David Gozal

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Circulating adropin concentrations in pediatric obstructive sleep apnea: potential relevance to endothelial function
    David Gozal
    Sections of Pediatric Sleep Medicine and Pediatric Pulmonology, Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, University of Chicago, Chicago, IL Electronic address
    J Pediatr 163:1122-6. 2013
  2. doi request reprint Serum, urine, and breath-related biomarkers in the diagnosis of obstructive sleep apnea in children: is it for real?
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Curr Opin Pulm Med 18:561-7. 2012
  3. pmc Childhood obesity and sleep: relatives, partners, or both?--a critical perspective on the evidence
    David Gozal
    Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Ann N Y Acad Sci 1264:135-41. 2012
  4. pmc Metabolic effects of intermittent hypoxia in mice: steady versus high-frequency applied hypoxia daily during the rest period
    Alba Carreras
    Dept of Pediatrics, Univ of Chicago, Chicago, IL 60637, USA
    Am J Physiol Regul Integr Comp Physiol 303:R700-9. 2012
  5. ncbi request reprint C-reactive protein and obstructive sleep apnea syndrome in children
    David Gozal
    Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Front Biosci (Elite Ed) 4:2410-22. 2012
  6. pmc Transcriptional landscape of bone marrow-derived very small embryonic-like stem cells during hypoxia
    Sina A Gharib
    Center for Lung Biology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA
    Respir Res 12:63. 2011
  7. pmc Physical activity attenuates intermittent hypoxia-induced spatial learning deficits and oxidative stress
    David Gozal
    Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, 5721 South Maryland Avenue, MC 8000, Suite K 160, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 182:104-12. 2010
  8. doi request reprint Neurocognitive and endothelial dysfunction in children with obstructive sleep apnea
    David Gozal
    Department of Pediatrics, University of Chicago, 5721 S Maryland Ave, MC 8000, Suite K 160, Chicago, IL 60637, USA
    Pediatrics 126:e1161-7. 2010
  9. doi request reprint Seasonal variability of sleep-disordered breathing in children
    David Gozal
    Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Pediatr Pulmonol 46:581-6. 2011
  10. pmc Sleep duration, sleep regularity, body weight, and metabolic homeostasis in school-aged children
    Karen Spruyt
    Department of Pediatrics, Comer Children s Hospital and Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Pediatrics 127:e345-52. 2011

Collaborators

Detail Information

Publications126 found, 100 shown here

  1. pmc Circulating adropin concentrations in pediatric obstructive sleep apnea: potential relevance to endothelial function
    David Gozal
    Sections of Pediatric Sleep Medicine and Pediatric Pulmonology, Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, University of Chicago, Chicago, IL Electronic address
    J Pediatr 163:1122-6. 2013
    ....
  2. doi request reprint Serum, urine, and breath-related biomarkers in the diagnosis of obstructive sleep apnea in children: is it for real?
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Curr Opin Pulm Med 18:561-7. 2012
    ....
  3. pmc Childhood obesity and sleep: relatives, partners, or both?--a critical perspective on the evidence
    David Gozal
    Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Ann N Y Acad Sci 1264:135-41. 2012
    ..The relative paucity of data on the topics covered in the perspective below should serve as a major incentive toward future research on these critically important concepts...
  4. pmc Metabolic effects of intermittent hypoxia in mice: steady versus high-frequency applied hypoxia daily during the rest period
    Alba Carreras
    Dept of Pediatrics, Univ of Chicago, Chicago, IL 60637, USA
    Am J Physiol Regul Integr Comp Physiol 303:R700-9. 2012
    ..Thus IH(H) and IH(L) elicit differential glucose homeostatic responses despite similar cumulative hypoxic profiles...
  5. ncbi request reprint C-reactive protein and obstructive sleep apnea syndrome in children
    David Gozal
    Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Front Biosci (Elite Ed) 4:2410-22. 2012
    ..In this paper, we will critically review the available evidence linking OSAS to systemic inflammation in children using CRP levels as the reporter biomarker...
  6. pmc Transcriptional landscape of bone marrow-derived very small embryonic-like stem cells during hypoxia
    Sina A Gharib
    Center for Lung Biology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA
    Respir Res 12:63. 2011
    ..While the effects of hypoxia on stem cells have been examined under in vitro conditions, the consequences of in vivo oxygen deprivation have not been studied...
  7. pmc Physical activity attenuates intermittent hypoxia-induced spatial learning deficits and oxidative stress
    David Gozal
    Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, 5721 South Maryland Avenue, MC 8000, Suite K 160, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 182:104-12. 2010
    ..Physical activity (PA) is now recognized as neuroprotective in models of neuronal injury and degeneration...
