William B Grant

Summary

Affiliation: University of Guelph
Country: USA

Publications

  1. ncbi request reprint An ecologic study of dietary and solar ultraviolet-B links to breast carcinoma mortality rates
    William B Grant
    Newport News, Virginia, USA
    Cancer 94:272-81. 2002
  2. ncbi request reprint An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation
    William B Grant
    Cancer 94:1867-75. 2002
  3. ncbi request reprint The significance of environmental factors in the etiology of Alzheimer's disease
    William B Grant
    12 Sir Francis Wyatt Place, Newport News, VA 23606 3660, USA
    J Alzheimers Dis 4:179-89. 2002
  4. ncbi request reprint A multicountry ecologic study of risk and risk reduction factors for prostate cancer mortality
    William B Grant
    12 Sir Francis Wyatt Place, Newport News, VA 23606 3660, USA
    Eur Urol 45:271-9. 2004
  5. ncbi request reprint Differences in vitamin-D status may explain black-white differences in breast cancer survival rates
    William B Grant
    J Natl Med Assoc 100:1040. 2008
  6. ncbi request reprint Re: Cancer as a risk factor for long-term cognitive deficits and dementia
    William B Grant
    J Natl Cancer Inst 97:1549; author reply 1550. 2005
  7. ncbi request reprint Re: Fruit and vegetable intake and risk of major chronic disease
    William B Grant
    J Natl Cancer Inst 97:608; author reply 608-9. 2005
  8. pmc Lower vitamin-D production from solar ultraviolet-B irradiance may explain some differences in cancer survival rates
    William B Grant
    Sunlight, Nutrition and Health Research Center, San Francisco, CA 94109 2529, USA
    J Natl Med Assoc 98:357-64. 2006
  9. ncbi request reprint The likely role of vitamin D from solar ultraviolet-B irradiance in increasing cancer survival
    William B Grant
    Sunlight, Nutrition and Health Research Center SUNARC, San Francisco, CA 94109 2529, USA
    Anticancer Res 26:2605-14. 2006
  10. ncbi request reprint The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates
    William B Grant
    Sunlight, Nutrition and Health Research Center SUNARC, 2107 Van Ness Avenue, Suite 403B, San Francisco, CA 94109 2529, USA
    Anticancer Res 26:2687-99. 2006

