Research Topics
| D GozalSummaryAffiliation: University of Louisville Country: USA Publications
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Detail Information
Publications
Obstructive sleep apnea in children: relative contributions of body mass index and adenotonsillar hypertrophyEhab Dayyat
Department of Pediatrics, Division of Pediatric Sleep Medicine, The University of Chicago, Chicago, IL 60637, USA
Chest 136:137-44. 2009..The obesity epidemic has prompted remarkable changes in the proportion of obese children who are referred for habitual snoring. However, the contribution of obesity to adenotonsillar hypertrophy remains undefined...
Increased susceptibility to intermittent hypoxia in aging rats: changes in proteasomal activity, neuronal apoptosis and spatial functionDavid Gozal
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
J Neurochem 86:1545-52. 2003....- Neurocognitive and behavioral morbidity in children with sleep disordersDavid Gozal
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Curr Opin Pulm Med 13:505-9. 2007..Particular focus is given to pediatric obstructive sleep apnea... - Systemic inflammation in non-obese children with obstructive sleep apneaDavid Gozal
Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Sleep Med 9:254-9. 2008..The changes in levels of pro-inflammatory cytokine IL-6 , and the anti-inflammatory cytokine IL-10, both of which play a major role in atherogenesis, a major consequence of OSA, have not specifically been assessed in pediatric patients... - Snoring during early childhood and academic performance at ages thirteen to fourteen yearsD Gozal
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
Pediatrics 107:1394-9. 2001..Obstructive sleep apnea syndrome in young children is associated with an adverse effect on learning. However, the long-term impact of sleep-disordered breathing (SDB) during early childhood on learning remains unknown... - APOE epsilon 4 allele, cognitive dysfunction, and obstructive sleep apnea in childrenDavid Gozal
Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, University of Louisville, Louisville, KY 40202, USA
Neurology 69:243-9. 2007..Considering the unique susceptibility of apolipoprotein E (ApoE) knock-out mice to an experimental model of OSA, we examined whether the APOE epsilon4 allele contributes to increased neurocognitive morbidity in pediatric OSA... - Obstructive sleep apnea in children: implications for the developing central nervous systemDavid Gozal
Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY 40202, USA
Semin Pediatr Neurol 15:100-6. 2008.... - C-reactive protein, obstructive sleep apnea, and cognitive dysfunction in school-aged childrenDavid Gozal
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Am J Respir Crit Care Med 176:188-93. 2007..Obstructive sleep apnea (OSA) in children is associated with substantial neurobehavioral and cognitive dysfunction. However, not all children with OSA exhibit altered cognitive performance... - Objective sleepiness measures in pediatric obstructive sleep apneaD Gozal
Kosair Children s Hospital Sleep Medicine and Apnea Center, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatrics 108:693-7. 2001..Excessive daytime sleepiness (EDS) occurs frequently in adult patients with obstructive sleep apnea (OSA). However, the incidence of EDS in children with OSA is unknown... - Sleep apnea in children--treatment considerationsDavid Gozal
Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Paediatr Respir Rev 7:S58-61. 2006.... - Gasping and autoresuscitation in the developing rat: effect of antecedent intermittent hypoxiaDavid Gozal
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
J Appl Physiol 92:1141-4. 2002..001 vs. RARA). We conclude that both prenatal and early postnatal IH adversely affect gasping and related survival mechanisms... - Oxidant stress and inflammation in the snoring child: confluent pathways to upper airway pathogenesis and end-organ morbidityDavid Gozal
Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, 570 S Preston Street, Suite 321, Louisville, KY 40202, USA
Sleep Med Rev 10:83-96. 2006..This hypothetical working model incorporates both dose-dependent disease severity components, as well as environmental and genetic elements of susceptibility... - New concepts in abnormalities of respiratory control in childrenDavid Gozal
Kosair Children s Hospital Research Institute, and Department of Pediatrics, University of Louisville, Kentucky 40202, USA
Curr Opin Pediatr 16:305-8. 2004..The explosion of technological breakthroughs in biology and medicine has facilitated our understanding of the fundamental mechanisms that govern the development of brain regions underlying respiratory control functions... - Consequences of snoring and sleep disordered breathing in childrenDavid Gozal
