Research Topics
Genomes and Genes
| David GozalSummaryAffiliation: University of Chicago Country: USA Publications
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Detail Information
Publications
Serum, urine, and breath-related biomarkers in the diagnosis of obstructive sleep apnea in children: is it for real?David Gozal
Section of Pediatric Sleep Medicine, Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
Curr Opin Pulm Med 18:561-7. 2012....
Childhood obesity and sleep: relatives, partners, or both?--a critical perspective on the evidenceDavid Gozal
Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
Ann N Y Acad Sci 1264:135-41. 2012..The relative paucity of data on the topics covered in the perspective below should serve as a major incentive toward future research on these critically important concepts...- Metabolic effects of intermittent hypoxia in mice: steady versus high-frequency applied hypoxia daily during the rest periodAlba Carreras
Dept of Pediatrics, Univ of Chicago, Chicago, IL 60637, USA
Am J Physiol Regul Integr Comp Physiol 303:R700-9. 2012..Thus IH(H) and IH(L) elicit differential glucose homeostatic responses despite similar cumulative hypoxic profiles... 
C-reactive protein and obstructive sleep apnea syndrome in childrenDavid Gozal
Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
Front Biosci (Elite Ed) 4:2410-22. 2012..In this paper, we will critically review the available evidence linking OSAS to systemic inflammation in children using CRP levels as the reporter biomarker...- Transcriptional landscape of bone marrow-derived very small embryonic-like stem cells during hypoxiaSina A Gharib
Center for Lung Biology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA
Respir Res 12:63. 2011..While the effects of hypoxia on stem cells have been examined under in vitro conditions, the consequences of in vivo oxygen deprivation have not been studied... - Neurocognitive and endothelial dysfunction in children with obstructive sleep apneaDavid Gozal
Department of Pediatrics, University of Chicago, 5721 S Maryland Ave, MC 8000, Suite K 160, Chicago, IL 60637, USA
Pediatrics 126:e1161-7. 2010..However, it is unclear whether these 2 frequent morbidities of OSAS in children represent similar or different underlying pathophysiological processes, because they have never been concurrently assessed in children... - New approaches to the diagnosis of sleep-disordered breathing in childrenDavid Gozal
Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, IL 60637, USA
Sleep Med 11:708-13. 2010.... - The obesity epidemic and disordered sleep during childhood and adolescenceDavid Gozal
Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, University of Chicago, 5721 S Maryland Avenue, MC 8000, Suite K 160, Chicago, IL 60637, USA
Adolesc Med State Art Rev 21:480-90, viii-ix. 2010..In addition, the potential reciprocal roles of obesity and obstructive sleep apnea in the facilitation of their pathophysiology are also reviewed, along with their amplificatory effects on their respective morbidities... - Sleep duration, sleep regularity, body weight, and metabolic homeostasis in school-aged childrenKaren Spruyt
Department of Pediatrics, Comer Children s Hospital and Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Pediatrics 127:e345-52. 2011..The goal was to explore the effects of duration and regularity of sleep schedules on BMI and the impact on metabolic regulation in children... - Seasonal variability of sleep-disordered breathing in childrenDavid Gozal
Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Pediatr Pulmonol 46:581-6. 2011..Snoring and sleep-disordered breathing (SDB) are frequent pediatric conditions. Although allergies and respiratory viruses have been pathophysiologically implicated in these conditions, their seasonal distribution has not been examined... - Physical activity attenuates intermittent hypoxia-induced spatial learning deficits and oxidative stressDavid Gozal
Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, 5721 South Maryland Avenue, MC 8000, Suite K 160, Chicago, IL 60637, USA
Am J Respir Crit Care Med 182:104-12. 2010..Physical activity (PA) is now recognized as neuroprotective in models of neuronal injury and degeneration... - Exogenous erythropoietin administration attenuates intermittent hypoxia-induced cognitive deficits in a murine model of sleep apneaEhab A Dayyat
Department of Pediatrics, Pritzker School of Medicine, Comer Children s Hospital, The University of Chicago, 5721 S, Maryland Avenue, Chicago, IL USA
BMC Neurosci 13:77. 2012..The hypoxia-sensitive gene erythropoietin (EPO) has emerged as a major endogenous neuroprotectant, and could be involved in IH-induced neuronal dysfunction... - Peripheral blood leukocyte gene expression patterns and metabolic parameters in habitually snoring and non-snoring children with normal polysomnographic findingsAbdelnaby Khalyfa