  8. doi request reprint Neurocognitive and endothelial dysfunction in children with obstructive sleep apnea
    David Gozal
    Department of Pediatrics, University of Chicago, 5721 S Maryland Ave, MC 8000, Suite K 160, Chicago, IL 60637, USA
    Pediatrics 126:e1161-7. 2010
    ..However, it is unclear whether these 2 frequent morbidities of OSAS in children represent similar or different underlying pathophysiological processes, because they have never been concurrently assessed in children...
  9. doi request reprint Seasonal variability of sleep-disordered breathing in children
    David Gozal
    Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Pediatr Pulmonol 46:581-6. 2011
    ..Snoring and sleep-disordered breathing (SDB) are frequent pediatric conditions. Although allergies and respiratory viruses have been pathophysiologically implicated in these conditions, their seasonal distribution has not been examined...
  10. pmc Sleep duration, sleep regularity, body weight, and metabolic homeostasis in school-aged children
    Karen Spruyt
    Department of Pediatrics, Comer Children s Hospital and Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Pediatrics 127:e345-52. 2011
    ..The goal was to explore the effects of duration and regularity of sleep schedules on BMI and the impact on metabolic regulation in children...
  11. doi request reprint New approaches to the diagnosis of sleep-disordered breathing in children
    David Gozal
    Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, IL 60637, USA
    Sleep Med 11:708-13. 2010
    ....
  12. ncbi request reprint The obesity epidemic and disordered sleep during childhood and adolescence
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, University of Chicago, 5721 S Maryland Avenue, MC 8000, Suite K 160, Chicago, IL 60637, USA
    Adolesc Med State Art Rev 21:480-90, viii-ix. 2010
    ..In addition, the potential reciprocal roles of obesity and obstructive sleep apnea in the facilitation of their pathophysiology are also reviewed, along with their amplificatory effects on their respective morbidities...
  13. pmc Exogenous erythropoietin administration attenuates intermittent hypoxia-induced cognitive deficits in a murine model of sleep apnea
    Ehab A Dayyat
    Department of Pediatrics, Pritzker School of Medicine, Comer Children s Hospital, The University of Chicago, 5721 S, Maryland Avenue, Chicago, IL USA
    BMC Neurosci 13:77. 2012
    ..The hypoxia-sensitive gene erythropoietin (EPO) has emerged as a major endogenous neuroprotectant, and could be involved in IH-induced neuronal dysfunction...
  14. pmc Peripheral blood leukocyte gene expression patterns and metabolic parameters in habitually snoring and non-snoring children with normal polysomnographic findings
    Abdelnaby Khalyfa
    Department of Pediatrics, University of Chicago, 5721 S Maryland Avenue, Chicago, IL 60637, USA
    Sleep 34:153-60. 2011
    ..Since increasing evidence suggest that PS may be associated with morbidity, we hypothesized that assessing genome-wide gene expression in peripheral blood leukocytes (PBL) will identify a distinct signature in PS children...
  15. pmc Increased cellular proliferation and inflammatory cytokines in tonsils derived from children with obstructive sleep apnea
    JinKwan Kim
    Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatr Res 66:423-8. 2009
    ..01). Thus, T cells are in a highly proliferative state in the tonsils of children with OSA and are associated with increased production of proinflammatory cytokines and TRX, when compared with children with RI...
  16. ncbi request reprint Platelet-activating factor receptor-deficient mice are protected from experimental sleep apnea-induced learning deficits
    Barry W Row
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    J Neurochem 89:189-96. 2004
    ..Collectively, these findings indicate that inflammatory signaling and neurobehavioral impairments induced by IH are mediated through PAF receptors...
  17. pmc A mixed cell culture model for assessment of proliferation in tonsillar tissues from children with obstructive sleep apnea or recurrent tonsillitis
    Laura D Serpero
    Division of Sleep Medicine, Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
    Laryngoscope 119:1005-10. 2009
    ..However, little is known on the determinants of lymphadenoid tissue proliferation in the pediatric upper airway...
  18. pmc Two-dimensional differential in-gel electrophoresis proteomic approaches reveal urine candidate biomarkers in pediatric obstructive sleep apnea
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    Am J Respir Crit Care Med 180:1253-61. 2009
    ..Sleep studies are laborious, expensive, inaccessible, and inconvenient for diagnosing obstructive sleep apnea (OSA) in children...
  19. pmc Transcriptomic analysis identifies phosphatases as novel targets for adenotonsillar hypertrophy of pediatric obstructive sleep apnea
    Abdelnaby Khalyfa
    Department of Pediatrics, University of Chicago, 5721 S Maryland Avenue, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 181:1114-20. 2010
    ..Mechanisms leading to the proliferation and hypertrophy of AT in children who subsequently develop OSA remain unknown, and surgical extirpation of AT is associated with potential morbidity and mortality...
