Brian B Graham

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. doi request reprint Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake
    Brian B Graham
    Department of Medicine, University of Colorado Denver, Aurora, Colorado
    Am J Physiol Lung Cell Mol Physiol 309:L435-40. 2015
  2. pmc Significant intrapulmonary Schistosoma egg antigens are not present in schistosomiasis-associated pulmonary hypertension
    Brian B Graham
    Department of Medicine, Program in Translational Lung Research, University of Colorado Denver, Denver, CO, USA
    Pulm Circ 1:456-61. 2011
  3. pmc Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling
    Brian B Graham
    Program in Translational Lung Research, Pulmonary and Critical Care Medicine, University of Colorado, Denver, Colorado, USA
    Am J Pathol 177:1549-61. 2010
  4. doi request reprint The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension
    Rahul Kumar
    1 Program in Translational Lung Research, Department of Medicine, Anschutz Medical Campus, Aurora, Colorado
    Am J Respir Crit Care Med 192:998-1008. 2015
  5. pmc Transforming growth factor-β signaling promotes pulmonary hypertension caused by Schistosoma mansoni
    Brian B Graham
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine B B G, J C, L G, J P, E D, L D, T T, L S, N D, R W V and Department of Pathology X J W, Anschutz Medical Campus, Aurora, CO Pulmonary Vascular Research Institute B B G, A B, H C C, G B, R M T Memorial S Jose Hospital, Universidade de Pernambuco in Recife, Recife, Brazil A B Division of Cardiology, University of Pittsburgh, Pittsburgh, PA H C C School of Pharmacy, University of Kent, Kent, UK G B and Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD T A W
    Circulation 128:1354-64. 2013
  6. doi request reprint Pathology of pulmonary hypertension
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, 12700 East 19th Avenue, Research Complex 2, room 9001, Aurora, CO 80045, USA Electronic address
    Clin Chest Med 34:639-50. 2013
  7. doi request reprint Schistosomiasis-associated pulmonary hypertension: pulmonary vascular disease: the global perspective
    Brian B Graham
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado at Denver, Aurora, CO 80045, USA
    Chest 137:20S-29S. 2010
  8. pmc Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation
    Aaron M Nadon
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado
    Am J Pathol 184:2382-9. 2014
  9. pmc Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung
    Rubin M Tuder
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, School of Medicine, 4200 East 9th Avenue, Campus Box C272, Denver, CO 80262, USA
    Am J Respir Cell Mol Biol 39:1-6. 2008
  10. pmc TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation
    Valeria M Borges
    Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 297:L586-95. 2009

