Research Topics
Species | Deborah GradySummaryAffiliation: University of California Country: USA Publications
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Publications
Reduced incidence of invasive breast cancer with raloxifene among women at increased coronary riskDeborah Grady
University of California, San Francisco, and San Francisco VA Medical Center, San Francisco, CA 94115, USA
J Natl Cancer Inst 100:854-61. 2008..Here, we provide further details about breast cancer incidence by tumor characteristics, duration of treatment, and subgroup...
MF101, a selective estrogen receptor beta modulator for the treatment of menopausal hot flushes: a phase II clinical trialDeborah Grady
University of California, San Francisco, San Francisco, CA 94115, USA
Menopause 16:458-65. 2009..To determine the optimal dose, safety, and efficacy of an estrogen receptor beta selective Chinese herbal extract, menopausal formula 101 (MF101), for treating hot flushes...
Discontinuation of postmenopausal hormone therapyDeborah Grady
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
Am J Med 118:163-5. 2005..For women who cannot tolerate even a slow taper, the value of symptom relief likely outweighs any increased risks due to HT use...
Is a shorter hot flash diary just as good as a 7-day diary?Deborah Grady
University of California, San Francisco, CA 94115, USA
Menopause 16:932-6. 2009..Our objective was to determine if a shorter diary for recording self-reported hot flashes is as accurate and precise as the traditional 7-day diary...
Ineffectiveness of sertraline for treatment of menopausal hot flushes: a randomized controlled trialDeborah Grady
University of California, San Francisco, and San Francisco VA Medical Center, San Francisco, California 94115, USA
Obstet Gynecol 109:823-30. 2007..To estimate the effect of the selective serotonin reuptake inhibitor sertraline on hot flush frequency and severity in perimenopausal and postmenopausal women...
Effect of Raloxifene on all-cause mortalityDeborah Grady
University of California, San Francisco, CA 94115, USA
Am J Med 123:469.e1-7. 2010..To assess the risk/benefit of raloxifene as a preventative treatment, we analyzed treatment effects on overall and cause-specific mortality...
Effect of ultra-low-dose transdermal estradiol on breast density in postmenopausal womenDeborah Grady
University of California Women s Health Clinical Research Center, San Francisco, CA 94115, USA
Menopause 14:391-6. 2007..The purpose of this study was to determine whether 2 years of treatment with ultra-low-dose transdermal estradiol results in a change in breast density...
Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal womenElizabeth Barrett-Connor
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093 0607, USA
N Engl J Med 355:125-37. 2006..The effect of raloxifene, a selective estrogen-receptor modulator, on coronary heart disease (CHD) and breast cancer is not established...
An intensive behavioral weight loss intervention and hot flushes in womenAlison J Huang
Department of Medicine, University of California, San Francisco, San Francisco, CA 94115, USA
Arch Intern Med 170:1161-7. 2010..Higher body mass index is associated with worse hot flushes during menopause but the effect of weight loss on flushing is unclear...
Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trialAlka M Kanaya
Division of General Internal Medicine, University of California, San Francisco, 1701 Divisadero Street, Suite 536, San Francisco, CA 94143 1732, USA
Ann Intern Med 138:1-9. 2003..Randomized trials of postmenopausal hormone therapy have found differing effects on fasting glucose levels. No trial has evaluated the effect of hormone therapy on diabetes incidence...
Effect of raloxifene on prevention of dementia and cognitive impairment in older women: the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trialKristine Yaffe
Department of Psychiatry, University of California, San Francisco, Box 181, 4150 Clement St, San Francisco, CA 94121, USA
Am J Psychiatry 162:683-90. 2005..This investigation examined whether raloxifene, a selective estrogen receptor modulator, affects the risk for Alzheimer's disease...
Renal insufficiency as an independent predictor of mortality among women with heart failureKirsten Bibbins-Domingo
Division of General Internal Medicine, San Francisco General Hospital, University of California at San Francisco, San Francisco, CA 94143 1364, USA
J Am Coll Cardiol 44:1593-600. 2004..We sought to explore the association between renal insufficiency and mortality among women with heart failure (HF) and to evaluate this risk by the presence of preserved or depressed systolic function...