  20. ncbi request reprint Adipokines in children with sleep disordered breathing
    Riva Tauman
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Sleep 30:443-9. 2007
    ..Therefore, we aimed to examine associations between circulating adipokines levels, insulin resistance, and measures of SDB in children...
  21. pmc Obstructive sleep apnea in children: relative contributions of body mass index and adenotonsillar hypertrophy
    Ehab Dayyat
    Department of Pediatrics, Division of Pediatric Sleep Medicine, The University of Chicago, Chicago, IL 60637, USA
    Chest 136:137-44. 2009
    ..The obesity epidemic has prompted remarkable changes in the proportion of obese children who are referred for habitual snoring. However, the contribution of obesity to adenotonsillar hypertrophy remains undefined...
  22. pmc Growth hormone releasing hormone (GHRH) signaling modulates intermittent hypoxia-induced oxidative stress and cognitive deficits in mouse
    Deepti Nair
    Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    J Neurochem 127:531-40. 2013
    ....
  23. pmc Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-α pathway
    Vijay Ramesh
    Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA
    J Neuroinflammation 9:91. 2012
    ..The aim of this study was to examine role of the TNF-α pathway after long-term sleep fragmentation in mice...
  24. ncbi request reprint Prevalence of epileptiform activity in healthy children during sleep
    Oscar Sans Capdevila
    Kosair Children s Hospital Sleep Medicine and Apnea Center, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 9:303-9. 2008
    ..This type of paroxysmal activity does not include the electroencephalographic (EEG) activity observed during a seizure. The prevalence of epileptiform activity in the general pediatric population is unknown...
  25. pmc Sleep measures and morning plasma TNF-alpha levels in children with sleep-disordered breathing
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    Sleep 33:319-25. 2010
    ..Since, at any given level of apnea-hypopnea index, there is significant variability in EDS, we hypothesized that morning tumor necrosis factor (TNF)-alpha plasma levels may provide a biologic correlate of EDS...
  26. ncbi request reprint Nitric oxide synthase and intermittent hypoxia-induced spatial learning deficits in the rat
    Richard C Li
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    Neurobiol Dis 17:44-53. 2004
    ..We conclude that IH is associated with a time-dependent induction of iNOS and that the increased expression of iNOS may play a critical role in the early pathophysiological events leading to IH-mediated neurobehavioral deficits...
  27. ncbi request reprint Intermittent hypoxia induces time-dependent changes in the protein kinase B signaling pathway in the hippocampal CA1 region of the rat
    Aviv Goldbart
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Neurobiol Dis 14:440-6. 2003
    ..Thus, IH induces time-dependent biphasic changes in AKT survival pathways within the CA1 region that are temporally correlated with the initial increases and subsequent decreases in neuronal apoptosis...
  28. ncbi request reprint Sleep pressure score: a new index of sleep disruption in snoring children
    Riva Tauman
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Kentucky 40202, USA
    Sleep 27:274-8. 2004
    ..We hypothesized that sleep architecture and arousal indexes may be altered relative to the severity of sleep-disordered breathing (SDB)...
  29. ncbi request reprint Reciprocal interactions between spontaneous and respiratory arousals in adults with suspected sleep-disordered breathing
    Riva Tauman
    Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    Sleep Med 7:229-34. 2006
    ..The aim of the present study was to assess the interactions between respiratory and spontaneous arousals in adults with suspected SDB, and to examine whether the SPS and the Epworth sleepiness scale (ESS) are correlated...
  30. ncbi request reprint Neurobehavioral implications of habitual snoring in children
    Louise M O'Brien
    Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 114:44-9. 2004
    ..However, PS has not been well evaluated, and it is unknown whether PS is associated with serious morbidity. This study investigated whether PS is associated with neurobehavioral deficits in children...
  31. pmc Sleep fragmentation induces cognitive deficits via nicotinamide adenine dinucleotide phosphate oxidase-dependent pathways in mouse
    Deepti Nair
    Department of Pediatrics, Pritzker School of Medicine, University of Chicago, IL 60637, USA
    Am J Respir Crit Care Med 184:1305-12. 2011
    ..We hypothesized that absence of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity is neuroprotective in SF-induced cognitive impairments...
  32. pmc Intermittent hypoxia-induced cognitive deficits are mediated by NADPH oxidase activity in a murine model of sleep apnea
    Deepti Nair
    Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e19847. 2011
    ..Excessive NADPH oxidase activity may play a role in IH-induced CNS dysfunction...