Collaborators

Detail Information

Publications13

  1. doi request reprint Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake
    Brian B Graham
    Department of Medicine, University of Colorado Denver, Aurora, Colorado
    Am J Physiol Lung Cell Mol Physiol 309:L435-40. 2015
    ..In the RV in rats with SPH, there is a major shift in metabolic substrate preference, largely due to decreased fatty acid uptake. ..
  2. pmc Significant intrapulmonary Schistosoma egg antigens are not present in schistosomiasis-associated pulmonary hypertension
    Brian B Graham
    Department of Medicine, Program in Translational Lung Research, University of Colorado Denver, Denver, CO, USA
    Pulm Circ 1:456-61. 2011
    ..This suggests that retained and persistent parasite proteins are not contributing to a localized immune response in the pathogenesis of this disease...
  3. pmc Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling
    Brian B Graham
    Program in Translational Lung Research, Pulmonary and Critical Care Medicine, University of Colorado, Denver, Colorado, USA
    Am J Pathol 177:1549-61. 2010
    ..Our data indicate that experimental schistosomiasis causes PH and potentially relies on up-regulated IL-13 signaling...
  4. doi request reprint The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension
    Rahul Kumar
    1 Program in Translational Lung Research, Department of Medicine, Anschutz Medical Campus, Aurora, Colorado
    Am J Respir Crit Care Med 192:998-1008. 2015
    ..Schistosoma mansoni exposure results in prototypical type-2 inflammation. Furthermore, transforming growth factor (TGF)-β signaling is required for experimental pulmonary hypertension (PH) caused by Schistosoma exposure...
  5. pmc Transforming growth factor-β signaling promotes pulmonary hypertension caused by Schistosoma mansoni
    Brian B Graham
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine B B G, J C, L G, J P, E D, L D, T T, L S, N D, R W V and Department of Pathology X J W, Anschutz Medical Campus, Aurora, CO Pulmonary Vascular Research Institute B B G, A B, H C C, G B, R M T Memorial S Jose Hospital, Universidade de Pernambuco in Recife, Recife, Brazil A B Division of Cardiology, University of Pittsburgh, Pittsburgh, PA H C C School of Pharmacy, University of Kent, Kent, UK G B and Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD T A W
    Circulation 128:1354-64. 2013
    ..We hypothesized that transforming growth factor-β (TGF-β) signaling as a consequence of Th2 inflammation is critical for the pathogenesis of this disease...
  6. doi request reprint Pathology of pulmonary hypertension
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, 12700 East 19th Avenue, Research Complex 2, room 9001, Aurora, CO 80045, USA Electronic address
    Clin Chest Med 34:639-50. 2013
    ..There was correlation between perivascular inflammation, remodeling, and hemodynamics. This article summarizes the pathologic features of the normal and abnormal pulmonary circulation, and correlations with animal models. ..
  7. doi request reprint Schistosomiasis-associated pulmonary hypertension: pulmonary vascular disease: the global perspective
    Brian B Graham
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado at Denver, Aurora, CO 80045, USA
    Chest 137:20S-29S. 2010
    ..Further research is needed into the pathogenic mechanism by which this parasitic infection results in pulmonary vascular remodeling and PH, which also may be informative regarding the etiology of other types of PH...
  8. pmc Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation
    Aaron M Nadon
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado
    Am J Pathol 184:2382-9. 2014
    ..These data suggest that epithelial mTORC1 activity plays a protective role against lung injury, and its inhibition by Rtp801 exacerbates alveolar injury caused by endotoxin. ..
  9. pmc Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung
    Rubin M Tuder
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, School of Medicine, 4200 East 9th Avenue, Campus Box C272, Denver, CO 80262, USA
    Am J Respir Cell Mol Biol 39:1-6. 2008
    ..Molecular switches, ontologically designed for the protection of the host, are now hijacked by injurious stresses (such as cigarette smoke), leading to organ damage...
  10. pmc TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation
    Valeria M Borges
    Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 297:L586-95. 2009
    ..These findings suggest that the presence of TNFalpha in the lung can alter the response of phagocytes to apoptotic cells leading to inflammatory cell recruitment and proinflammatory mediator production...
  11. pmc Pulmonary veins in the normal lung and pulmonary hypertension due to left heart disease
    James M Hunt
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Univ of Colorado Denver, Anschutz Medical Campus, Research 2 9th Floor, Rm 9001 Mail stop C 272, 12700 East 19th Ave, Aurora, CO 80045
    Am J Physiol Lung Cell Mol Physiol 305:L725-36. 2013
    ..Our data indicate that remodeling of pulmonary veins is an integral part of PH-LHD and that pulmonary veins share some key features present in remodeled yet not normotensive pulmonary arteries...
  12. pmc The crossroads of iron with hypoxia and cellular metabolism. Implications in the pathobiology of pulmonary hypertension
    Jeffrey C Robinson
    1 Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado and
    Am J Respir Cell Mol Biol 51:721-9. 2014
    ..Given the potential importance of iron supplementation in patients with the disease and the broad cellular functions of iron, we review its role in processes that pertain to PAH. ..
  13. pmc Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, USA
    Am J Respir Crit Care Med 185:260-6. 2012
    ..These investigations have led to novel approaches in the diagnosis and therapy of pulmonary hypertension...