A A Grace

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Regulation of conditioned responses of basolateral amygdala neurons
    Anthony A Grace
    Departments of Neuroscience and Psychiatry, University of Pittsburgh, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:489-93. 2002
  2. ncbi request reprint Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
    Anthony A Grace
    Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Trends Neurosci 30:220-7. 2007
  3. ncbi request reprint Disruption of cortical-limbic interaction as a substrate for comorbidity
    A A Grace
    Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neurotox Res 10:93-101. 2006
  4. ncbi request reprint Dopamine modulates excitability of basolateral amygdala neurons in vitro
    Sven Kroner
    Center for Neural Basics Cognition, Deptartment of Neuroscience, University of Pittsburgh, Pittsburgh, Penssylvania
    J Neurophysiol 93:1598-610. 2005
  5. ncbi request reprint Dopamine attenuates prefrontal cortical suppression of sensory inputs to the basolateral amygdala of rats
    J A Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 21:4090-103. 2001
  6. ncbi request reprint The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction
    S R Laviolette
    Department of Neuroscience, The University of Pittsburgh, Pittsburgh, 458 Crawford Hall, Pennsylvania 15260, USA
    Cell Mol Life Sci 63:1597-613. 2006
  7. pmc A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia
    Holly Moore
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 60:253-64. 2006
  8. ncbi request reprint Opposing influence of basolateral amygdala and footshock stimulation on neurons of the central amygdala
    J Amiel Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 59:801-11. 2006
  9. ncbi request reprint Modulation of basolateral amygdala neuronal firing and afferent drive by dopamine receptor activation in vivo
    J A Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 19:11027-39. 1999
  10. ncbi request reprint Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons
    S B Floresco
    Departments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 21:4915-22. 2001

Research Grants

  1. NEUROPHYSIOLOGY OF BASAL GANGLIA SYSTEM
    Anthony Grace; Fiscal Year: 2002
  2. GATING OF INFORMATION FLOW WITHIN THE NUCLEUS ACCUMBENS
    Anthony Grace; Fiscal Year: 2007

Detail Information

Publications86

  1. ncbi request reprint Regulation of conditioned responses of basolateral amygdala neurons
    Anthony A Grace
    Departments of Neuroscience and Psychiatry, University of Pittsburgh, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:489-93. 2002
    ..Furthermore, sensory-related inputs will be further enhanced by the increased excitability of BLA neurons. This situation is expected to maximize affective responses to sensory stimuli, as well as plasticity...
  2. ncbi request reprint Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
    Anthony A Grace
    Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Trends Neurosci 30:220-7. 2007
    ....
  3. ncbi request reprint Disruption of cortical-limbic interaction as a substrate for comorbidity
    A A Grace
    Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neurotox Res 10:93-101. 2006
    ..This would appear to be a common underlying process that may leave the individual susceptible to drug abuse and to the onset or exacerbation of psychiatric disorders such as schizophrenia and depression...
  4. ncbi request reprint Dopamine modulates excitability of basolateral amygdala neurons in vitro
    Sven Kroner
    Center for Neural Basics Cognition, Deptartment of Neuroscience, University of Pittsburgh, Pittsburgh, Penssylvania
    J Neurophysiol 93:1598-610. 2005
    ....
  5. ncbi request reprint Dopamine attenuates prefrontal cortical suppression of sensory inputs to the basolateral amygdala of rats
    J A Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 21:4090-103. 2001
    ..In situations of enhanced DA levels in the BLA, such as during stress and after amphetamine administration, mPFC regulation of BLA will be dampened, leading to a disinhibition of sensory-driven affective responses...
  6. ncbi request reprint The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction
    S R Laviolette
    Department of Neuroscience, The University of Pittsburgh, Pittsburgh, 458 Crawford Hall, Pennsylvania 15260, USA
    Cell Mol Life Sci 63:1597-613. 2006
    ....
  7. pmc A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia
    Holly Moore
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 60:253-64. 2006
    ..Specifically, we tested whether this manipulation leads to disruptions of frontal and limbic corticostriatal circuit function, while producing schizophrenia-like, region-dependent reductions in gray matter in cortex and thalamus...