Predictors of heart failure among women with coronary diseaseKirsten Bibbins-Domingo
Division of General Internal Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94143 1364, USA
Circulation 110:1424-30. 2004..We determined the risk factors for developing heart failure among postmenopausal women with established coronary disease...
Persistent hot flushes in older postmenopausal womenAlison J Huang
Department of Medicine, University of California San Francisco, USA
Arch Intern Med 168:840-6. 2008..To examine the prevalence, natural history, and predictors of hot flushes in older postmenopausal women...
Hot flushes, coronary heart disease, and hormone therapy in postmenopausal womenAlison J Huang
Departments of Medicine, University of California, San Francisco, CA 94115, USA
Menopause 16:639-43. 2009..The aim of this study was to examine interactions between hot flushes, estrogen plus progestogen therapy (EPT), and coronary heart disease (CHD) events in postmenopausal women with CHD...
Effect of hormone therapy on mortality rates among women with heart failure and coronary artery diseaseKirsten Bibbins-Domingo
Division of General Internal Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
Am J Cardiol 95:289-91. 2005..Over the 4.1-year follow-up, estrogen plus progestin use had no effect on all-cause mortality (hazard ratio 1.0, 95% confidence interval 0.7 to 1.4, p = 0.8) in women with heart failure and coronary disease...
The rise and fall of menopausal hormone therapyElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, 92093 0607, USA
Annu Rev Public Health 26:115-40. 2005..Differences between EPT and ET may reflect chance, baseline differences between the EPT and ET cohorts, or a progestin effect. Studies of younger women and lower HT doses with intermediate endpoints are beginning...
Oophorectomy vs ovarian conservation with hysterectomy: cardiovascular disease, hip fracture, and cancer in the Women's Health Initiative Observational StudyVanessa L Jacoby
Departments of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94115, USA
Arch Intern Med 171:760-8. 2011..Elective bilateral salpingo-oophorectomy (BSO) is routinely performed with hysterectomy for benign conditions despite conflicting data on long-term outcomes...
Effect of postmenopausal hormone therapy on cognitive function: the Heart and Estrogen/progestin Replacement StudyDeborah Grady
Department of Epidemiology and Biostatistics, University of California San Francisco, 1635 Divisidero Street, Suite 600, San Francisco, CA 94115, USA
Am J Med 113:543-8. 2002..To determine if hormone therapy results in better cognitive function in older postmenopausal women...
Effects of ultra-low-dose transdermal estradiol on cognition and health-related quality of lifeKristine Yaffe
Department of Psychiatry, University of California, San Francisco, CA 94121, USA
Arch Neurol 63:945-50. 2006..The effect of an ultra-low- dose of unopposed transdermal estradiol on cognition and health-related quality of life is unknown...
The sensitivity and specificity of a simple test to distinguish between urge and stress urinary incontinenceJeanette S Brown
University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, California 94115, USA
Ann Intern Med 144:715-23. 2006..Because treatments differ, urge incontinence should be distinguished from stress incontinence. To make this distinction, current guidelines recommend an extensive evaluation that is too time-consuming for primary care practice...
Postmenopausal hormone therapy: does it cause incontinence?Jody E Steinauer
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Obstet Gynecol 106:940-5. 2005..To estimate the effect of hormone therapy on risk of stress and urge urinary incontinence...
The effect of ultralow-dose transdermal estradiol on sexual function in postmenopausal womenAlison Huang
Department of Medicine, University of California San Francisco School of Medicine, San Francisco, CA, USA
Am J Obstet Gynecol 198:265.e1-7. 2008..This study was undertaken to examine the effect of ultralow-dose transdermal estradiol on sexual function in postmenopausal women...
Raloxifene and risk for stroke based on the framingham stroke risk scoreElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, Calif 92093 0607, USA
Am J Med 122:754-61. 2009..We assessed whether this risk is concentrated in postmenopausal women already at high stroke risk...