  33. doi request reprint Genome-wide gene expression profiling in children with non-obese obstructive sleep apnea
    Abdelnaby Khalyfa
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 10:75-86. 2009
    ..If left untreated, OSA may lead to significant cardiovascular and neurocognitive and behavioral morbidities. We hypothesized that pediatric OSA would lead to altered gene expression in circulating leukocytes...
  34. pmc DNA methylation in inflammatory genes among children with obstructive sleep apnea
    JinKwan Kim
    Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, Illinois 60637, USA
    Am J Respir Crit Care Med 185:330-8. 2012
    ..Because not all children with OSA exhibit increased systemic inflammation, genetic and environmental factors may be affecting patterns of DNA methylation in genes subserving inflammatory functions...
  35. pmc Endothelial dysfunction in children without hypertension: potential contributions of obesity and obstructive sleep apnea
    Rakesh Bhattacharjee
    Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA
    Chest 141:682-91. 2012
    ..Endothelial dysfunction can develop in the context of both obesity and obstructive sleep apnea (OSA) in children. However, the potential interactions between OSA and obesity have not been defined...
  36. pmc A mediation model linking body weight, cognition, and sleep-disordered breathing
    Karen Spruyt
    Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, IL 60637, USA
    Am J Respir Crit Care Med 185:199-205. 2012
    ....
  37. ncbi request reprint Proteomic identification of a novel protein regulated in CA1 and CA3 hippocampal regions during intermittent hypoxia
    Jon B Klein
    Department of Medicine, Core Proteomics Laboratory, Kidney Disease Program, University of Louisville, 570 South Preston Street, Suite 102, Louisville, KY 40202, USA
    Respir Physiol Neurobiol 136:91-103. 2003
    ....
  38. pmc Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels
    Abdelnaby Khalyfa
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL, USA
    Lipids Health Dis 9:18. 2010
    ..The purpose of this study was to measure FABP4 plasma levels, assess FABP4 allelic variants, and explore potential associations with fasting glucose and insulin levels in young school-age children with and without obesity...
  39. pmc Endothelial dysfunction in obese non-hypertensive children without evidence of sleep disordered breathing
    Rakesh Bhattacharjee
    Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Kentucky, USA
    BMC Pediatr 10:8. 2010
    ..It is unknown whether obesity causes endothelial dysfunction in children in the absence of OSAS. This study examines endothelial function in obese and non-obese children without OSAS...
  40. pmc Endothelial progenitor cells and vascular dysfunction in children with obstructive sleep apnea
    Leila Kheirandish-Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, The University of Chicago, 5721 S Maryland Avenue, MC 8000, Suite K 160, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 182:92-7. 2010
    ..Endothelial dysfunction is a potential complication of obstructive sleep apnea syndrome (OSAS) in children ascribed to systemic inflammatory changes. However, not all children with OSAS will manifest endothelial dysfunction...
  41. pmc Monocarboxylate transporter 2 and stroke severity in a rodent model of sleep apnea
    Yang Wang
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 31:10241-8. 2011
    ..Efforts to develop agonists of MCT2 should provide opportunities to ameliorate the overall outcome of stroke...
  42. doi request reprint Plasma IGF-1 levels and cognitive dysfunction in children with obstructive sleep apnea
    David Gozal
    Kosair Children s Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville School of Medicine, 570 S Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 10:167-73. 2009
    ..Since IGF-1 is neuroprotective, we hypothesized that higher systemic IGF-1 levels may identify children at lower susceptibility for cognitive morbidity...
  43. pmc Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apnea
    Bharat Bhushan
    Department of Pediatrics, Comer Children s Hospital, University of Chicago, Chicago, IL 60637, USA
    Sleep Med 12:666-71. 2011
    ..Therefore, we assessed plasma FABP4 levels and FABP4 allelic variants in obese and non-obese children with and without OSA...
  44. ncbi request reprint Increased susceptibility to intermittent hypoxia in aging rats: changes in proteasomal activity, neuronal apoptosis and spatial function
    David Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
    J Neurochem 86:1545-52. 2003
    ....
  45. ncbi request reprint Apolipoprotein E-deficient mice exhibit increased vulnerability to intermittent hypoxia-induced spatial learning deficits
    Leila Kheirandish
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, KY 40202, USA
    Sleep 28:1412-7. 2005
    ....
  46. ncbi request reprint Peripheral arterial tonometry events and electroencephalographic arousals in children
    Riva Tauman
    Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Sleep 27:502-6. 2004
    ..We investigated whether PAT events during sleep are associated with visually recognizable electroencephalographic arousals in healthy children and in children with sleep-disordered breathing...
