Igor Grant

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Association between chronic caregiving stress and impaired endothelial function in the elderly
    Brent T Mausbach
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0680, USA
    J Am Coll Cardiol 55:2599-606. 2010
  2. pmc Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline
    Igor Grant
    From the University of California I G, D R F, R D, S P W, F V, R J E, S L L, T D M, J H A, J A M, i A, A G, C F N, D M S, R K H, San Diego the University of Washington A C C, C M M, Seattle Washington University D B C, St Louis, MO University of Texas Medical Branch B B G, Galveston Johns Hopkins University J C M, Baltimore, MD and The Icahn School of Medicine at Mount Sinai S M, D M S, New York, NY
    Neurology 82:2055-62. 2014
  3. pmc Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals
    Kenny Lin
    University of California San Diego, San Diego, CA 92093, USA
    J Clin Exp Neuropsychol 33:326-34. 2011
  4. pmc Medical marijuana: clearing away the smoke
    Igor Grant
    Center for Medicinal Cannabis Research University of California, San Diego San Diego, CA, USA
    Open Neurol J 6:18-25. 2012
  5. pmc Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer's disease
    Andrew J Levine
    Department of Neurology, National Neurological AIDS Bank, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA
    BMC Med Genomics 6:4. 2013
  6. ncbi request reprint Non-acute (residual) neurocognitive effects of cannabis use: a meta-analytic study
    Igor Grant
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Int Neuropsychol Soc 9:679-89. 2003
  7. ncbi request reprint Health consequences of Alzheimer's caregiving transitions: effects of placement and bereavement
    Igor Grant
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0680, USA
    Psychosom Med 64:477-86. 2002
  8. ncbi request reprint Evaluating the neurocognitive complications of SLE. Lessons from HIV disease
    I Grant
    Department of Psychiatry, University of California, San Diego 92093 0680, USA
    Ann N Y Acad Sci 823:18-43. 1997
  9. pmc Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinence
    Jennifer E Iudicello
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
    J Clin Exp Neuropsychol 32:704-18. 2010
  10. pmc Real-world impact of neurocognitive deficits in acute and early HIV infection
    Katie L Doyle
    Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA, USA
    J Neurovirol 19:565-73. 2013

Detail Information

Publications173 found, 100 shown here

  1. pmc Association between chronic caregiving stress and impaired endothelial function in the elderly
    Brent T Mausbach
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0680, USA
    J Am Coll Cardiol 55:2599-606. 2010
    ..We examined the relationship between chronic caregiving stress and endothelial function...
  2. pmc Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline
    Igor Grant
    From the University of California I G, D R F, R D, S P W, F V, R J E, S L L, T D M, J H A, J A M, i A, A G, C F N, D M S, R K H, San Diego the University of Washington A C C, C M M, Seattle Washington University D B C, St Louis, MO University of Texas Medical Branch B B G, Galveston Johns Hopkins University J C M, Baltimore, MD and The Icahn School of Medicine at Mount Sinai S M, D M S, New York, NY
    Neurology 82:2055-62. 2014
    ..We investigated whether HIV-infected persons with ANI were more likely than those who were neurocognitively normal (NCN) to experience a decline in everyday functioning (symptomatic decline)...
  3. pmc Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals
    Kenny Lin
    University of California San Diego, San Diego, CA 92093, USA
    J Clin Exp Neuropsychol 33:326-34. 2011
    ..One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms...
  4. pmc Medical marijuana: clearing away the smoke
    Igor Grant
    Center for Medicinal Cannabis Research University of California, San Diego San Diego, CA, USA
    Open Neurol J 6:18-25. 2012
    ..We present an algorithm that may be useful to physicians in determining whether cannabis might be recommended as a treatment in jurisdictions where such use is permitted...
  5. pmc Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer's disease
    Andrew J Levine
    Department of Neurology, National Neurological AIDS Bank, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA
    BMC Med Genomics 6:4. 2013
    ..Additionally, we compare these data to those derived from brains of individuals with Alzheimer's disease (AD) in order to identify common pathways of neuropathogenesis...
  6. ncbi request reprint Non-acute (residual) neurocognitive effects of cannabis use: a meta-analytic study
    Igor Grant
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Int Neuropsychol Soc 9:679-89. 2003
    ....
  7. ncbi request reprint Health consequences of Alzheimer's caregiving transitions: effects of placement and bereavement
    Igor Grant
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0680, USA
    Psychosom Med 64:477-86. 2002
    ....
  8. ncbi request reprint Evaluating the neurocognitive complications of SLE. Lessons from HIV disease
    I Grant
    Department of Psychiatry, University of California, San Diego 92093 0680, USA
    Ann N Y Acad Sci 823:18-43. 1997
    ..A reliable and valid neurocognitive diagnosis is the first step in monitoring patients clinically, in designing research aimed at neuropathogenesis, or in the design of treatment trials geared toward neuroprotection or neuroremediation...
  9. pmc Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinence
    Jennifer E Iudicello
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
    J Clin Exp Neuropsychol 32:704-18. 2010
    ..These results suggest partial recovery of neuropsychological functioning and improvement in affective distress upon sustained abstinence from MA that may extend beyond a year or more...
  10. pmc Real-world impact of neurocognitive deficits in acute and early HIV infection
    Katie L Doyle
    Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA, USA
    J Neurovirol 19:565-73. 2013
    ....
