M Sean Grady

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Neuronal and glial cell number in the hippocampus after experimental traumatic brain injury: analysis by stereological estimation
    M Sean Grady
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 20:929-41. 2003
  2. doi request reprint Transoral robotic surgery of craniocervical junction and atlantoaxial spine: a cadaveric study
    John Y K Lee
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosurg Spine 12:13-8. 2010
  3. ncbi request reprint Response of the contralateral hippocampus to lateral fluid percussion brain injury
    Lorriann D Tran
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 23:1330-42. 2006
  4. pmc Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus
    Sunil Patel
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fluids Barriers CNS 9:7. 2012
  5. ncbi request reprint Decompressive craniectomy for elevated intracranial pressure and its effect on the cumulative ischemic burden and therapeutic intensity levels after severe traumatic brain injury
    Gregory M Weiner
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Neurosurgery 66:1111-8; discussion 1118-9. 2010
  6. pmc Cognitive outcome following brain injury and treatment with an inhibitor of Nogo-A in association with an attenuated downregulation of hippocampal growth-associated protein-43 expression
    Niklas Marklund
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, USA
    J Neurosurg 107:844-53. 2007
  7. ncbi request reprint Reduced mortality rate in patients with severe traumatic brain injury treated with brain tissue oxygen monitoring
    Michael F Stiefel
    Department of Neurosurgery and Division of Trauma Surgery and Surgical Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Neurosurg 103:805-11. 2005
  8. ncbi request reprint The effect of nimodipine on cerebral oxygenation in patients with poor-grade subarachnoid hemorrhage
    Michael F Stiefel
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Neurosurg 101:594-9. 2004
  9. doi request reprint Transoral robotic surgery of the skull base: a cadaver and feasibility study
    John Y K Lee
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    ORL J Otorhinolaryngol Relat Spec 72:181-7. 2010
  10. ncbi request reprint Inbred mouse strains as a tool to analyze hippocampal neuronal loss after brain injury: a stereological study
    Brent M Witgen
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 23:1320-9. 2006

Detail Information

Publications44

  1. ncbi request reprint Neuronal and glial cell number in the hippocampus after experimental traumatic brain injury: analysis by stereological estimation
    M Sean Grady
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 20:929-41. 2003
    ..The implications of the observed cell population changes are discussed in relation to the reported cognitive deficits associated with both lateral and midline FP brain injury...
  2. doi request reprint Transoral robotic surgery of craniocervical junction and atlantoaxial spine: a cadaveric study
    John Y K Lee
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosurg Spine 12:13-8. 2010
    ..The goal of this study was to determine the potential role and current limitations of the da Vinci surgical robot in transoral decompression of craniocervical junction (CCJ)...
  3. ncbi request reprint Response of the contralateral hippocampus to lateral fluid percussion brain injury
    Lorriann D Tran
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 23:1330-42. 2006
    ..The cognitive recovery observed after human traumatic brain injury may stem from a differential injury exposure and time course of recovery between homologous regions of the two hemispheres...
  4. pmc Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus
    Sunil Patel
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fluids Barriers CNS 9:7. 2012
    ..abstract:..
  5. ncbi request reprint Decompressive craniectomy for elevated intracranial pressure and its effect on the cumulative ischemic burden and therapeutic intensity levels after severe traumatic brain injury
    Gregory M Weiner
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Neurosurgery 66:1111-8; discussion 1118-9. 2010
    ..Increased intracranial pressure (ICP) can cause brain ischemia and compromised brain oxygen (PbtO2 < or = 20 mm Hg) after severe traumatic brain injury (TBI)...
  6. pmc Cognitive outcome following brain injury and treatment with an inhibitor of Nogo-A in association with an attenuated downregulation of hippocampal growth-associated protein-43 expression
    Niklas Marklund
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, USA
    J Neurosurg 107:844-53. 2007
    ..To elucidate a potential molecular response to Nogo-A inhibition, we evaluated the effects of 7B12 on hippocampal GAP-43 expression...
