Clarisa R Gracia

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Ovarian tissue cryopreservation for fertility preservation in cancer patients: successful establishment and feasibility of a multidisciplinary collaboration
    Clarisa R Gracia
    Departments of Obstetrics Gynecology, University of Pennsylvania, 3701 Market Street, Suite 800, Philadelphia, PA 19104, USA
    J Assist Reprod Genet 29:495-502. 2012
  2. pmc Thyroid function during controlled ovarian hyperstimulation as part of in vitro fertilization
    Clarisa R Gracia
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 97:585-91. 2012
  3. doi request reprint Impact of cancer therapies on ovarian reserve
    Clarisa R Gracia
    Department of Obstetrics Gynecology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Fertil Steril 97:134-40.e1. 2012
  4. ncbi request reprint Predictors of decreased libido in women during the late reproductive years
    Clarisa R Gracia
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Menopause 11:144-50. 2004
  5. ncbi request reprint Occupational exposures and male infertility
    Clarisa R Gracia
    Division of Reproductive Endocrinology and Infertility, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Epidemiol 162:729-33. 2005
  6. ncbi request reprint Hormones and sexuality during transition to menopause
    Clarisa R Gracia
    Department of Obstetrics Gynecology, Center for Clinical Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 109:831-40. 2007
  7. ncbi request reprint Defining menopause status: creation of a new definition to identify the early changes of the menopausal transition
    Clarisa R Gracia
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Menopause 12:128-35. 2005
  8. ncbi request reprint Acute consequences of the menopausal transition: the rise of common menopausal symptoms
    Clarisa R Gracia
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Endocrinol Metab Clin North Am 33:675-89. 2004
  9. doi request reprint Sexual function in first-time contraceptive ring and contraceptive patch users
    Clarisa R Gracia
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Fertil Steril 93:21-8. 2010
  10. ncbi request reprint Predicting participation in prospective studies of ovarian aging
    Deborah B Nelson
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, USA
    Menopause 11:543-8. 2004

Detail Information

Publications46

  1. pmc Ovarian tissue cryopreservation for fertility preservation in cancer patients: successful establishment and feasibility of a multidisciplinary collaboration
    Clarisa R Gracia
    Departments of Obstetrics Gynecology, University of Pennsylvania, 3701 Market Street, Suite 800, Philadelphia, PA 19104, USA
    J Assist Reprod Genet 29:495-502. 2012
    ..As advancements in cancer therapies have led to dramatic improvements in long term survival, there has been increasing interest in methods to expand fertility preservation options for cancer patients...
  2. pmc Thyroid function during controlled ovarian hyperstimulation as part of in vitro fertilization
    Clarisa R Gracia
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 97:585-91. 2012
    ..To determine the exact nature and timing of alterations in thyroid function throughout controlled ovarian hyperstimulation (COH)...
  3. doi request reprint Impact of cancer therapies on ovarian reserve
    Clarisa R Gracia
    Department of Obstetrics Gynecology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Fertil Steril 97:134-40.e1. 2012
    ..To determine whether measures of ovarian reserve differ between females exposed to cancer therapies in a dose-dependent manner as compared with healthy controls of similar age and late reproductive age...
  4. ncbi request reprint Predictors of decreased libido in women during the late reproductive years
    Clarisa R Gracia
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Menopause 11:144-50. 2004
    ..To identify risk factors for decreased libido among women in the late reproductive years...
  5. ncbi request reprint Occupational exposures and male infertility
    Clarisa R Gracia
    Division of Reproductive Endocrinology and Infertility, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Epidemiol 162:729-33. 2005
    ..Overall, no clear, clinically important associations between occupational exposures and male infertility could be identified in this study...
  6. ncbi request reprint Hormones and sexuality during transition to menopause
    Clarisa R Gracia
    Department of Obstetrics Gynecology, Center for Clinical Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 109:831-40. 2007
    ..To examine the relationship between reproductive hormonal dynamics and sexual dysfunction assessed in a cohort of women approaching menopause...
  7. ncbi request reprint Defining menopause status: creation of a new definition to identify the early changes of the menopausal transition
    Clarisa R Gracia
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Menopause 12:128-35. 2005
    ..The objective of this study was to determine which definition captures the earliest hormonal changes in the menopausal transition...
  8. ncbi request reprint Acute consequences of the menopausal transition: the rise of common menopausal symptoms
    Clarisa R Gracia
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Endocrinol Metab Clin North Am 33:675-89. 2004
    ..This article re-views the current evidence regarding the acute symptoms of the menopausal transition, including vasomotor symptoms, mood changes, sleep problems, and changes in sexual functioning...