  47. ncbi request reprint Plasma C-reactive protein levels among children with sleep-disordered breathing
    Riva Tauman
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 113:e564-9. 2004
    ..We hypothesized that elevated CRP plasma levels would also be present among children with SDB...
  48. ncbi request reprint Correlates of sleep and pediatric bipolar disorder
    Rochelle C Mehl
    Department of Pediatrics, Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, University of Louisville, KY 40202, USA
    Sleep 29:193-7. 2006
    ..To determine, based on a large community sample, the prevalence and associated sleep characteristics of children with a bipolar mood disturbance behavioral profile...
  49. ncbi request reprint The effect of stimulants on sleep characteristics in children with attention deficit/hyperactivity disorder
    Louise M O'Brien
    Kosair Children s Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Sleep Med 4:309-16. 2003
    ..To investigate the effects of stimulant medications on subjective and objective sleep characteristics of children with attention deficit/hyperactivity disorder (ADHD) compared with control children...
  50. pmc Prevalence of recurrent otitis media in habitually snoring school-aged children
    David Gozal
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 9:549-54. 2008
    ..However, it remains unclear whether habitually snoring children have a higher prevalence of ROM and whether they require tympanostomy tube placement more frequently...
  51. pmc Intermittent hypoxia mobilizes bone marrow-derived very small embryonic-like stem cells and activates developmental transcriptional programs in mice
    Sina A Gharib
    Center for Lung Biology and UW Medicine Sleep Instiute, Department of Medicine, University of Washington, WA, USA
    Sleep 33:1439-46. 2010
    ..We hypothesized that exposure to intermittent hypoxia (IH) can mobilize VSELs from the bone marrow (BM) to peripheral blood (PB) in mice and can activate distinct transcriptional programs...
  52. ncbi request reprint Gamma-amino butyric acid type B receptors stimulate neutrophil chemotaxis during ischemia-reperfusion
    Madhavi J Rane
    Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    J Immunol 174:7242-9. 2005
    ..The GABA(B)R potentially plays a significant role in the inflammatory response and neutrophil-dependent ischemia-reperfusion injury such as stroke...
  53. pmc Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea
    Ehab Dayyat
    Department of Pediatrics, Division of Sleep Medicine and Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY, USA
    Chest 135:1142-9. 2009
    ..The abundant expression of leukotrienes (LTs) and their receptors in adenotonsillar tissues of children with obstructive sleep apnea (OSA) suggest that LT antagonists could be useful in treating OSA...
  54. pmc Leukocyte telomere length and plasma catestatin and myeloid-related protein 8/14 concentrations in children with obstructive sleep apnea
    JinKwan Kim
    Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, 5721 S Maryland Ave, Chicago, IL 60637, USA
    Chest 138:91-9. 2010
    ..Leukocyte telomere length (LTL) reflects not only chronologic age but also the burden of disease. We hypothesized that LTL would be decreased in children with OSA...
  55. ncbi request reprint Cyclooxygenase 2 and intermittent hypoxia-induced spatial deficits in the rat
    Richard C Li
    Kosair Children s Hospital Research Institute, 570 South Preston Street, Suite 321, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 168:469-75. 2003
    ..We conclude that IH induces upregulation and activation of COX-2 in rat cortex and that COX-2 may play a role in IH-mediated neurobehavioral deficits...
  56. pmc Neuroglobin protects neurons against oxidative stress in global ischemia
    Richard Changxun Li
    Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    J Cereb Blood Flow Metab 30:1874-82. 2010
    ..Furthermore, CA1 neuronal injury was also markedly reduced. Thus, Ngb may confer protection against ischemia-reperfusion injury in the brain through its intrinsic antioxidant properties...
  57. ncbi request reprint Sleep pressure correlates of cognitive and behavioral morbidity in snoring children
    Louise M O'Brien
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, KY 40202, USA
    Sleep 27:279-82. 2004
    ..A sleep pressure score (SPS) with a cutoff value of 0.25 was derived from analysis of a large cohort of snoring and control children. Neurocognitive batteries were applied to examine the potential effect of SPS...
  58. ncbi request reprint Neurobehavioral correlates of sleep-disordered breathing in children
    Louise M O'Brien
    Department of Pediatrics, Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, Universtiy of Louisville, KY 40202, USA
    J Sleep Res 13:165-72. 2004
    ..Furthermore, total arousal index was negatively correlated with neurocognitive abilities, suggesting a role for sleep fragmentation in pediatric SDB-induced cognitive dysfunction...
  59. ncbi request reprint Anatomical changes in selected cardio-respiratory brainstem nuclei following early post-natal chronic intermittent hypoxia
    Stephen R Reeves
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, KY 40202, USA
    Neurosci Lett 402:233-7. 2006
    ..Thus, CIH-associated cardio-respiratory metaplasticity is accompanied by substantial structural changes within both the nTS and Namb...
