Research Topics
Species | A A GraceSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Disruption of cortical-limbic interaction as a substrate for comorbidityA A Grace
Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neurotox Res 10:93-101. 2006..This would appear to be a common underlying process that may leave the individual susceptible to drug abuse and to the onset or exacerbation of psychiatric disorders such as schizophrenia and depression...- The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant cravingA A Grace
Department of Neuroscience, University of Pittsburgh, PA 15260, USA
Addiction 95:S119-28. 2000.... - Gating of information flow within the limbic system and the pathophysiology of schizophreniaA A Grace
Department of Neuroscience, University of Pittsburgh, 458 Crawford Hall, Pittsburgh, PA, USA
Brain Res Brain Res Rev 31:330-41. 2000.... - Dopamine attenuates prefrontal cortical suppression of sensory inputs to the basolateral amygdala of ratsJ A Rosenkranz
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 21:4090-103. 2001..In situations of enhanced DA levels in the BLA, such as during stress and after amphetamine administration, mPFC regulation of BLA will be dampened, leading to a disinhibition of sensory-driven affective responses... - Modulation of basolateral amygdala neuronal firing and afferent drive by dopamine receptor activation in vivoJ A Rosenkranz
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 19:11027-39. 1999.... - The effects of dopamine-depleting brain lesions on the electrophysiological activity of rat substantia nigra dopamine neuronsJ R Hollerman
University of Pittsburgh, Department of Behavioral Neuroscience, PA 15260
Brain Res 533:203-12. 1990..In this way, the remaining DA neurons would maintain the wide dynamic range of electrophysiological responsivity that may be necessary for the normal function of the extrapyramidal motor system... - Acute haloperidol administration induces depolarization block of nigral dopamine neurons in rats after partial dopamine lesionsJ R Hollerman
Department of Behavioral Neuroscience, University of Pittsburgh, PA
Neurosci Lett 96:82-8. 1989.... - Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neuronsS B Floresco
Departments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 21:4915-22. 2001..As a result, dysfunctions in hippocampal circuitries may contribute to the hyperexcitable state of the DA system that is present in schizophrenia... - The depolarization block hypothesis of neuroleptic action: implications for the etiology and treatment of schizophreniaA A Grace
Department of Behavioral Neuroscience, University of Pittsburgh, PA
J Neural Transm Suppl 36:91-131. 1992.... - Depletion of dopamine in the prefrontal cortex decreases the basal electrophysiological activity of mesolimbic dopamine neuronsD G Harden
Depts of Neuroscience and Psychiatry, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
Brain Res 794:96-102. 1998..Thus, the magnitude of increase in action potential-dependent DA release that occurs in response to a challenge may be augmented in lesioned rats... 
Anxiogenic modulation of spontaneous and evoked neuronal activity in the basolateral amygdalaD M Buffalari
Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuroscience 163:1069-77. 2009....- Interaction of benztropine and haloperidol actions on rat substantia nigra dopamine cell electrophysiological activity in vivoC L Todd
Department of Neuroscience, Center for Neuroscience, University of Pittsburgh, PA 15260, USA
Brain Res Bull 48:219-22. 1999..The increase in burst firing seen in the presence of haloperidol may mediate some of the therapeutic effects of benztropine in the treatment of antipsychotic drug-induced movement disorders... - Compensatory responses to nigrostriatal bundle injury. Studies with 6-hydroxydopamine in an animal model of parkinsonismM J Zigmond
Department of Behavioral Neuroscience and Psychiatry, University of Pittsburgh, PA 15260
Mol Chem Neuropathol 10:185-200. 1989..Collectively, these alterations permit a few residual DA neurons to maintain a normal level of control over cellular activity in the striatum... - Activity-dependent depression of medial prefrontal cortex inputs to accumbens neurons by the basolateral amygdalaV B McGinty
Department of Neuroscience, and the Center for Neuroscience, University of Pittsburgh, A210 Langley Hall, Pittsburgh, PA 15260, USA
Neuroscience 162:1429-36. 2009..The ability of the BLA to suppress mPFC-to-NAcc signaling may be a mechanism by which normal or pathologically heightened emotional states disrupt goal-directed behavior in favor of emotionally-driven responses... - Stimulation of D1-type dopamine receptors enhances excitability in prefrontal cortical pyramidal neurons in a state-dependent mannerA Lavin
Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
Neuroscience 104:335-46. 2001..From these data we suggest that dopamine exerts state-dependent modulatory effects on the excitability of neurons in deep layers of the prefrontal cortex... - The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addictionS R Laviolette
Department of Neuroscience, The University of Pittsburgh, Pittsburgh, 458 Crawford Hall, Pennsylvania 15260, USA