Department of Pediatrics, University of Chicago, 5721 S Maryland Avenue, Chicago, IL 60637, USA
Sleep 34:153-60. 2011..Since increasing evidence suggest that PS may be associated with morbidity, we hypothesized that assessing genome-wide gene expression in peripheral blood leukocytes (PBL) will identify a distinct signature in PS children... - Platelet-activating factor receptor-deficient mice are protected from experimental sleep apnea-induced learning deficitsBarry W Row
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
J Neurochem 89:189-96. 2004..Collectively, these findings indicate that inflammatory signaling and neurobehavioral impairments induced by IH are mediated through PAF receptors... - Increased cellular proliferation and inflammatory cytokines in tonsils derived from children with obstructive sleep apneaJinKwan Kim
Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatr Res 66:423-8. 2009..01). Thus, T cells are in a highly proliferative state in the tonsils of children with OSA and are associated with increased production of proinflammatory cytokines and TRX, when compared with children with RI... - A mixed cell culture model for assessment of proliferation in tonsillar tissues from children with obstructive sleep apnea or recurrent tonsillitisLaura D Serpero
Division of Sleep Medicine, Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
Laryngoscope 119:1005-10. 2009..However, little is known on the determinants of lymphadenoid tissue proliferation in the pediatric upper airway... - Transcriptomic analysis identifies phosphatases as novel targets for adenotonsillar hypertrophy of pediatric obstructive sleep apneaAbdelnaby Khalyfa
Department of Pediatrics, University of Chicago, 5721 S Maryland Avenue, Chicago, IL 60637, USA
Am J Respir Crit Care Med 181:1114-20. 2010..Mechanisms leading to the proliferation and hypertrophy of AT in children who subsequently develop OSA remain unknown, and surgical extirpation of AT is associated with potential morbidity and mortality... - Adipokines in children with sleep disordered breathingRiva Tauman
Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Sleep 30:443-9. 2007..Therefore, we aimed to examine associations between circulating adipokines levels, insulin resistance, and measures of SDB in children... - Obstructive sleep apnea in children: relative contributions of body mass index and adenotonsillar hypertrophyEhab Dayyat
Department of Pediatrics, Division of Pediatric Sleep Medicine, The University of Chicago, Chicago, IL 60637, USA
Chest 136:137-44. 2009..The obesity epidemic has prompted remarkable changes in the proportion of obese children who are referred for habitual snoring. However, the contribution of obesity to adenotonsillar hypertrophy remains undefined... - Two-dimensional differential in-gel electrophoresis proteomic approaches reveal urine candidate biomarkers in pediatric obstructive sleep apneaDavid Gozal
Section of Pediatric Sleep Medicine, Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
Am J Respir Crit Care Med 180:1253-61. 2009..Sleep studies are laborious, expensive, inaccessible, and inconvenient for diagnosing obstructive sleep apnea (OSA) in children... - Prevalence of epileptiform activity in healthy children during sleepOscar Sans Capdevila
Kosair Children s Hospital Sleep Medicine and Apnea Center, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Sleep Med 9:303-9. 2008..This type of paroxysmal activity does not include the electroencephalographic (EEG) activity observed during a seizure. The prevalence of epileptiform activity in the general pediatric population is unknown... - Sleep measures and morning plasma TNF-alpha levels in children with sleep-disordered breathingDavid Gozal
Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
Sleep 33:319-25. 2010..Since, at any given level of apnea-hypopnea index, there is significant variability in EDS, we hypothesized that morning tumor necrosis factor (TNF)-alpha plasma levels may provide a biologic correlate of EDS... - Nitric oxide synthase and intermittent hypoxia-induced spatial learning deficits in the ratRichard C Li
Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
Neurobiol Dis 17:44-53. 2004..We conclude that IH is associated with a time-dependent induction of iNOS and that the increased expression of iNOS may play a critical role in the early pathophysiological events leading to IH-mediated neurobehavioral deficits... - Genome-wide gene expression profiling in children with non-obese obstructive sleep apneaAbdelnaby Khalyfa
