A A Grace

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Disruption of cortical-limbic interaction as a substrate for comorbidity
    A A Grace
    Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neurotox Res 10:93-101. 2006
  2. ncbi request reprint The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving
    A A Grace
    Department of Neuroscience, University of Pittsburgh, PA 15260, USA
    Addiction 95:S119-28. 2000
  3. ncbi request reprint Gating of information flow within the limbic system and the pathophysiology of schizophrenia
    A A Grace
    Department of Neuroscience, University of Pittsburgh, 458 Crawford Hall, Pittsburgh, PA, USA
    Brain Res Brain Res Rev 31:330-41. 2000
  4. ncbi request reprint Dopamine attenuates prefrontal cortical suppression of sensory inputs to the basolateral amygdala of rats
    J A Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 21:4090-103. 2001
  5. ncbi request reprint Modulation of basolateral amygdala neuronal firing and afferent drive by dopamine receptor activation in vivo
    J A Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 19:11027-39. 1999
  6. ncbi request reprint The effects of dopamine-depleting brain lesions on the electrophysiological activity of rat substantia nigra dopamine neurons
    J R Hollerman
    University of Pittsburgh, Department of Behavioral Neuroscience, PA 15260
    Brain Res 533:203-12. 1990
  7. ncbi request reprint Acute haloperidol administration induces depolarization block of nigral dopamine neurons in rats after partial dopamine lesions
    J R Hollerman
    Department of Behavioral Neuroscience, University of Pittsburgh, PA
    Neurosci Lett 96:82-8. 1989
  8. ncbi request reprint Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons
    S B Floresco
    Departments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 21:4915-22. 2001
  9. ncbi request reprint The depolarization block hypothesis of neuroleptic action: implications for the etiology and treatment of schizophrenia
    A A Grace
    Department of Behavioral Neuroscience, University of Pittsburgh, PA
    J Neural Transm Suppl 36:91-131. 1992
  10. ncbi request reprint Depletion of dopamine in the prefrontal cortex decreases the basal electrophysiological activity of mesolimbic dopamine neurons
    D G Harden
    Depts of Neuroscience and Psychiatry, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    Brain Res 794:96-102. 1998

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Disruption of cortical-limbic interaction as a substrate for comorbidity
    A A Grace
    Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neurotox Res 10:93-101. 2006
    ..This would appear to be a common underlying process that may leave the individual susceptible to drug abuse and to the onset or exacerbation of psychiatric disorders such as schizophrenia and depression...
  2. ncbi request reprint The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving
    A A Grace
    Department of Neuroscience, University of Pittsburgh, PA 15260, USA
    Addiction 95:S119-28. 2000
    ....
  3. ncbi request reprint Gating of information flow within the limbic system and the pathophysiology of schizophrenia
    A A Grace
    Department of Neuroscience, University of Pittsburgh, 458 Crawford Hall, Pittsburgh, PA, USA
    Brain Res Brain Res Rev 31:330-41. 2000
    ....
  4. ncbi request reprint Dopamine attenuates prefrontal cortical suppression of sensory inputs to the basolateral amygdala of rats
    J A Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 21:4090-103. 2001
    ..In situations of enhanced DA levels in the BLA, such as during stress and after amphetamine administration, mPFC regulation of BLA will be dampened, leading to a disinhibition of sensory-driven affective responses...
  5. ncbi request reprint Modulation of basolateral amygdala neuronal firing and afferent drive by dopamine receptor activation in vivo
    J A Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 19:11027-39. 1999
    ....
  6. ncbi request reprint The effects of dopamine-depleting brain lesions on the electrophysiological activity of rat substantia nigra dopamine neurons
    J R Hollerman
    University of Pittsburgh, Department of Behavioral Neuroscience, PA 15260
    Brain Res 533:203-12. 1990
    ..In this way, the remaining DA neurons would maintain the wide dynamic range of electrophysiological responsivity that may be necessary for the normal function of the extrapyramidal motor system...
  7. ncbi request reprint Acute haloperidol administration induces depolarization block of nigral dopamine neurons in rats after partial dopamine lesions
    J R Hollerman
    Department of Behavioral Neuroscience, University of Pittsburgh, PA
    Neurosci Lett 96:82-8. 1989
    ....