  60. pmc Neuroglobin protects PC12 cells against oxidative stress
    Richard C Li
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Brain Res 1190:159-66. 2008
    ..Thus, Ngb plays a protective role against oxidative stress, which appears to be primarily mediated by intrinsic Ngb antioxidant properties...
  61. ncbi request reprint Urinary protein expression patterns in children with sleep-disordered breathing: preliminary findings
    Jyoti Krishna
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Sleep Med 7:221-7. 2006
    ..The aim of this study was therefore to analyze proteins in human urine and assess whether differential expression of particular proteins is associated with the presence of OSA...
  62. pmc Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea
    Aviv D Goldbart
    Department of Pediatrics, Kosair Children s Hospital Research Institute, and Department of Surgery, Division of Ear Nose and Throat, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatr Res 62:489-94. 2007
    ....
  63. ncbi request reprint Impaired control of renal sympathetic nerve activity following neonatal intermittent hypoxia in rats
    Galia K Soukhova-O'Hare
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    Neurosci Lett 399:181-5. 2006
    ..We conclude that postnatal intermittent hypoxia causes long-lasting impairment in chemoreceptor and baroreceptor control of renal nerve activity...
  64. pmc Obstructive sleep apnea in poorly controlled asthmatic children: effect of adenotonsillectomy
    Leila Kheirandish-Gozal
    Sections of Pediatric Pulmonology and Pediatric Sleep Medicine, Department of Pediatrics, University of Chicago, Chicago, Illinois 60637 1470, USA
    Pediatr Pulmonol 46:913-8. 2011
    ....
  65. ncbi request reprint Sleep and neurobehavioral characteristics of 5- to 7-year-old children with parentally reported symptoms of attention-deficit/hyperactivity disorder
    Louise M O'Brien
    Kosair Children s Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 111:554-63. 2003
    ....
  66. doi request reprint Nocturnal polysomnographic characteristics of habitually snoring children initially referred to pediatric ENT or sleep clinics
    Rakesh Bhattacharjee
    Department of Pediatrics, University of Louisville, KY 40202, USA
    Sleep Med 10:1031-4. 2009
    ..To determine clinical and polysomnographic characteristics of children initially referred by primary care physicians (PCP) to either otolaryngology or sleep clinics for a history of habitual snoring...
  67. pmc C-reactive protein, obstructive sleep apnea, and cognitive dysfunction in school-aged children
    David Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 176:188-93. 2007
    ..Obstructive sleep apnea (OSA) in children is associated with substantial neurobehavioral and cognitive dysfunction. However, not all children with OSA exhibit altered cognitive performance...
  68. ncbi request reprint Autonomic dysfunction in children with sleep-disordered breathing
    Louise M O'Brien
    Kosair Children s Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Sleep 28:747-52. 2005
    ..To measure sympathetic responses in children with and without sleep-disordered breathing...
  69. pmc A randomized trial of adenotonsillectomy for childhood sleep apnea
    Carole L Marcus
    Department of Pediatrics, Sleep Center, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, USA
    N Engl J Med 368:2366-76. 2013
    ....
  70. pmc Macrophage migration inhibitory factor gene polymorphisms and plasma levels in children with obstructive sleep apnea
    Abdelnaby Khalyfa
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL 60637, USA
    Pediatr Pulmonol 47:1001-11. 2012
    ..In adults with OSA, serum levels of macrophage migration inhibitory factor (MIF) are elevated. Therefore, we assessed plasma MIF levels and MIF allelic variant frequencies in children with and without OSA (NOSA)...
  71. pmc Human apolipoprotein E4 targeted replacement in mice reveals increased susceptibility to sleep disruption and intermittent hypoxia
    Navita Kaushal
    Department of Pediatrics, Section of Pediatric Sleep Medicine, The University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Regul Integr Comp Physiol 303:R19-29. 2012
    ....
  72. pmc Socially isolated mice exhibit a blunted homeostatic sleep response to acute sleep deprivation compared to socially paired mice
    Navita Kaushal
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Brain Res 1454:65-79. 2012
    ..The homeostatic processes altered by SD are differentially affected in paired and isolated mice, suggesting that the social context of isolation stress may adversely affect the quantity and quality of sleep in mice...
  73. ncbi request reprint Nocturnal body position in sleeping children with and without obstructive sleep apnea
    Ehab Dayyat
    Kosair Children s Hospital Sleep Medicine and Apnea Center, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatr Pulmonol 42:374-9. 2007
    ..Although tonsillar size is not associated with positional differences in breathing, the presence or absence of obesity markedly modifies the effect of body position on respiratory disturbance...