  8. ncbi request reprint Opposing influence of basolateral amygdala and footshock stimulation on neurons of the central amygdala
    J Amiel Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 59:801-11. 2006
    ..It is unknown whether this difference is represented by distinct activity patterns of single Cem neurons. Furthermore, the nature of the interaction between the BLA and Cem is unknown...
  9. ncbi request reprint Modulation of basolateral amygdala neuronal firing and afferent drive by dopamine receptor activation in vivo
    J A Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 19:11027-39. 1999
    ....
  10. ncbi request reprint Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons
    S B Floresco
    Departments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 21:4915-22. 2001
    ..As a result, dysfunctions in hippocampal circuitries may contribute to the hyperexcitable state of the DA system that is present in schizophrenia...
  11. ncbi request reprint The effects of dopamine-depleting brain lesions on the electrophysiological activity of rat substantia nigra dopamine neurons
    J R Hollerman
    University of Pittsburgh, Department of Behavioral Neuroscience, PA 15260
    Brain Res 533:203-12. 1990
    ..In this way, the remaining DA neurons would maintain the wide dynamic range of electrophysiological responsivity that may be necessary for the normal function of the extrapyramidal motor system...
  12. ncbi request reprint Prenatal disruption of neocortical development alters prefrontal cortical neuron responses to dopamine in adult rats
    Antonieta Lavin
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 30:1426-35. 2005
    ..These results are consistent with a rewiring of the corticolimbic system in response to neurodevelopmental insults...
  13. ncbi request reprint Chronic cold stress alters prefrontal cortical modulation of amygdala neuronal activity in rats
    Cynthia M Correll
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Biol Psychiatry 58:382-91. 2005
    ..Little is known, however, about how the physiology of amygdala neurons is altered by chronic stressors or the role of the prefrontal cortex in these changes...
  14. ncbi request reprint The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuli
    J Amiel Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 23:11054-64. 2003
    ..This may be attributable to the loss of PFC-imposed inhibition of the emotional response to a stimulus but may also include the formation or diminished extinction of inappropriate associations...
  15. ncbi request reprint Cannabinoids Potentiate Emotional Learning Plasticity in Neurons of the Medial Prefrontal Cortex through Basolateral Amygdala Inputs
    Steven R Laviolette
    Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 26:6458-68. 2006
    ..These results are the first demonstration that cannabinoid signaling in the mPFC can modulate the magnitude of neuronal emotional learning plasticity and memory formation through functional inputs from the BLA...
  16. ncbi request reprint Acute haloperidol administration induces depolarization block of nigral dopamine neurons in rats after partial dopamine lesions
    J R Hollerman
    Department of Behavioral Neuroscience, University of Pittsburgh, PA
    Neurosci Lett 96:82-8. 1989
    ....
  17. pmc Activity-dependent depression of medial prefrontal cortex inputs to accumbens neurons by the basolateral amygdala
    V B McGinty
    Department of Neuroscience, and the Center for Neuroscience, University of Pittsburgh, A210 Langley Hall, Pittsburgh, PA 15260, USA
    Neuroscience 162:1429-36. 2009
    ..The ability of the BLA to suppress mPFC-to-NAcc signaling may be a mechanism by which normal or pathologically heightened emotional states disrupt goal-directed behavior in favor of emotionally-driven responses...
  18. ncbi request reprint Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex
    LeeAnn H Miner
    Department of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 26:1571-8. 2006
    ....
  19. pmc Anxiogenic modulation of spontaneous and evoked neuronal activity in the basolateral amygdala
    D M Buffalari
    Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuroscience 163:1069-77. 2009
    ....
  20. ncbi request reprint Stimulation of D1-type dopamine receptors enhances excitability in prefrontal cortical pyramidal neurons in a state-dependent manner
    A Lavin
    Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    Neuroscience 104:335-46. 2001
    ..From these data we suggest that dopamine exerts state-dependent modulatory effects on the excitability of neurons in deep layers of the prefrontal cortex...
  21. ncbi request reprint Depletion of dopamine in the prefrontal cortex decreases the basal electrophysiological activity of mesolimbic dopamine neurons
    D G Harden
    Depts of Neuroscience and Psychiatry, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    Brain Res 794:96-102. 1998
    ..Thus, the magnitude of increase in action potential-dependent DA release that occurs in response to a challenge may be augmented in lesioned rats...