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Sleep Med 10:75-86. 2009..If left untreated, OSA may lead to significant cardiovascular and neurocognitive and behavioral morbidities. We hypothesized that pediatric OSA would lead to altered gene expression in circulating leukocytes... - Sleep fragmentation induces cognitive deficits via nicotinamide adenine dinucleotide phosphate oxidase-dependent pathways in mouseDeepti Nair
Department of Pediatrics, Pritzker School of Medicine, University of Chicago, IL 60637, USA
Am J Respir Crit Care Med 184:1305-12. 2011..We hypothesized that absence of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity is neuroprotective in SF-induced cognitive impairments... - Intermittent hypoxia induces time-dependent changes in the protein kinase B signaling pathway in the hippocampal CA1 region of the ratAviv Goldbart
Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Neurobiol Dis 14:440-6. 2003..Thus, IH induces time-dependent biphasic changes in AKT survival pathways within the CA1 region that are temporally correlated with the initial increases and subsequent decreases in neuronal apoptosis... - Endothelial dysfunction in children without hypertension: potential contributions of obesity and obstructive sleep apneaRakesh Bhattacharjee
Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA
Chest 141:682-91. 2012..Endothelial dysfunction can develop in the context of both obesity and obstructive sleep apnea (OSA) in children. However, the potential interactions between OSA and obesity have not been defined... - DNA methylation in inflammatory genes among children with obstructive sleep apneaJinKwan Kim
Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, Illinois 60637, USA
Am J Respir Crit Care Med 185:330-8. 2012..Because not all children with OSA exhibit increased systemic inflammation, genetic and environmental factors may be affecting patterns of DNA methylation in genes subserving inflammatory functions... - A mediation model linking body weight, cognition, and sleep-disordered breathingKaren Spruyt
Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, IL 60637, USA
Am J Respir Crit Care Med 185:199-205. 2012.... - Proteomic identification of a novel protein regulated in CA1 and CA3 hippocampal regions during intermittent hypoxiaJon B Klein
Department of Medicine, Core Proteomics Laboratory, Kidney Disease Program, University of Louisville, 570 South Preston Street, Suite 102, Louisville, KY 40202, USA
Respir Physiol Neurobiol 136:91-103. 2003.... - Plasma IGF-1 levels and cognitive dysfunction in children with obstructive sleep apneaDavid Gozal
Kosair Children s Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville School of Medicine, 570 S Preston Street, Suite 204, Louisville, KY 40202, USA
Sleep Med 10:167-73. 2009..Since IGF-1 is neuroprotective, we hypothesized that higher systemic IGF-1 levels may identify children at lower susceptibility for cognitive morbidity... - Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levelsAbdelnaby Khalyfa
Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL, USA
Lipids Health Dis 9:18. 2010..The purpose of this study was to measure FABP4 plasma levels, assess FABP4 allelic variants, and explore potential associations with fasting glucose and insulin levels in young school-age children with and without obesity... - Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apneaBharat Bhushan
Department of Pediatrics, Comer Children s Hospital, University of Chicago, Chicago, IL 60637, USA
Sleep Med 12:666-71. 2011..Therefore, we assessed plasma FABP4 levels and FABP4 allelic variants in obese and non-obese children with and without OSA... - Monocarboxylate transporter 2 and stroke severity in a rodent model of sleep apneaYang Wang
Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
J Neurosci 31:10241-8. 2011..Efforts to develop agonists of MCT2 should provide opportunities to ameliorate the overall outcome of stroke... - Endothelial dysfunction in obese non-hypertensive children without evidence of sleep disordered breathingRakesh Bhattacharjee
Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Kentucky, USA
BMC Pediatr 10:8. 2010..It is unknown whether obesity causes endothelial dysfunction in children in the absence of OSAS. This study examines endothelial function in obese and non-obese children without OSAS... - Endothelial progenitor cells and vascular dysfunction in children with obstructive sleep apneaLeila Kheirandish-Gozal
Section of Pediatric Sleep Medicine, Department of Pediatrics, The University of Chicago, 5721 S Maryland Avenue, MC 8000, Suite K 160, Chicago, IL 60637, USA
Am J Respir Crit Care Med 182:92-7. 2010..Endothelial dysfunction is a potential complication of obstructive sleep apnea syndrome (OSAS) in children ascribed to systemic inflammatory changes. However, not all children with OSAS will manifest endothelial dysfunction... - Intermittent hypoxia mobilizes bone marrow-derived very small embryonic-like stem cells and activates developmental transcriptional programs in miceSina A Gharib