  74. ncbi request reprint Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain
    Richard C Li
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, KY 40202, USA
    Brain Res 1096:173-9. 2006
    ..Furthermore, disparities between Ngb and Cygb responses to hypoxia further suggest that these two globins may play divergent roles in brain...
  75. doi request reprint Catecholamine alterations in pediatric obstructive sleep apnea: effect of obesity
    Ayelet B Snow
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Pediatr Pulmonol 44:559-67. 2009
    ..Moreover, urinary catecholamine excretion is altered in obese patients. We hypothesized that morning urine catecholamine levels would be correlated with the severity of obstructive sleep apnea and degree of obesity in children...
  76. ncbi request reprint Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats
    Stephen R Reeves
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, Suite 204, 570 South Preston St, Louisville, KY 40202, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1664-71. 2006
    ..e., metaplasticity) and markedly differ from previously reported increased neural plasticity changes induced by CIH in adult rats...
  77. ncbi request reprint Ethnic difference in periodic limb movements in children
    Cheryl R Holbrook
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, Louisville, KY 40202, USA
    Sleep Med 8:240-6. 2007
    ..Ethnic differences in sleep architecture and other routinely assessed sleep parameters have not been critically assessed, thus the aim of this study was to compare sleep characteristics in African-American and Caucasian children...
  78. pmc Systemic inflammation in non-obese children with obstructive sleep apnea
    David Gozal
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 9:254-9. 2008
    ..The changes in levels of pro-inflammatory cytokine IL-6 , and the anti-inflammatory cytokine IL-10, both of which play a major role in atherogenesis, a major consequence of OSA, have not specifically been assessed in pediatric patients...
  79. pmc Sleep-disordered breathing and verbal skills in school-aged community children
    Sarah Morsbach Honaker
    Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, Kentucky, USA
    Dev Neuropsychol 34:588-600. 2009
    ..Although overall cognitive performances of SBD children remain in normative range, their problematic verbal skills may ultimately adversely affect academic performances or socioemotional behaviors...
  80. pmc Erectile dysfunction in a murine model of sleep apnea
    Galia K Soukhova-O'Hare
    Kosair Children s Hospital Research Institute, University of Louisville, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 178:644-50. 2008
    ..Erectile dysfunction (ED) is frequent in obstructive sleep apnea syndrome (OSAS). Chronic intermittent hypoxia (CIH), one of the hallmarks of OSAS, could mediate ED...
  81. ncbi request reprint Potential usefulness of noninvasive autonomic monitoring in recognition of arousals in normal healthy children
    David Gozal
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    J Clin Sleep Med 3:41-7. 2007
    ..Because arousals are associated with increases in sympathetic tone, measurement of sympathetic activity using noninvasive techniques could provide useful surrogate markers for arousals in children...
  82. ncbi request reprint Psychiatric symptoms in children with insomnia referred to a pediatric sleep medicine center
    Anna Ivanenko
    Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 571 S Preston Street Suite 321, Louisville, KY 40202, USA
    Sleep Med 5:253-9. 2004
    ..To assess the frequency and nature of clinical and psychiatric symptoms in children referred to a pediatric sleep center for evaluation of insomnia...
  83. ncbi request reprint Differential metabolic adaptation to acute and long-term hypoxia in rat primary cortical astrocytes
    Céline Véga
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, Kentucky 40202, USA
    J Neurochem 97:872-83. 2006
    ....
  84. doi request reprint Dietary and physical activity patterns in children with obstructive sleep apnea
    Karen Spruyt
    Division of Pediatric Sleep Medicine, Department of Pediatrics, and Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY, USA
    J Pediatr 156:724-30, 730.e1-730.e3. 2010
    ..To assess dietary and physical activity patterns and morning circulating blood levels of the orexigenic hormones ghrelin and visfatin in children with either obesity, obstructive sleep apnea (OSA), or both conditions...
  85. pmc Inefficient or insufficient encoding as potential primary deficit in neurodevelopmental performance among children with OSA
    Karen Spruyt
    Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, Kentucky, USA
    Dev Neuropsychol 34:601-14. 2009
    ..We hypothesize that inefficient/insufficient encoding may account for the primary deficit...
  86. ncbi request reprint Oxidant stress and inflammation in the snoring child: confluent pathways to upper airway pathogenesis and end-organ morbidity
    David Gozal
    Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, 570 S Preston Street, Suite 321, Louisville, KY 40202, USA
    Sleep Med Rev 10:83-96. 2006
    ..This hypothetical working model incorporates both dose-dependent disease severity components, as well as environmental and genetic elements of susceptibility...