  22. pmc Hippocampal dysfunction and disruption of dopamine system regulation in an animal model of schizophrenia
    Daniel J Lodge
    Department of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neurotox Res 14:97-104. 2008
    ..Moreover, this suggests an alternate pharmacotherapeutic approach based on the normalization of hippocampal activity in the treatment of schizophrenia in humans...
  23. pmc Chronic cold stress increases excitatory effects of norepinephrine on spontaneous and evoked activity of basolateral amygdala neurons
    Deanne M Buffalari
    Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh PA 15260, USA
    Int J Neuropsychopharmacol 12:95-107. 2009
    ....
  24. ncbi request reprint The depolarization block hypothesis of neuroleptic action: implications for the etiology and treatment of schizophrenia
    A A Grace
    Department of Behavioral Neuroscience, University of Pittsburgh, PA
    J Neural Transm Suppl 36:91-131. 1992
    ....
  25. pmc Dopamine modulation of hippocampal-prefrontal cortical interaction drives memory-guided behavior
    Yukiori Goto
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Cereb Cortex 18:1407-14. 2008
    ..These results provide a unique perspective on the mechanism of memory-based goal-directed behavior...
  26. ncbi request reprint The dopamine system and the pathophysiology of schizophrenia: a basic science perspective
    Yukiori Goto
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Int Rev Neurobiol 78:41-68. 2007
    ....
  27. ncbi request reprint Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
    Stan B Floresco
    Department of Neuroscienc, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, Pennsylvania 15260, USA
    Nat Neurosci 6:968-73. 2003
    ....
  28. ncbi request reprint Affective conditioning in the basolateral amygdala of anesthetized rats is modulated by dopamine and prefrontal cortical inputs
    J Amiel Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Ann N Y Acad Sci 985:488-91. 2003
  29. ncbi request reprint Compensatory responses to nigrostriatal bundle injury. Studies with 6-hydroxydopamine in an animal model of parkinsonism
    M J Zigmond
    Department of Behavioral Neuroscience and Psychiatry, University of Pittsburgh, PA 15260
    Mol Chem Neuropathol 10:185-200. 1989
    ..Collectively, these alterations permit a few residual DA neurons to maintain a normal level of control over cellular activity in the striatum...
  30. ncbi request reprint Interaction of benztropine and haloperidol actions on rat substantia nigra dopamine cell electrophysiological activity in vivo
    C L Todd
    Department of Neuroscience, Center for Neuroscience, University of Pittsburgh, PA 15260, USA
    Brain Res Bull 48:219-22. 1999
    ..The increase in burst firing seen in the presence of haloperidol may mediate some of the therapeutic effects of benztropine in the treatment of antipsychotic drug-induced movement disorders...
  31. ncbi request reprint Alterations in electrophysiological activity and dye coupling of striatal spiny and aspiny neurons in dopamine-denervated rat striatum recorded in vivo
    S P Onn
    Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260, USA
    Synapse 33:1-15. 1999
    ..Therefore, gap junction conductance as reflected by dye coupling appears to undergo upregulation as a consequence of compromises in nigrostriatal and mesolimbic dopamine transmission...
  32. ncbi request reprint Acute and chronic corticotropin-releasing factor 1 receptor blockade inhibits cocaine-induced dopamine release: correlation with dopamine neuron activity
    D J Lodge
    Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    J Pharmacol Exp Ther 314:201-6. 2005
    ....
  33. pmc The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons
    D J Lodge
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Proc Natl Acad Sci U S A 103:5167-72. 2006
    ..These data show that the LDTg is critical to normal DA function, and thus, pathology within this region may lead to aberrant DA signaling...
  34. pmc Dopamine and cyclic-AMP regulated phosphoprotein-32-dependent modulation of prefrontal cortical input and intercellular coupling in mouse accumbens spiny and aspiny neurons
    S P Onn
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuroscience 151:802-16. 2008
    ....
  35. pmc Antipsychotic drug-induced increases in ventral tegmental area dopamine neuron population activity via activation of the nucleus accumbens-ventral pallidum pathway
    Ornella Valenti
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Int J Neuropsychopharmacol 13:845-60. 2010
    ..This provides an important insight into the relationship between altered DA neuron activity and potential antipsychotic efficacy...