  9. doi request reprint Sexual function in first-time contraceptive ring and contraceptive patch users
    Clarisa R Gracia
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Fertil Steril 93:21-8. 2010
    ..To assess sexual function of first-time users of the contraceptive ring and contraceptive patch...
  10. ncbi request reprint Predicting participation in prospective studies of ovarian aging
    Deborah B Nelson
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, USA
    Menopause 11:543-8. 2004
    ....
  11. ncbi request reprint Tubal ligation does not affect hormonal changes during the early menopausal transition
    Deborah B Nelson
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Contraception 71:104-10. 2005
    ..To determine if women with a bilateral tubal ligation (BTL) were more likely to experience hormonal changes indicative of the transition to menopause or an increase in menopausal symptoms compared to women without a BTL...
  12. ncbi request reprint The relationship between obesity and race on inhibin B during the menopause transition
    Clarisa R Gracia
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Menopause 12:559-66. 2005
    ..The purpose of this study was to determine the relationship among inhibin B levels, body mass index (BMI), and race during the menopause transition...
  13. pmc Contribution of the rate of change of antim├╝llerian hormone in estimating time to menopause for late reproductive-age women
    Ellen W Freeman
    Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 98:1254-9.e1-2. 2012
    ..We hypothesized that the rate of change between two measures of AMH reflects follicular atresia and varies among women independent of age...
  14. pmc Association of cyclophosphamide drug-metabolizing enzyme polymorphisms and chemotherapy-related ovarian failure in breast cancer survivors
    H Irene Su
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19146, USA
    Fertil Steril 94:645-54. 2010
    ..To determine if genetic variation in chemotherapy metabolism are associated with risk of ovarian failure in breast cancer patients after adjuvant chemotherapy...
  15. pmc Body size affects measures of ovarian reserve in late reproductive age women
    H Irene Su
    Department of Obstetrics, Division of Reproductive Endocrinology and Infertility, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Menopause 15:857-61. 2008
    ..To examine the association between obesity and serum and ultrasound measures of ovarian reserve in late reproductive age women...
  16. doi request reprint Pregnancy after cancer: results from a prospective cohort study of cancer survivors
    Katherine E Dillon
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania
    Pediatr Blood Cancer 60:2001-6. 2013
    ..The purpose of this study was to compare measures of ovarian reserve (MOR) and pregnancy rates in young female cancer survivors and similar-aged controls...
  17. pmc Obesity and reproductive hormone levels in the transition to menopause
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA, USA
    Menopause 17:718-26. 2010
    ..The aim of this study was to estimate associations of obesity with reproductive hormone levels as women progress from premenopausal to postmenopausal status...
  18. pmc Effects of reproductive history on symptoms of menopause: a brief report
    Deborah B Nelson
    Department of Public Health and Obstetrics and Gynecology, Temple University, Philadelphia, PA, USA
    Menopause 18:1143-8. 2011
    ..The aim of this study was to examine the relationship between reproductive history and menopausal symptoms among urban women...
  19. pmc Antral follicle count provides additive information to hormone measures for determining ovarian function in breast cancer survivors
    H Irene Su
    Division of Reproductive Endocrinology and Infertility, University of California, San Diego, California, USA
    Fertil Steril 95:1857-9. 2011
    ..Therefore, ultrasound appears to be a tool that may not only corroborate, but also add to the accuracy of hormone measures for determining ovarian function in breast cancer survivors...
  20. pmc Effect of hormone metabolism genotypes on steroid hormone levels and menopausal symptoms in a prospective population-based cohort of women experiencing the menopausal transition
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Menopause 17:1026-34. 2010
    ..This study evaluated whether genes involved in the metabolism of steroid hormones are associated with hormone levels or menopausal symptoms...
  21. doi request reprint Symptoms in the menopausal transition: hormone and behavioral correlates
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Obstet Gynecol 111:127-36. 2008
    ..To estimate the association of headache, irritability, mood swings, anxiety, and concentration difficulties with menopausal stage and with reproductive hormones in the menopausal transition...
  22. ncbi request reprint The role of anxiety and hormonal changes in menopausal hot flashes
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Menopause 12:258-66. 2005
    ..To estimate the association of anxiety with menopausal hot flashes in the early transition to menopause...
  23. pmc Duration of menopausal hot flushes and associated risk factors
    Ellen W Freeman
    Department of Obstetrics Gynecology, the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Obstet Gynecol 117:1095-104. 2011
    ..To estimate the duration of moderate-to-severe menopausal hot flushes and identify potential risk factors for hot flush duration...