  11. pmc Neurocognitive consequences of HIV infection in older adults: an evaluation of the "cortical" hypothesis
    J Cobb Scott
    HIV Neurobehavioral Research Center, Department of Psychiatry, University of California San Diego, San Diego, CA, USA
    AIDS Behav 15:1187-96. 2011
    ..Thus, in this sample of older HIV-infected individuals, the combined effects of HIV and aging do not appear to result in a "cortical" pattern of cognitive deficits...
  12. pmc Effects of gender and dementia severity on Alzheimer's disease caregivers' sleep and biomarkers of coagulation and inflammation
    Paul J Mills
    Department of Psychiatry, University of California at San Diego, La Jolla, CA, USA
    Brain Behav Immun 23:605-10. 2009
    ..This study examined the effects of caregiver gender and severity of the spouse's dementia on sleep, coagulation, and inflammation in the caregiver...
  13. pmc Methamphetamine use parameters do not predict neuropsychological impairment in currently abstinent dependent adults
    Mariana Cherner
    Department of Psychiatry, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0847, USA
    Drug Alcohol Depend 106:154-63. 2010
    ..The apparent lack of correspondence between substance use parameters and cognitive impairment suggests the need for further study of individual differences in vulnerability to the neurotoxic effects of methamphetamine...
  14. pmc Effects of Alzheimer caregiving on allostatic load
    Susan K Roepke
    San Diego State University and University of California, San Diego Joint Doctoral Program in Clinical Psychology, La Jolla, California 92093 0680, USA
    J Health Psychol 16:58-69. 2011
    ..In conclusion, allostatic load may represent a link explaining how stress translates to downstream pathology, but more work is necessary to understand the role of psychological factors...
  15. pmc A 5-year longitudinal study of the relationships between stress, coping, and immune cell beta(2)-adrenergic receptor sensitivity
    Brent T Mausbach
    Department of Psychiatry, University of California at San Diego, La Jolla, CA, USA
    Psychiatry Res 160:247-55. 2008
    ..However, increased mastery is associated with increased receptor sensitivity, and may therefore serve as a resource factor for improved health in this population...
  16. pmc Continued high prevalence and adverse clinical impact of human immunodeficiency virus-associated sensory neuropathy in the era of combination antiretroviral therapy: the CHARTER Study
    Ronald J Ellis
    HIV Neurobehavioral Research Center, Department of Neurosciences, University of California, San Diego, San Diego, CA 92103, USA
    Arch Neurol 67:552-8. 2010
    ..To provide updated estimates of the prevalence and clinical impact of human immunodeficiency virus-associated sensory neuropathy (HIV-SN) and neuropathic pain due to HIV-SN in the combination antiretroviral therapy (CART) era...
  17. pmc Neurobehavioral effects of HIV-1 infection in China and the United States: a pilot study
    Lucette A Cysique
    Department of Psychiatry, University of California at San Diego, and VA San Diego Health Care System, La Jolla, California 92093 0603, USA
    J Int Neuropsychol Soc 13:781-90. 2007
    ..To inform the development of such norms, a much larger study of demographic effects will be needed, especially considering the wide range of education in that country...
  18. pmc Persistent versus transient depressive symptoms in relation to platelet hyperactivation: a longitudinal analysis of dementia caregivers
    Kirstin Aschbacher
    Department of Psychiatry, University of California, San Diego, USA
    J Affect Disord 116:80-7. 2009
    ..The primary objective was to investigate whether persistent depressive symptoms would relate to elevated platelet activation in response to acute psychological stress over a three-year period...
  19. ncbi request reprint Longitudinal platelet reactivity to acute psychological stress among older men and women
    Kirstin Aschbacher
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Stress 12:426-33. 2009
    ..The results demonstrate that laboratory acute stress tests continued to produce robust platelet reactivity on three activation markers among older adults over 3 years...
  20. ncbi request reprint The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of disease
    Scott L Letendre
    Department of Medicine, University of California San Diego, CA 92103, USA
    AIDS 19:S72-8. 2005
    ..To determine the effects of hepatitis C virus (HCV) infection on neuropsychological (NP) performance...
  21. ncbi request reprint Coping processes and hemostatic reactivity to acute stress in dementia caregivers
    Kirstin Aschbacher
    Department of Psychiatry, School of Medicine, University of California, San Diego, California, USA
    Psychosom Med 67:964-71. 2005
    ..A hypercoagulable stress response might contribute to the increased cardiovascular risk in Alzheimer's caregivers...
  22. pmc Personal mastery is associated with reduced sympathetic arousal in stressed Alzheimer caregivers
    Susan K Roepke
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0680, USA
    Am J Geriatr Psychiatry 16:310-7. 2008
    ..This study examines the relationship between mastery and sympathetic arousal in elderly caregivers, as measured by norepinephrine (NE) reactivity to an acute psychological stressor...
  23. ncbi request reprint The impact of neuropsychological functioning and depressed mood on functional complaints in HIV-1 infection and methamphetamine dependence
    Joseph R Sadek
    University of California, San Diego, CA, USA
    J Clin Exp Neuropsychol 29:266-76. 2007
    ..Additional research is needed to clarify the potentially reciprocal causal relationships between depressive symptoms and impairment in everyday functioning...
