:2588-95. 2003
    ..It is reasonable to include urine MCP-1 excretion among candidate surrogate markers in controlled, longitudinal studies of ADPKD...
  32. ncbi Identification of a forskolin-like molecule in human renal cysts
    William C Putnam
    Midwest Research Institute, Kansas City, Missouri, USA
    J Am Soc Nephrol 18:934-43. 2007
    ..It is concluded that forskolin may have a role in promoting the enlargement of cysts in autosomal dominant PKD and recommended that patients avoid oral and parenteral preparations that contain this compound...
  33. ncbi Characterization of large rearrangements in autosomal dominant polycystic kidney disease and the PKD1/TSC2 contiguous gene syndrome
    Mark B Consugar
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 74:1468-79. 2008
    ..Our assay improves detection levels and the reliability of molecular testing of patients with ADPKD...
  34. ncbi Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys
    Erik M Schwiebert
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Renal Physiol 282:F763-75. 2002
    ..Therefore, we hypothesize that autocrine purinergic signaling may augment detrimentally cyst volume expansion in ADPKD or tubule dilation in ARPKD, accelerating disease progression...
  35. ncbi Therapy for polycystic kidney disease? It's water, stupid!
    Jared J Grantham
    J Am Soc Nephrol 19:1-7. 2008
  36. ncbi Comparison of methods for determining renal function decline in early autosomal dominant polycystic kidney disease: the consortium of radiologic imaging studies of polycystic kidney disease cohort
    Andrew D Rule
    Division of Nephrology, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, and University of Alabama, Birmingham, USA
    J Am Soc Nephrol 17:854-62. 2006
    ..Misclassification from changes in non-GFR factors (e.g., creatinine production, tubular secretion) conservatively biased associations with eGFR. Misclassification from method imprecision attenuated associations with creatinine clearance...
  37. ncbi Magnetic resonance measurements of renal blood flow and disease progression in autosomal dominant polycystic kidney disease
    Vicente E Torres
    Mayo Clinic College of Medicine, Rochester, MN 55901, USA
    Clin J Am Soc Nephrol 2:112-20. 2007
    ..TKV and RBF were independent predictors of GFR decline (functional disease progression). In ADPKD, RBF reduction (1) parallels TKV increase, (2) precedes GFR decline, and (3) predicts structural and functional disease progression...
  38. ncbi Magnetic resonance measurements of renal blood flow as a marker of disease severity in autosomal-dominant polycystic kidney disease
    Bernard F King
    Department of Medicine (Renal Division, University of Alabama, Birmingham, Alabama, USA
    Kidney Int 64:2214-21. 2003
    ....
  39. ncbi Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort
    Arlene B Chapman
    Department of Medicine Renal Division, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Kidney Int 64:1035-45. 2003
    ....
  40. ncbi Comprehensive molecular diagnostics in autosomal dominant polycystic kidney disease
    Sandro Rossetti
    Division of Nephrology, Mayo Clinic, Rochester, MN 55905, USA
    J Am Soc Nephrol 18:2143-60. 2007
    ..Although nondefinite mutation data must be treated with care in the clinical setting, this study shows the potential for molecular diagnostics in ADPKD that is likely to become increasingly important as therapies become available...
  41. ncbi Secretion of cytokines and growth factors into autosomal dominant polycystic kidney disease liver cyst fluid
    Matthew T Nichols
    Division of Gastroenterology, University of Colorado Health Sciences Center, Denver, CO, USA
    Hepatology 40:836-46. 2004
    ..Interruption of these signaling pathways may provide therapeutic targets for inhibiting liver cyst expansion...
  42. ncbi Cyst number but not the rate of cystic growth is associated with the mutated gene in autosomal dominant polycystic kidney disease
    Peter C Harris
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Am Soc Nephrol 17:3013-9. 2006
    ..These insights will inform the development of targeted therapies in autosomal dominant PKD...
  43. ncbi Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort
    Kyongtae T Bae
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin J Am Soc Nephrol 1:64-9. 2006
    ..Hepatic cysts are more prevalent and larger in total cyst volume in women than in men. Hepatic cyst prevalence and aggregate total hepatic cyst volume increased with age...

Research Grants2

  1. Kansas Polycystic Kidney Imaging Program (CRISPII)
    Jared Grantham; Fiscal Year: 2007
    ....