  24. ncbi request reprint Randomized controlled pilot trial of luteal phase recombinant FSH stimulation in poor responders
    Suleena Kansal Kalra
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Reprod Biomed Online 17:745-50. 2008
    ..02) and >16 mm (P = 0.02) on day of HCG administration. IVF outcomes with luteal phase FSH compared with follicular phase FSH were similar. Luteal phase initiation of FSH is a safe and potential alternative protocol in poor responders...
  25. ncbi request reprint Hormones and menopausal status as predictors of depression in women in transition to menopause
    Ellen W Freeman
    Departments of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Mudd Suite, 3701 Market Street, Philadelphia, PA 19104 5509, USA
    Arch Gen Psychiatry 61:62-70. 2004
    ..Associations between depressed mood and hormonal changes during transition to menopause are controversial. To our knowledge, there has been no prospective study of these associations in women commencing when they are premenopausal...
  26. ncbi request reprint Symptoms associated with menopausal transition and reproductive hormones in midlife women
    Ellen W Freeman
    Departments of Obstetrics Gynecology, Psychiatry, University of Pennsylvania, 3701 Market Street, Philadelphia, PA 19104, USA
    Obstet Gynecol 110:230-40. 2007
    ....
  27. ncbi request reprint Risk factors for ectopic pregnancy in women with symptomatic first-trimester pregnancies
    Kurt T Barnhart
    Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, USA
    Fertil Steril 86:36-43. 2006
    ..To evaluate the association between ectopic pregnancy (EP) and clinical and historical factors among women presenting with pain and/or bleeding in early pregnancy...
  28. pmc Response to ovarian stimulation in patients facing gonadotoxic therapy
    Lauren N C Johnson
    Reproductive Endocrinology and Infertility, University of Pennsylvania, 3701 Market St, Philadelphia, PA 19104, USA
    Reprod Biomed Online 26:337-44. 2013
    ..Patients who received letrozole required higher gonadotrophin doses and produced more immature oocytes, suggesting that response to ovarian stimulation may be impaired in patients with hormone-sensitive cancers receiving letrozole...
  29. pmc Antimullerian hormone and inhibin B are hormone measures of ovarian function in late reproductive-aged breast cancer survivors
    H Irene Su
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer 116:592-9. 2010
    ....
  30. ncbi request reprint Effect of physical activity on menopausal symptoms among urban women
    Deborah B Nelson
    Department of Public Health, College of Health Professions, Temple University, Philadelphia, PA 19122, USA
    Med Sci Sports Exerc 40:50-8. 2008
    ..To determine whether physical activity, measured by expended kilocalories per week (kcal.wk), decreases the risk of menopausal symptoms among African American and Caucasian women...
  31. pmc Anti-mullerian hormone as a predictor of time to menopause in late reproductive age women
    Ellen W Freeman
    Department of Obstetrics Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 97:1673-80. 2012
    ..Anti-mullerian hormone (AMH) has emerged as a marker of ovarian reserve and a possible surrogate measure of reproductive aging...
  32. ncbi request reprint Association of anti-mullerian hormone levels with obesity in late reproductive-age women
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 87:101-6. 2007
    ..To describe anti-mullerian hormone (AMH) levels in healthy late reproductive age women and test the hypothesis that AMH levels are lower in obese compared to non-obese women...
  33. pmc Pretreatment antim├╝llerian hormone levels determine rate of posttherapy ovarian reserve recovery: acute changes in ovarian reserve during and after chemotherapy
    Katherine E Dillon
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 99:477-83. 2013
    ..To identify factors associated with ovarian reserve impairment during and immediately after chemotherapy...
  34. doi request reprint Pediatric and young adult patients and oncofertility
    Katherine E Dillon
    University of Pennsylvania, 3701 Market Street, Philadelphia, PA 19104, USA
    Curr Treat Options Oncol 13:161-73. 2012
    ..It is the only option currently available to prepubertal girls. No fertility preservation options exist for prepubertal boys though some institutions may offer experimental testicular tissue cryopreservation...
  35. doi request reprint Perinatal morbidity after in vitro fertilization is lower with frozen embryo transfer
    Suleena Kansal Kalra
    Division of Reproductive Endocrinology and Infertility, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Fertil Steril 95:548-53. 2011
    ..To study the association of perinatal outcome and IVF transfer type in a group of infertility patients with standardized treatment and similar prognosis...
  36. pmc Ovarian stimulation and embryo banking for fertility preservation in a woman with severe mixed connective tissue disease: Is it safe?