  7. ncbi request reprint Reduced mortality rate in patients with severe traumatic brain injury treated with brain tissue oxygen monitoring
    Michael F Stiefel
    Department of Neurosurgery and Division of Trauma Surgery and Surgical Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Neurosurg 103:805-11. 2005
    ..The authors therefore determined whether the addition of a brain tissue oxygen tension (PO2) monitor in the treatment of TBI was associated with an improved patient outcome...
  8. ncbi request reprint The effect of nimodipine on cerebral oxygenation in patients with poor-grade subarachnoid hemorrhage
    Michael F Stiefel
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Neurosurg 101:594-9. 2004
    ..In addition, adverse systemic effects such as hypotension have been described. The authors investigated the effect of nimodipine on brain tissue PO2...
  9. doi request reprint Transoral robotic surgery of the skull base: a cadaver and feasibility study
    John Y K Lee
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    ORL J Otorhinolaryngol Relat Spec 72:181-7. 2010
    ..The goal of this study was to determine the potential role as well as the current limitations of the da Vinci Surgical System robot in transoral surgery of the skull base...
  10. ncbi request reprint Inbred mouse strains as a tool to analyze hippocampal neuronal loss after brain injury: a stereological study
    Brent M Witgen
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 23:1320-9. 2006
    ..The loss of neurons appears to be restricted to the first week post-injury, and the remaining neurons may serve as a substrate for recovery...
  11. doi request reprint Is aggressive treatment of traumatic brain injury cost-effective?
    Robert G Whitmore
    Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosurg 116:1106-13. 2012
    ..The object of this study was to determine whether aggressive treatment of severe traumatic brain injury (TBI), including invasive intracranial monitoring and decompressive craniectomy, is cost-effective...
  12. doi request reprint Brain hyperthermia after traumatic brain injury does not reduce brain oxygen
    Alejandro M Spiotta
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Neurosurgery 62:864-72; discussion 872. 2008
    ..In this study, we examined the relationship between brain temperature (BT) and core body temperature and the relationship between BT and brain tissue oxygen (BtO2) to determine whether hyperthermia adversely affects BtO2...
  13. pmc Acute cognitive impairment after lateral fluid percussion brain injury recovers by 1 month: evaluation by conditioned fear response
    Jonathan Lifshitz
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    Behav Brain Res 177:347-57. 2007
    ..Hence, the acute injury-induced cognitive impairment may persist while transient pathophysiological sequelae are underway, and improve as global dysfunction subsides...
  14. doi request reprint Endoscopic endonasal resection of anterior skull base meningiomas and mucosa: implications for resection, reconstruction, and recurrence
    John Y K Lee
    Department of Neurosurgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19106, United States
    J Neurol Surg A Cent Eur Neurosurg 74:12-7. 2013
    ..The implications of this finding are discussed with respect to resection, reconstruction, and recurrence...
  15. ncbi request reprint Injury-induced alterations in CNS electrophysiology
    Akiva S Cohen
    Department of Pediatrics, University of Pennsylvania, School of Medicine and Division of Neurology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Prog Brain Res 161:143-69. 2007
    ....
  16. pmc Harvested human neurons engineered as live nervous tissue constructs: implications for transplantation. Laboratory investigation
    Jason H Huang
    Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York, USA
    J Neurosurg 108:343-7. 2008
    ..The authors chose to evaluate human dorsal root ganglion (DRG) neurons due to their robustness in culture...
  17. pmc Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults
    Meeri N Kim
    Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104, USA
    Neurocrit Care 12:173-80. 2010
    ....
  18. ncbi request reprint Brain tissue oxygen practice guidelines using the LICOX CMP monitoring system
    Eileen Maloney Wilensky
    Neurosurgery Clinical Research Division NCRD and In House CRNP PA Rotation Team, Hospital of the University of Pennsylvania, Department of Neurosurgery, 3400 Spruce St, Philadelphia 19104, USA
    J Neurosci Nurs 37:278-88. 2005
    ....