Division of Sleep Medicine, Department of Pediatrics, Kosair Children's Hospital Research Institute, University of Louisville, Baxter Biomedical Research Building, Suite 321, 571 S. Preston Street, Louisville, KY 40202, USA
Pediatr Pulmonol Suppl 26:166-8. 2004 - Snoring and obstructive sleep apnoea in children: why should we treat?David Gozal
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, USA
Paediatr Respir Rev 5:S371-6. 2004..More importantly, if timely diagnosis and intervention are not implemented, some of these morbid complications may not be completely reversible, leading to long-lasting residual consequences... - Respiratory effects of gestational intermittent hypoxia in the developing ratDavid Gozal
Kosair Children s Hospital Research Institute, University of Louisville, 570 S Preston Street, Ste 321, Louisville, KY 40202, USA
Am J Respir Crit Care Med 167:1540-7. 2003..We conclude that gestational intermittent hypoxia elicits long-lasting alterations in the control of breathing. We postulate that such IH-induced respiratory plasticity may create selective vulnerability to hypoxia during development... - Temporal aspects of spatial task performance during intermittent hypoxia in the rat: evidence for neurogenesisDavid Gozal
Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 South Preston St, Louisville, KY 40202 USA
Eur J Neurosci 18:2335-42. 2003.... - Increased upper airway collapsibility in children with obstructive sleep apnea during wakefulnessDavid Gozal
Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Am J Respir Crit Care Med 169:163-7. 2004..Thus, upper airway dynamic testing during wakefulness in response to a topical airway anesthetic may provide a useful clinical adjunct to the evaluation of snoring children, with more accurate identification of those children with SDB... - Prevalence of recurrent otitis media in habitually snoring school-aged childrenDavid Gozal
Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Sleep Med 9:549-54. 2008..However, it remains unclear whether habitually snoring children have a higher prevalence of ROM and whether they require tympanostomy tube placement more frequently... - Circulating vascular endothelial growth factor levels in patients with obstructive sleep apneaDavid Gozal
Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, KY 40202, USA
Sleep 25:59-65. 2002..Vascular endothelial growth factor (VEGF) has detectable levels in the circulation and its expression is highly regulated by oxygen tension. We therefore hypothesized that serum VEGF levels will be elevated in patients with OSA... 
Obesity and excessive daytime sleepiness in prepubertal children with obstructive sleep apneaDavid Gozal
Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, Louisville, KY 40202, USA
Pediatrics 123:13-8. 2009..However, it remains unclear whether obesity modifies the relative frequency of daytime symptoms such as excessive daytime sleepiness...- Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomyDavid Gozal
Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 S Preston St, Suite 204, Louisville, KY 40202, USA
Circulation 116:2307-14. 2007..However, it remains unclear whether endothelial dysfunction occurs in pediatric OSA and whether it is reversible on effective treatment of OSA... - Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much moreDavid Gozal
Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Am J Respir Crit Care Med 177:369-75. 2008.... - The multiple challenges of obstructive sleep apnea in children: morbidity and treatmentDavid Gozal
Division of Pediatric Sleep Medicine, Department of Pediatrics, and Kosair Children s Hospital Research Institute, University of Louisville, Louisville, Kentucky, USA
Curr Opin Pediatr 20:654-8. 2008..In addition, the conceptual framework whereby a childhood condition such as OSA can be linked to specific adult diseases will be presented... - Metabolic alterations and systemic inflammation in obstructive sleep apnea among nonobese and obese prepubertal childrenDavid Gozal
Kosair Children s Hospital Research Institute, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Am J Respir Crit Care Med 177:1142-9. 2008..In contrast, OSA in prepubertal children does not appear to correlate with the magnitude of such metabolic derangements... - Plasma IGF-1 levels and cognitive dysfunction in children with obstructive sleep apneaDavid Gozal
Kosair Children s Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville School of Medicine, 570 S Preston Street, Suite 204, Louisville, KY 40202, USA
Sleep Med 10:167-73. 2009..Since IGF-1 is neuroprotective, we hypothesized that higher systemic IGF-1 levels may identify children at lower susceptibility for cognitive morbidity... - In vivo PDGF beta receptor activation in the dorsocaudal brainstem of the rat prevents hypoxia-induced apoptosis via activation of Akt and BADN Simakajornboon