    Vasileios D Sioulas
    Division of Reproductive Endocrinology and Infertility, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Assist Reprod Genet 29:271-5. 2012
    ..To report the first case of using assisted reproductive technologies (ART) for fertility preservation in a patient with mixed connective tissue disease (MCTD), secondary pulmonary hypertension (PH) and antiphospholipid syndrome (APS)...
  37. doi request reprint Ovarian preservation in a young patient with Gorlin syndrome and multiple bilateral ovarian masses
    Christopher B Morse
    University of Pennsylvania Medical Center, Department of Obstetrics and Gynecology, Reproductive Research Unit, 3701 Market Street, Suite 810, Philadelphia, PA 19104, USA
    Fertil Steril 96:e47-50. 2011
    ..To report a case of bilateral ovarian fibromas and ovarian leiomyomas in a young patient with Gorlin syndrome and to highlight issues of fertility preservation, ovarian conservation, and preimplantation genetic diagnosis in this population...
  38. ncbi request reprint Risk factors for spontaneous abortion in early symptomatic first-trimester pregnancies
    Clarisa R Gracia
    Department of Obstetrics and Gynecology, Penn Fertility Care, University of Pennsylvania Medical Center, 3701 Market Street, Philadelphia, PA 19104, USA
    Obstet Gynecol 106:993-9. 2005
    ..To evaluate the association of an ultimate diagnosis of miscarriage with various clinical symptoms and historical factors in a cohort of women presenting with pain, bleeding, or both in the first trimester of pregnancy...
  39. doi request reprint Fertility preservation in patients with haematological disorders: a retrospective cohort study
    Suneeta Senapati
    Department of Obstetrics and Gynecology, University of Pennsylvania, United States Electronic address
    Reprod Biomed Online 28:92-8. 2014
    ..Thus while ovarian reserve may be impaired, response to ovarian stimulation and IVF may be acceptable for these women. ..
  40. ncbi request reprint Fertility risk in pediatric and adolescent cancers
    Clarisa R Gracia
    University of Pennsylvania, USA
    Cancer Treat Res 138:57-72. 2007
  41. doi request reprint Symptomatic fibroids in two patients on hormone replacement therapy with primary ovarian failure secondary to prepubertal gonadotoxic cancer treatment
    Suleena Kansal Kalra
    Division of Reproductive Endocrinology and Infertility, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Womens Health (Larchmt) 17:1035-7. 2008
    ..We report two childhood cancer patients with primary ovarian failure who underwent exogenous hormone-induced puberty and had symptomatic fibroids while on hormone replacement therapy (HRT)...
  42. ncbi request reprint Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis
    George Kovalevsky
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia, USA
    Arch Intern Med 164:558-63. 2004
    ..The relationship between FVL, G20210A, and RPL has been investigated with conflicting results. This study analyzed existing data to determine whether an association exists...
  43. doi request reprint What is normal ovarian reserve?
    Katherine E Dillon
    Division of Reproductive Endocrinology and Infertility, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Semin Reprod Med 31:427-36. 2013
    ..Currently, these biomarkers are insufficient as predictors of fertility potential or advancement to menopause and no definitive determinations can be made about what constitutes "normal" levels of each measure. ..
  44. ncbi request reprint Presumed diagnosis of ectopic pregnancy
    Kurt T Barnhart
    Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center, Philadelphia 10104, USA
    Obstet Gynecol 100:505-10. 2002
    ..To evaluate the accuracy of the diagnosis of presumed ectopic pregnancy...
  45. ncbi request reprint Sexual dysfunction is common and overlooked in female patients with hypertension
    Wendy Brooks Barr
    J Sex Marital Ther 29:247-8; author reply 249. 2003
  46. ncbi request reprint Usefulness of pipelle endometrial biopsy in the diagnosis of women at risk for ectopic pregnancy
    Kurt T Barnhart
    Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Am J Obstet Gynecol 188:906-9. 2003
    ..The purpose of this study was to determine the accuracy of endometrial Pipelle (Unimar) biopsy to detect chorionic villi in suspected ectopic pregnancy...

Research Grants5

  1. Assessing Fertility Potential in Pediatric Cancer Survivors
    Clarisa Gracia; Fiscal Year: 2007
    ....
  2. Ovarian Reserve After Cancer: Longitudinal Effects (The ORACLE Study)
    Clarisa R Gracia; Fiscal Year: 2010
    ..The findings of this research will have a major impact on patient counseling and targeting fertility preservation efforts. ..