Ian M Gralnek

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Racial differences in the impact of irritable bowel syndrome on health-related quality of life
    Ian M Gralnek
    VA Greater Los Angeles Health Care System, Los Angeles, CA, USA
    J Clin Gastroenterol 38:782-9. 2004
  2. ncbi request reprint Treatment alternatives for hepatitis B cirrhosis: a cost-effectiveness analysis
    Fasiha Kanwal
    Division of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Gastroenterol 101:2076-89. 2006
  3. ncbi request reprint Impact of chronic viral hepatitis on health-related quality of life in HIV: results from a nationally representative sample
    Fasiha Kanwal
    VA Greater Los Angeles Health Care System, Division of Gastroenterology Hepatology, David Geffen School of Medicine at UCLA, 90073, USA
    Am J Gastroenterol 100:1984-94. 2005
  4. ncbi request reprint Comparing rates of dyspepsia with Coxibs vs NSAID+PPI: a meta-analysis
    Brennan M R Spiegel
    Division of Gastroenterology and Hepatology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, Calif 90073, USA
    Am J Med 119:448.e27-36. 2006
  5. ncbi request reprint Treatment alternatives for chronic hepatitis B virus infection: a cost-effectiveness analysis
    Fasiha Kanwal
    Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California, Los Angeles, and Center for the Study of Digestive Healthcare Quality and Outcomes, Los Angeles, California 90073, USA
    Ann Intern Med 142:821-31. 2005
  6. ncbi request reprint Obscure-overt gastrointestinal bleeding
    Ian M Gralnek
    David Geffen School of Medicine at University of California Los Angeles, Veterans Affairs Greater Los Angeles Healthcare System, USA
    Gastroenterology 128:1424-30. 2005
  7. ncbi request reprint Clinical determinants of health-related quality of life in patients with irritable bowel syndrome
    Brennan M R Spiegel
    Division of Gastroenterology, the VA Greater Los Angeles Healthcare System, CA 90073, USA
    Arch Intern Med 164:1773-80. 2004
  8. ncbi request reprint The quality of published health economic analyses in digestive diseases: a systematic review and quantitative appraisal
    Brennan M R Spiegel
    Division of Gastroenterology, Veteran s Affairs Greater Los Angeles Healthcare System, California, USA
    Gastroenterology 127:403-11. 2004
  9. ncbi request reprint Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea: a cost-effectiveness analysis
    Brennan M R Spiegel
    Division of Gastroenterology and Hepatology, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Building 115, Room 215B, Los Angeles, CA 90073, USA
    Gastroenterology 126:1721-32. 2004
  10. ncbi request reprint The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritis
    Brennan M R Spiegel
    Veterans Administration Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California, CURE Digestive Diseases Research Center, Los Angeles, CA 90073, USA
    Ann Intern Med 138:795-806. 2003

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Racial differences in the impact of irritable bowel syndrome on health-related quality of life
    Ian M Gralnek
    VA Greater Los Angeles Health Care System, Los Angeles, CA, USA
    J Clin Gastroenterol 38:782-9. 2004
    ..To compare the impact of irritable bowel syndrome (IBS) on health related quality of life (HRQOI) for non-white and white IBS patients...
  2. ncbi request reprint Treatment alternatives for hepatitis B cirrhosis: a cost-effectiveness analysis
    Fasiha Kanwal
    Division of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Gastroenterol 101:2076-89. 2006
    ..Lamivudine is effective but is limited by viral resistance. In contrast, adefovir and entecavir have lower viral resistance, but are more expensive. The most cost-effective approach is uncertain...
  3. ncbi request reprint Impact of chronic viral hepatitis on health-related quality of life in HIV: results from a nationally representative sample
    Fasiha Kanwal
    VA Greater Los Angeles Health Care System, Division of Gastroenterology Hepatology, David Geffen School of Medicine at UCLA, 90073, USA
    Am J Gastroenterol 100:1984-94. 2005
    ..We compared health-related quality of life (HRQOL) of patients with HIV and hepatitis C virus (HCV) or HIV and hepatitis B virus (HBV) coinfection to those with HIV monoinfection...
  4. ncbi request reprint Comparing rates of dyspepsia with Coxibs vs NSAID+PPI: a meta-analysis
    Brennan M R Spiegel
    Division of Gastroenterology and Hepatology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, Calif 90073, USA
    Am J Med 119:448.e27-36. 2006
    ....