  36. pmc Amphetamine activation of hippocampal drive of mesolimbic dopamine neurons: a mechanism of behavioral sensitization
    Daniel J Lodge
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 28:7876-82. 2008
    ....
  37. pmc Dopamine system dysregulation by the ventral subiculum as the common pathophysiological basis for schizophrenia psychosis, psychostimulant abuse, and stress
    Anthony A Grace
    Department of Neuroscience, University of Pittsburgh, A210 Langley Hall, Pittsburgh, PA 15260, USA
    Neurotox Res 18:367-76. 2010
    ..On the other hand, this could point to the ventral subiculum as an effective site of therapeutic intervention in the treatment or even the prevention of schizophrenia...
  38. pmc Aberrant striatal plasticity is specifically associated with dyskinesia following levodopa treatment
    Pauline Belujon
    Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Mov Disord 25:1568-76. 2010
    ..Such information is critical for understanding the cellular mechanisms underlying one of the major caveats to L-dopa therapy...
  39. doi request reprint Physiology of the normal and dopamine-depleted basal ganglia: insights into levodopa pharmacotherapy
    Anthony A Grace
    Department of Neuroscience, Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Mov Disord 23:S560-9. 2008
    ..Continuous administration of Levodopa may circumvent this sensitization process, enabling a therapeutic response without limbic and motor side effects...
  40. ncbi request reprint Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia
    Daniel J Lodge
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 27:11424-30. 2007
    ..These data provide a direct link between hippocampal dysfunction and the hyper-responsivity of the DA system that is believed to underlie the augmented response to amphetamine in animal models and psychosis in schizophrenia patients...
  41. pmc Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophrenia
    Daniel J Lodge
    Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, A210 Langley Hall, Pittsburgh, PA 15260, USA
    Behav Brain Res 204:306-12. 2009
    ..Thus gestational MAM administration has been demonstrated to induce a pathodevelopmental process leading to neuroanatomical and behavioral phenotypes consistent with that observed in schizophrenia in humans...
  42. pmc Critical role of the prefrontal cortex in the regulation of hippocampus-accumbens information flow
    Pauline Belujon
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 28:9797-805. 2008
    ..Therefore, inactivation of the mPFC, as would occur with mPFC leukotomy in schizophrenia, may prevent the abnormal vSub drive of the NAc...
  43. pmc Entorhinal cortex inhibits medial prefrontal cortex and modulates the activity states of electrophysiologically characterized pyramidal neurons in vivo
    Ornella Valenti
    University of Pittsburgh, Department of Neuroscience, Psychiatry and Psychology, Pittsburgh, PA 15260, USA
    Cereb Cortex 19:658-74. 2009
    ....
  44. pmc Chronic cold exposure increases RGS7 expression and decreases alpha(2)-autoreceptor-mediated inhibition of noradrenergic locus coeruleus neurons
    Hank P Jedema
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Eur J Neurosci 27:2433-43. 2008
    ....
  45. pmc A loss of parvalbumin-containing interneurons is associated with diminished oscillatory activity in an animal model of schizophrenia
    Daniel J Lodge
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 29:2344-54. 2009
    ..Such information is central to gaining a better understanding of the disease pathophysiology and alternate pharmacotherapeutic approaches...
  46. pmc Hippocampus, amygdala, and stress: interacting systems that affect susceptibility to addiction
    Pauline Belujon
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Ann N Y Acad Sci 1216:114-21. 2011
    ..In particular, we will focus on two main afferents to the NAc, the basolateral amygdala and the ventral subiculum of the hippocampus, and their interactions with the locus coeruleus-norepinephrine system...
  47. pmc Selective activation of medial prefrontal-to-accumbens projection neurons by amygdala stimulation and Pavlovian conditioned stimuli
    Vincent B McGinty
    Department of Neuroscience, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Cereb Cortex 18:1961-72. 2008
    ....
  48. pmc Nucleus accumbens deep brain stimulation produces region-specific alterations in local field potential oscillations and evoked responses in vivo
    Clinton B McCracken
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 29:5354-63. 2009
    ....