Constance S Kaufman Pediatric Pulmonary Research Laboratory, Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
Brain Res 895:111-8. 2001..We conclude that PDGFR-dependent in vivo activation of both Akt and BAD during hypoxia prevents induction of apoptosis, and may contribute to the increased hypoxic tolerance of brainstem neurons... - Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injuryW Xu
Department of Pediatrics, Kosair Children's Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
Spinal Cord 43:204-13. 2005..Thus, antioxidants/antioxidant enzyme intervention combined with other therapy may provide an effective approach to alleviate spinal cord injury-induced motor neuron damage and motor dysfunction... - Hypoxia induces c-Fos protein expression in NMDA but not AMPA glutamate receptor labeled neurons within the nucleus tractus solitarii of the conscious ratD Gozal
Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
Neurosci Lett 262:93-6. 1999..These data suggest a predominant role for NMDA but not for AMPA glutamate receptors in nTS mediated components of the hypoxic response... - AMPA glutamate receptors and respiratory control in the developing rat: anatomic and pharmacological aspectsG M Whitney
Department of Pediatrics, Constance S Kaufman Pediatric Pulmonary Research Laboratory, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
Am J Physiol Regul Integr Comp Physiol 278:R520-8. 2000..Furthermore, the role of non-NMDA receptors in respiratory control of conscious neonatal rats appears to be limited to modest, albeit significant, regulation of breathing pattern... - Nitric oxide modulates anoxia-induced gasping in the developing ratD Gozal
Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
Biol Neonate 73:264-74. 1998..We postulate that higher NO brainstem concentrations may favor early autoresuscitation but be detrimental to overall survival during prolonged asphyxia... - NF-kappaB induction during in vivo hypoxia in dorsocaudal brain stem of rat: effect of MK-801 and L-NAMEE Gozal
Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
J Appl Physiol 85:372-6. 1998..Thus NMDA-receptor activation in the dorsocaudal brain stem during hypoxia elicits in NF-kappaB activity marked enhancements that are unaffected after NOS blockade... - Brainstem activation of platelet-derived growth factor-beta receptor modulates the late phase of the hypoxic ventilatory responseD Gozal
Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana, USA
J Neurochem 74:310-9. 2000.... - Corticosteroids suppress in vitro tonsillar proliferation in children with obstructive sleep apnoeaL Kheirandish-Gozal
Department of Pediatrics, Division of Sleep Medicine, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY, USA
Eur Respir J 33:1077-84. 2009.... - Neuroglobin protects neurons against oxidative stress in global ischemiaRichard Changxun Li
Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
J Cereb Blood Flow Metab 30:1874-82. 2010..Furthermore, CA1 neuronal injury was also markedly reduced. Thus, Ngb may confer protection against ischemia-reperfusion injury in the brain through its intrinsic antioxidant properties... - Cardiorespiratory responses to systemic administration of a protein kinase C inhibitor in conscious ratsD Gozal
Constance S Kaufman Pediatric Pulmonary Research Laboratory, Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
J Appl Physiol 84:641-8. 1998..We postulate that PKC plays an important role in signal transduction pathways within brain regions underlying respiratory control... - Brainstem nitric oxide tissue levels correlate with anoxia-induced gasping activity in the developing ratD Gozal
Kosair Children s Hospital Research Institute, Departments of Pediatrics, Pharmacology and Toxicology, University of Louisville School of Medicine, KY 40202, USA
Biol Neonate 79:122-30. 2001..We conclude that anoxia-induced gasping neurogenesis is modulated via NMDA-NO mechanisms in the developing rat. We postulate that higher NO brainstem concentrations may favor early autoresuscitation, but limit anoxic tolerance... - High fat/refined carbohydrate diet enhances the susceptibility to spatial learning deficits in rats exposed to intermittent hypoxiaA D Goldbart
Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Brain Res 1090:190-6. 2006.... - Signaling pathways of the acute hypoxic ventilatory response in the nucleus tractus solitariusD Gozal
Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 S Preston Street, Ste 321, Louisville, KY 40202, USA
Respir Physiol 121:209-21. 2000.... - Hypoxemia and obesity modulate plasma C-reactive protein and interleukin-6 levels in sleep-disordered breathingRiva Tauman
Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