  5. ncbi request reprint Treatment alternatives for chronic hepatitis B virus infection: a cost-effectiveness analysis
    Fasiha Kanwal
    Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California, Los Angeles, and Center for the Study of Digestive Healthcare Quality and Outcomes, Los Angeles, California 90073, USA
    Ann Intern Med 142:821-31. 2005
    ..Interferon has clinically significant side effects, and lamivudine is associated with viral resistance. In contrast, adefovir is safe and has lower viral resistance but is more expensive. The most cost-effective approach is uncertain...
  6. ncbi request reprint Obscure-overt gastrointestinal bleeding
    Ian M Gralnek
    David Geffen School of Medicine at University of California Los Angeles, Veterans Affairs Greater Los Angeles Healthcare System, USA
    Gastroenterology 128:1424-30. 2005
  7. ncbi request reprint Clinical determinants of health-related quality of life in patients with irritable bowel syndrome
    Brennan M R Spiegel
    Division of Gastroenterology, the VA Greater Los Angeles Healthcare System, CA 90073, USA
    Arch Intern Med 164:1773-80. 2004
    ..The identification of predictive factors could allow physicians to better assess HRQOL without using misleading clinical clues. We, therefore, sought to identify determinants of HRQOL in patients with IBS...
  8. ncbi request reprint The quality of published health economic analyses in digestive diseases: a systematic review and quantitative appraisal
    Brennan M R Spiegel
    Division of Gastroenterology, Veteran s Affairs Greater Los Angeles Healthcare System, California, USA
    Gastroenterology 127:403-11. 2004
    ..We sought to appraise the quality of health economic analyses in digestive diseases, and to identify predictors of study quality...
  9. ncbi request reprint Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea: a cost-effectiveness analysis
    Brennan M R Spiegel
    Division of Gastroenterology and Hepatology, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Building 115, Room 215B, Los Angeles, CA 90073, USA
    Gastroenterology 126:1721-32. 2004
    ..Because the symptoms of CS respond to a gluten-free diet, testing for CS in IBS may prevent years of morbidity and attendant expense. We sought to determine whether this might be a cost-effective diagnostic strategy in IBS-D...
  10. ncbi request reprint The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritis
    Brennan M R Spiegel
    Veterans Administration Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California, CURE Digestive Diseases Research Center, Los Angeles, CA 90073, USA
    Ann Intern Med 138:795-806. 2003
    ..However, their absolute risk reduction is small and the cost-effectiveness of treatment is uncertain...
  11. ncbi request reprint Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clots
    Dennis M Jensen
    CURE Digestive Disease Research Center, UCLA School of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Gastroenterology 123:407-13. 2002
    ..Our purpose was to test the hypothesis that patients treated with combination endoscopic therapy would have significantly lower rebleeding rates than those treated with medical therapy...
  12. ncbi request reprint Are physician-derived disease severity indices associated with health-related quality of life in patients with end-stage liver disease?
    Fasiha Kanwal
    VA Greater Los Angeles Health Care System, David Geffen School of Medicine at UCLA, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Am J Gastroenterol 99:1726-32. 2004
    ..However, there are no data evaluating the associations between MELD scores and patient reports of health-related quality of life (HRQOL)...
  13. ncbi request reprint Utilization of health care resources for low-risk patients with acute, nonvariceal upper GI hemorrhage: an historical cohort study
    Gareth S Dulai
    Department of Medicine, Division of Digestive Diseases, UCLA School of Medicine, Los Angeles, CA 90073, USA
    Gastrointest Endosc 55:321-7. 2002
    ..Low-risk patients (Rockall score less-than-or-equal 2) may be candidates for early discharge...
  14. ncbi request reprint Colonic stent vs. emergency surgery for management of acute left-sided malignant colonic obstruction: a decision analysis
    Laura E Targownik
    Division of Digestive Diseases, School of Medicine, UCLA Center for the Health Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
    Gastrointest Endosc 60:865-74. 2004
    ..This study sought to determine the cost-effectiveness of colonic stent vs. surgery for emergent management of acute malignant colonic obstruction...
  15. ncbi request reprint Major stigmata of recent hemorrhage on rectal ulcers in patients with severe hematochezia: Endoscopic diagnosis, treatment, and outcomes
    Fasiha Kanwal
    Division of Digestive Diseases and Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
    Gastrointest Endosc 57:462-8. 2003
    ..Endoscopic diagnosis and treatment of hematochezia caused by rectal ulcers is poorly described...
