Joey Granger

Summary

Affiliation: University of Mississippi Medical Center
Country: USA

Publications

  1. ncbi request reprint Pathophysiology of pregnancy-induced hypertension
    J P Granger
    Department of Physiology, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Am J Hypertens 14:178S-185S. 2001
  2. ncbi request reprint Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction
    J P Granger
    Department of Physiology, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, USA
    Hypertension 38:718-22. 2001
  3. ncbi request reprint Maternal and fetal adaptations during pregnancy: lessons in regulatory and integrative physiology
    Joey P Granger
    Department of Physiology and Biophysics, University of Mississippi, Jackson, Mississippi 39216, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1289-92. 2002
  4. pmc Autoantibodies to the angiotensin type I receptor in response to placental ischemia and tumor necrosis factor alpha in pregnant rats
    Babbette LaMarca
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 52:1168-72. 2008
  5. ncbi request reprint Endothelin, the kidney, and hypertension
    Joey P Granger
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, 39216 4505, USA
    Curr Hypertens Rep 8:298-303. 2006
  6. ncbi request reprint Mechanisms of pressure natriuresis
    Joey P Granger
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Curr Hypertens Rep 4:152-9. 2002
  7. ncbi request reprint Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction
    Joey P Granger
    Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS, USA
    Microcirculation 9:147-60. 2002
  8. ncbi request reprint Cytochrome P-450 inhibition attenuates hypertension induced by reductions in uterine perfusion pressure in pregnant rats
    Maria T Llinas
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505
    Hypertension 43:623-8. 2004
  9. pmc Role of angiotensin II type I receptor agonistic autoantibodies (AT1-AA) in preeclampsia
    Babbette LaMarca
    Department of Physiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Curr Opin Pharmacol 11:175-9. 2011
  10. ncbi request reprint Effects of reduced uterine perfusion pressure on blood pressure and metabolic factors in pregnant rats
    Jeffrey Gilbert
    Department of Physiology and the Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Hypertens 20:686-91. 2007

Research Grants

  1. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 1992
  2. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2007
  3. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2007
  4. Renal Microcirculatory and Tubular Dynamics
    Joey Granger; Fiscal Year: 2004
  5. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2004
  6. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2009

