Ian M Gralnek
Affiliation: University of California
- Racial differences in the impact of irritable bowel syndrome on health-related quality of lifeIan M Gralnek
VA Greater Los Angeles Health Care System, Los Angeles, CA, USA
J Clin Gastroenterol 38:782-9. 2004..To compare the impact of irritable bowel syndrome (IBS) on health related quality of life (HRQOI) for non-white and white IBS patients...
- Treatment alternatives for hepatitis B cirrhosis: a cost-effectiveness analysisFasiha Kanwal
Division of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Am J Gastroenterol 101:2076-89. 2006..Lamivudine is effective but is limited by viral resistance. In contrast, adefovir and entecavir have lower viral resistance, but are more expensive. The most cost-effective approach is uncertain...
- Impact of chronic viral hepatitis on health-related quality of life in HIV: results from a nationally representative sampleFasiha Kanwal
VA Greater Los Angeles Health Care System, Division of Gastroenterology Hepatology, David Geffen School of Medicine at UCLA, 90073, USA
Am J Gastroenterol 100:1984-94. 2005..We compared health-related quality of life (HRQOL) of patients with HIV and hepatitis C virus (HCV) or HIV and hepatitis B virus (HBV) coinfection to those with HIV monoinfection...
- Comparing rates of dyspepsia with Coxibs vs NSAID+PPI: a meta-analysisBrennan M R Spiegel
Division of Gastroenterology and Hepatology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, Calif 90073, USA
Am J Med 119:448.e27-36. 2006....
- Treatment alternatives for chronic hepatitis B virus infection: a cost-effectiveness analysisFasiha Kanwal
Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California, Los Angeles, and Center for the Study of Digestive Healthcare Quality and Outcomes, Los Angeles, California 90073, USA
Ann Intern Med 142:821-31. 2005..Interferon has clinically significant side effects, and lamivudine is associated with viral resistance. In contrast, adefovir is safe and has lower viral resistance but is more expensive. The most cost-effective approach is uncertain...
- Obscure-overt gastrointestinal bleedingIan M Gralnek
David Geffen School of Medicine at University of California Los Angeles, Veterans Affairs Greater Los Angeles Healthcare System, USA
Gastroenterology 128:1424-30. 2005
- Clinical determinants of health-related quality of life in patients with irritable bowel syndromeBrennan M R Spiegel
Division of Gastroenterology, the VA Greater Los Angeles Healthcare System, CA 90073, USA
Arch Intern Med 164:1773-80. 2004..The identification of predictive factors could allow physicians to better assess HRQOL without using misleading clinical clues. We, therefore, sought to identify determinants of HRQOL in patients with IBS...
- The quality of published health economic analyses in digestive diseases: a systematic review and quantitative appraisalBrennan M R Spiegel
Division of Gastroenterology, Veteran s Affairs Greater Los Angeles Healthcare System, California, USA
Gastroenterology 127:403-11. 2004..We sought to appraise the quality of health economic analyses in digestive diseases, and to identify predictors of study quality...
- Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea: a cost-effectiveness analysisBrennan M R Spiegel
Division of Gastroenterology and Hepatology, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Building 115, Room 215B, Los Angeles, CA 90073, USA
Gastroenterology 126:1721-32. 2004..Because the symptoms of CS respond to a gluten-free diet, testing for CS in IBS may prevent years of morbidity and attendant expense. We sought to determine whether this might be a cost-effective diagnostic strategy in IBS-D...
- The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritisBrennan M R Spiegel
Veterans Administration Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California, CURE Digestive Diseases Research Center, Los Angeles, CA 90073, USA
Ann Intern Med 138:795-806. 2003..However, their absolute risk reduction is small and the cost-effectiveness of treatment is uncertain...
- Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clotsDennis M Jensen
CURE Digestive Disease Research Center, UCLA School of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Gastroenterology 123:407-13. 2002..Our purpose was to test the hypothesis that patients treated with combination endoscopic therapy would have significantly lower rebleeding rates than those treated with medical therapy...
- Are physician-derived disease severity indices associated with health-related quality of life in patients with end-stage liver disease?Fasiha Kanwal
VA Greater Los Angeles Health Care System, David Geffen School of Medicine at UCLA, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Am J Gastroenterol 99:1726-32. 2004..However, there are no data evaluating the associations between MELD scores and patient reports of health-related quality of life (HRQOL)...