Sleep Breath 11:77-84. 2007..03) and correlated with AHI (r = 0.28, p = 0.003) and SpO(2) nadir (r = -0.24, p = 0.02). Children with SDB display significant severity-dependent increases in plasma CRP and IL-6 levels independent of obesity... - Platelet-activating factor receptor-deficient mice are protected from experimental sleep apnea-induced learning deficitsBarry W Row
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
J Neurochem 89:189-96. 2004..Collectively, these findings indicate that inflammatory signaling and neurobehavioral impairments induced by IH are mediated through PAF receptors... - Intermittent hypoxic exposure during light phase induces changes in cAMP response element binding protein activity in the rat CA1 hippocampal region: water maze performance correlatesA Goldbart
Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Suite 321, 570 South Preston Street, Louisville, KY 40202, USA
Neuroscience 122:585-90. 2003..We suggest that CREB changes play an important role in the neurocognitive morbidity of SDB patients... - Developmental differences in cortical and hippocampal vulnerability to intermittent hypoxia in the ratE Gozal
Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
Neurosci Lett 305:197-201. 2001.... - Hypoxic ventilatory roll-off is associated with decreases in protein kinase C activation within the nucleus tractus solitarius of the ratD Gozal
Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
Brain Res 774:246-9. 1997..Thus, alterations in PKC activity within the NTS which occur over time during hypoxia are isoform-selective and coincide with changes in ventilation... - Protein kinase C modulation of ventilatory response to hypoxia in nucleus tractus solitarii of conscious ratsE Gozal
Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
J Appl Physiol 84:1982-90. 1998..These studies suggest that, in the adult rat, PKC activation in the NTS mediates essential components of the acute hypoxic ventilatory response... - Sleep and neurobehavioral characteristics of 5- to 7-year-old children with parentally reported symptoms of attention-deficit/hyperactivity disorderCheryl R Holbrook
Kosair Children's Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatrics 111:554-63. 2003..Furthermore, SDB can lead to mild ADHD-like behaviors that can be readily misperceived and potentially delay the diagnosis and appropriate treatment... - Intermittent hypoxia induces time-dependent changes in the protein kinase B signaling pathway in the hippocampal CA1 region of the ratAviv Goldbart
Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Neurobiol Dis 14:440-6. 2003..Thus, IH induces time-dependent biphasic changes in AKT survival pathways within the CA1 region that are temporally correlated with the initial increases and subsequent decreases in neuronal apoptosis... - Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in ratsR C Li
Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Neuroscience 196:237-50. 2011..Thus, exogenous GH may provide a viable therapeutic intervention to protect IH-vulnerable brain regions from SDB-associated neuronal loss and associated neurocognitive dysfunction... - Developmental patterns of NF-kappaB activation during acute hypoxia in the caudal brainstem of the ratN Simakajornboon
Constance S. Kaufman Pediatric Pulmonary Research Laboratory, Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
Brain Res Dev Brain Res 127:175-83. 2001..We postulate that postnatal regulation of NF-kappaB complex expression and function may underlie fundamental genomic processes mediating developmental changes in neuronal hypoxic tolerance... - Cognition, sleep and respiration in at-risk children treated for obstructive sleep apnoeaH E Montgomery-Downs
Division of Pediatric Sleep Medicine, Dept of Pediatrics, University of Louisville, Louisville, KY, USA
Eur Respir J 25:336-42. 2005.... - Intranasal steroids and oral leukotriene modifier therapy in residual sleep-disordered breathing after tonsillectomy and adenoidectomy in childrenLeila Kheirandish
Kosair Children's Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatrics 117:e61-6. 2006..CONCLUSIONS: Combined anti-inflammatory therapy that consists of oral montelukast and intranasal budesonide effectively improves and/or normalizes respiratory and sleep disturbances in children with residual SDB after T&A... - Correlates of sleep and pediatric bipolar disorderRochelle C Mehl
Department of Pediatrics, Kosair Children's Hospital Research Institute and Division of Pediatric Sleep Medicine, University of Louisville, KY 40202, USA
Sleep 29:193-7. 2006..Prevalence rates of pediatric bipolar disorder, as assessed by the Child Behavior Checklist, are consistent with those found in the adult bipolar population... - Reciprocal interactions between spontaneous and respiratory arousals in adults with suspected sleep-disordered breathingRiva Tauman
Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children's Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
Sleep Med 7:229-34. 2006.... - Urinary protein expression patterns in children with sleep-disordered breathing: preliminary findingsJyoti Krishna
Division of Pediatric Sleep Medicine and Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY 40202, USA
Sleep Med 7:221-7. 2006.... - Neurocognitive and endothelial dysfunction in children with obstructive sleep apneaDavid Gozal
Department of Pediatrics, University of Chicago, 5721 S Maryland Ave, MC 8000, Suite K 160, Chicago, IL 60637, USA
Pediatrics 126:e1161-7. 2010..However, it is unclear whether these 2 frequent morbidities of OSAS in children represent similar or different underlying pathophysiological processes, because they have never been concurrently assessed in children... - Neurocognitive dysfunction in children with sleep disordersLeila Kheirandish
Child and Youth Project and Division of Paediatric Sleep Medicine, Department of Paediatrics, University of Louisville School of Medicine, Louisville, KY 40202, USA
Dev Sci 9:388-99. 2006..This article takes a critical look at the current literature on these issues, reviews the major findings and discusses such findings in conjunction with those derived from pertinent animal models... - Plasma C-reactive protein in nonobese children with obstructive sleep apnea before and after adenotonsillectomyLeila Kheirandish-Gozal
Kosair Children's Hospital Research Institute, University of Louisville School of Medicine, KY 40202, USA
J Clin Sleep Med 2:301-4. 2006..Thus, obstructive sleep apnea induces a systemic inflammatory response in children, which, if left untreated, may potentially lead to cardiovascular morbidity... - The scoring of respiratory events in sleep: reliability and validitySusan Redline
Department of Pediatrics, Case Western Reserve University, Cleveland, OH, WA 44106 6033, USA
J Clin Sleep Med 3:169-200. 2007.... - Sleep pressure score: a new index of sleep disruption in snoring childrenRiva Tauman
Kosair Children's Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Kentucky 40202, USA
Sleep 27:274-8. 2004..An algorithm allowing for calculation of sleep propensity and disturbed sleep homeostasis in children who snore is proposed and may be of practical value in the assessment of sleepiness... - Endothelial dysfunction in obese non-hypertensive children without evidence of sleep disordered breathingRakesh Bhattacharjee
Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Kentucky, USA
BMC Pediatr 10:8. 2010..It is unknown whether obesity causes endothelial dysfunction in children in the absence of OSAS. This study examines endothelial function in obese and non-obese children without OSAS... - Sleep pressure correlates of cognitive and behavioral morbidity in snoring childrenRiva Tauman
Kosair Children's Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, KY 40202, USA
Sleep 27:279-82. 2004.... - Vascular endothelial growth factor in the cerebrospinal fluid of infants who died of sudden infant death syndrome: evidence for antecedent hypoxiaKimberly L Jones
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Pediatrics 111:358-63. 2003..The vascular endothelial growth factor (VEGF) gene is highly sensitive to changes in tissue partial oxygen tension, and changes in genomic and protein expression occur even after changes in oxygenation within the physiologic range... - Sleep in children with attention deficit/hyperactivity disorderD Gozal
Department of Pediatrics, Kosair Children's Hospital Sleep Medicine and Apnea Center, University of Louisville School of Medicine, Louisville, KY 40202, US
Minerva Pediatr 56:585-601. 2004..This review addresses both these issues and provides a concise yet timely assessment of the potential links between sleep disorders and ADHD... - Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apneaW Xu
Kosair Children's Hospital Research Institute, Department of Pediatrics, 215 Baxter Building I, 570 South Preston Street, University of Louisville, Louisville, KY 40202, USA
Neuroscience 126:313-23. 2004..Taken together, these findings suggest that the increased ROS production and oxidative stress propagation contribute, at least partially, to CIH-mediated cortical neuronal apoptosis and neurocognitive dysfunction... - Neurobehavioral implications of habitual snoring in childrenCarolyn B Mervis
Kosair Children's Hospital Research Institute and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatrics 114:44-9. 2004..Larger studies are urgently required because current guidelines for treatment of snoring in children may require reevaluation... - Impaired control of renal sympathetic nerve activity following neonatal intermittent hypoxia in ratsGalia K Soukhova-O'Hare
Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
Neurosci Lett 399:181-5. 2006..We conclude that postnatal intermittent hypoxia causes long-lasting impairment in chemoreceptor and baroreceptor control of renal nerve activity... - Cardiovascular complications of obstructive sleep apnea syndrome: evidence from childrenRakesh Bhattacharjee
Kosair Children s Hospital Research Institute, Louisville, KY 40202, USA
Prog Cardiovasc Dis 51:416-33. 2009..In this review, we will present the specific cardiovascular complications that have thus far been described in children with OSAS, with reference to pertinent mechanisms, and potential implications... - Domoic acid lesions in nucleus of the solitary tract: time-dependent recovery of hypoxic ventilatory response and peripheral afferent axonal plasticityZixi Cheng
Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
J Neurosci 22:3215-26. 2002..The adult brainstem/NTS has self-repairing capabilities and will compensate for functional losses after structural damage by rewiring of its neural circuitry... - Plasma C-reactive protein levels among children with sleep-disordered breathingRiva Tauman
Kosair Children's Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatrics 113:e564-9. 2004..The intermittent hypoxemia and sleep fragmentation of SDB may underlie inflammatory responses, the magnitude of which may ultimately lead to the cardiovascular, cognitive, and behavioral morbidities of SDB... - Cerebral oximetry improves detection of sickle cell patients at risk for nocturnal cerebral hypoxiaAshok B Raj
Department of Pediatrics, Division of Hematology, School of Medicine, University of Louisville, Louisville, Kentucky, USA
Pediatr Pulmonol 41:1088-94. 2006..71 (0.66-0.81) vs. SCD 0.59 (0.52-0.65); P = 0.011]. Our findings suggest that SCD patients may be at increased risk of cerebral hypoxia during both wakefulness and sleep... - Green tea catechin polyphenols attenuate behavioral and oxidative responses to intermittent hypoxiaIsabel C Burckhardt
Kosair Children s Hospital Research Institute, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Am J Respir Crit Care Med 177:1135-41. 2008..We hypothesized that green tea catechin polyphenols (GTPs) may attenuate IH-induced neurobehavioral deficits by reducing IH-induced NADPH oxidase expression, lipid peroxidation, and inflammation... - The effect of chronic or intermittent hypoxia on cognition in childhood: a review of the evidenceJoel L Bass
Department of Pediatrics, Newton Wellesley Hospital, MassGeneral Hospital for Children, Harvard Medical School, Newton, Massachusetts 02462, USA
Pediatrics 114:805-16. 2004.... - Apolipoprotein E-deficient mice exhibit increased vulnerability to intermittent hypoxia-induced spatial learning deficitsLeila Kheirandish
Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, KY 40202, USA
Sleep 28:1412-7. 2005.... - Postnatal intermittent hypoxia alters baroreflex function in adult ratsZixi Jack Cheng
Department of Pediatrics, Kosair Children's Hospital Research Institute, 570 S Preston St, Suite 321, University of Louisville, Louisville, Kentucky 40202, USA
Am J Physiol Heart Circ Physiol 290:H1157-64. 2006..001) and vagal axon varicose contacts by 56% (P < 0.001) compared with controls. We conclude that reduction of vagal efferent projections in cardiac ganglia could be a cause of long-term modifications in baroreflex function... - Prevalence of epileptiform activity in healthy children during sleepOscar Sans Capdevila
Kosair Children s Hospital Sleep Medicine and Apnea Center, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Sleep Med 9:303-9. 2008..This type of paroxysmal activity does not include the electroencephalographic (EEG) activity observed during a seizure. The prevalence of epileptiform activity in the general pediatric population is unknown... - Two-dimensional differential in-gel electrophoresis proteomic approaches reveal urine candidate biomarkers in pediatric obstructive sleep apneaDavid Gozal
Section of Pediatric Sleep Medicine, Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
Am J Respir Crit Care Med 180:1253-61. 2009..Sleep studies are laborious, expensive, inaccessible, and inconvenient for diagnosing obstructive sleep apnea (OSA) in children... - A mixed cell culture model for assessment of proliferation in tonsillar tissues from children with obstructive sleep apnea or recurrent tonsillitisLaura D Serpero
Division of Sleep Medicine, Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
Laryngoscope 119:1005-10. 2009..However, little is known on the determinants of lymphadenoid tissue proliferation in the pediatric upper airway... - Passive motion of the extremities modifies alveolar ventilation during sleep in patients with congenital central hypoventilation syndromeD Gozal