Collaborators

Detail Information

Publications50

  1. ncbi request reprint An ecologic study of dietary and solar ultraviolet-B links to breast carcinoma mortality rates
    William B Grant
    Newport News, Virginia, USA
    Cancer 94:272-81. 2002
    ..Case-control and cohort studies generally find a variety of chemical, nonfat dietary, environmental, genetic, lifestyle, and reproductive factors to be important...
  2. ncbi request reprint An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation
    William B Grant
    Cancer 94:1867-75. 2002
    ..The purpose of the current study was to determine how many types of cancer are affected by solar radiation and how many premature deaths from cancer occur due to insufficient ultraviolet (UV)-B radiation...
  3. ncbi request reprint The significance of environmental factors in the etiology of Alzheimer's disease
    William B Grant
    12 Sir Francis Wyatt Place, Newport News, VA 23606 3660, USA
    J Alzheimers Dis 4:179-89. 2002
    ..Diet, aluminum, and viral infections may increase the prevalence of AD by eliciting inflammation, which may cause the neurological damage that results in AD...
  4. ncbi request reprint A multicountry ecologic study of risk and risk reduction factors for prostate cancer mortality
    William B Grant
    12 Sir Francis Wyatt Place, Newport News, VA 23606 3660, USA
    Eur Urol 45:271-9. 2004
    ..The objective of this research is to identify and determine the relative importance of dietary and environmental risk and risk reduction factors for prostate cancer mortality...
  5. ncbi request reprint Differences in vitamin-D status may explain black-white differences in breast cancer survival rates
    William B Grant
    J Natl Med Assoc 100:1040. 2008
  6. ncbi request reprint Re: Cancer as a risk factor for long-term cognitive deficits and dementia
    William B Grant
    J Natl Cancer Inst 97:1549; author reply 1550. 2005
  7. ncbi request reprint Re: Fruit and vegetable intake and risk of major chronic disease
    William B Grant
    J Natl Cancer Inst 97:608; author reply 608-9. 2005
  8. pmc Lower vitamin-D production from solar ultraviolet-B irradiance may explain some differences in cancer survival rates
    William B Grant
    Sunlight, Nutrition and Health Research Center, San Francisco, CA 94109 2529, USA
    J Natl Med Assoc 98:357-64. 2006
    ..Based on these results, it seems worthwhile to conduct observational, prevention and intervention studies to further test the hypothesis that vitamin D can reduce the risk of cancer incidence and death...
  9. ncbi request reprint The likely role of vitamin D from solar ultraviolet-B irradiance in increasing cancer survival
    William B Grant
    Sunlight, Nutrition and Health Research Center SUNARC, San Francisco, CA 94109 2529, USA
    Anticancer Res 26:2605-14. 2006
    ..Solar ultraviolet-B (UVB) and vitamin D have been found inversely correlated with cancer incidence, mortality, and survival rates in many studies...
  10. ncbi request reprint The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates
    William B Grant
    Sunlight, Nutrition and Health Research Center SUNARC, 2107 Van Ness Avenue, Suite 403B, San Francisco, CA 94109 2529, USA
    Anticancer Res 26:2687-99. 2006
    ..However, the previous ecologic study of UVB and cancer mortality rates in the U.S. (Grant, 2002) did not include other risk factors in the analysis...
  11. ncbi request reprint Does solar ultraviolet irradiation affect cancer mortality rates in China?
    William B Grant
    SUNARC, San Francisco, CA 94109 2510, USA
    Asian Pac J Cancer Prev 8:236-42. 2007
    ..Liver cancer and NPC are linked to viruses, and UVR may increase the risk through immunosuppression. Further studies are warranted...
  12. ncbi request reprint Is ultraviolet B irradiance inversely associated with incidence rates of endometrial cancer: an ecological study of 107 countries
    Sharif B Mohr
    Department of Family and Preventive Medicine 0631C, University of California San Diego, La Jolla CA, USA
    Prev Med 45:327-31. 2007
    ....
  13. doi request reprint Re: Prospective study of vitamin D and cancer mortality in the United States
    William B Grant
    J Natl Cancer Inst 100:826. 2008
  14. doi request reprint Ecologic approach is a powerful tool for cancer research
    William B Grant
    Eur J Cancer Prev 17:384. 2008
  15. ncbi request reprint Ecologic studies of solar UV-B radiation and cancer mortality rates
    William B Grant
    Recent Results Cancer Res 164:371-7. 2003
    ..These studies add further support for the role of UV-B radiation and vitamin D in reducing the risk of a large number of cancers...
  16. ncbi request reprint An ecologic study of cancer mortality rates in Spain with respect to indices of solar UVB irradiance and smoking
    William B Grant