Cell Mol Life Sci 63:1597-613. 2006.... - Alterations in electrophysiological activity and dye coupling of striatal spiny and aspiny neurons in dopamine-denervated rat striatum recorded in vivoS P Onn
Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260, USA
Synapse 33:1-15. 1999..Therefore, gap junction conductance as reflected by dye coupling appears to undergo upregulation as a consequence of compromises in nigrostriatal and mesolimbic dopamine transmission... - Dopamine receptor subtypes selectively modulate excitatory afferents from the hippocampus and amygdala to rat nucleus accumbens neuronsA Charara
Departments of Neuroscience and Psychiatry, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
Neuropsychopharmacology 28:1412-21. 2003..Such facilitation or attenuation of hippocampal afferents against a background of suppression of other afferents would permit the hippocampus to have a dominant influence over behavior during periods of exploration... - DARPP-32: regulator of the efficacy of dopaminergic neurotransmissionA A Fienberg
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
Science 281:838-42. 1998..The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission... - Dopamine and cyclic-AMP regulated phosphoprotein-32-dependent modulation of prefrontal cortical input and intercellular coupling in mouse accumbens spiny and aspiny neuronsS P Onn
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
Neuroscience 151:802-16. 2008.... - Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heartM J Killeen
Physiological Laboratory, University of Cambridge, Cambridge, UK
Acta Physiol (Oxf) 189:33-46. 2007..Hypokalaemia is associated with a lethal form of ventricular tachycardia (VT), torsade de pointes, through pathophysiological mechanisms requiring clarification... - The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neuronsD J Lodge
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Proc Natl Acad Sci U S A 103:5167-72. 2006..These data show that the LDTg is critical to normal DA function, and thus, pathology within this region may lead to aberrant DA signaling... - Direct examination of local regulation of membrane activity in striatal and prefrontal cortical neurons in vivo using simultaneous intracellular recording and microdialysisAnthony R West
Department of Neuroscience, Center for Neuroscience, 446 Crawford Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Pharmacol Exp Ther 301:867-77. 2002..We conclude that the use of local microdialysis with intracellular recording is a powerful method for studying local receptor regulation of synaptic activity in vivo... - Acute and chronic corticotropin-releasing factor 1 receptor blockade inhibits cocaine-induced dopamine release: correlation with dopamine neuron activityD J Lodge
Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
J Pharmacol Exp Ther 314:201-6. 2005.... - Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardiumM D Lowe
Department of Cardiology, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE, UK
Heart 86:45-51. 2001..The increase in dispersion of repolarisation provides a mechanism whereby catecholamines acting through this receptor subtype may trigger ventricular arrhythmias... - Chronic cold exposure potentiates CRH-evoked increases in electrophysiologic activity of locus coeruleus neuronsH P Jedema
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Biol Psychiatry 49:351-9. 2001..The altered functional capacity of LC neurons in rats after continuous cold exposure may represent an experimental model to examine the role of central noradrenergic neurons in anxiety and mood disorders... - Separation of early afterdepolarizations from arrhythmogenic substrate in the isolated perfused hypokalaemic murine heart through modifiers of calcium homeostasisM J Killeen
Physiological Laboratory, University of Cambridge, Cambridge, UK
Acta Physiol (Oxf) 191:43-58. 2007..We resolved roles for early afterdepolarizations (EADs) and transmural gradients of repolarization in arrhythmogenesis in Langendorff-perfused hypokalaemic murine hearts paced from the right ventricular epicardium... - Pharmacological separation of early afterdepolarizations from arrhythmogenic substrate in DeltaKPQ Scn5a murine hearts modelling human long QT 3 syndromeG Thomas
Section of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Cambridge, UK
Acta Physiol (Oxf) 192:505-17. 2008..To perform an empirical, pharmacological, separation of early afterdepolarizations (EADs) and transmural gradients of repolarization in arrhythmogenesis in a genetically modified mouse heart modelling human long QT syndrome (LQT) 3... - Effects of potassium channel openers in the isolated perfused hypokalaemic murine heartM J Killeen
Physiological Laboratory, University of Cambridge, Cambridge, UK
Acta Physiol (Oxf) 193:25-36. 2008..We explored the anti-arrhythmic efficacy of K(+) channel activation in the hypokalaemic murine heart using NS1643 and nicorandil, compounds which augment I(Kr) and I(KATP) respectively... - Volume regulation is defective in renal proximal tubule cells isolated from KCNE1 knockout miceI D Millar
Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
Exp Physiol 89:173-80. 2004..One cell population is capable of RVD in the absence of HCO3-, whereas RVD in the other cell population has an absolute requirement for HCO3-. The HCO3- dependent RVD requires the normal expression of KCNE1...