- Utilization of health care resources for low-risk patients with acute, nonvariceal upper GI hemorrhage: an historical cohort studyGareth S Dulai
Department of Medicine, Division of Digestive Diseases, UCLA School of Medicine, Los Angeles, CA 90073, USA
Gastrointest Endosc 55:321-7. 2002..Low-risk patients (Rockall score less-than-or-equal 2) may be candidates for early discharge...
- Colonic stent vs. emergency surgery for management of acute left-sided malignant colonic obstruction: a decision analysisLaura E Targownik
Division of Digestive Diseases, School of Medicine, UCLA Center for the Health Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
Gastrointest Endosc 60:865-74. 2004..This study sought to determine the cost-effectiveness of colonic stent vs. surgery for emergent management of acute malignant colonic obstruction...
- Major stigmata of recent hemorrhage on rectal ulcers in patients with severe hematochezia: Endoscopic diagnosis, treatment, and outcomesFasiha Kanwal
Division of Digestive Diseases and Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
Gastrointest Endosc 57:462-8. 2003..Endoscopic diagnosis and treatment of hematochezia caused by rectal ulcers is poorly described...
- Combination endoscopic band ligation and sclerotherapy compared with endoscopic band ligation alone for the secondary prophylaxis of esophageal variceal hemorrhage: a meta-analysisHetal A Karsan
VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, Center for the Health Sciences, Division of Digestive Diseases, Los Angeles, California 90073, USA
Dig Dis Sci 50:399-406. 2005..Moreover, combination EBL and sclerotherapy had more esophageal stricture formation than EBL alone...
- The cost-effectiveness and budget impact of intravenous versus oral proton pump inhibitors in peptic ulcer hemorrhageBrennan M R Spiegel
Division of Gastroenterology, Veteran s Administration Greater Los Angeles Healthcare System, California, USA
Clin Gastroenterol Hepatol 4:988-997. 2006....
- Is a negative colonoscopy associated with reassurance or improved health-related quality of life in irritable bowel syndrome?Brennan M R Spiegel
Division of Gastroenterology, VA Greater Los Angeles Healthcare System, CA 90073, USA
Gastrointest Endosc 62:892-9. 2005..However, no previous data have measured these effects. We sought to measure the association of a normal colonoscopy with reassurance and HRQOL in patients with IBS aged <50 years...
- An evaluation of endoscopic indications and findings related to nonvariceal upper-GI hemorrhage in a large multicenter consortiumBrintha K Enestvedt
Department of Internal Medicine, Oregon Health and Sciences University, Portland, Oregon 97214, USA
Gastrointest Endosc 67:422-9. 2008..There is limited information about patients with UGIH who are evaluated by endoscopy at nonacademic settings, which comprise the majority of endoscopic practices in the United States...
- Outpatient management of "low-risk" nonvariceal upper GI hemorrhage. Are we ready to put evidence into practice?Ian M Gralnek
Gastrointest Endosc 55:131-4. 2002
- Management of acute bleeding from a peptic ulcerIan M Gralnek
Department of Gastroenterology and Gastrointestinal Outcomes Unit, Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
N Engl J Med 359:928-37. 2008
- The cost-effectiveness of hepatic venous pressure gradient monitoring in the prevention of recurrent variceal hemorrhageLaura E Targownik
Section of Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada
Am J Gastroenterol 99:1306-15. 2004..Combination of beta-blocker and nitrate therapy, guided by hepatic venous pressure gradient (HVPG) monitoring, is a novel alternative strategy. We sought to determine the cost-effectiveness of these competing strategies...
- Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placeboJay L Goldstein
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Clin Gastroenterol Hepatol 3:133-41. 2005..In a multicenter, double-blind, placebo-controlled trial with video capsule endoscopy (VCE) we prospectively evaluated the incidence of small bowel injury in healthy subjects treated with celecoxib compared to naproxen plus omeprazole...
- Budget impact of tegaserod on a managed care organization formularyMichael A Bloom
Innovative Health Solutions, Brookline, Massachusetts, USA
Am J Manag Care 11:S27-34. 2005..When the associated budget impact of adding tegaserod to its formulary is absorbed across an entire MCO population, the PMPM impact of tegaserod is small...
- Capsule endoscopy may reclassify pediatric inflammatory bowel disease: a historical analysisStanley A Cohen
Children s Center for Digestive Health Care, Children s Healthcare of Atlanta, Atlanta, GA 30342, USA
J Pediatr Gastroenterol Nutr 47:31-6. 2008....