  24. ncbi request reprint Effects of methamphetamine dependence and HIV infection on cerebral morphology
    Terry L Jernigan
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 9151B, USA
    Am J Psychiatry 162:1461-72. 2005
    ..The authors examined the separate and combined effects of methamphetamine dependence and HIV infection on brain morphology...
  25. ncbi request reprint Sleep disturbance, norepinephrine, and D-dimer are all related in elderly caregivers of people with Alzheimer disease
    Brent T Mausbach
    Department of Psychiatry, University of California, San Diego, CA 92093 0682, USA
    Sleep 29:1347-52. 2006
    ..In this study, we examined if sleep disturbance of elderly caregivers was associated with physiologic markers of cardiovascular risk, including plasma norepinephrine, epinephrine, and the hemostasis marker D-dimer...
  26. ncbi request reprint Effects of placement and bereavement on psychological well-being and cardiovascular risk in Alzheimer's caregivers: a longitudinal analysis
    Brent T Mausbach
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0680, USA
    J Psychosom Res 62:439-45. 2007
    ..We examined the impact of Alzheimer caregiver transitions (i.e., placement and bereavement) on psychological outcomes and on plasma D-dimer levels, an end product of the coagulation cascade associated with increased cardiovascular risk...
  27. pmc Prospective memory deficits are associated with unemployment in persons living with HIV infection
    Steven Paul Woods
    Department of Psychiatry, University of California, San Diego, USA
    Rehabil Psychol 56:77-84. 2011
    ..To determine whether deficits in prospective memory (i.e., "remembering to remember") confer an increased risk of unemployment in individuals living with chronic HIV infection...
  28. pmc The semantic relatedness of cue-intention pairings influences event-based prospective memory failures in older adults with HIV infection
    Steven Paul Woods
    HIV Neurobehavioral Research Center, Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 32:398-407. 2010
    ....
  29. pmc Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural China
    Robert K Heaton
    HIV Neurobehavioral Research Center HNRC, Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0603, USA
    J Neurovirol 14:536-49. 2008
    ..These findings indicate that HAND is likely to be an important feature of HIV infection in developing countries, underscoring the need for international efforts to develop CNS-relevant treatments...
  30. pmc Effects of depressive and anxious symptoms on norepinephrine and platelet P-selectin responses to acute psychological stress among elderly caregivers
    Kirstin Aschbacher
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla CA 92093 0680, USA
    Brain Behav Immun 22:493-502. 2008
    ....
  31. pmc Psychometric characteristics of the memory for intentions screening test
    Steven Paul Woods
    Department of Psychiatry, University of California, San Diego, CA, USA
    Clin Neuropsychol 22:864-78. 2008
    ..Recommendations are provided regarding future research to enhance the clinical usefulness of the MIST...
  32. pmc Dopamine receptor D3 genetic polymorphism (rs6280TC) is associated with rates of cognitive impairment in methamphetamine-dependent men with HIV: preliminary findings
    Saurabh Gupta
    Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, MC 0603, La Jolla, CA 92093 0603, USA
    J Neurovirol 17:239-47. 2011
    ..3%) in this group had higher impairment rates (pā€‰=ā€‰0.05) than TT carriers (33.3%). These findings support the theory that rs6280TC influences the frequency of CI in HIV-positive/METH-positive males...
  33. pmc Negative mood and sexual behavior among non-monogamous men who have sex with men in the context of methamphetamine and HIV
    C A Bousman
    University of California San Diego, HIV Neurobehavioral Research Center, Department of Psychiatry, La Jolla, California 92103, USA
    J Affect Disord 119:84-91. 2009
    ..This study examined the contextual influence of METH, HIV-infection and their combination on mood states and sexual behavior...
  34. pmc Human immunodeficiency virus infection heightens concurrent risk of functional dependence in persons with long-term methamphetamine use
    Kaitlin Blackstone
    From the Joint Doctoral Program in Clinical Psychology KB and EW, San Diego State University and University of California San Diego, San Diego, CA and Department of Psychiatry JEI, EEM, DJM, DRF, RJE, IG, and SPW, University of California San Diego, San Diego
    J Addict Med 7:255-63. 2013
    ..Disability among long-term methamphetamine (MA) users is multifactorial. This study examined the additive adverse impact of human immunodeficiency virus (HIV) infection, a common comorbidity in MA users, on functional dependence...
  35. pmc HIV-infected individuals with co-occurring bipolar disorder evidence poor antiretroviral and psychiatric medication adherence
    David J Moore
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA
    AIDS Behav 16:2257-66. 2012
    ..Given the high overlap of HIV and BD, and the observed medication adherence difficulties for these persons, specialized adherence improvement interventions are needed...
  36. pmc Demographically corrected norms for African Americans and Caucasians on the Hopkins Verbal Learning Test-Revised, Brief Visuospatial Memory Test-Revised, Stroop Color and Word Test, and Wisconsin Card Sorting Test 64-Card Version
    Marc A Norman
    Department of Psychiatry, University of California, San Diego, CA, USA
    J Clin Exp Neuropsychol 33:793-804. 2011
    ..Findings support the need to consider extended demographic contributions to neuropsychological test performance in clinical and research settings...
  37. pmc Prospective memory in HIV infection: is "remembering to remember" a unique predictor of self-reported medication management?