  16. ncbi request reprint Combination endoscopic band ligation and sclerotherapy compared with endoscopic band ligation alone for the secondary prophylaxis of esophageal variceal hemorrhage: a meta-analysis
    Hetal A Karsan
    VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, Center for the Health Sciences, Division of Digestive Diseases, Los Angeles, California 90073, USA
    Dig Dis Sci 50:399-406. 2005
    ..Moreover, combination EBL and sclerotherapy had more esophageal stricture formation than EBL alone...
  17. ncbi request reprint The cost-effectiveness and budget impact of intravenous versus oral proton pump inhibitors in peptic ulcer hemorrhage
    Brennan M R Spiegel
    Division of Gastroenterology, Veteran s Administration Greater Los Angeles Healthcare System, California, USA
    Clin Gastroenterol Hepatol 4:988-997. 2006
    ....
  18. ncbi request reprint Is a negative colonoscopy associated with reassurance or improved health-related quality of life in irritable bowel syndrome?
    Brennan M R Spiegel
    Division of Gastroenterology, VA Greater Los Angeles Healthcare System, CA 90073, USA
    Gastrointest Endosc 62:892-9. 2005
    ..However, no previous data have measured these effects. We sought to measure the association of a normal colonoscopy with reassurance and HRQOL in patients with IBS aged <50 years...
  19. doi request reprint An evaluation of endoscopic indications and findings related to nonvariceal upper-GI hemorrhage in a large multicenter consortium
    Brintha K Enestvedt
    Department of Internal Medicine, Oregon Health and Sciences University, Portland, Oregon 97214, USA
    Gastrointest Endosc 67:422-9. 2008
    ..There is limited information about patients with UGIH who are evaluated by endoscopy at nonacademic settings, which comprise the majority of endoscopic practices in the United States...
  20. ncbi request reprint Outpatient management of "low-risk" nonvariceal upper GI hemorrhage. Are we ready to put evidence into practice?
    Ian M Gralnek
    Gastrointest Endosc 55:131-4. 2002
  21. doi request reprint Management of acute bleeding from a peptic ulcer
    Ian M Gralnek
    Department of Gastroenterology and Gastrointestinal Outcomes Unit, Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    N Engl J Med 359:928-37. 2008
  22. ncbi request reprint The cost-effectiveness of hepatic venous pressure gradient monitoring in the prevention of recurrent variceal hemorrhage
    Laura E Targownik
    Section of Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 99:1306-15. 2004
    ..Combination of beta-blocker and nitrate therapy, guided by hepatic venous pressure gradient (HVPG) monitoring, is a novel alternative strategy. We sought to determine the cost-effectiveness of these competing strategies...
  23. ncbi request reprint Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo
    Jay L Goldstein
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Clin Gastroenterol Hepatol 3:133-41. 2005
    ..In a multicenter, double-blind, placebo-controlled trial with video capsule endoscopy (VCE) we prospectively evaluated the incidence of small bowel injury in healthy subjects treated with celecoxib compared to naproxen plus omeprazole...
  24. ncbi request reprint Budget impact of tegaserod on a managed care organization formulary
    Michael A Bloom
    Innovative Health Solutions, Brookline, Massachusetts, USA
    Am J Manag Care 11:S27-34. 2005
    ..When the associated budget impact of adding tegaserod to its formulary is absorbed across an entire MCO population, the PMPM impact of tegaserod is small...
  25. doi request reprint Capsule endoscopy may reclassify pediatric inflammatory bowel disease: a historical analysis
    Stanley A Cohen
    Children s Center for Digestive Health Care, Children s Healthcare of Atlanta, Atlanta, GA 30342, USA
    J Pediatr Gastroenterol Nutr 47:31-6. 2008
    ....
  26. pmc Management of obscure occult gastrointestinal bleeding: a cost-minimization analysis
    Ma Somsouk
    Department of Gastrointestinal Health Outcomes, Policy and Economics Research Program, University of California, San Francisco, 513 Parnassus Avenue, Box 0538, San Francisco, California 94143, USA
    Clin Gastroenterol Hepatol 6:661-70. 2008
    ..A cost-minimization analysis determined the optimal initial management strategy for obscure occult gastrointestinal bleeding (OGIB)...