    Sunlight, Nutrition, and Health Research Center SUNARC 2115 Van Ness Ave, MB 101 San Francisco, CA 94109 2510, USA
    Int J Cancer 120:1123-8. 2007
    ..They also provide more evidence that melanoma and NMSC have different etiologies...
  17. ncbi request reprint An ecological study of cancer mortality rates including indices for dietary iron and zinc
    William B Grant
    Sunlight, Nutrition and Health Research Center, San Francisco, CA 94109 1603, USA
    Anticancer Res 28:1955-63. 2008
    ..Dietary iron and zinc affect the risk of cancer, with dietary iron generally correlated with increased risk and dietary zinc with reduced risk. However, zinc supplements have been found correlated with increased risk of cancer...
  18. ncbi request reprint Vitamin D and prevention of breast cancer: pooled analysis
    Cedric F Garland
    Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Steroid Biochem Mol Biol 103:708-11. 2007
    ....
  19. ncbi request reprint What is the dose-response relationship between vitamin D and cancer risk?
    Cedric F Garland
    Department of Family and Preventive Medicine, School of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Nutr Rev 65:S91-5. 2007
  20. ncbi request reprint The effect of solar UVB doses and vitamin D production, skin cancer action spectra, and smoking in explaining links between skin cancers and solid tumours
    William B Grant
    Sunlight, Nutrition, and Health Research Center SUNARC, San Francisco, CA 94109, USA
    Eur J Cancer 44:12-5. 2008
    ..In Nordic countries, less skin is generally exposed (in head and neck regions, the most frequent sites of squamous cell carcinoma) resulting in reduced vitamin D production...
  21. ncbi request reprint The role of vitamin D3 in preventing infections
    William B Grant
    Age Ageing 37:121-2. 2008
  22. pmc Vitamin D may reduce prostate cancer metastasis by several mechanisms including blocking Stat3
    William B Grant
    Am J Pathol 173:1589-90. 2008
  23. doi request reprint Vitamin D, periodontal disease, tooth loss, and cancer risk
    William B Grant
    Lancet Oncol 9:612-3. 2008
  24. doi request reprint Vitamin D and the seasonality of type 2 diabetes
    Peter Doro
    Med Hypotheses 71:317-8. 2008
  25. doi request reprint Relationship between low ultraviolet B irradiance and higher breast cancer risk in 107 countries
    Sharif B Mohr
    Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California 92093 0631, USA
    Breast J 14:255-60. 2008
    ..81 (p < 0.0001). There was a protective effect of UVB irradiance on risk of breast cancer that was independent of fertility rate, proportion of the population overweight, alcohol intake, animal energy intake, and other covariates...
  26. doi request reprint The health benefits of vitamin D greatly outweigh the health risks
    William B Grant
    Bioessays 30:506-7; author reply 510-1. 2008
  27. doi request reprint Solar ultraviolet irradiance and cancer incidence and mortality
    William B Grant
    Sunlight, Nutrition and Health Research Center SUNARC, San Francisco, CA, USA
    Adv Exp Med Biol 624:16-30. 2008
    ..These findings are probably still approximately correct, if not on the low side, with respect to vitamin D because of the additional benefits found recently, such as protection against infectious diseases...
  28. doi request reprint Solar ultraviolet B radiation compared with prostate cancer incidence and mortality rates in United States
    Janet L Colli
    Department of Urology, University of Alabama, Birmingham, School of Medicine, Birmingham, Alabama 35294, USA
    Urology 71:531-5. 2008
    ..Another objective was to explore whether the annual prostate cancer rates correlated more strongly with the cumulative UVB exposure for the year or for exposure during certain seasons...
  29. doi request reprint Hypothesis--ultraviolet-B irradiance and vitamin D reduce the risk of viral infections and thus their sequelae, including autoimmune diseases and some cancers
    William B Grant
    Sunlight, Nutrition, and Health Research Center, San Francisco, CA, USA
    Photochem Photobiol 84:356-65. 2008
    ..In general, the evidence supports the hypothesis. However, further work is required to evaluate this hypothesis...
  30. ncbi request reprint An estimate of cancer mortality rate reductions in Europe and the US with 1,000 IU of oral vitamin D per day
    William B Grant
    Sunlight, Nutrition and Health Research Center, San Francisco, CA 94109 2510, USA
    Recent Results Cancer Res 174:225-34. 2007
    ..Providing 1,000 IU of vitamin D per day for all adult Americans would cost about $1 billion; the expected benefits for cancer would be in the range of $16-25 billion in addition to other health benefits of vitamin D...
  31. ncbi request reprint Vitamin D and Cancer Risk among American Indians
    William B Grant
    Cancer Epidemiol Biomarkers Prev 16:183. 2007