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Pathophysiology of pregnancy-induced hypertension
    J P Granger
    Department of Physiology, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Am J Hypertens 14:178S-185S. 2001
    ..More effective strategies for the prevention of preeclampsia should be forthcoming once the underlying pathophysiologic mechanisms that are involved in PIH are completely understood...
  2. ncbi request reprint Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction
    J P Granger
    Department of Physiology, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, USA
    Hypertension 38:718-22. 2001
    ..Results from ongoing basic and clinical studies, however, should provide new and important information regarding the physiological mechanisms responsible for the elevation in arterial pressure in women with preeclampsia...
  3. ncbi request reprint Maternal and fetal adaptations during pregnancy: lessons in regulatory and integrative physiology
    Joey P Granger
    Department of Physiology and Biophysics, University of Mississippi, Jackson, Mississippi 39216, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1289-92. 2002
  4. pmc Autoantibodies to the angiotensin type I receptor in response to placental ischemia and tumor necrosis factor alpha in pregnant rats
    Babbette LaMarca
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 52:1168-72. 2008
    ..05). Collectively, these data indicate that placental ischemia and TNF-alpha are important stimuli of AT1-AA, and activation of the AT1 receptor appears to, in part, mediate hypertension produced by RUPP and TNF-alpha in pregnant rats...
  5. ncbi request reprint Endothelin, the kidney, and hypertension
    Joey P Granger
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, 39216 4505, USA
    Curr Hypertens Rep 8:298-303. 2006
    ....
  6. ncbi request reprint Mechanisms of pressure natriuresis
    Joey P Granger
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Curr Hypertens Rep 4:152-9. 2002
    ....
  7. ncbi request reprint Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction
    Joey P Granger
    Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS, USA
    Microcirculation 9:147-60. 2002
    ..The quantitative importance of the various endothelial and humoral factors in mediating the vasoconstriction and elevation in arterial pressure during preeclampsia has also not been completely elucidated...
  8. ncbi request reprint Cytochrome P-450 inhibition attenuates hypertension induced by reductions in uterine perfusion pressure in pregnant rats
    Maria T Llinas
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505
    Hypertension 43:623-8. 2004
    ..In contrast, renal epoxygenase activity did not change in these animals. These results suggest that 20-HETE contributes to hypertension and renal vasoconstriction induced by chronic RUPP in pregnant rats...
  9. pmc Role of angiotensin II type I receptor agonistic autoantibodies (AT1-AA) in preeclampsia
    Babbette LaMarca
    Department of Physiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Curr Opin Pharmacol 11:175-9. 2011
    ....
  10. ncbi request reprint Effects of reduced uterine perfusion pressure on blood pressure and metabolic factors in pregnant rats
    Jeffrey Gilbert
    Department of Physiology and the Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Hypertens 20:686-91. 2007
    ..Currently it is unclear whether these metabolic aberrations presage preeclampsia, or if these manifestations result from placental ischemia and the ensuing proinflammatory state usually present in preeclampsia...
  11. pmc Recombinant vascular endothelial growth factor 121 infusion lowers blood pressure and improves renal function in rats with placentalischemia-induced hypertension
    Jeffrey S Gilbert
    Department of Physiology and the Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Miss 39216 4505, USA
    Hypertension 55:380-5. 2010
    ..The present results suggest that VEGF(121) may be a candidate molecule for management of preeclampsia and its related complications...
  12. pmc Role of endothelin in mediating soluble fms-like tyrosine kinase 1-induced hypertension in pregnant rats
    Sydney R Murphy
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Miss 39216 4505, USA
    Hypertension 55:394-8. 2010
    ..In conclusion, this study demonstrates that endothelin 1, via endothelin type A receptor activation, plays an important role in mediating the hypertension in response to excess sFlt-1 during pregnancy...
  13. ncbi request reprint Enhanced endothelin synthesis by endothelial cells exposed to sera from pregnant rats with decreased uterine perfusion
    Lyndsay Roberts
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 47:615-8. 2006
    ..These data indicate that serum from pregnant rats exposed to reductions in uterine perfusion enhances endothelin production by endothelial cells via by AT1 receptor activation...
  14. ncbi request reprint Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of interleukin 6
    Giovani Gadonski
    Department of Physiology and Obstetrics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Miss 39216 4505, USA
    Hypertension 48:711-6. 2006
    ..In summary, these data indicate that plasma IL-6 is elevated in response to chronic reductions in uterine perfusion in pregnant rats and that a comparable elevation in plasma IL-6 increases AP and reduces renal function in pregnant rats...
  15. ncbi request reprint Reduced uterine perfusion pressure (RUPP) model for studying cardiovascular-renal dysfunction in response to placental ischemia
    Joey P Granger
