P Grammas

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's disease
    P Grammas
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, 975 NE 10th Street, Biomedical Research Center, Oklahoma City, OK 73104, USA
    J Alzheimers Dis 4:217-23. 2002
  2. pmc Microvessels from Alzheimer's disease brains kill neurons in vitro
    P Grammas
    Department of Pathology, The Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Am J Pathol 154:337-42. 1999
  3. ncbi request reprint The effect of age and injury on the expression of inducible nitric oxide synthase in facial motor neurons in F344 rats
    J M Jacob
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Mech Ageing Dev 107:205-18. 1999
  4. ncbi request reprint Inflammatory factors are elevated in brain microvessels in Alzheimer's disease
    P Grammas
    Department of Pathology, University of Oklahoma Health Sciences Center, 975 N E 10th Street, Oklahoma City, OK 73104, USA
    Neurobiol Aging 22:837-42. 2001
  5. ncbi request reprint Mechanisms of cell death in primary cortical neurons and PC12 cells
    U Reimann-Philipp
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Neurosci Res 64:654-60. 2001
  6. ncbi request reprint A damaged microcirculation contributes to neuronal cell death in Alzheimer's disease
    P Grammas
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, 975 NE 10th Street, Oklahoma City, OK, 73104, USA
    Neurobiol Aging 21:199-205. 2000
  7. ncbi request reprint Differential glucose uptake in retina- and brain-derived endothelial cells
    T T Rajah
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Microvasc Res 62:236-42. 2001
  8. ncbi request reprint Protein kinase C-zeta activity but not level is decreased in Alzheimer's disease microvessels
    P Moore
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Neurosci Lett 254:29-32. 1998

Collaborators

  • M Yamada
  • J M Jacob
  • T T Rajah
  • U Reimann-Philipp
  • P Moore
  • P H Weigel
  • A L Olson
  • R Ovase
  • V Christiansen
  • J White

Detail Information

Publications8

  1. ncbi request reprint The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's disease
    P Grammas
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, 975 NE 10th Street, Biomedical Research Center, Oklahoma City, OK 73104, USA
    J Alzheimers Dis 4:217-23. 2002
    ....
  2. pmc Microvessels from Alzheimer's disease brains kill neurons in vitro
    P Grammas
    Department of Pathology, The Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Am J Pathol 154:337-42. 1999
    ..The neurotoxic factor is soluble and likely a protein, because its activity is heat labile and trypsin sensitive. These findings implicate a novel mechanism of vascular-mediated neuronal cell death in Alzheimer's disease...
  3. ncbi request reprint The effect of age and injury on the expression of inducible nitric oxide synthase in facial motor neurons in F344 rats
    J M Jacob
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Mech Ageing Dev 107:205-18. 1999
    ..These data suggest that aging and injury differentially affect the expression of iNOS and that the up-regulation of iNOS may be important for the availability of nitric oxide in the aged or injured nervous system...
  4. ncbi request reprint Inflammatory factors are elevated in brain microvessels in Alzheimer's disease
    P Grammas
    Department of Pathology, University of Oklahoma Health Sciences Center, 975 N E 10th Street, Oklahoma City, OK 73104, USA
    Neurobiol Aging 22:837-42. 2001
    ..These results suggest that the cerebral microcirculation contributes inflammatory mediators to the milieu of the AD brain and may be involved in the pathogenesis of neuronal injury and death in this disorder...
  5. ncbi request reprint Mechanisms of cell death in primary cortical neurons and PC12 cells
    U Reimann-Philipp
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Neurosci Res 64:654-60. 2001
    ..These data suggest mechanisms involved in neuronal cell death utilize multiple pathways that vary depending on the neurotoxic insult and are also influenced by subtle differences among neuronal cell phenotypes...
  6. ncbi request reprint A damaged microcirculation contributes to neuronal cell death in Alzheimer's disease
    P Grammas
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, 975 NE 10th Street, Oklahoma City, OK, 73104, USA
    Neurobiol Aging 21:199-205. 2000
    ....
  7. ncbi request reprint Differential glucose uptake in retina- and brain-derived endothelial cells
    T T Rajah
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Microvasc Res 62:236-42. 2001
    ....
  8. ncbi request reprint Protein kinase C-zeta activity but not level is decreased in Alzheimer's disease microvessels
    P Moore
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Neurosci Lett 254:29-32. 1998
    ....