Placebo adherence and mortality in the Heart and Estrogen/Progestin Replacement StudyAmy M Padula
School of Public Health, University of California, Berkeley, CA, USA
Am J Med 125:804-10. 2012..Secondary aims included assessment of the association between placebo adherence and cause-specific morbidity and mortality...
Hot flushes, bone mineral density, and fractures in older postmenopausal womenAlison Huang
San Francisco Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California 94121, USA
Obstet Gynecol 109:841-7. 2007..To assess whether greater severity of hot flushes is associated with bone loss or fracture risk in older postmenopausal women...
Noncardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II)Stephen Hulley
Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143 0560, USA
JAMA 288:58-66. 2002..The Heart and Estrogen/progestin Replacement Study (HERS) was a randomized trial of estrogen plus progestin therapy after menopause...
A 60-year-old woman trying to discontinue hormone replacement therapyDeborah Grady
University of California, San Francisco, 74 New Montgomery St, Suite 600, San Francisco, CA 94105, USA
JAMA 287:2130-7. 2002
The "costs" of urinary incontinence for womenLeslee L Subak
Department of Obstetrics, Gynecology, University of California, San Francisco 94115, USA
Obstet Gynecol 107:908-16. 2006..To estimate costs of routine care for female urinary incontinence, health-related quality of life, and willingness to pay for incontinence improvement...
Raloxifene and colorectal cancerJudith M E Walsh
Division of General Internal Medicine, University of California, San Francisco, USA
J Womens Health (Larchmt) 14:299-305. 2005..To determine the effect of raloxifene on colorectal cancer (CRC) risk...
Safety and adverse effects associated with raloxifene: multiple outcomes of raloxifene evaluationDeborah Grady
University of California San Francisco, 1634 Divisadero Street, Suite 600, San Francisco, CA 94115, USA
Obstet Gynecol 104:837-44. 2004..To examine the effect of raloxifene on major adverse events that occur with postmenopausal estrogen therapy or tamoxifen...
Effects of ultralow-dose transdermal estradiol on bone mineral density: a randomized clinical trialBruce Ettinger
Division of Research, Kaiser Permanente Medical Care Program, Oakland, California, USA
Obstet Gynecol 104:443-51. 2004..5%, 95% confidence interval 0-7.3%). CONCLUSION: Postmenopausal treatment with low-dose, unopposed estradiol increased bone mineral density and decreased markers of bone turnover without causing endometrial hyperplasia...
Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trialElizabeth Barrett-Connor
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego School of Medicine, 9500 Gilman Dr, No 0607, La Jolla, CA 92093 0607, USA
JAMA 287:847-57. 2002..Raloxifene, a selective estrogen receptor modulator, improves cardiovascular risk factors, but its effect on cardiovascular events is unknown...
Postmenopausal hormones--therapy for symptoms onlyDeborah Grady
Department of Epidemiology and Biostatistics, University of California, San Francisco, and the San Francisco Veterans Affairs Medical Center, San Francisco, USA
N Engl J Med 348:1835-7. 2003
Comparison of methods to measure low serum estradiol levels in postmenopausal womenJennifer S Lee
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA
J Clin Endocrinol Metab 91:3791-7. 2006..Accurate measurement of low serum estradiol (E(2) < 30 pg/ml or < 110 pmol/liter) is needed to study relationships between endogenous E(2) and risks of diseases in older women...
Association of total and central obesity with mortality in postmenopausal women with coronary heart diseaseAlka M Kanaya
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 64115, USA
Am J Epidemiol 158:1161-70. 2003....
Weight loss to treat urinary incontinence in overweight and obese womenLeslee L Subak
University of California, San Francisco, San Francisco, USA
N Engl J Med 360:481-90. 2009..Obesity is an established and modifiable risk factor for urinary incontinence, but conclusive evidence for a beneficial effect of weight loss on urinary incontinence is lacking...
The day-to-day impact of urogenital aging: perspectives from racially/ethnically diverse womenAlison J Huang
Department of Medicine, University of California, San Francisco, CA, USA
J Gen Intern Med 25:45-51. 2010..Urogenital symptoms affect up to half of women after menopause, but their impact on women's day-to-day functioning and wellbeing is poorly understood...
Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II)Deborah Grady
Department of Epidemiology and Biostatistics, University of California, San Francisco, 74 New Montgomery St, Suite 600, San Francisco, CA 94105, USA
JAMA 288:49-57. 2002..However, in the hormone group, findings did suggest a higher risk of CHD events during the first year, and a decreased risk during years 3 to 5...
Explaining the sex difference in coronary heart disease mortality among patients with type 2 diabetes mellitus: a meta-analysisAlka M Kanaya
Department of Medicine, Division of General Internal Medicine, University of California, San Diego, USA
Arch Intern Med 162:1737-45. 2002..Most studies suggest that diabetes is a stronger coronary heart disease (CHD) risk factor for women than men, but few have adjusted their results for classic CHD risk factors: age, hypertension, total cholesterol level, and smoking...
Oophorectomy as a risk factor for coronary heart diseaseVanessa L Jacoby
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, School of Medicine, San Francisco, CA 94115, USA
Am J Obstet Gynecol 200:140.e1-9. 2009..The objective of the study was to examine the relationship between bilateral oophorectomy (BSO) and risk of coronary heart disease (CHD)...
Clinical trials in stem cell transplantation: guidelines for scientific and ethical reviewBernard Lo
Program in Medical Ethics and Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0903, USA
Clin Trials 5:517-22. 2008..Transplantation of cells derived through the manipulation of pluripotent stem cells may involve great uncertainty and the possibility of serious risks...
Feasibility and acceptability of restorative yoga for treatment of hot flushes: a pilot trialBeth E Cohen
General Internal Medicine Section, San Francisco Veterans Affairs Medical Center, CA 94121 1598, USA
Maturitas 56:198-204. 2007..To determine the feasibility and acceptability of a restorative yoga intervention for the treatment of hot flushes in postmenopausal women...
Clinical practice. Management of menopausal symptomsDeborah Grady
Women's Health Clinical Research Center, University of California, San Francisco, CA 94115, USA
N Engl J Med 355:2338-47. 2006
Restorative yoga in adults with metabolic syndrome: a randomized, controlled pilot trialBeth E Cohen
Department of General Internal Medicine, University of California, San Francisco, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
Metab Syndr Relat Disord 6:223-9. 2008..We conducted a randomized controlled pilot trial to determine whether a restorative yoga intervention was feasible and acceptable in underactive, overweight adults with metabolic syndrome...
Estrogen receptor 1 polymorphisms and risk of cognitive impairment in older womenKristine Yaffe
Department of Psychiatry, University of California San Francisco, Box 111G, 4150 Clement Street, San Francisco, CA 94121, USA
Biol Psychiatry 51:677-82. 2002..We investigated whether estrogen receptor 1 (ESR1) polymorphisms are associated with risk of developing cognitive impairment in older women...
Serum lipoprotein levels, statin use, and cognitive function in older womenKristine Yaffe
Departments of Psychiatry and Neurology, University of California, San Francisco, 4150 Clement St, Campus Box 111G, San Francisco, CA 94121, USA
Arch Neurol 59:378-84. 2002..Serum lipoprotein levels may be important predictors of cognitive function, and drugs that lower cholesterol may be effective for the prevention of cognitive impairment...
Commentary: Improving participant recruitment in clinical and translational researchNariman Nasser
Participant Recruitment Service, University of California, San Francisco, San Francisco, California 94143 0126, USA
Acad Med 86:1334-5. 2011..Participant recruitment must be improved if clinical and translational research is to meet its promise of improving health...
Evaluation of abnormal mammography results and palpable breast abnormalitiesKarla Kerlikowske
University of California, San Francisco, General Internal Medicine Section, Department of Veterans Affairs, San Francisco, California 94121, USA
Ann Intern Med 139:274-84. 2003....
Predictors of difficulty when discontinuing postmenopausal hormone therapyDeborah Grady
Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
Obstet Gynecol 102:1233-9. 2003..To describe the experiences of postmenopausal women who try to stop hormone therapy and to identify characteristics associated with inability to stop...