    Steven Paul Woods
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Arch Clin Neuropsychol 23:257-70. 2008
    ..The potential benefits of individualized remediation strategies that are informed by conceptual models of ProM and specifically target medication adherence warrant further exploration...
  38. pmc Clinical factors related to brain structure in HIV: the CHARTER study
    Terry L Jernigan
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive M C 0115, La Jolla, CA, USA
    J Neurovirol 17:248-57. 2011
    ..Brain structural integrity in HIV likely reflects dynamic effects of current immune status and HIV replication, superimposed on residual effects associated with severe prior immunosuppression...
  39. ncbi request reprint Effects of human immunodeficiency virus and methamphetamine on cerebral metabolites measured with magnetic resonance spectroscopy
    Michael J Taylor
    VA San Diego Healthcare System, San Diego, California, USA
    J Neurovirol 13:150-9. 2007
    ..This evidence indicates when HIV is poorly suppressed, METH may modify the effects of the virus on neuronal integrity...
  40. ncbi request reprint Methamphetamine use, impulsivity, and sexual risk behavior among HIV-positive men who have sex with men
    Shirley J Semple
    Department of Psychiatry, University of California, La Jolla, CA 92093 0680, USA
    J Addict Dis 25:105-14. 2006
    ..This suggests that targeting impulsivity in interventions may help reduce sexual risk behaviors in high intensity meth-using HIV-positive MSM...
  41. ncbi request reprint Relationship of antiretroviral treatment to postmortem brain tissue viral load in human immunodeficiency virus-infected patients
    Dianne Langford
    Department of Pathology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurovirol 12:100-7. 2006
    ..Furthermore, such strategies might help to prevent the development of ARV resistance...
  42. ncbi request reprint Dementia severity of the care receiver predicts procoagulant response in Alzheimer caregivers
    Kirstin Aschbacher
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Am J Geriatr Psychiatry 14:694-703. 2006
    ..Research has demonstrated that spousal dementia caregivers have elevated levels of D-dimer relative to their non-caregiving peers...
  43. pmc Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system
    Scott Letendre
    University of California, San Diego, 150 W Washington St, San Diego, CA 92103, USA
    Arch Neurol 65:65-70. 2008
    ..To evaluate whether penetration of a combination regimen into the central nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is associated with lower cerebrospinal fluid (CSF) viral load...
  44. pmc Frequency and predictors of self-reported prospective memory complaints in individuals infected with HIV
    Steven Paul Woods
    Department of Psychiatry, University of California, San Diego 92103, USA
    Arch Clin Neuropsychol 22:187-95. 2007
    ....
  45. pmc Leisure activities, caregiving demands and catecholamine levels in dementia caregivers
    Elizabeth A Chattillion
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California, San Diego, CA, USA
    Psychol Health 27:1134-49. 2012
    ..Further support for these findings may impact psychological treatments for distressed caregivers...
  46. pmc Synergistic effects of HIV infection and older age on daily functioning
    Erin E Morgan
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Acquir Immune Defic Syndr 61:341-8. 2012
    ..To determine whether HIV infection and aging act synergistically to disrupt everyday functioning...
  47. pmc A longitudinal analysis of the relations among stress, depressive symptoms, leisure satisfaction, and endothelial function in caregivers
    Brent T Mausbach
    Department of Psychiatry, University of California San Diego, La Jolla 92093 0680, USA
    Health Psychol 31:433-40. 2012
    ..This study examined the longitudinal associations between stress, depressive symptoms, leisure satisfaction, and endothelial function as measured by FMD...
  48. pmc Sustained attention deficits among HIV-positive individuals with comorbid bipolar disorder
    Carolina Posada
    San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
    J Neuropsychiatry Clin Neurosci 24:61-70. 2012
    ....
  49. pmc Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling
    Amy D Paulino
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0624, USA
    J Neurovirol 17:327-40. 2011
    ..These pathways provide novel targets for development of neuroprotective treatments for HCV involvement of the CNS...
  50. pmc Relationship between chronic stress and carotid intima-media thickness (IMT) in elderly Alzheimer's disease caregivers
    Susan K Roepke
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California, San Diego, San Diego, CA, USA
    Stress 15:121-9. 2012
    ..These findings provide more evidence of the link between chronic caregiving stress and cardiovascular disease and indicate that enduring the experience of caregiving over a period of years might be associated with atherosclerotic burden...
  51. pmc Intraindividual variability in HIV infection: evidence for greater neurocognitive dispersion in older HIV seropositive adults
    Erin E Morgan
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    Neuropsychology 25:645-54. 2011
    ..To our knowledge, no studies have yet examined dispersion in an aging HIV-infected sample...
  52. ncbi request reprint Stress-related reduction in personal mastery is associated with reduced immune cell beta2-adrenergic receptor sensitivity
    Brent T Mausbach
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0680, U S A
    Int Psychogeriatr 19:935-46. 2007
    ..The purpose of this study was to investigate whether stress-related experience of depressive symptoms and reductions in personal mastery were related to alterations in ss2-adrenergic receptor sensitivity...
  53. ncbi request reprint Spousal caregivers of patients with Alzheimer's disease show longitudinal increases in plasma level of tissue-type plasminogen activator antigen
    Brent T Mausbach
    Department of Psychiatry 0680, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0680, USA
    Psychosom Med 69:816-22. 2007
    ..Caring for a spouse with Alzheimer's disease has been associated with increased mortality and reduced time to developing cardiovascular disease (CVD), possibly due to impaired fibrinolysis resulting from chronic stress...