  8. ncbi request reprint Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons
    S B Floresco
    Departments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 21:4915-22. 2001
    ..As a result, dysfunctions in hippocampal circuitries may contribute to the hyperexcitable state of the DA system that is present in schizophrenia...
  9. ncbi request reprint The depolarization block hypothesis of neuroleptic action: implications for the etiology and treatment of schizophrenia
    A A Grace
    Department of Behavioral Neuroscience, University of Pittsburgh, PA
    J Neural Transm Suppl 36:91-131. 1992
    ....
  10. ncbi request reprint Depletion of dopamine in the prefrontal cortex decreases the basal electrophysiological activity of mesolimbic dopamine neurons
    D G Harden
    Depts of Neuroscience and Psychiatry, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    Brain Res 794:96-102. 1998
    ..Thus, the magnitude of increase in action potential-dependent DA release that occurs in response to a challenge may be augmented in lesioned rats...
  11. pmc Anxiogenic modulation of spontaneous and evoked neuronal activity in the basolateral amygdala
    D M Buffalari
    Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuroscience 163:1069-77. 2009
    ....
  12. ncbi request reprint Interaction of benztropine and haloperidol actions on rat substantia nigra dopamine cell electrophysiological activity in vivo
    C L Todd
    Department of Neuroscience, Center for Neuroscience, University of Pittsburgh, PA 15260, USA
    Brain Res Bull 48:219-22. 1999
    ..The increase in burst firing seen in the presence of haloperidol may mediate some of the therapeutic effects of benztropine in the treatment of antipsychotic drug-induced movement disorders...
  13. ncbi request reprint Compensatory responses to nigrostriatal bundle injury. Studies with 6-hydroxydopamine in an animal model of parkinsonism
    M J Zigmond
    Department of Behavioral Neuroscience and Psychiatry, University of Pittsburgh, PA 15260
    Mol Chem Neuropathol 10:185-200. 1989
    ..Collectively, these alterations permit a few residual DA neurons to maintain a normal level of control over cellular activity in the striatum...
  14. pmc Activity-dependent depression of medial prefrontal cortex inputs to accumbens neurons by the basolateral amygdala
    V B McGinty
    Department of Neuroscience, and the Center for Neuroscience, University of Pittsburgh, A210 Langley Hall, Pittsburgh, PA 15260, USA
    Neuroscience 162:1429-36. 2009
    ..The ability of the BLA to suppress mPFC-to-NAcc signaling may be a mechanism by which normal or pathologically heightened emotional states disrupt goal-directed behavior in favor of emotionally-driven responses...
  15. ncbi request reprint Stimulation of D1-type dopamine receptors enhances excitability in prefrontal cortical pyramidal neurons in a state-dependent manner
    A Lavin
    Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    Neuroscience 104:335-46. 2001
    ..From these data we suggest that dopamine exerts state-dependent modulatory effects on the excitability of neurons in deep layers of the prefrontal cortex...
  16. ncbi request reprint The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction
    S R Laviolette
    Department of Neuroscience, The University of Pittsburgh, Pittsburgh, 458 Crawford Hall, Pennsylvania 15260, USA
    Cell Mol Life Sci 63:1597-613. 2006
    ....
  17. ncbi request reprint Alterations in electrophysiological activity and dye coupling of striatal spiny and aspiny neurons in dopamine-denervated rat striatum recorded in vivo
    S P Onn
    Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260, USA
    Synapse 33:1-15. 1999
    ..Therefore, gap junction conductance as reflected by dye coupling appears to undergo upregulation as a consequence of compromises in nigrostriatal and mesolimbic dopamine transmission...
  18. ncbi request reprint Dopamine receptor subtypes selectively modulate excitatory afferents from the hippocampus and amygdala to rat nucleus accumbens neurons
    A Charara
    Departments of Neuroscience and Psychiatry, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 28:1412-21. 2003
    ..Such facilitation or attenuation of hippocampal afferents against a background of suppression of other afferents would permit the hippocampus to have a dominant influence over behavior during periods of exploration...