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Am J Respir Crit Care Med 162:1747-51. 2000..We speculate that such effect may provide future noninvasive ventilatory support strategies in patients with CCHS and mild phenotypic expression of their disease... - Mild sustained and intermittent hypoxia induce apoptosis in PC-12 cells via different mechanismsEvelyne Gozal
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston St, Suite 321, Louisville, KY 40202, USA
Am J Physiol Cell Physiol 288:C535-42. 2005.... - Respiratory muscle training in neuromuscular disease: long-term effects on strength and load perceptionD Gozal
Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
Med Sci Sports Exerc 31:1522-7. 1999..Deterioration of respiratory muscle function in patients with neuromuscular disorders is primarily responsible for the high morbidity and mortality associated with these diseases... - Excitotoxic preconditioning elicited by both glutamate and hypoxia and abolished by lactate transport inhibition in rat hippocampal slicesA Schurr
Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
Neurosci Lett 307:151-4. 2001..These results indicate that excitotoxic PC and hypoxic PC share similar mechanisms that possibly involve lactate production and its neuronal utilization... - Novel insights into congenital hypoventilation syndromeD Gozal
Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
Curr Opin Pulm Med 5:335-8. 1999.... - Potentiation of hypoxic ventilatory response by hyperoxia in the conscious rat: putative role of nitric oxideD Gozal
Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
J Appl Physiol 85:129-32. 1998..1 +/- 35.6 ml/min in hypoxia; +O2 vs. -O2: P not significant). We conclude that in the conscious rat nNOS activation mediates essential components of the HVR potentiation elicited by a previous short hyperoxic exposure... - Psychiatric symptoms in children with insomnia referred to a pediatric sleep medicine centerAnna Ivanenko
Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children's Hospital Research Institute, University of Louisville School of Medicine, 571 S. Preston Street Suite 321, Louisville, KY 40202, USA
Sleep Med 5:253-9. 2004..CONCLUSION: The vast majority of children presenting with persistent insomnia exhibit clinical symptoms of an accompanying psychiatric disorder, suggesting that comprehensive psychometric assessments are warranted in this population... - Sleep, sleep disorders and inflammation in childrenDavid Gozal
Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL 60637, USA
Sleep Med 10:S12-6. 2009.... - Adipokines in children with sleep disordered breathingRiva Tauman
Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Sleep 30:443-9. 2007..Therefore, we aimed to examine associations between circulating adipokines levels, insulin resistance, and measures of SDB in children... - Endothelial progenitor cells and vascular dysfunction in children with obstructive sleep apneaLeila Kheirandish-Gozal
Section of Pediatric Sleep Medicine, Department of Pediatrics, The University of Chicago, 5721 S Maryland Avenue, MC 8000, Suite K 160, Chicago, IL 60637, USA
Am J Respir Crit Care Med 182:92-7. 2010..Endothelial dysfunction is a potential complication of obstructive sleep apnea syndrome (OSAS) in children ascribed to systemic inflammatory changes. However, not all children with OSAS will manifest endothelial dysfunction... - Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult ratsStephen R Reeves
Department of Pediatrics, Kosair Children's Hospital Research Institute, University of Louisville School of Medicine, Suite 204, 570 South Preston St, Louisville, KY 40202, USA
Am J Physiol Regul Integr Comp Physiol 290:R1664-71. 2006..e., metaplasticity) and markedly differ from previously reported increased neural plasticity changes induced by CIH in adult rats... - Autonomic dysfunction in children with sleep-disordered breathingDavid Gozal
Kosair Children's Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Sleep 28:747-52. 2005..CONCLUSION: Children with sleep-disordered breathing have altered autonomic nervous system regulation as evidenced by increased sympathetic vascular reactivity during wakefulness... - Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteinsJon B Klein
Core Proteomics Laboratory, University of Louisville, Kentucky 40202, USA
J Biol Chem 280:31870-81. 2005..We concluded that Akt phosphorylates VCP in vitro and in vivo, and VCP phosphorylation releases it from ubiquitinated substrate protein(s) possibly allowing ubiquitinated protein(s) to be degraded by the proteosome... - Obesity rather than severity of sleep-disordered breathing as the major determinant of insulin resistance and altered lipidemia in snoring childrenRiva Tauman