  49. pmc Cortico-Basal Ganglia reward network: microcircuitry
    Susan R Sesack
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 35:27-47. 2010
    ..A fuller appreciation of the circuitry interconnecting the nucleus accumbens and ventral tegmental area should serve to advance discovery of new treatment options for these conditions...
  50. ncbi request reprint High-frequency deep brain stimulation of the nucleus accumbens region suppresses neuronal activity and selectively modulates afferent drive in rat orbitofrontal cortex in vivo
    Clinton B McCracken
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 27:12601-10. 2007
    ..Moreover, selective potentiation of input to these inhibitory circuits may also contribute to the therapeutic effects produced by DBS in OCD patients...
  51. ncbi request reprint Noradrenergic modulation of basolateral amygdala neuronal activity: opposing influences of alpha-2 and beta receptor activation
    Deanne M Buffalari
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 27:12358-66. 2007
    ..The interaction between these two structures is particularly relevant with regard to their known involvement in stress responses and stress-related disorders...
  52. ncbi request reprint The hippocampus modulates dopamine neuron responsivity by regulating the intensity of phasic neuron activation
    Daniel J Lodge
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 31:1356-61. 2006
    ....
  53. ncbi request reprint Gating of hippocampal-evoked activity in prefrontal cortical neurons by inputs from the mediodorsal thalamus and ventral tegmental area
    Stan B Floresco
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15206, USA
    J Neurosci 23:3930-43. 2003
    ..Thus, both the MD and VTA exert a complex gating action over PFC neural activity, either facilitating or inhibiting firing in the hippocampal-PFC pathway depending on the frequency and relative timing of the arrival of afferent input...
  54. ncbi request reprint Chronic exposure to cold stress alters electrophysiological properties of locus coeruleus neurons recorded in vitro
    Hank P Jedema
    Department of Neuroscience, University of Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 28:63-72. 2003
    ....
  55. ncbi request reprint Corticotropin-releasing hormone directly activates noradrenergic neurons of the locus ceruleus recorded in vitro
    Hank P Jedema
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 24:9703-13. 2004
    ....
  56. ncbi request reprint Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior
    Yukiori Goto
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nat Neurosci 8:805-12. 2005
    ..These results suggest that the dynamics of DA release regulate the balance between limbic and cortical drive through activation and inactivation of DA receptor subtypes in the accumbens, and this regulates goal-directed behavior...
  57. ncbi request reprint Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning
    J Amiel Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nature 417:282-7. 2002
    ..These results demonstrate that conditioning and habituation processes produce opposite effects on LAT neurons and that dopamine is important in these events, consistent with its role in emotional memory formation...
  58. ncbi request reprint Regulation of striatal dopamine neurotransmission by nitric oxide: effector pathways and signaling mechanisms
    Anthony R West
    Department of Neuroscience, 446 Crawford Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Synapse 44:227-45. 2002
    ....
  59. ncbi request reprint A subpopulation of neurons in the medial prefrontal cortex encodes emotional learning with burst and frequency codes through a dopamine D4 receptor-dependent basolateral amygdala input
    Steven R Laviolette
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 25:6066-75. 2005
    ..These results demonstrate that individual neurons in the mPFC that receive a functional input from the BLA actively encode emotional learning and that this process depends on DA D4 receptor stimulation in the mPFC...
  60. ncbi request reprint Cellular mechanisms of infralimbic and prelimbic prefrontal cortical inhibition and dopaminergic modulation of basolateral amygdala neurons in vivo
    J Amiel Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 22:324-37. 2002
    ..DA receptor activation enhanced neuronal input resistance by a postsynaptic mechanism (via DA D2 receptors), suppressed spontaneously occurring and PFC-evoked PSPs (via DA D1 receptors), and enhanced Te3-evoked PSPs...
  61. ncbi request reprint Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: disruption by cocaine sensitization
    Yukiori Goto
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuron 47:255-66. 2005
    ..Thus, interactions of limbic-prefrontal cortical synaptic plasticity and its dysfunction within the accumbens could underlie complex information processing deficits observed in individuals following psychostimulant administration...
  62. ncbi request reprint Alterations in medial prefrontal cortical activity and plasticity in rats with disruption of cortical development
    Yukiori Goto
    Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260, USA
    Biol Psychiatry 60:1259-67. 2006
    ..Thus, a genetic predisposition can lead to developmental compromises that may leave the system more susceptible to deficits induced by subsequent environmental variables such as stress...