  54. ncbi request reprint Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairment
    David J Moore
    HIV Neurobehavioral Research Center and University of California, San Diego, California 92161, USA
    AIDS 20:879-87. 2006
    ..To determine the association of markers of regional neurodegeneration (ND) at autopsy to degree of neurocognitive impairment in persons with HIV...
  55. pmc Predictive validity of demographically adjusted normative standards for the HIV Dementia Scale
    Erin E Morgan
    Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California San Diego, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 30:83-90. 2008
    ..The application of demographically adjusted normative standards on the HDS improves the clinical applicability and accuracy of this cognitive screening measure in the detection of HIV-1-associated neurocognitive disorders...
  56. pmc Impairments in fine-motor coordination and speed of information processing predict declines in everyday functioning in hepatitis C infection
    Ofilio Vigil
    Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
    J Clin Exp Neuropsychol 30:805-15. 2008
    ....
  57. pmc Human immunodeficiency virus protease inhibitors and risk for peripheral neuropathy
    Ronald J Ellis
    University of California, San Diego, San Diego, CA, USA
    Ann Neurol 64:566-72. 2008
    ..Confirmation of peripheral nerve toxicity with PIs could substantially limit their long-term use in highly active ARV therapy...
  58. pmc Is prospective memory a dissociable cognitive function in HIV infection?
    Saurabh Gupta
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 32:898-908. 2010
    ..The results of this study lend further evidence to the dissociability of ProM in HIV infection, are consistent with prior studies in healthy adults, and contribute to a growing literature on the construct validity of ProM in HIV disease...
  59. pmc CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy
    Ronald J Ellis
    University of California, San Diego, USA
    AIDS 25:1747-51. 2011
    ..The present study evaluated the probability of neuropsychological impairment (NPI) and HAND as a function of CD4 nadir in an HIV-positive cohort...
  60. pmc Spontaneous strategy use protects against visual working memory deficits in older adults infected with HIV
    Steven Paul Woods
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Clin Neuropsychol 25:724-33. 2010
    ....
  61. pmc Neuropsychological performance in mainland china: the effect of urban/rural residence and self-reported daily academic skill use
    Saurabh Gupta
    Department of Psychiatry, University of California, San Diego, San Diego, California, USA
    J Int Neuropsychol Soc 17:163-73. 2011
    ..Controlling for academic skill use abrogated most U/R differences but revealed rural advantages in select measures of visual reasoning and motor dexterity...
  62. pmc Normative data and validation of a regression based summary score for assessing meaningful neuropsychological change
    Lucette A Cysique
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California at San Diego, San Diego, CA, USA
    J Clin Exp Neuropsychol 33:505-22. 2011
    ..Correction for practice effects based on normative data improved the consistency of NP impairment classification in a clinically stable longitudinal cohort after baseline...
  63. ncbi request reprint Increased human immunodeficiency virus loads in active methamphetamine users are explained by reduced effectiveness of antiretroviral therapy
    Ronald J Ellis
    Department of Neurosciences, University of California San Diego, San Diego, California, USA
    J Infect Dis 188:1820-6. 2003
    ..In contrast, abstinent former METH abusers (METH(+)Tox-) receiving HAART effectively suppressed viral replication. These data suggest that abstinence programs are a key component of effective treatment of HIV in METH-abusing populations...
  64. pmc Etravirine in CSF is highly protein bound
    Anh Nguyen
    Department of Pediatrics Rady Children s Hospital, University of California San Diego, 3020 Childrens Way, San Diego, CA 92123, USA
    J Antimicrob Chemother 68:1161-8. 2013
    ..The objective of this study was to compare total and unbound etravirine concentrations in CSF with plasma concentrations and the in vitro median inhibitory concentration (IC50) for wild-type HIV (0.9 ng/mL)...
  65. pmc Neurocognitive deficits are associated with unemployment in chronic methamphetamine users
    Erica Weber
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California, San Diego, San Diego, CA, United States
    Drug Alcohol Depend 125:146-53. 2012
    ..Unemployment rates are high among chronic methamphetamine (MA) users and carry a significant economic burden, yet little is known about the neurocognitive and psychiatric predictors of employment in this vulnerable population...
  66. pmc Family history of dementia predicts worse neuropsychological functioning among HIV-infected persons
    David J Moore
    Dept of Psychiatry, University of California, San Diego UCSD and the HIV Neurobehavioral Research Center HNRC, UCSD, CA, USA
    J Neuropsychiatry Clin Neurosci 23:316-23. 2011
    ..Thus, FHD appears to be a risk factor for HAND; the mechanism(s) underlying how FHD contributes to NP impairment among HIV+ persons warrants study...
  67. pmc Carotid plaque in Alzheimer caregivers and the role of sympathoadrenal arousal
    Susan K Roepke
    San Diego State University University of California, San Diego, USA
    Psychosom Med 73:206-13. 2011
    ..Providing care for a spouse with Alzheimer's disease has been associated with an increased risk of coronary heart disease, potentially due to the impact of caregiving stress on the atherosclerotic disease process...