  27. ncbi request reprint Hospital care for low-risk patients with acute, nonvariceal upper GI hemorrhage: a comparison of neighboring community and tertiary care centers
    Tommy T Oei
    VA Greater Los Angeles Healthcare System, California 90073, USA
    Am J Gastroenterol 97:2271-8. 2002
    ..Use of the Rockall Risk score, a simple validated scoring index that predicts outcomes in UGIH, may help to identify these low risk patients...
  28. ncbi request reprint Evaluation of capsule endoscopy in active, mild-to-moderate, overt, obscure GI bleeding
    Periklis Apostolopoulos
    Department of Gastroenterology, Army Share Fund NIMTS Hospital, Athens, Greece
    Gastrointest Endosc 66:1174-81. 2007
    ..The role of capsule endoscopy (CE) in the diagnosis of active mild-to-moderate GI bleeding (GIB) immediately after a negative EGD and ileocolonoscopy has not been prospectively evaluated...
  29. ncbi request reprint Preventing complications of endoscopic hemostasis in acute upper gastrointestinal hemorrhage
    Matti Waterman
    Department of Gastroenterology, Rambam Medical Center, Haifa, Israel
    Gastrointest Endosc Clin N Am 17:157-67, viii. 2007
    ..Although uncommon, procedure-related complications may occur. This article reviews the risks attributable to endoscopic hemostasis in acute UGIH and how to help prevent these complications...
  30. ncbi request reprint Esomeprazole versus other proton pump inhibitors in erosive esophagitis: a meta-analysis of randomized clinical trials
    Ian M Gralnek
    Rambam Medical Center, Department of Gastroenterology, GI Outcomes Unit, Faculty of Medicine, Technion Institute of Technology, Haifa, Israel
    Clin Gastroenterol Hepatol 4:1452-8. 2006
    ..We performed a meta-analysis to calculate the pooled effect of esomeprazole on healing rates, symptom relief, and adverse events versus competing PPIs in EE...
  31. ncbi request reprint Endoscopic research: funding opportunities and mechanisms from the ASGE and beyond
    Ian M Gralnek
    Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Gastrointest Endosc 64:S16-8. 2006
  32. ncbi request reprint Endoscopic screening for esophageal varices in cirrhosis: Is it ever cost effective?
    Brennan M R Spiegel
    Division of Gastroenterology, Greater Los Angeles VA Healthcare System, CA 90073, USA
    Hepatology 37:366-77. 2003
    ....
  33. ncbi request reprint Management of acute nonvariceal upper gastrointestinal hemorrhage: comparison of an American and a Canadian medical centre
    Laura E Targownik
    Veterans Affairs Greater Los Angeles Health Care System, California, USA
    Can J Gastroenterol 17:489-95. 2003
    ..The aim of the present study was to compare the structure, process and outcomes of care between a Canadian and an American tertiary care medical centre in the management of acute nonvariceal UGIH...
  34. ncbi request reprint Nonvariceal upper gastrointestinal bleeding: epidemiology and diagnosis
    Eric Esrailian
    David Geffen School of Medicine at UCLA, VA Greater Los Angeles Healthcare System, UCLA VA Center for Outcomes Research and Education, CA 90073, USA
    Gastroenterol Clin North Am 34:589-605. 2005
    ..This article reviews the most recent epidemiologic data on acute nonvariceal upper gastrointestinal bleeding and outlines important aspects of making the diagnosis...
  35. ncbi request reprint Incremental value of upper endoscopy for triage of patients with acute non-variceal upper-GI hemorrhage
    Ian M Gralnek
    Department of Medicine, VA Greater Los Angeles Healthcare System, and Department of Medicine, CURE Digestive Diseases Research Center, UCLA Center for the Health Sciences, David Geffen School of Medicine at UCLA, California 90073, USA
    Gastrointest Endosc 60:9-14. 2004
    ....
  36. ncbi request reprint Systematic review of the effects of n-3 fatty acids in inflammatory bowel disease
    Catherine H Maclean
    Southern California Evidence Based Practice Center, Santa Monica, CA 90407 2138, USA
    Am J Clin Nutr 82:611-9. 2005
    ..n-3 Fatty acids are purported to have health effects in patients with inflammatory bowel disease (IBD), but studies have reported mixed results...
  37. ncbi request reprint Portal hypertensive enteropathy in a patient with polycystic liver disease: a unique endoscopic finding
    Shou Jiang Tang
    Division of Digestive Diseases, Center for Health Sciences, University of California at Los Angeles UCLA, USA
    Gastrointest Endosc 56:924-6. 2002