Center for Lung Biology and UW Medicine Sleep Instiute, Department of Medicine, University of Washington, WA, USA
Sleep 33:1439-46. 2010..We hypothesized that exposure to intermittent hypoxia (IH) can mobilize VSELs from the bone marrow (BM) to peripheral blood (PB) in mice and can activate distinct transcriptional programs... - Gamma-amino butyric acid type B receptors stimulate neutrophil chemotaxis during ischemia-reperfusionMadhavi J Rane
Department of Medicine, University of Louisville, Louisville, KY 40202, USA
J Immunol 174:7242-9. 2005..The GABA(B)R potentially plays a significant role in the inflammatory response and neutrophil-dependent ischemia-reperfusion injury such as stroke... - Reciprocal interactions between spontaneous and respiratory arousals in adults with suspected sleep-disordered breathingRiva Tauman
Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children's Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
Sleep Med 7:229-34. 2006.... - Sleep pressure score: a new index of sleep disruption in snoring childrenRiva Tauman
Kosair Children's Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Kentucky 40202, USA
Sleep 27:274-8. 2004..An algorithm allowing for calculation of sleep propensity and disturbed sleep homeostasis in children who snore is proposed and may be of practical value in the assessment of sleepiness... - Increased susceptibility to intermittent hypoxia in aging rats: changes in proteasomal activity, neuronal apoptosis and spatial functionDavid Gozal
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
J Neurochem 86:1545-52. 2003.... - Prevalence of recurrent otitis media in habitually snoring school-aged childrenDavid Gozal
Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Sleep Med 9:549-54. 2008..However, it remains unclear whether habitually snoring children have a higher prevalence of ROM and whether they require tympanostomy tube placement more frequently... - Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apneaEhab Dayyat
Department of Pediatrics, Division of Sleep Medicine and Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY, USA
Chest 135:1142-9. 2009..The abundant expression of leukotrienes (LTs) and their receptors in adenotonsillar tissues of children with obstructive sleep apnea (OSA) suggest that LT antagonists could be useful in treating OSA... - Neurobehavioral implications of habitual snoring in childrenCarolyn B Mervis
Kosair Children's Hospital Research Institute and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatrics 114:44-9. 2004..Larger studies are urgently required because current guidelines for treatment of snoring in children may require reevaluation... - Leukocyte telomere length and plasma catestatin and myeloid-related protein 8/14 concentrations in children with obstructive sleep apneaJinKwan Kim
Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, 5721 S Maryland Ave, Chicago, IL 60637, USA
Chest 138:91-9. 2010..Leukocyte telomere length (LTL) reflects not only chronologic age but also the burden of disease. We hypothesized that LTL would be decreased in children with OSA... - Apolipoprotein E-deficient mice exhibit increased vulnerability to intermittent hypoxia-induced spatial learning deficitsLeila Kheirandish
Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, KY 40202, USA
Sleep 28:1412-7. 2005.... - Urinary protein expression patterns in children with sleep-disordered breathing: preliminary findingsJyoti Krishna
Division of Pediatric Sleep Medicine and Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY 40202, USA
Sleep Med 7:221-7. 2006.... - Cyclooxygenase 2 and intermittent hypoxia-induced spatial deficits in the ratRichard C Li
Kosair Children's Hospital Research Institute, 570 South Preston Street, Suite 321, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Am J Respir Crit Care Med 168:469-75. 2003..We conclude that IH induces upregulation and activation of COX-2 in rat cortex and that COX-2 may play a role in IH-mediated neurobehavioral deficits... - Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apneaAviv D Goldbart
Department of Pediatrics, Kosair Children s Hospital Research Institute, and Department of Surgery, Division of Ear Nose and Throat, University of Louisville, Louisville, Kentucky 40202, USA
Pediatr Res 62:489-94. 2007.... - Intermittent hypoxia-induced cognitive deficits are mediated by NADPH oxidase activity in a murine model of sleep apneaDeepti Nair
Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America
PLoS ONE 6:e19847. 2011..Excessive NADPH oxidase activity may play a role in IH-induced CNS dysfunction... - Neuroglobin protects neurons against oxidative stress in global ischemiaRichard Changxun Li
Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
J Cereb Blood Flow Metab 30:1874-82. 2010..Furthermore, CA1 neuronal injury was also markedly reduced. Thus, Ngb may confer protection against ischemia-reperfusion injury in the brain through its intrinsic antioxidant properties... - Impaired control of renal sympathetic nerve activity following neonatal intermittent hypoxia in ratsGalia K Soukhova-O'Hare
Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
Neurosci Lett 399:181-5. 2006..We conclude that postnatal intermittent hypoxia causes long-lasting impairment in chemoreceptor and baroreceptor control of renal nerve activity... - Correlates of sleep and pediatric bipolar disorderRochelle C Mehl
Department of Pediatrics, Kosair Children's Hospital Research Institute and Division of Pediatric Sleep Medicine, University of Louisville, KY 40202, USA
Sleep 29:193-7. 2006..Prevalence rates of pediatric bipolar disorder, as assessed by the Child Behavior Checklist, are consistent with those found in the adult bipolar population... - Plasma C-reactive protein levels among children with sleep-disordered breathingRiva Tauman
Kosair Children's Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatrics 113:e564-9. 2004..The intermittent hypoxemia and sleep fragmentation of SDB may underlie inflammatory responses, the magnitude of which may ultimately lead to the cardiovascular, cognitive, and behavioral morbidities of SDB... - Sleep and neurobehavioral characteristics of 5- to 7-year-old children with parentally reported symptoms of attention-deficit/hyperactivity disorderCheryl R Holbrook
Kosair Children's Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatrics 111:554-63. 2003..Furthermore, SDB can lead to mild ADHD-like behaviors that can be readily misperceived and potentially delay the diagnosis and appropriate treatment... - C-reactive protein, obstructive sleep apnea, and cognitive dysfunction in school-aged childrenDavid Gozal
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Am J Respir Crit Care Med 176:188-93. 2007..Obstructive sleep apnea (OSA) in children is associated with substantial neurobehavioral and cognitive dysfunction. However, not all children with OSA exhibit altered cognitive performance... - Nocturnal polysomnographic characteristics of habitually snoring children initially referred to pediatric ENT or sleep clinicsRakesh Bhattacharjee
Department of Pediatrics, University of Louisville, KY 40202, USA
Sleep Med 10:1031-4. 2009..To determine clinical and polysomnographic characteristics of children initially referred by primary care physicians (PCP) to either otolaryngology or sleep clinics for a history of habitual snoring... - Obstructive sleep apnea in poorly controlled asthmatic children: effect of adenotonsillectomyLeila Kheirandish-Gozal
Sections of Pediatric Pulmonology and Pediatric Sleep Medicine, Department of Pediatrics, University of Chicago, Chicago, Illinois 60637 1470, USA
Pediatr Pulmonol 46:913-8. 2011.... - The effect of stimulants on sleep characteristics in children with attention deficit/hyperactivity disorderAnna Ivanenko
Kosair Children's Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Sleep Med 4:309-16. 2003..s.). CONCLUSIONS: Despite the high prevalence of reported sleep disturbance in children with ADHD, stimulant medication appears to have minimal effects on subjective and objective sleep characteristics in children with reported ADHD... - Peripheral arterial tonometry events and electroencephalographic arousals in childrenRiva Tauman
Kosair Children's Hospital Research Institute and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Sleep 27:502-6. 2004..Nevertheless, these data further support the contention that adult criteria for the measurement for arousals may not be adequate in children... - Macrophage migration inhibitory factor gene polymorphisms and plasma levels in children with obstructive sleep apneaAbdelnaby Khalyfa
Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL 60637, USA
Pediatr Pulmonol 47:1001-11. 2012..In adults with OSA, serum levels of macrophage migration inhibitory factor (MIF) are elevated. Therefore, we assessed plasma MIF levels and MIF allelic variant frequencies in children with and without OSA (NOSA)... - Human apolipoprotein E4 targeted replacement in mice reveals increased susceptibility to sleep disruption and intermittent hypoxiaNavita Kaushal
Department of Pediatrics, Section of Pediatric Sleep Medicine, The University of Chicago, Chicago, IL 60637, USA
Am J Physiol Regul Integr Comp Physiol 303:R19-29. 2012.... - Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-α pathwayVijay Ramesh
Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA
J Neuroinflammation 9:91. 2012..The aim of this study was to examine role of the TNF-α pathway after long-term sleep fragmentation in mice... - Socially isolated mice exhibit a blunted homeostatic sleep response to acute sleep deprivation compared to socially paired miceNavita Kaushal
Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, Louisville, KY 40202, USA
Brain Res 1454:65-79. 2012..The homeostatic processes altered by SD are differentially affected in paired and isolated mice, suggesting that the social context of isolation stress may adversely affect the quantity and quality of sleep in mice... - Nocturnal body position in sleeping children with and without obstructive sleep apneaEhab Dayyat
Kosair Children s Hospital Sleep Medicine and Apnea Center, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatr Pulmonol 42:374-9. 2007..Although tonsillar size is not associated with positional differences in breathing, the presence or absence of obesity markedly modifies the effect of body position on respiratory disturbance... - Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brainRichard C Li
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, KY 40202, USA
Brain Res 1096:173-9. 2006..Furthermore, disparities between Ngb and Cygb responses to hypoxia further suggest that these two globins may play divergent roles in brain... - Catecholamine alterations in pediatric obstructive sleep apnea: effect of obesityAyelet B Snow
Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Pediatr Pulmonol 44:559-67. 2009..Moreover, urinary catecholamine excretion is altered in obese patients. We hypothesized that morning urine catecholamine levels would be correlated with the severity of obstructive sleep apnea and degree of obesity in children... - Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult ratsStephen R Reeves
Department of Pediatrics, Kosair Children's Hospital Research Institute, University of Louisville School of Medicine, Suite 204, 570 South Preston St, Louisville, KY 40202, USA
Am J Physiol Regul Integr Comp Physiol 290:R1664-71. 2006..e., metaplasticity) and markedly differ from previously reported increased neural plasticity changes induced by CIH in adult rats... - Sleep-disordered breathing and verbal skills in school-aged community childrenSarah Morsbach Honaker
Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, Kentucky, USA
Dev Neuropsychol 34:588-600. 2009..Although overall cognitive performances of SBD children remain in normative range, their problematic verbal skills may ultimately adversely affect academic performances or socioemotional behaviors... - Systemic inflammation in non-obese children with obstructive sleep apneaDavid Gozal
Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Sleep Med 9:254-9. 2008..The changes in levels of pro-inflammatory cytokine IL-6 , and the anti-inflammatory cytokine IL-10, both of which play a major role in atherogenesis, a major consequence of OSA, have not specifically been assessed in pediatric patients... - Ethnic difference in periodic limb movements in childrenCheryl R Holbrook
Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, Louisville, KY 40202, USA
Sleep Med 8:240-6. 2007..Ethnic differences in sleep architecture and other routinely assessed sleep parameters have not been critically assessed, thus the aim of this study was to compare sleep characteristics in African-American and Caucasian children... - Differential metabolic adaptation to acute and long-term hypoxia in rat primary cortical astrocytesCéline Véga
Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, Kentucky 40202, USA
J Neurochem 97:872-83. 2006.... - Anatomical changes in selected cardio-respiratory brainstem nuclei following early post-natal chronic intermittent hypoxiaStephen R Reeves
Department of Pediatrics, Kosair Children's Hospital Research Institute, University of Louisville School of Medicine, KY 40202, USA
Neurosci Lett 402:233-7. 2006..Thus, CIH-associated cardio-respiratory metaplasticity is accompanied by substantial structural changes within both the nTS and Namb... - Neurobehavioral correlates of sleep-disordered breathing in childrenCarolyn B Mervis
Department of Pediatrics, Kosair Children's Hospital Research Institute and Division of Pediatric Sleep Medicine, Universtiy of Louisville, KY 40202, USA
J Sleep Res 13:165-72. 2004..Furthermore, total arousal index was negatively correlated with neurocognitive abilities, suggesting a role for sleep fragmentation in pediatric SDB-induced cognitive dysfunction... - Erectile dysfunction in a murine model of sleep apneaGalia K Soukhova-O'Hare
Kosair Children s Hospital Research Institute, University of Louisville, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Am J Respir Crit Care Med 178:644-50. 2008..Erectile dysfunction (ED) is frequent in obstructive sleep apnea syndrome (OSAS). Chronic intermittent hypoxia (CIH), one of the hallmarks of OSAS, could mediate ED... - Psychiatric symptoms in children with insomnia referred to a pediatric sleep medicine centerAnna Ivanenko
Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children's Hospital Research Institute, University of Louisville School of Medicine, 571 S. Preston Street Suite 321, Louisville, KY 40202, USA
Sleep Med 5:253-9. 2004..CONCLUSION: The vast majority of children presenting with persistent insomnia exhibit clinical symptoms of an accompanying psychiatric disorder, suggesting that comprehensive psychometric assessments are warranted in this population... - Sleep pressure correlates of cognitive and behavioral morbidity in snoring childrenRiva Tauman
Kosair Children's Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, KY 40202, USA
Sleep 27:279-82. 2004.... - Potential usefulness of noninvasive autonomic monitoring in recognition of arousals in normal healthy childrenDavid Gozal
Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
J Clin Sleep Med 3:41-7. 2007..Because arousals are associated with increases in sympathetic tone, measurement of sympathetic activity using noninvasive techniques could provide useful surrogate markers for arousals in children... - Autonomic dysfunction in children with sleep-disordered breathingDavid Gozal
Kosair Children's Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Sleep 28:747-52. 2005..CONCLUSION: Children with sleep-disordered breathing have altered autonomic nervous system regulation as evidenced by increased sympathetic vascular reactivity during wakefulness... - Oxidant stress and inflammation in the snoring child: confluent pathways to upper airway pathogenesis and end-organ morbidityDavid Gozal
Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, 570 S Preston Street, Suite 321, Louisville, KY 40202, USA
Sleep Med Rev 10:83-96. 2006..This hypothetical working model incorporates both dose-dependent disease severity components, as well as environmental and genetic elements of susceptibility... - Inefficient or insufficient encoding as potential primary deficit in neurodevelopmental performance among children with OSAKaren Spruyt
Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, Kentucky, USA
Dev Neuropsychol 34:601-14. 2009..We hypothesize that inefficient/insufficient encoding may account for the primary deficit... - Dietary and physical activity patterns in children with obstructive sleep apneaKaren Spruyt
Division of Pediatric Sleep Medicine, Department of Pediatrics, and Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY, USA
J Pediatr 156:724-30, 730.e1-730.e3. 2010..To assess dietary and physical activity patterns and morning circulating blood levels of the orexigenic hormones ghrelin and visfatin in children with either obesity, obstructive sleep apnea (OSA), or both conditions... - Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomyDavid Gozal
Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 S Preston St, Suite 204, Louisville, KY 40202, USA
Circulation 116:2307-14. 2007..However, it remains unclear whether endothelial dysfunction occurs in pediatric OSA and whether it is reversible on effective treatment of OSA... - Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much moreDavid Gozal
Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Am J Respir Crit Care Med 177:369-75. 2008.... - Circulating microparticles in children with sleep disordered breathingJinKwan Kim
Section of Pediatric Sleep Medicine, Department of Pediatrics, Comer Children s Hospital, University of Chicago, Chicago, IL, USA
Chest 140:408-17. 2011..Endothelial dysfunction is a common complication of pediatric obstructive sleep apnea (OSA). Circulating cell-derived microparticles (MPs) have emerged as reliable biomarkers of endothelial dysfunction and atherosclerosis... - Metabolic alterations and systemic inflammation in obstructive sleep apnea among nonobese and obese prepubertal childrenDavid Gozal
Kosair Children s Hospital Research Institute, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Am J Respir Crit Care Med 177:1142-9. 2008..In contrast, OSA in prepubertal children does not appear to correlate with the magnitude of such metabolic derangements... - Sleep assessments in healthy school-aged children using actigraphy: concordance with polysomnographyKaren Spruyt
Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
J Sleep Res 20:223-32. 2011..Thus, caution is advocated in drawing definitive conclusions from ACT during evaluation of the sleep-disturbed child... - Autonomic alterations and endothelial dysfunction in pediatric obstructive sleep apneaLeila Kheirandish-Gozal
Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, IL 60637, USA