  68. ncbi request reprint Sexual risk behavior of HIV-positive methamphetamine-using men who have sex with men: the role of partner serostatus and partner type
    Shirley J Semple
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0680, USA
    Arch Sex Behav 35:461-71. 2006
    ....
  69. pmc Psychiatric context of human immunodeficiency virus infection among former plasma donors in rural China
    J Hampton Atkinson
    HIV Neurobehavioral Research Center, University of California, San Diego, 220 Dickinson St, San Diego, CA 92103, USA
    J Affect Disord 130:421-8. 2011
    ..Little is known of the psychiatric and substance use disorder characteristics of this population, or their impact on everyday function, employment, and life quality...
  70. pmc Variable patterns of neuropsychological performance in HIV-1 infection
    S Dawes
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92093 0603, USA
    J Clin Exp Neuropsychol 30:613-26. 2008
    ..Thus, there does not appear to be a single, prototypical pattern of neuropsychological impairment associated with HIV infection for this battery of representative neuropsychological tests...
  71. ncbi request reprint Avoidant coping partially mediates the relationship between patient problem behaviors and depressive symptoms in spousal Alzheimer caregivers
    Brent T Mausbach
    Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0680, USA
    Am J Geriatr Psychiatry 14:299-306. 2006
    ..The purpose of this study was to test a mediational model of the associations between patient problem behaviors, escape-avoidance coping, and depressive symptoms in Alzheimer caregivers...
  72. pmc Misremembering future intentions in methamphetamine-dependent individuals
    Jennifer E Iudicello
    Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA, USA
    Clin Neuropsychol 25:269-86. 2011
    ..Findings suggest that individuals with MA dependence experience difficulty in the strategic components involved in the retrieval of future intentions and are discussed with regard to their implications for everyday functioning...
  73. pmc Select resistance-associated mutations in blood are associated with lower CSF viral loads and better neuropsychological performance
    George K Hightower
    University of California, San Diego, La Jolla, CA 92037, USA
    Virology 394:243-8. 2009
    ..Our study evaluated whether antiretroviral resistance was associated with viral loads in the cerebrospinal fluid (CSF) and better neuropsychological (NP) performance...
  74. doi request reprint Cognitive functioning during highly active antiretroviral therapy interruption in human immunodeficiency virus type 1 infection
    Meredith E Childers
    Department of Neurosciences, University of California at San Diego, San Diego, California 92103, USA
    J Neurovirol 14:550-7. 2008
    ..TIs of up to 6 months appear to be neurocognitively and psychiatrically safe for most patients...
  75. pmc White matter tract injury and cognitive impairment in human immunodeficiency virus-infected individuals
    Assawin Gongvatana
    San Diego State University University of California, San Diego, Joint Doctoral Program in Clinical Psychology, San Diego and La Jolla, California, USA
    J Neurovirol 15:187-95. 2009
    ..The study also confirms that CNS injury is evident in persons infected with HIV despite effective antiretroviral treatment...
  76. pmc Cognitive mechanisms of switching in HIV-associated category fluency deficits
    Jennifer E Iudicello
    Joint Doctoral Program in Clinical Psychology, San Diego State University, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 30:797-804. 2008
    ..g., mental flexibility), perhaps reflecting underlying neuropathology within prefrontostriatal networks...
  77. ncbi request reprint The impact of HIV-associated neuropsychological impairment on everyday functioning
    Robert K Heaton
    Department of Psychiatry, University of California at San Diego, and VA San Diego Health Care System, La Jolla, 92093 0603, USA
    J Int Neuropsychol Soc 10:317-31. 2004
    ..Finally, there is a need for additional research investigating the apparently independent effect of depression on level of everyday functioning in HIV infected persons...
  78. pmc Implications of hepatitis C virus infection for behavioral symptoms and activities of daily living
    Carolina Posada
    San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
    J Clin Exp Neuropsychol 32:637-44. 2010
    ..These results show that a subset of HCV-infected individuals report clinically elevated behavioral symptoms. Clinical implications for the assessment and management of elevated behavioral symptoms in HCV are discussed...
  79. pmc Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependence
    Chad A Bousman
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92103, USA
    Psychiatry Res 178:295-8. 2010
    ..Results provide preliminary support for further exploration and validation of candidate single nucleotide polymorphisms (SNPs) for methamphetamine (METH) dependence reported among Asian populations across other ethnic/ancestral groups...
  80. pmc The moderating role of personal mastery on the relationship between caregiving status and multiple dimensions of fatigue
    Susan K Roepke
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California, San Diego, USA
    Int J Geriatr Psychiatry 24:1453-62. 2009
    ..The objective of this study was to examine whether personal mastery moderates the relationship between caregiving status (caregiver/non-caregiver) and multiple dimensions of fatigue...
  81. pmc A neuropsychological investigation of multitasking in HIV infection: implications for everyday functioning
    J Cobb Scott
    San Diego State University and University of California, San Diego, CA, USA
    Neuropsychology 25:511-9. 2011
    ..The aim of this study was to assess the predictive and ecological validity of a novel multitasking measure in HIV infection...
  82. ncbi request reprint Additive deleterious effects of methamphetamine dependence and immunosuppression on neuropsychological functioning in HIV infection
    Catherine L Carey
    Department of Psychiatry, HIV Neurobehavioral Research Center, San Diego State University and University of California San Diego, 150 W Washington Street, San Diego, CA 92103, USA
    AIDS Behav 10:185-90. 2006
    ....