Menopausal symptoms in older women and the effects of treatment with hormone therapyVanessa M Barnabei
Medical College of Wisconsin, Milwaukee 53226, USA
Obstet Gynecol 100:1209-18. 2002..The frequency and severity of such symptoms and response to hormone therapy in older women have not been well documented...
Baseline characteristics of participants in the Raloxifene Use for The Heart (RUTH) trialNanette Kass Wenger
Emory University, Atlanta, Georgia 30303, USA
Am J Cardiol 90:1204-10. 2002....
Factor V Leiden, hormone replacement therapy, and risk of venous thromboembolic events in women with coronary diseaseDavid M Herrington
Department of Internal Medicine, Sections on Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Arterioscler Thromb Vasc Biol 22:1012-7. 2002..If factor V Leiden genotyping becomes less expensive, it could be cost effective to screen for the presence of the mutation before instituting HRT in women with coronary disease...
Myocardial infarction during menses: lessons from trials and errorsDeborah Grady
Am J Med 114:611-2. 2003
The effect of ultralow-dose transdermal estradiol on urinary incontinence in postmenopausal womenL Elaine Waetjen
Department of Obstetrics and Gynecology, University of California Davis, 4860 Y Street, Suite 2500, Sacramento, CA 95817, USA
Obstet Gynecol 106:946-52. 2005..To estimate the effect of 2 years of treatment with ultralow-dose transdermal estradiol (E2) on incontinence in postmenopausal women...
Effects of ultralow-dose transdermal estradiol on postmenopausal symptoms in women aged 60 to 80 yearsSusan Diem
Department of Medicine, University of Minnesota, Minneapolis, 55415, USA
Menopause 13:130-8. 2006..To investigate the effect of ultralow-dose transdermal estradiol on postmenopausal symptoms and side effects in a cohort of largely asymptomatic postmenopausal women aged 60 to 80 years...
The WHI estrogen-alone trial--do things look any better?Stephen B Hulley
JAMA 291:1769-71. 2004
Helping women stop postmenopausal hormone therapyDeborah Grady
Menopause 13:323-4. 2006
Evidence-based guidelines for cardiovascular disease prevention in women. American Heart Association scientific statementLori Mosca
Arterioscler Thromb Vasc Biol 24:e29-50. 2004
The prognostic value of normal exercise myocardial perfusion imaging and exercise echocardiography: a meta-analysisLouise D Metz
Department of Medicine, New York University School of Medicine, New York, New York, USA
J Am Coll Cardiol 49:227-37. 2007....
Uterine and vaginal effects of unopposed ultralow-dose transdermal estradiolSusan R Johnson
Department of Obstetrics and Gynecology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52242, USA
Obstet Gynecol 105:779-87. 2005..To investigate uterine effects of unopposed ultralow-dose transdermal estradiol administered to postmenopausal women for 2 years...
Effects of raloxifene on fracture risk in postmenopausal women: the Raloxifene Use for the Heart TrialKristine E Ensrud
Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
J Bone Miner Res 23:112-20. 2008..Treatment with raloxifene for 5 yr reduced the risk of clinical vertebral fractures, but not nonvertebral fractures, irrespective of the presence or absence of risk factors for fracture...
Evidence-based guidelines for cardiovascular disease prevention in womenLori Mosca
J Am Coll Cardiol 43:900-21. 2004
Effect of the Women's Health Initiative on women's decisions to discontinue postmenopausal hormone therapyBruce Ettinger
Division of Research, Kaiser Permanente Northern California, Oakland, Oakland, California 94611 5714, USA
Obstet Gynecol 102:1225-32. 2003....
Postmenopausal hormone therapyDeborah Grady
BMJ 334:860-1. 2007
Alternatives to estrogen for treatment of hot flashes: are they effective and safe?Jeffrey A Tice
JAMA 295:2076-8. 2006
Planning for closeout--from Day OneRodger Shepherd
University of California, San Francisco Veterans Affairs Medical Center 94115, United States
Contemp Clin Trials 29:136-9. 2008..Three advantages of beginning early to plan for closeout are described and approaches to planning closeout are suggested...
