Eleonora Grandi

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A novel computational model of the human ventricular action potential and Ca transient
    Eleonora Grandi
    Department of Pharmacology, University of California, 451 Health Sciences Drive, GBSF Room 3513, Davis, CA 95616 8636, USA
    J Mol Cell Cardiol 48:112-21. 2010
  2. pmc Interplay of voltage and Ca-dependent inactivation of L-type Ca current
    Eleonora Grandi
    Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, GBSF 3506, Davis, CA 95616, USA
    Prog Biophys Mol Biol 103:44-50. 2010
  3. pmc Theoretical study of L-type Ca(2+) current inactivation kinetics during action potential repolarization and early afterdepolarizations
    Stefano Morotti
    Department of Pharmacology, University of California, Davis, CA 95616 8636, USA
    J Physiol 590:4465-81. 2012
  4. pmc Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias
    Anthony W Herren
    Department of Pharmacology, University of California Davis, Davis, California
    Am J Physiol Heart Circ Physiol 305:H431-45. 2013
  5. pmc β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets
    Yuanfang Xie
    Department of Pharmacology, University of California Davis, Davis, CA, USA
    J Mol Cell Cardiol 58:153-61. 2013
  6. pmc Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation
    Eleonora Grandi
    Department of Pharmacology, University of California, Davis, 451 Health Sciences Dr, GBSF Room 3513, Davis, CA 95616 8636, USA
    Circ Res 109:1055-66. 2011
  7. pmc How does β-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation?
    Yuanfang Xie
    Department of Pharmacology, University of California Davis, 451 Health Sciences Drive, GBSF Room 3502, Davis, CA 95616 8636, USA
    Europace 16:452-7. 2014
  8. pmc Human atrial fibrillation: insights from computational electrophysiological models
    Donald M Bers
    Department of Pharmacology, University of California at Davis, Davis, CA 95616 8636, USA
    Trends Cardiovasc Med 21:145-50. 2011
  9. pmc Calcium/calmodulin-dependent kinase II regulation of cardiac ion channels
    Donald M Bers
    Department of Pharmacology, University of California, Davis, Davis, CA 95616 8636, USA
    J Cardiovasc Pharmacol 54:180-7. 2009

Collaborators

Detail Information

Publications9

  1. pmc A novel computational model of the human ventricular action potential and Ca transient
    Eleonora Grandi
    Department of Pharmacology, University of California, 451 Health Sciences Drive, GBSF Room 3513, Davis, CA 95616 8636, USA
    J Mol Cell Cardiol 48:112-21. 2010
    ..We conclude that this model provides a useful framework to explore excitation-contraction coupling mechanisms and repolarization abnormalities at the single myocyte level...
  2. pmc Interplay of voltage and Ca-dependent inactivation of L-type Ca current
    Eleonora Grandi
    Department of Pharmacology, University of California, Davis, 451 Health Sciences Drive, GBSF 3506, Davis, CA 95616, USA
    Prog Biophys Mol Biol 103:44-50. 2010
    ..This complicates VDI analysis experimentally, but raises intriguing new questions about how the molecular mechanisms of VDI differ for divalent and monovalent currents through LTCCs...
  3. pmc Theoretical study of L-type Ca(2+) current inactivation kinetics during action potential repolarization and early afterdepolarizations
    Stefano Morotti
    Department of Pharmacology, University of California, Davis, CA 95616 8636, USA
    J Physiol 590:4465-81. 2012
    ..Our model accurately describes ECC and allows dissection of the relative contributions of different Ca(2+) sources to total CDI, and the relative roles of CDI and VDI, during normal and abnormal repolarization...
  4. pmc Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias
    Anthony W Herren
    Department of Pharmacology, University of California Davis, Davis, California
    Am J Physiol Heart Circ Physiol 305:H431-45. 2013
    ..Understanding the mechanisms of altered NaV1.5 expression and function is crucial for gaining insight into arrhythmogenesis and developing novel therapeutic strategies. ..
  5. pmc β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets
    Yuanfang Xie
    Department of Pharmacology, University of California Davis, Davis, CA, USA
    J Mol Cell Cardiol 58:153-61. 2013
    ..5) RyR phosphorylation has little effect on either transient EAD type. Our study emphasizes the importance of understanding non-steady state kinetics of several systems in mediating β-adrenergic-induced EADs and arrhythmias...
  6. pmc Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation
    Eleonora Grandi
    Department of Pharmacology, University of California, Davis, 451 Health Sciences Dr, GBSF Room 3513, Davis, CA 95616 8636, USA
    Circ Res 109:1055-66. 2011
    ..Understanding atrial fibrillation (AF) requires integrated understanding of ionic currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited...
  7. pmc How does β-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation?
    Yuanfang Xie
    Department of Pharmacology, University of California Davis, 451 Health Sciences Drive, GBSF Room 3502, Davis, CA 95616 8636, USA
    Europace 16:452-7. 2014
    ..In this study, we aimed at investigating how βAR signalling affects the transition from VT to VF...
  8. pmc Human atrial fibrillation: insights from computational electrophysiological models
    Donald M Bers
    Department of Pharmacology, University of California at Davis, Davis, CA 95616 8636, USA
    Trends Cardiovasc Med 21:145-50. 2011
    ..Potential new avenues of investigation and model development are suggested...
  9. pmc Calcium/calmodulin-dependent kinase II regulation of cardiac ion channels
    Donald M Bers
    Department of Pharmacology, University of California, Davis, Davis, CA 95616 8636, USA
    J Cardiovasc Pharmacol 54:180-7. 2009
    ..In this review, we summarize the modulatory effects of CaMKII on cardiac ion channel function and expression and illustrate potential implications in the onset of arrhythmias via a computer model...