  83. pmc Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapy
    T Dianne Langford
    Department of Pathology, University of California, San Diego, CA, USA
    AIDS 16:1019-29. 2002
    ....
  84. ncbi request reprint Association of negative life event stress with coagulation activity in elderly Alzheimer caregivers
    Roland von Kanel
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0680, USA
    Psychosom Med 65:145-50. 2003
    ..We wondered whether negative life stress might affect hemostatic function in caregivers...
  85. ncbi request reprint Temperament and risky behaviors: a pathway to HIV?
    David J Moore
    San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA 92103, USA
    J Affect Disord 85:191-200. 2005
    ..Because dispositional characteristics are likely to influence this process, we examined the association between temperament and HIV serostatus in subjects with heavy use of drugs and various sexual risk behaviors...
  86. ncbi request reprint Effects of HIV-1 infection and aging on neurobehavioral functioning: preliminary findings
    Marianna Cherner
    Department of Psychiatry, University of California San Diego, La Jolla, 92093 0603, USA
    AIDS 18:S27-34. 2004
    ..In a cross-sectional observational study, we compared the neuropsychological profiles of 67 HIV-positive patients aged at least 50 years with those of 52 participants aged 35 years or less...
  87. pmc Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder
    Erick T Tatro
    Department of Psychiatry 0603, University of California at San Diego, La Jolla, San Diego, CA 92093 0603, USA
    J Neuroimmune Pharmacol 4:218-26. 2009
    ..Instead, an increase in FKBP51 at both the transcript (FKBP5) and protein level correlated with MDD. Increased FKBP4 expression of correlated to HIV(+)MDD but not to HIV without MDD...
  88. ncbi request reprint Semantic clustering inefficiency in HIV-associated dementia
    Assawin Gongvatana
    University of California, San Diego, 150 West Washington Street, 2nd Floor, San Diego, CA 92103, USA
    J Neuropsychiatry Clin Neurosci 19:36-42. 2007
    ..Findings suggest that HIV-associated dementia is associated with inefficient use of higher-level encoding and retrieval strategies, perhaps mediated by a disruption of fronto-basal ganglia systems...
  89. ncbi request reprint Work-related abilities in schizophrenia and HIV infection
    Elizabeth W Twamley
    University of California, San Diego, Department of Psychiatry, San Diego, California 92103, USA
    J Nerv Ment Dis 194:268-74. 2006
    ....
  90. ncbi request reprint Binge use of methamphetamine among HIV-positive men who have sex with men: pilot data and HIV prevention implications
    Shirley J Semple
    University of California, San Diego, La Jolla 92093 0680, USA
    AIDS Educ Prev 15:133-47. 2003
    ..The findings are discussed in relation to drug treatment approaches and the development of behavioral interventions...
  91. ncbi request reprint Patterns of selective neuronal damage in methamphetamine-user AIDS patients
    Dianne Langford
    Department of Pathology, University of California at San Francisco, La Jolla, CA 92093 0624, USA
    J Acquir Immune Defic Syndr 34:467-74. 2003
    ..In combination, METH and HIV may increase neuronal cell injury and death, thereby enhancing brain metabolic disturbances observed in clinical populations of HIV-positive METH abusers...
  92. ncbi request reprint Enhancing antiretroviral therapy for human immunodeficiency virus cognitive disorders
    Scott L Letendre
    HIV Neurobehavioral Research Center, University of California at San Diego, San Diego, CA 92103, USA
    Ann Neurol 56:416-23. 2004
    ..Including CSF-penetrating drugs in the ART regimen and monitoring CSF viral load may be indicated for individuals with HIV-associated cognitive impairment...
  93. ncbi request reprint Effects of alcoholism and gender on brain metabolism
    Brian C Schweinsburg
    Veterans Affairs San Diego Health Care Syatem, University of California, San Diego, CA 92161, USA
    Am J Psychiatry 160:1180-3. 2003
    ..Proton magnetic resonance spectroscopy was used to evaluate gender influences on alcohol-associated changes in brain metabolism...
  94. pmc The functional impact of HIV-associated neuropsychological impairment in Spanish-speaking adults: a pilot study
    Monica Rivera Mindt
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 25:122-32. 2003
    ..These results, though preliminary, suggest that Spanish language functional assessments are potentially valid tools for detecting everyday functioning deficits associated with NP impairments in HIV-infected Spanish-speakers...
  95. ncbi request reprint Sleep in spousal caregivers of people with Alzheimer's disease
    Christine L McKibbin
    Department of Psychiatry, University of California San Diego, CA, USA
    Sleep 28:1245-50. 2005
    ..This study examined differences in objective and subjective measures of sleep between caregivers and noncaregivers...
  96. pmc The relationship between AIDS retinal cotton wool spots and neuropsychological impairment in HIV-positive individuals in the pre-highly active antiretroviral therapy era
    William R Freeman
    Department of Ophthalmology, Shiley Eye Center, University of California San Diego, La Jolla, CA 92093, USA
    Ocul Immunol Inflamm 12:25-33. 2004
    ....
  97. ncbi request reprint Is hepatitis C infection associated with increased risk of depression in persons with methamphetamine dependence?