  32. ncbi request reprint A meta-analysis of second cancers after a diagnosis of nonmelanoma skin cancer: additional evidence that solar ultraviolet-B irradiance reduces the risk of internal cancers
    William B Grant
    J Steroid Biochem Mol Biol 103:668-74. 2007
    ..This assumption has been questioned...
  33. ncbi request reprint Evidence supporting the role of vitamin D in reducing the risk of cancer
    William B Grant
    J Intern Med 252:178-9; author reply 179-80. 2002
  34. ncbi request reprint Vitamin D as a risk reduction factor for colorectal cancer
    William B Grant
    Am Fam Physician 67:465. 2003
  35. ncbi request reprint Diet and risk of dementia: does fat matter? The Rotterdam Study
    William B Grant
    Neurology 60:2020-1. 2003
  36. ncbi request reprint Health benefits of solar UV-B radiation through the production of vitamin D. Comment and response
    William B Grant
    Photochem Photobiol Sci 2:1307-8; discussion 1308-10. 2003
  37. ncbi request reprint Obesity and Alzheimer disease: roles of diet and genetics
    William B Grant
    Arch Intern Med 164:109-10; author reply 110. 2004
  38. ncbi request reprint Year 2000 prevalence of Alzheimer disease in the United States
    William B Grant
    Arch Neurol 61:802-3; author reply 803. 2004
  39. ncbi request reprint Solar UV-B radiation is linked to the geographic variation of mortality from systemic lupus erythematosus in the USA
    William B Grant
    Lupus 13:281-2. 2004
  40. ncbi request reprint Geographic variation of prostate cancer mortality rates in the United States: Implications for prostate cancer risk related to vitamin D
    William B Grant
    Int J Cancer 111:470-1; author reply 472. 2004
  41. ncbi request reprint A critical review of studies on vitamin D in relation to colorectal cancer
    William B Grant
    SUNARC, San Francisco, CA 94109, USA
    Nutr Cancer 48:115-23. 2004
    ..Further study is required to elucidate the mechanisms and develop guidelines for optimal vitamin D sources and serum levels of vitamin D metabolites...
  42. ncbi request reprint Air pollution and breast cancer
    William B Grant
    Epidemiology 16:421. 2005
  43. ncbi request reprint Comparisons of estimated economic burdens due to insufficient solar ultraviolet irradiance and vitamin D and excess solar UV irradiance for the United States
    William B Grant
    Sunlight, Nutrition and Health Research Center SUNARC, 2107 Van Ness Avenue, Suite 403B, San Francisco, CA 94109 2529, USA
    Photochem Photobiol 81:1276-86. 2005
    ..Further research is required to confirm these estimates...
  44. ncbi request reprint Commentary: time for public health action on vitamin D for cancer risk reduction
    William B Grant
    Sunlight, Nutrition and Health Research Center, SUNARC, 2107 Van Ness Avenue, Suite 403B, San Francisco, CA 94109 2529, USA
    Int J Epidemiol 35:224-5. 2006
  45. ncbi request reprint Smoking, alcohol, diet and low vitamin D overlooked as modern cancer risk factors
    William B Grant
    Int J Cancer 119:722; author reply 723. 2006
  46. ncbi request reprint Epidemiology of disease risks in relation to vitamin D insufficiency
    William B Grant
    Sunlight, Nutrition and Health Research Center SUNARC, 2107 Van Ness Avenue, Suite 403B, San Francisco, CA 94109 2529, USA
    Prog Biophys Mol Biol 92:65-79. 2006
    ..It is noted that mechanisms whereby vitamin D exerts its effect are generally well understood for the various conditions and diseases discussed here...
  47. ncbi request reprint Are low ultraviolet B and high animal protein intake associated with risk of renal cancer?
    Sharif B Mohr
    Department of Family and Preventive Medicine, University of California, San Diego, CA, USA
    Int J Cancer 119:2705-9. 2006
    ..0001) were positively associated (R(2) = 0.68, p < 0.0001). Lower levels of UVB irradiance and higher intakes of calories from animal sources were independently associated with higher incidence rates of kidney cancer...
  48. ncbi request reprint Cholecalciferol, not ergocalciferol, should be used for vitamin D supplementation
    William B Grant
    Age Ageing 35:645; author reply 645. 2006
  49. ncbi request reprint Role of ultraviolet B irradiance and vitamin D in prevention of ovarian cancer
    Cedric F Garland
    Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California 92093 0631, USA
    Am J Prev Med 31:512-4. 2006
    ..This suggests that lower levels of solar irradiance might be associated with higher risk of ovarian cancer. Laboratory findings also suggest that low levels of vitamin D metabolites could play a role in the etiology of ovarian cancer...
  50. ncbi request reprint Comments on E. Giovannucci, "Insulin, insulin-like growth factors and colon cancer: a review of the evidence"
    William B Grant
    J Nutr 132:2324; author reply 2325. 2002