  63. ncbi request reprint Opposite influences of endogenous dopamine D1 and D2 receptor activation on activity states and electrophysiological properties of striatal neurons: studies combining in vivo intracellular recordings and reverse microdialysis
    Anthony R West
    Department of Neuroscience, Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 22:294-304. 2002
    ..Moreover, a significant component of D2 receptor-mediated inhibition of striatal neuron activity in vivo occurs via suppression of excitatory synaptic transmission...
  64. pmc Timing-dependent regulation of evoked spiking in nucleus accumbens neurons by integration of limbic and prefrontal cortical inputs
    Vincent B McGinty
    Dept of Neuroscience, A210 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260
    J Neurophysiol 101:1823-35. 2009
    ..These interactions may be crucial integrative mechanisms that allow motivational and cognitive information to produce appropriate reward-directed actions...
  65. ncbi request reprint Gating of information flow within the limbic system and the pathophysiology of schizophrenia
    A A Grace
    Department of Neuroscience, University of Pittsburgh, 458 Crawford Hall, Pittsburgh, PA, USA
    Brain Res Brain Res Rev 31:330-41. 2000
    ....
  66. ncbi request reprint The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving
    A A Grace
    Department of Neuroscience, University of Pittsburgh, PA 15260, USA
    Addiction 95:S119-28. 2000
    ....
  67. ncbi request reprint Dopamine receptor subtypes selectively modulate excitatory afferents from the hippocampus and amygdala to rat nucleus accumbens neurons
    A Charara
    Departments of Neuroscience and Psychiatry, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 28:1412-21. 2003
    ..Such facilitation or attenuation of hippocampal afferents against a background of suppression of other afferents would permit the hippocampus to have a dominant influence over behavior during periods of exploration...
  68. ncbi request reprint A role for electrotonic coupling in the striatum in the expression of dopamine receptor-mediated stereotypies
    Holly Moore
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 27:980-92. 2002
    ..These results may be relevant to diseases and pharmacotherapies associated with disruptions of motor and possibly cognitive sequencing...
  69. ncbi request reprint Developmental pathology, dopamine, and stress: a model for the age of onset of schizophrenia symptoms
    Judy L Thompson
    Department of Psychology, University of Pittsburgh, PA 15260, USA
    Schizophr Bull 30:875-900. 2004
    ....
  70. ncbi request reprint Chronic cold exposure potentiates CRH-evoked increases in electrophysiologic activity of locus coeruleus neurons
    H P Jedema
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 49:351-9. 2001
    ..The altered functional capacity of LC neurons in rats after continuous cold exposure may represent an experimental model to examine the role of central noradrenergic neurons in anxiety and mood disorders...
  71. ncbi request reprint Direct examination of local regulation of membrane activity in striatal and prefrontal cortical neurons in vivo using simultaneous intracellular recording and microdialysis
    Anthony R West
    Department of Neuroscience, Center for Neuroscience, 446 Crawford Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Pharmacol Exp Ther 301:867-77. 2002
    ..We conclude that the use of local microdialysis with intracellular recording is a powerful method for studying local receptor regulation of synaptic activity in vivo...
  72. ncbi request reprint Elevated intrasynaptic dopamine release in Tourette's syndrome measured by PET
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Psychiatry 159:1329-36. 2002
    ..The objective of this study was to test the hypothesis that presynaptic dopamine release from the striatum is abnormal in adults with Tourette's syndrome...
  73. ncbi request reprint Dopamine modulation of membrane excitability in striatal spiny neurons is altered in DARPP-32 knockout mice
    Shao Pii Onn
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Pharmacol Exp Ther 306:870-9. 2003
    ..In contrast, D2 agonist applied simultaneously with the D1 agonist only produced a reduction in excitability. This type of D1-dependent modulation was not present in slices from the DARPP-32 knockout mice...
  74. ncbi request reprint Cooperativity between hippocampal-prefrontal short-term plasticity through associative long-term potentiation
    Hitoshi Kawashima
    Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Brain Res 1109:37-44. 2006
    ..These results indicate that the mPFC functionally integrates discrete sources of hippocampal information via cooperativity between short- and long-term plasticity...