  19. doi request reprint Deep brain stimulation in the treatment of obesity
    Casey H Halpern
    Department of Neurosurgery, Center for Weight and Eating Disorders, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosurg 109:625-34. 2008
    ..The authors conclude that deep brain stimulation should be strongly considered as a promising therapeutic option for patients suffering from refractory obesity...
  20. doi request reprint Resident duty hour regulation and patient safety: establishing a balance between concerns about resident fatigue and adequate training in neurosurgery
    M Sean Grady
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neurosurg 110:828-36. 2009
    ..The authors conclude that there must be an adequate balance between the risks associated with resident fatigue and those associated with an inexperienced neurosurgical work force for public health...
  21. ncbi request reprint Hypoxia is important in the biology and aggression of human glial brain tumors
    Sydney M Evans
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6072, USA
    Clin Cancer Res 10:8177-84. 2004
    ..1% oxygen) was present in 5 of 12 grade 4 tumors. A correlation between more rapid tumor recurrence and hypoxia was demonstrated with EF5 binding, but this relationship was not predicted by Eppendorf measurements...
  22. doi request reprint Hypoglossal nerve palsy missed and misinterpreted: the hidden skull base
    Kim O Learned
    Division of Neuroradiology, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Comput Assist Tomogr 36:718-24. 2012
    ..Understanding radiological patterns of tongue denervation is important to prevent misinterpretation. Close evaluation of the skull base is critical as hypoglossal palsies resulting from pathology here are often overlooked...
  23. doi request reprint Microthrombosis after experimental subarachnoid hemorrhage: time course and effect of red blood cell-bound thrombin-activated pro-urokinase and clazosentan
    Jared M Pisapia
    Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Neurol 233:357-63. 2012
    ..Microclots may be safely reduced using a novel form of thromboprophylaxis provided by RBC-targeted scFv/uPA-T and represent a potential target for therapeutic intervention in the treatment of DCI...
  24. ncbi request reprint Lateral fluid percussion brain injury: a 15-year review and evaluation
    Hilaire J Thompson
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 22:42-75. 2005
    ....
  25. doi request reprint Comparison of endoscopic and microscopic removal of pituitary adenomas: single-surgeon experience and the learning curve
    BERT W O'MALLEY
    Departments of Otorhinolaryngology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Neurosurg Focus 25:E10. 2008
    ..They also attempted to determine the learning curve associated with a surgical team converting to endoscopic techniques...
  26. ncbi request reprint Da Vinci Robot-assisted transoral odontoidectomy for basilar invagination
    John Y K Lee
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    ORL J Otorhinolaryngol Relat Spec 72:91-5. 2010
    ..These problems, and the corollary aversion to the procedure felt by many neurosurgeons, led our group to investigate an alternative approach...
  27. pmc Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue
    Ditte Lovatt
    1 Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, USA 2
    Nat Methods 11:190-6. 2014
    ..The TIVA methodology is, to our knowledge, the first noninvasive approach for capturing mRNA from live single cells in their natural microenvironment. ..
  28. doi request reprint Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology
    David A Wolk
    Penn Memory Center, 3615 Chestnut St, Philadelphia, PA 19104, USA
    Arch Neurol 68:1398-403. 2011
    ..To determine the correspondence of in vivo quantitative estimates of brain uptake of fluorine 18-labeled flutemetamol with immunohistochemical estimates of amyloid levels in patients who underwent previous biopsy...
  29. ncbi request reprint Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampus
    Jonathan Lifshitz
    Head Injury Center, Department of Neurosurgery, University of Pensylvania, Philadelphia, Pensylvania 19104 6316, USA
    J Cereb Blood Flow Metab 23:219-31. 2003
    ..The heterogeneous mitochondrial response to TBI may underlie posttraumatic metabolic dysfunction and contribute to the pathophysiology of TBI...
  30. ncbi request reprint Cerebral oxygenation following decompressive hemicraniectomy for the treatment of refractory intracranial hypertension
    Michael F Stiefel
    Department of Neurosurgery, Division of Trauma Surgery and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Neurosurg 101:241-7. 2004
    ..Whether and when to use DCH, however, remain unclear. The authors therefore studied the effects of DCH on cerebral O2 to develop a better understanding of the effects of this treatment on the recovery from injury and disease...