Sleep Med 11:714-20. 2010.... - Leukotriene B4 receptor-1 mediates intermittent hypoxia-induced atherogenesisRichard C Li
Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA
Am J Respir Crit Care Med 184:124-31. 2011..Leukotriene B4 (LTB4) production is increased in patients with obstructive sleep apnea and negatively correlates to hypoxic levels during sleep, with continuous positive airway pressure therapy decreasing LTB4 production... - The scoring of respiratory events in sleep: reliability and validitySusan Redline
Department of Pediatrics, Case Western Reserve University, Cleveland, OH, WA 44106 6033, USA
J Clin Sleep Med 3:169-200. 2007.... - Sleep, sleep disorders and inflammation in childrenDavid Gozal
Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL 60637, USA
Sleep Med 10:S12-6. 2009.... - Hypoxemia and obesity modulate plasma C-reactive protein and interleukin-6 levels in sleep-disordered breathingRiva Tauman
Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
Sleep Breath 11:77-84. 2007..03) and correlated with AHI (r = 0.28, p = 0.003) and SpO(2) nadir (r = -0.24, p = 0.02). Children with SDB display significant severity-dependent increases in plasma CRP and IL-6 levels independent of obesity... - Development of pediatric sleep questionnaires as diagnostic or epidemiological tools: a brief review of dos and don'tsKaren Spruyt
Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Sleep Med Rev 15:7-17. 2011..e., how any questionnaire, inventory, log, or diary should be created and evaluated, and also provide illustrative examples to further underline the potential pitfalls that are inherently embedded in every step of tool development... - Pediatric sleep questionnaires as diagnostic or epidemiological tools: a review of currently available instrumentsKaren Spruyt
Department of Pediatrics, Comer Children s Hospital, The University of Chicago, 5721 S Maryland Avenue, MC 8000, Suite K 160 Chicago, IL 60637, USA
Sleep Med Rev 15:19-32. 2011.... - Proteomic analysis of CA1 and CA3 regions of rat hippocampus and differential susceptibility to intermittent hypoxiaEvelyne Gozal
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40204, USA
J Neurochem 83:331-45. 2002..These findings provide initial insights into mechanisms underlying differences in susceptibility to hypoxia in neural tissue, and may allow for future delineation of interventional strategies aiming to enhance neuronal adaptation to IH... - Serum proteomic patterns associated with sleep-disordered breathing in childrenZahoor A Shah
Department of Pediatrics, University of Louisville, Kentucky 40202, USA
Pediatr Res 59:466-70. 2006..Identification and sequencing of those differentially expressed proteins discovered through proteomic strategies may lead to future development of serum-based diagnostic tests for OSA in snoring children... - Health-related quality of life and depressive symptoms in children with suspected sleep-disordered breathingValerie McLaughlin Crabtree
Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, KY 40202, USA
Sleep 27:1131-8. 2004..However, the impact of SDB on mood and quality of life and the confounder effect of obesity in this setting are unclear... - Unbiased categorical classification of pediatric sleep disordered breathingKaren Spruyt
Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Sleep 33:1341-7. 2010..Although recognizable entities clearly exist under the SDB spectrum, neither the number of SDB categories nor their specific criteria have been critically defined... - Intranasal steroids and oral leukotriene modifier therapy in residual sleep-disordered breathing after tonsillectomy and adenoidectomy in childrenLeila Kheirandish
Kosair Children's Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatrics 117:e61-6. 2006..CONCLUSIONS: Combined anti-inflammatory therapy that consists of oral montelukast and intranasal budesonide effectively improves and/or normalizes respiratory and sleep disturbances in children with residual SDB after T&A... - Neurocognitive dysfunction in children with sleep disordersLeila Kheirandish
Child and Youth Project and Division of Paediatric Sleep Medicine, Department of Paediatrics, University of Louisville School of Medicine, Louisville, KY 40202, USA
Dev Sci 9:388-99. 2006..This article takes a critical look at the current literature on these issues, reviews the major findings and discusses such findings in conjunction with those derived from pertinent animal models... - Obesity and excessive daytime sleepiness in prepubertal children with obstructive sleep apneaDavid Gozal
Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, Louisville, KY 40202, USA
Pediatrics 123:13-8. 2009..However, it remains unclear whether obesity modifies the relative frequency of daytime symptoms such as excessive daytime sleepiness...