    Ofilio Vigil
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA
    Am J Addict 16:418-23. 2007
    ..Results from this study suggest that HCV infection does not confer an additive effect on the severity of depressive symptoms or the prevalence of major depression in persons with MA dependence...
  98. ncbi request reprint Acute procoagulant stress response as a dynamic measure of allostatic load in Alzheimer caregivers
    Roland von Kanel
    Department of Psychiatry, University of California San Diego, La Jolla 92093 0680, USA
    Ann Behav Med 26:42-8. 2003
    ..The acute procoagulant stress response might constitute a dynamic mediator of allostatic load in Alzheimer caregivers...
  99. ncbi request reprint Genetic attributes of cerebrospinal fluid-derived HIV-1 env
    Satish K Pillai
    University of California San Diego, Department of Medicine NCIRE, La Jolla, CA 94121, USA
    Brain 129:1872-83. 2006
    ..Furthermore, neurological impairment may be influenced by mutations within the viral V3 loop sequence...
  100. ncbi request reprint Perceived behavior of others and AIDS risk behavior among heterosexually-identified methamphetamine users
    Shirley J Semple
    University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0680, USA
    J Psychoactive Drugs . 2006
    ..Strategies for addressing negative social influences in the context of sexual risk reduction interventions are described...
  101. ncbi request reprint Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection
    Catherine L Carey
    Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 26:307-19. 2004
    ..71 to 1.00. These findings support the validity of the GDS as a clinically useful way of summarizing results on NP testing...

Research Grants22

  1. California NeuroAIDS Tissue Network
    Igor Grant; Fiscal Year: 2007
    ..The CNTN will coordinate its work closely with that of the other NNTC sites to assure that the entire NNTC develops as a national and international resource for research on neuroAIDS. ..
  2. Alzheimer Caregiver Coping: Mental and Physical Health
    Igor Grant; Fiscal Year: 2007
    ..This study will provide a basis for a mechanistic understanding of the path from CG stress to CV morbidity in elderly CG, and opens the possibility of targeted interventions to reduce this risk. ..
  3. INTERNATIONAL CORE
    Igor Grant; Fiscal Year: 2007
    ..abstract_text> ..
  4. Alzheimer Caregiver Coping: Mental and Physical Health
    Igor Grant; Fiscal Year: 2009
    ..This study will provide a basis for a mechanistic understanding of the path from CG stress to CV morbidity in elderly CG, and opens the possibility of targeted interventions to reduce this risk. ..
  5. Alzheimer Caregiver Coping: Mental and Physical Health
    Igor Grant; Fiscal Year: 2005
    ..The results of this research should bring us closer to understanding the physiological and molecular mechanisms underlying increased morbidity in elderly persons under chronic stress. ..
  6. Alzheimer Caregiver Coping: Mental and Physical Health
    Igor Grant; Fiscal Year: 2005
    ..The results of this research should bring us closer to understanding the physiological and molecular mechanisms underlying increased morbidity in elderly persons under chronic stress. ..
  7. ALZHEIMER CAREGIVER COPING--MENTAL AND PHYSICAL HEALTH
    Igor Grant; Fiscal Year: 1999
    ..The data from this phase should move caregiver research closer to understanding mechanisms linking caregiver stress, physiological response, and health. ..
  8. ALZHEIMER CAREGIVER COPING--MENTAL AND PHYSICAL HEALTH
    Igor Grant; Fiscal Year: 1999
    ..The data from this phase should move caregiver research closer to understanding mechanisms linking caregiver stress, physiological response, and health. ..
  9. ALZHEIMER CAREGIVER COPING--MENTAL AND PHYSICAL HEALTH
    Igor Grant; Fiscal Year: 1999
    ..The data from this phase should move caregiver research closer to understanding mechanisms linking caregiver stress, physiological response, and health. ..
  10. ALZHEIMER CAREGIVER COPING--MENTAL AND PHYSICAL HEALTH
    Igor Grant; Fiscal Year: 2000
    ..The data from this phase should move caregiver research closer to understanding mechanisms linking caregiver stress, physiological response, and health. ..
  11. Alzheimer Caregiver Coping: Mental and Physical Health
    Igor Grant; Fiscal Year: 2001
    ..The results of this research should bring us closer to understanding the physiological and molecular mechanisms underlying increased morbidity in elderly persons under chronic stress. ..
  12. Alzheimer Caregiver Coping: Mental and Physical Health
    Igor Grant; Fiscal Year: 2002
    ..The results of this research should bring us closer to understanding the physiological and molecular mechanisms underlying increased morbidity in elderly persons under chronic stress. ..
  13. Alzheimer Caregiver Coping: Mental and Physical Health
    Igor Grant; Fiscal Year: 2003
    ..The results of this research should bring us closer to understanding the physiological and molecular mechanisms underlying increased morbidity in elderly persons under chronic stress. ..
  14. Alzheimer Caregiver Coping: Mental and Physical Health
    Igor Grant; Fiscal Year: 2004
    ..The results of this research should bring us closer to understanding the physiological and molecular mechanisms underlying increased morbidity in elderly persons under chronic stress. ..
  15. Alzheimer Caregiver Coping: Mental and Physical Health
    Igor Grant; Fiscal Year: 2010
    ..This study will provide a basis for a mechanistic understanding of the path from CG stress to CV morbidity in elderly CG, and opens the possibility of targeted interventions to reduce this risk. ..