  31. pmc Clinically silent somatotroph adenomas are common
    Alisha N Wade
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 3400 Civic Center Boulevard, 12 135 Translational Research Center, Philadelphia, Pennsylvania 19104, USA
    Eur J Endocrinol 165:39-44. 2011
    ..The relative frequency of each presentation is unknown. The goal of this study was, therefore, to determine the frequency of clinically silent somatotroph adenomas, a group that is potentially recognizable in vivo...
  32. ncbi request reprint Translating surgical research to clinical practice
    M Sean Grady
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin Neurosurg 54:106-9. 2007
  33. doi request reprint Endoscopic resection of advanced anterior skull base lesions: oncologically safe?
    Marc A Cohen
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    ORL J Otorhinolaryngol Relat Spec 71:123-8. 2009
    ..2) Understand the difference in patient morbidity with endoscopic surgery compared to traditional CFR...
  34. pmc Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology
    Roy Hamilton
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Ann Neurol 68:535-40. 2010
    ....
  35. pmc The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study
    Sydney M Evans
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Transl Oncol 3:160-9. 2010
    ..0291). In summary, patients had a worse prognosis if the [EF5/Ki-67(Binding)]/[Tumor(binding)] ratio was high. A hypothesis for the mechanisms and translational significance of these findings is discussed...
  36. ncbi request reprint Impaired fibrinolysis and traumatic brain injury in mice
    Diego Morales
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania School of Medicine, and Veterans Administrations Medical Center, Philadelphia, Pennsylvania 19106, USA
    J Neurotrauma 23:976-84. 2006
    ..05). These results demonstrate that the absence of uPA in mice aggravates acute motor deficit and exacerbates cortical tissue loss following CCI brain injury, and suggests a neuroprotective role of the fibrinolytic process following TBI...
  37. ncbi request reprint Lumbar vertebral hemangioma presenting with the acute onset of neurological symptoms. Case report
    H Isaac Chen
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosurg Spine 7:80-5. 2007
    ..Vertebral hemangiomas can be treated effectively with interventional techniques such as embolization and ethanol injection...
  38. pmc A panel of neuron-enriched proteins as markers for traumatic brain injury in humans
    Robert Siman
    Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 26:1867-77. 2009
    ..Our results identify neuron-enriched proteins that may serve as a panel of CSF and blood surrogate markers for the minimally invasive detection, management, mechanistic, and therapeutic evaluation of human TBI...
  39. ncbi request reprint Intracranial hypotension after intraoperative lumbar cerebrospinal fluid drainage
    Uzma Samadani
    Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Neurosurgery 52:148-51; discussion 151-2. 2003
    ..Intraoperative lumbar cerebrospinal fluid drainage is frequently performed in a variety of neurosurgical procedures. A retrospective review is presented of the complications of lumbar cerebrospinal fluid drainage...
  40. ncbi request reprint What we research: survey of American Association of Neurological Surgeons and Congress of Neurological Surgeons member publications
    Mark G Burnett
    Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosurg 100:73-8. 2004
    ....
  41. doi request reprint Thalamic deep brain stimulation for midbrain tremor secondary to cystic degeneration of the brainstem
    Matthew R Sanborn
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
    Stereotact Funct Neurosurg 87:128-33. 2009
    ....
  42. ncbi request reprint What's new in neurological surgery
    M Sean Grady
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
    J Am Coll Surg 199:109-13. 2004
  43. ncbi request reprint February 2002: 29-year-old woman with a skull mass for 2 months
    Kar Ming Fung
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, USA
    Brain Pathol 12:393-4, 397. 2002
    ..Electron microscopy confirmed the presence Birbeck granules. The final diagnosis was Langerhans' cell histiocytosis (histiocytosis X) of the skull...
  44. ncbi request reprint Decompressive craniectomy
    M Sean Grady
    J Neurosurg 104:467-8; discussion 468. 2006