    Department of Physiology and Biophysics, University of Missisippi Medical Center, Jackson, MS, USA
    Methods Mol Med 122:383-92. 2006
    ..This chapter details the methods we use in our laboratory to produce the reduced uterine perfusion pressure (RUPP) model in the pregnant rat...
  16. pmc Role of sex steroids in modulating tumor necrosis factor alpha-induced changes in vascular function and blood pressure
    Babbette D LaMarca
    Department of Physiology and Center for Excellence in Cardiovascular and Renal Research, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Hypertens 20:1216-21. 2007
    ..In the present study, we tested the hypothesis that levels of ovarian hormones to mimic pregnancy are required for TNF-alpha-induced changes in vascular function and blood pressure in rats...
  17. ncbi request reprint Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction
    Jeffrey S Gilbert
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Physiol Heart Circ Physiol 294:H541-50. 2008
    ....
  18. doi request reprint Hypertension and cardiovascular disease in women
    John E Hall
    Department of Physiology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 51:951. 2008
  19. ncbi request reprint Inflammatory cytokines in the pathophysiology of hypertension during preeclampsia
    Babbette D LaMarca
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Curr Hypertens Rep 9:480-5. 2007
    ..These findings suggest that inflammatory cytokines elevate blood pressure during pregnancy by activating multiple neurohumoral and endothelial factors...
  20. pmc Pathophysiology of hypertension in response to placental ischemia during pregnancy: a central role for endothelin?
    Babbette D LaMarca
    Department of Physiology, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Gend Med 5:S133-8. 2008
    ..The initiating event in preeclampsia has been postulated to involve reduced placental perfusion, which leads to widespread dysfunction of the maternal vascular endothelium...
  21. ncbi request reprint Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease
    Jane F Reckelhoff
    Dept of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 289:F941-8. 2005
    ..This review presents an overview of the data from human and animal studies in which the role of androgens in promoting renal and cardiovascular diseases has been investigated...
  22. ncbi request reprint Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats
    B Babbette D LaMarca
    Department of Physiology, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 46:82-6. 2005
    ..These results suggest an important role for endothelin in mediating TNF-alpha-induced hypertension in pregnant rats...
  23. ncbi request reprint Enhanced [Ca2+]i in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressure
    Jason G Murphy
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216, USA
    Am J Physiol Heart Circ Physiol 284:H393-403. 2003
    ....
  24. ncbi request reprint Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models
    Raouf A Khalil
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 283:R29-45. 2002
    ....
  25. ncbi request reprint Enhanced thromboxane synthesis during chronic reductions in uterine perfusion pressure in pregnant rats
    Maria T Llinas
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Am J Hypertens 15:793-7. 2002
    ..The purpose of this study was to determine the role of thromboxane A2 (TXA2) in a conscious, chronically instrumented rat model of pregnancy-induced hypertension (PIH) produced by chronic reductions in uterine perfusion pressure (RUPP)...
  26. ncbi request reprint Inducible nitric oxide synthase inhibition attenuates renal hemodynamics during pregnancy
    Barbara T Alexander
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Hypertension 39:586-90. 2002
    ..0 +/- 1.1 mL/min; virgin, pregnant, and EIT, respectively). Therefore, these findings suggest that inducible nitric oxide synthase may play an important role in mediating the renal hemodynamic changes that occur during normal pregnancy...
  27. ncbi request reprint Low-salt diet enhances vascular reactivity and Ca(2+) entry in pregnant rats with normal and reduced uterine perfusion pressure
    Jena B Giardina
    Department of Physiology and Biophysics and Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Hypertension 39:368-74. 2002
    ....
  28. ncbi request reprint Tumor necrosis factor-alpha-induced hypertension in pregnant rats results in decreased renal neuronal nitric oxide synthase expression
    Barbara T Alexander
    Department of Physiology, Center for Excellence in Cardiovascular Renal Research Center, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Am J Hypertens 15:170-5. 2002
    ..The purpose of this study was to determine the role of the nitric oxide (NO) system in TNF-alpha-induced hypertension in pregnant rats...
  29. ncbi request reprint Evaluation of a rat model of preeclampsia for HELLP syndrome characteristics
    Christy M Isler
    Department of Obstetrics and Gynecology, East Carolina University Brody School of Medicine, Greenville, North Carolina, USA
    J Soc Gynecol Investig 10:151-3. 2003
    ..To determine whether a rat model of preeclampsia includes features consistent with HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome...
  30. ncbi request reprint Endothelin
    Joey P Granger
    University of Mississippi Medical Center, Jackson 39216, USA
    Am J Physiol Regul Integr Comp Physiol 285:R298-301. 2003
  31. ncbi request reprint Role of reactive oxygen species in endothelin-induced hypertension
    Mona H Sedeek