- Management of obscure occult gastrointestinal bleeding: a cost-minimization analysisMa Somsouk
Department of Gastrointestinal Health Outcomes, Policy and Economics Research Program, University of California, San Francisco, 513 Parnassus Avenue, Box 0538, San Francisco, California 94143, USA
Clin Gastroenterol Hepatol 6:661-70. 2008..A cost-minimization analysis determined the optimal initial management strategy for obscure occult gastrointestinal bleeding (OGIB)...
- Hospital care for low-risk patients with acute, nonvariceal upper GI hemorrhage: a comparison of neighboring community and tertiary care centersTommy T Oei
VA Greater Los Angeles Healthcare System, California 90073, USA
Am J Gastroenterol 97:2271-8. 2002..Use of the Rockall Risk score, a simple validated scoring index that predicts outcomes in UGIH, may help to identify these low risk patients...
- Evaluation of capsule endoscopy in active, mild-to-moderate, overt, obscure GI bleedingPeriklis Apostolopoulos
Department of Gastroenterology, Army Share Fund NIMTS Hospital, Athens, Greece
Gastrointest Endosc 66:1174-81. 2007..The role of capsule endoscopy (CE) in the diagnosis of active mild-to-moderate GI bleeding (GIB) immediately after a negative EGD and ileocolonoscopy has not been prospectively evaluated...
- Preventing complications of endoscopic hemostasis in acute upper gastrointestinal hemorrhageMatti Waterman
Department of Gastroenterology, Rambam Medical Center, Haifa, Israel
Gastrointest Endosc Clin N Am 17:157-67, viii. 2007..Although uncommon, procedure-related complications may occur. This article reviews the risks attributable to endoscopic hemostasis in acute UGIH and how to help prevent these complications...
- Esomeprazole versus other proton pump inhibitors in erosive esophagitis: a meta-analysis of randomized clinical trialsIan M Gralnek
Rambam Medical Center, Department of Gastroenterology, GI Outcomes Unit, Faculty of Medicine, Technion Institute of Technology, Haifa, Israel
Clin Gastroenterol Hepatol 4:1452-8. 2006..We performed a meta-analysis to calculate the pooled effect of esomeprazole on healing rates, symptom relief, and adverse events versus competing PPIs in EE...
- Endoscopic research: funding opportunities and mechanisms from the ASGE and beyondIan M Gralnek
Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
Gastrointest Endosc 64:S16-8. 2006
- Endoscopic screening for esophageal varices in cirrhosis: Is it ever cost effective?Brennan M R Spiegel
Division of Gastroenterology, Greater Los Angeles VA Healthcare System, CA 90073, USA
Hepatology 37:366-77. 2003....
- Management of acute nonvariceal upper gastrointestinal hemorrhage: comparison of an American and a Canadian medical centreLaura E Targownik
Veterans Affairs Greater Los Angeles Health Care System, California, USA
Can J Gastroenterol 17:489-95. 2003..The aim of the present study was to compare the structure, process and outcomes of care between a Canadian and an American tertiary care medical centre in the management of acute nonvariceal UGIH...
- Nonvariceal upper gastrointestinal bleeding: epidemiology and diagnosisEric Esrailian
David Geffen School of Medicine at UCLA, VA Greater Los Angeles Healthcare System, UCLA VA Center for Outcomes Research and Education, CA 90073, USA
Gastroenterol Clin North Am 34:589-605. 2005..This article reviews the most recent epidemiologic data on acute nonvariceal upper gastrointestinal bleeding and outlines important aspects of making the diagnosis...
- Incremental value of upper endoscopy for triage of patients with acute non-variceal upper-GI hemorrhageIan M Gralnek
Department of Medicine, VA Greater Los Angeles Healthcare System, and Department of Medicine, CURE Digestive Diseases Research Center, UCLA Center for the Health Sciences, David Geffen School of Medicine at UCLA, California 90073, USA
Gastrointest Endosc 60:9-14. 2004....
- Systematic review of the effects of n-3 fatty acids in inflammatory bowel diseaseCatherine H Maclean
Southern California Evidence Based Practice Center, Santa Monica, CA 90407 2138, USA
Am J Clin Nutr 82:611-9. 2005..n-3 Fatty acids are purported to have health effects in patients with inflammatory bowel disease (IBD), but studies have reported mixed results...
- Portal hypertensive enteropathy in a patient with polycystic liver disease: a unique endoscopic findingShou Jiang Tang
Division of Digestive Diseases, Center for Health Sciences, University of California at Los Angeles UCLA, USA
Gastrointest Endosc 56:924-6. 2002