J R Grandis

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival
    J Rubin Grandis
    Department of Otolaryngology, University of Pittsburgh School of Medicine, and University of Pittsburgh Cancer Institute, PA, USA
    J Natl Cancer Inst 90:824-32. 1998
  2. pmc Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro
    J R Grandis
    Department of Otolaryngology, University of Pittsburgh School of Medicine and the University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Clin Invest 102:1385-92. 1998
  3. pmc Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
    J R Grandis
    Department of Otolaryngology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 97:4227-32. 2000
  4. ncbi request reprint Abrogation of transforming growth factor-alpha/epidermal growth factor receptor autocrine signaling by an RXR-selective retinoid (LGD1069, Targretin) in head and neck cancer cell lines
    J I Song
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Cancer Res 61:5919-25. 2001
  5. pmc PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells
    Q Sun
    Department of Pathology, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Oncogene 28:2348-57. 2009
  6. pmc Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation
    S E Wheeler
    Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Oncogene 29:5135-45. 2010
  7. pmc Collagen type XI α1 facilitates head and neck squamous cell cancer growth and invasion
    J C Sok
    Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Br J Cancer 109:3049-56. 2013
  8. ncbi request reprint Targeting growth factor receptors: integration of novel therapeutics in the management of head and neck cancer
    M N Lango
    Department of Otolaryngology, University of Pittsburgh School of Medicine and the University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Oncol 13:168-75. 2001
  9. pmc STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines
    W Zhou
    Laboratory and Pathology Service, Pittsburgh VAMC, PA, USA
    Br J Cancer 95:164-71. 2006
  10. ncbi request reprint Differential activation of apoptosis regulatory pathways during monocytic vs granulocytic differentiation: a requirement for Bcl-X(L)and XIAP in the prolonged survival of monocytic cells
    M B Miranda
    Department of Medicine, University of Pittsburgh and the University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Leukemia 17:390-400. 2003

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival
    J Rubin Grandis
    Department of Otolaryngology, University of Pittsburgh School of Medicine, and University of Pittsburgh Cancer Institute, PA, USA
    J Natl Cancer Inst 90:824-32. 1998
    ....
  2. pmc Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro
    J R Grandis
    Department of Otolaryngology, University of Pittsburgh School of Medicine and the University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Clin Invest 102:1385-92. 1998
    ..Thus, TGF-alpha/EGFR-mediated autocrine growth of transformed epithelial cells is dependent on activation of Stat3 but not Stat1...
  3. pmc Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
    J R Grandis
    Department of Otolaryngology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 97:4227-32. 2000
    ..These findings provide evidence that constitutively activated Stat3 is an early event in head and neck carcinogenesis that contributes to the loss of growth control by an anti-apoptotic mechanism...
  4. ncbi request reprint Abrogation of transforming growth factor-alpha/epidermal growth factor receptor autocrine signaling by an RXR-selective retinoid (LGD1069, Targretin) in head and neck cancer cell lines
    J I Song
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Cancer Res 61:5919-25. 2001
    ..Abrogation of constitutive Stat3 activation was seen with LGD1069 treatment. These results suggest that an RXR-selective retinoic acid decreases SCCHN proliferation in part by interfering with TGF-alpha/EGFR autocrine signaling...
  5. pmc PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells
    Q Sun
    Department of Pathology, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Oncogene 28:2348-57. 2009
    ..Our results suggest that PUMA induction through p73 represents a new mechanism of EGFR inhibitor-induced apoptosis, and provide potential ways for enhancing and predicting the sensitivity to EGFR-targeted therapies in HNSCC...
  6. pmc Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation
    S E Wheeler
    Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Oncogene 29:5135-45. 2010
    ..These results suggest that EGFRvIII mediates HNSCC cell migration and invasion by increased STAT3 activation and induction of HIF1-α, which contribute to cetuximab resistance in EGFRvIII-expressing HNSCC tumors...
  7. pmc Collagen type XI α1 facilitates head and neck squamous cell cancer growth and invasion
    J C Sok
    Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Br J Cancer 109:3049-56. 2013
    ..Currently, the functional significance of colXIα1 is not understood...
  8. ncbi request reprint Targeting growth factor receptors: integration of novel therapeutics in the management of head and neck cancer
    M N Lango
    Department of Otolaryngology, University of Pittsburgh School of Medicine and the University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Oncol 13:168-75. 2001
    ..As erbB family member interactions and downstream signaling pathways are elucidated in head and neck squamous cell carcinoma, specific targeting strategies may become incorporated into standard treatment approaches...
  9. pmc STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines
    W Zhou
    Laboratory and Pathology Service, Pittsburgh VAMC, PA, USA
    Br J Cancer 95:164-71. 2006
    ..These findings suggest a molecular basis for the STAT3 dependence of EGFR-mediated prostate tumour progression...
  10. ncbi request reprint Differential activation of apoptosis regulatory pathways during monocytic vs granulocytic differentiation: a requirement for Bcl-X(L)and XIAP in the prolonged survival of monocytic cells
    M B Miranda
    Department of Medicine, University of Pittsburgh and the University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Leukemia 17:390-400. 2003
    ....
  11. ncbi request reprint The role of topical antibiotic prophylaxis in patients undergoing contaminated head and neck surgery with flap reconstruction
    J P Simons
    Department of Otolaryngology, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pennsylvania 15213, USA
    Laryngoscope 111:329-35. 2001
    ..However, the addition of topical piperacillin/tazobactam does not appear to enhance the prophylactic benefit of parenteral antibiotics alone...
  12. pmc Phase I trial of pemetrexed in combination with cetuximab and concurrent radiotherapy in patients with head and neck cancer
    A Argiris
    University of Pittsburgh Cancer Institute, Division of Hematology Oncology, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
    Ann Oncol 22:2482-8. 2011
    ..We studied the combination of pemetrexed, a multi-targeted antifolate, and cetuximab, an mAb against the epidermal growth factor receptor, with radiotherapy in poor prognosis head and neck cancer...
  13. ncbi request reprint Gene therapy for the treatment of oral squamous cell carcinoma
    S Xi
    Department of Otolaryngology, University of Pittsburgh School of Medicine, PA, USA
    J Dent Res 82:11-6. 2003
    ..This review discusses the techniques used in cancer gene therapy for oral squamous cell carcinoma and summarizes the ongoing strategies that are being evaluated in clinical trials...