  19. ncbi request reprint DARPP-32: regulator of the efficacy of dopaminergic neurotransmission
    A A Fienberg
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Science 281:838-42. 1998
    ..The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission...
  20. pmc Dopamine and cyclic-AMP regulated phosphoprotein-32-dependent modulation of prefrontal cortical input and intercellular coupling in mouse accumbens spiny and aspiny neurons
    S P Onn
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuroscience 151:802-16. 2008
    ....
  21. pmc Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart
    M J Killeen
    Physiological Laboratory, University of Cambridge, Cambridge, UK
    Acta Physiol (Oxf) 189:33-46. 2007
    ..Hypokalaemia is associated with a lethal form of ventricular tachycardia (VT), torsade de pointes, through pathophysiological mechanisms requiring clarification...
  22. pmc The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons
    D J Lodge
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Proc Natl Acad Sci U S A 103:5167-72. 2006
    ..These data show that the LDTg is critical to normal DA function, and thus, pathology within this region may lead to aberrant DA signaling...
  23. ncbi request reprint Direct examination of local regulation of membrane activity in striatal and prefrontal cortical neurons in vivo using simultaneous intracellular recording and microdialysis
    Anthony R West
    Department of Neuroscience, Center for Neuroscience, 446 Crawford Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Pharmacol Exp Ther 301:867-77. 2002
    ..We conclude that the use of local microdialysis with intracellular recording is a powerful method for studying local receptor regulation of synaptic activity in vivo...
  24. ncbi request reprint Acute and chronic corticotropin-releasing factor 1 receptor blockade inhibits cocaine-induced dopamine release: correlation with dopamine neuron activity
    D J Lodge
    Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    J Pharmacol Exp Ther 314:201-6. 2005
    ....
  25. pmc Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium
    M D Lowe
    Department of Cardiology, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE, UK
    Heart 86:45-51. 2001
    ..The increase in dispersion of repolarisation provides a mechanism whereby catecholamines acting through this receptor subtype may trigger ventricular arrhythmias...
  26. ncbi request reprint Chronic cold exposure potentiates CRH-evoked increases in electrophysiologic activity of locus coeruleus neurons
    H P Jedema
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 49:351-9. 2001
    ..The altered functional capacity of LC neurons in rats after continuous cold exposure may represent an experimental model to examine the role of central noradrenergic neurons in anxiety and mood disorders...
  27. pmc Separation of early afterdepolarizations from arrhythmogenic substrate in the isolated perfused hypokalaemic murine heart through modifiers of calcium homeostasis
    M J Killeen
    Physiological Laboratory, University of Cambridge, Cambridge, UK
    Acta Physiol (Oxf) 191:43-58. 2007
    ..We resolved roles for early afterdepolarizations (EADs) and transmural gradients of repolarization in arrhythmogenesis in Langendorff-perfused hypokalaemic murine hearts paced from the right ventricular epicardium...
  28. pmc Pharmacological separation of early afterdepolarizations from arrhythmogenic substrate in DeltaKPQ Scn5a murine hearts modelling human long QT 3 syndrome
    G Thomas
    Section of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Cambridge, UK
    Acta Physiol (Oxf) 192:505-17. 2008
    ..To perform an empirical, pharmacological, separation of early afterdepolarizations (EADs) and transmural gradients of repolarization in arrhythmogenesis in a genetically modified mouse heart modelling human long QT syndrome (LQT) 3...
  29. pmc Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart
    M J Killeen
    Physiological Laboratory, University of Cambridge, Cambridge, UK
    Acta Physiol (Oxf) 193:25-36. 2008
    ..We explored the anti-arrhythmic efficacy of K(+) channel activation in the hypokalaemic murine heart using NS1643 and nicorandil, compounds which augment I(Kr) and I(KATP) respectively...
  30. ncbi request reprint Volume regulation is defective in renal proximal tubule cells isolated from KCNE1 knockout mice
    I D Millar
    Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
    Exp Physiol 89:173-80. 2004
    ..One cell population is capable of RVD in the absence of HCO3-, whereas RVD in the other cell population has an absolute requirement for HCO3-. The HCO3- dependent RVD requires the normal expression of KCNE1...