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Miss 39216 4505, USA
    Hypertension 42:806-10. 2003
    ..These data indicate that formation of reactive oxygen species may play an important role in mediating hypertension induced by chronic elevations in endothelin...
  32. ncbi request reprint L-arginine attenuates hypertension in pregnant rats with reduced uterine perfusion pressure
    Barbara T Alexander
    Department of Physiology and Biophysics, and the Center for Excellence in Cardiovascular Renal Research Center, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 43:832-6. 2004
    ..Thus, these results suggest that l-arginine supplementation may be beneficial in attenuating the hypertension in preeclampsia...
  33. ncbi request reprint Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha-induced hypertension in pregnant rats
    Justin R Davis
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 282:R390-9. 2002
    ..The results support a role for TNF-alpha as one possible mediator of the increased vascular resistance associated with pregnancy-induced hypertension...
  34. ncbi request reprint Inflammatory cytokines, vascular function, and hypertension
    Joey P Granger
    Am J Physiol Regul Integr Comp Physiol 286:R989-90. 2004
  35. ncbi request reprint Antisense oligodeoxynucleotides directed against a novel angiotensinogen mRNA-stabilizing protein reduce blood pressure in spontaneously hypertensive rats
    Christoph P R Klett
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA
    Am J Physiol Regul Integr Comp Physiol 287:R619-26. 2004
    ..5 mg x kg(-1) x day(-1) for 3 days: -36 mmHg). These data suggest an important role of the mRNA-stabilizing protein for hepatic and extrahepatic angiotensinogen expression and MAP in the SHR...
  36. ncbi request reprint TNF-alpha enhances contraction and inhibits endothelial NO-cGMP relaxation in systemic vessels of pregnant rats
    Jena B Giardina
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 283:R130-43. 2002
    ..The results support a direct role for TNF-alpha as a possible mediator of increased vascular resistance associated with pregnancy-induced hypertension...
  37. pmc Recent progress toward the understanding of the pathophysiology of hypertension during preeclampsia
    Babbette D LaMarca
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Hypertension 51:982-8. 2008
  38. doi request reprint ACE2 and ANG-(1-7) in the gravid uterus: the new players on the block
    Jeffrey S Gilbert
    Am J Physiol Regul Integr Comp Physiol 294:R915-6. 2008
  39. ncbi request reprint Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of tumor necrosis factor-alpha
    B Babbette D LaMarca
    Department of Physiology and Obstetrics Gynecology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 46:1022-5. 2005
    ..6+/-0.4 mL/min in the control group. In summary, these data suggest that TNF-alpha may play an important role in mediating the increased arterial pressure in response to chronic RUPPs in pregnant rats...
  40. ncbi request reprint Endothelin-induced increases in Ca2+ entry mechanisms of vascular contraction are enhanced during high-salt diet
    Leah Smith
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, USA
    Hypertension 41:787-93. 2003
    ..The results suggest that ET increases the sensitivity of the mechanisms of vascular smooth muscle contraction to high dietary salt intake and may, in part, explain the possible role of ET in salt-sensitive hypertension...
  41. ncbi request reprint Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble fms-like tyrosine kinase-1 expression
    Jeffrey S Gilbert
    Department of Physiology and the Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 50:1142-7. 2007
    ..These data also indicate that the RUPP model of pregnancy-induced hypertension may provide an invaluable model for mechanistic studies into the role of sFlt-1 in the pathogenesis preeclampsia...
  42. ncbi request reprint An emerging role for inflammatory cytokines in hypertension
    Joey P Granger
    Am J Physiol Heart Circ Physiol 290:H923-4. 2006
  43. ncbi request reprint Dietary salt enhances benzamil-sensitive component of myogenic constriction in mesenteric arteries
    Nikki L Jernigan
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216 4505, USA
    Am J Physiol Heart Circ Physiol 294:H409-20. 2008
    ..These data suggest that dietary sodium regulates ENaC expression and the quantitative importance of the vascular ENaC signaling pathway contributing to myogenic constriction...

Research Grants16

  1. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 1992
    ....
  2. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2007
    ..a decrease in renal medullary production of 20 HETE 3) To test the hypothesis that abnormalities in renal medullary endothelin production and/or ETB receptor function mediate the hypertension in Dahl salt-sensitive rats ..
  3. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2007
    ..is due to a decrease in renal medullary production of 20-HETE; 3) To test the hypothesis that abnormalities in renal medullary endothelin production and/or ETB receptor function mediate the hypertension in Dahl salt-sensitive rats ..
  4. Renal Microcirculatory and Tubular Dynamics
    Joey Granger; Fiscal Year: 2004
    ....
  5. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2004
    ....
  6. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2009
    ..a decrease in renal medullary production of 20 HETE 3) To test the hypothesis that abnormalities in renal medullary endothelin production and/or ETB receptor function mediate the hypertension in Dahl salt-sensitive rats ..