  87. ncbi request reprint Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy
    David Gozal
    Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 S Preston St, Suite 204, Louisville, KY 40202, USA
    Circulation 116:2307-14. 2007
    ..However, it remains unclear whether endothelial dysfunction occurs in pediatric OSA and whether it is reversible on effective treatment of OSA...
  88. pmc Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much more
    David Gozal
    Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 177:369-75. 2008
    ....
  89. doi request reprint Circulating microparticles in children with sleep disordered breathing
    JinKwan Kim
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Comer Children s Hospital, University of Chicago, Chicago, IL, USA
    Chest 140:408-17. 2011
    ..Endothelial dysfunction is a common complication of pediatric obstructive sleep apnea (OSA). Circulating cell-derived microparticles (MPs) have emerged as reliable biomarkers of endothelial dysfunction and atherosclerosis...
  90. pmc Metabolic alterations and systemic inflammation in obstructive sleep apnea among nonobese and obese prepubertal children
    David Gozal
    Kosair Children s Hospital Research Institute, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 177:1142-9. 2008
    ..In contrast, OSA in prepubertal children does not appear to correlate with the magnitude of such metabolic derangements...
  91. pmc Leukotriene B4 receptor-1 mediates intermittent hypoxia-induced atherogenesis
    Richard C Li
    Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 184:124-31. 2011
    ..Leukotriene B4 (LTB4) production is increased in patients with obstructive sleep apnea and negatively correlates to hypoxic levels during sleep, with continuous positive airway pressure therapy decreasing LTB4 production...
  92. doi request reprint Autonomic alterations and endothelial dysfunction in pediatric obstructive sleep apnea
    Leila Kheirandish-Gozal
    Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, IL 60637, USA
    Sleep Med 11:714-20. 2010
    ....
  93. pmc Sleep assessments in healthy school-aged children using actigraphy: concordance with polysomnography
    Karen Spruyt
    Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Sleep Res 20:223-32. 2011
    ..Thus, caution is advocated in drawing definitive conclusions from ACT during evaluation of the sleep-disturbed child...
  94. ncbi request reprint The scoring of respiratory events in sleep: reliability and validity
    Susan Redline
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH, WA 44106 6033, USA
    J Clin Sleep Med 3:169-200. 2007
    ....
  95. doi request reprint Sleep, sleep disorders and inflammation in children
    David Gozal
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL 60637, USA
    Sleep Med 10:S12-6. 2009
    ....
  96. ncbi request reprint Hypoxemia and obesity modulate plasma C-reactive protein and interleukin-6 levels in sleep-disordered breathing
    Riva Tauman
    Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    Sleep Breath 11:77-84. 2007
    ..03) and correlated with AHI (r = 0.28, p = 0.003) and SpO(2) nadir (r = -0.24, p = 0.02). Children with SDB display significant severity-dependent increases in plasma CRP and IL-6 levels independent of obesity...
  97. pmc Development of pediatric sleep questionnaires as diagnostic or epidemiological tools: a brief review of dos and don'ts
    Karen Spruyt
    Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Sleep Med Rev 15:7-17. 2011
    ..e., how any questionnaire, inventory, log, or diary should be created and evaluated, and also provide illustrative examples to further underline the potential pitfalls that are inherently embedded in every step of tool development...
  98. pmc Pediatric sleep questionnaires as diagnostic or epidemiological tools: a review of currently available instruments
    Karen Spruyt
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, 5721 S Maryland Avenue, MC 8000, Suite K 160 Chicago, IL 60637, USA
    Sleep Med Rev 15:19-32. 2011
    ....
  99. ncbi request reprint Proteomic analysis of CA1 and CA3 regions of rat hippocampus and differential susceptibility to intermittent hypoxia
    Evelyne Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40204, USA
    J Neurochem 83:331-45. 2002
    ..These findings provide initial insights into mechanisms underlying differences in susceptibility to hypoxia in neural tissue, and may allow for future delineation of interventional strategies aiming to enhance neuronal adaptation to IH...
  100. ncbi request reprint Serum proteomic patterns associated with sleep-disordered breathing in children
    Zahoor A Shah
    Department of Pediatrics, University of Louisville, Kentucky 40202, USA
    Pediatr Res 59:466-70. 2006
    ..Identification and sequencing of those differentially expressed proteins discovered through proteomic strategies may lead to future development of serum-based diagnostic tests for OSA in snoring children...
  101. pmc Unbiased categorical classification of pediatric sleep disordered breathing
    Karen Spruyt
    Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Sleep 33:1341-7. 2010
    ..Although recognizable entities clearly exist under the SDB spectrum, neither the number of SDB categories nor their specific criteria have been critically defined...