Division of Pediatric Sleep Medicine and Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatrics 116:e66-73. 2005..CONCLUSIONS: Among children with suspected SDB, insulin resistance and dyslipidemia seem to be determined primarily by the degree of body adiposity rather than by the severity of SDB... - Cyclooxygenase 2 and intermittent hypoxia-induced spatial deficits in the ratRichard C Li
Kosair Children's Hospital Research Institute, 570 South Preston Street, Suite 321, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Am J Respir Crit Care Med 168:469-75. 2003..We conclude that IH induces upregulation and activation of COX-2 in rat cortex and that COX-2 may play a role in IH-mediated neurobehavioral deficits... - Behavioural and neurocognitive implications of snoring and obstructive sleep apnoea in children: facts and theoryDavid Gozal
Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, KY 40202, USA
Paediatr Respir Rev 3:3-9. 2002..This paper reviews the available information and attempts to provide the rationale for early diagnosis and treatment of OSA in children... - Persistence of obstructive sleep apnea syndrome in children after adenotonsillectomyRiva Tauman
Kosair Children's Hospital Research Institute and the Department of Pediatrics, Division of Pediatric Sleep Medicine, University of Louisville, Louisville, Kentucky, USA
J Pediatr 149:803-8. 2006..Obesity and AHI at diagnosis are the major determinant for surgical outcome. When normalization of respiratory measures occurs after surgery, normalization of sleep architecture will also ensue... - Periodic limb movement disorder of sleep in childrenValerie McLaughlin Crabtree
Kosair Children's Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville School of Medicine, 571 S. Preston Street, Louisville, KY 40202, USA
J Sleep Res 12:73-81. 2003..We postulate that rather than a direct relationship between ADHD and PLMD, this link may be mediated by the presence of reduced REM sleep and more importantly by the sleep fragmentation associated with PLM-induced arousals... - Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the ratBarry W Row
Kosair Children's Hospital Research Institute, University of Louisville, Baxter Biomedical Research Building, Suite 321, 570 South Preston Street, Louisville, KY 40202, USA
Am J Respir Crit Care Med 167:1548-53. 2003..Collectively, these findings indicate that the IH exposure is associated with increased oxidative stress, which is likely to play an important role in the behavioral impairments observed in a rodent model of sleep-disordered breathing... - Nocturnal body position in sleeping children with and without obstructive sleep apneaEhab Dayyat
Kosair Children s Hospital Sleep Medicine and Apnea Center, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
Pediatr Pulmonol 42:374-9. 2007..Although tonsillar size is not associated with positional differences in breathing, the presence or absence of obesity markedly modifies the effect of body position on respiratory disturbance... - Spatial pre-training attenuates hippocampal impairments in rats exposed to intermittent hypoxiaBarry W Row
Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Baxter Biomedical Research Building, Suite 321, 570 South Preston Street, Louisville, KY 40202, USA
Neurosci Lett 339:67-71. 2003..Further, IH-induced decreases in CREB phosphorylation were attenuated by pre-training. We conclude that prior exposure to the water maze behavioral requirements attenuates the behavioral deficits occurring after IH exposure... - Obstructive sleep apnoea is associated with impaired pictorial memory task acquisition and retention in childrenL Kheirandish-Gozal
Kosair Children s Hospital Research Institute and Division of Paediatric Sleep, Dept of Paediatrics, Medicine, University of Louisville, Louisville, KY, USA
Eur Respir J 36:164-9. 2010..Thus, both acquisition and retention of newly learned material are compromised. These findings confirm and expand on the presence of known cognitive deficits in children with OSA... - Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the ratD Gozal
Kosair Children s Hospital Research Institute, Departments of Pediatrics, Pharmacology, and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
J Neurosci 21:2442-50. 2001..Furthermore, EHYP impaired performance during acquisition of a cognitive spatial task without affecting sensorimotor function. Such changes may underlie components of the learning and memory impairments found in OSA... - PDGF-beta receptor expression in the dorsocaudal brainstem parallels hypoxic ventilatory depression in the developing ratV Vlasic
Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, 570 S. Preston Street, Louisville, KY 40202
Pediatr Res 50:236-41. 2001..We conclude that PDGF-beta receptor activation during hypoxia is an important contributor to HVD at all postnatal ages but more particularly in the immature rat...