  75. ncbi request reprint Dopamine D1 and D4 receptor subtypes differentially modulate recurrent excitatory synapses in prefrontal cortical pyramidal neurons
    Shao Pii Onn
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuropsychopharmacology 31:318-38. 2006
    ....
  76. ncbi request reprint Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuropsychopharmacology 31:2716-27. 2006
    ..These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine...
  77. pmc The Yin and Yang of dopamine release: a new perspective
    Yukiori Goto
    Department of Psychiatry, McGill University, Research and Training Building, 1033 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    Neuropharmacology 53:583-7. 2007
    ....
  78. pmc Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET
    Dean F Wong
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA
    Neuropsychopharmacology 33:1239-51. 2008
    ..The finding of decreased SERT BP, and the possible elevation in 5-HT2AR in individuals with TS who had increased DA rel, suggest a condition of increased phasic DA rel modulated by low 5-HT in concomitant OCD...
  79. ncbi request reprint The hippocampal-VTA loop: controlling the entry of information into long-term memory
    John E Lisman
    Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
    Neuron 46:703-13. 2005
    ..These findings support a model whereby the hippocampal-VTA loop regulates the entry of information into long-term memory...
  80. ncbi request reprint Impaired brain development in the rat following prenatal exposure to methylazoxymethanol acetate at gestational day 17 and neurotrophin distribution
    Marco Fiore
    Department of Biological Psychiatry, University of Groningen, Hanzeplein 1, 9713 EZ Groningen, The Netherlands
    Neuroreport 15:1791-5. 2004
    ..The present study is the first to show long-lasting effects of a single prenatal exposure to a neurotoxin on adult levels of neurotrophins in brain regions implicated in neuropsychiatric disorders...
  81. pmc Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
    John E Lisman
    Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Trends Neurosci 31:234-42. 2008
    ..iii) Nicotine enhances the output of interneurons, and might thereby contribute to its therapeutic effect in schizophrenia...
  82. ncbi request reprint The nitric oxide-guanylyl cyclase signaling pathway modulates membrane activity States and electrophysiological properties of striatal medium spiny neurons recorded in vivo
    Anthony R West
    Department of Neuroscience, Finch University of Health Sciences The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 24:1924-35. 2004
    ..These results indicate that, in the intact animal, the NO signaling pathway exerts a powerful tonic modulatory influence over the membrane activity of striatal MSNs via the activation of GC and stimulation of cGMP production...
  83. ncbi request reprint Electrophysiological interactions between striatal glutamatergic and dopaminergic systems
    Anthony R West
    Department of Neuroscience, Finch University of Health Sciences The Chicago Medical School, North Chicago, Illinois 60064, USA
    Ann N Y Acad Sci 1003:53-74. 2003
    ....
  84. pmc The rostral anterior cingulate cortex modulates the efficiency of amygdala-dependent fear learning
    Stephanie Bissiere
    Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    Biol Psychiatry 63:821-31. 2008
    ..The aim of this study is to investigate a possible top-down control of a specific rACC sub-region over amygdala activation during pavlovian fear acquisition...
  85. ncbi request reprint The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes
    Robert M Bilder
    Department of Psychiatry, David Geffen School of Medicine and Psychology, UCLA Neuropsychiatric Institute, University of California at Los Angeles, Los Angeles, CA, USA
    Neuropsychopharmacology 29:1943-61. 2004
    ....
  86. ncbi request reprint Developing predictive animal models and establishing a preclinical trials network for assessing treatment effects on cognition in schizophrenia
    Stan B Floresco
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Schizophr Bull 31:888-94. 2005
    ....

Research Grants2

  1. NEUROPHYSIOLOGY OF BASAL GANGLIA SYSTEM
    Anthony Grace; Fiscal Year: 2002
    ..Each technique is advanced to address specific research questions rather than simply expanding my technical base. ..
  2. GATING OF INFORMATION FLOW WITHIN THE NUCLEUS ACCUMBENS
    Anthony Grace; Fiscal Year: 2007
    ..The results will provide important new information regarding how these systems interact in normal and pathological states, and how function may be restored to a disordered dopamine system. ..