D Gozal

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Obstructive sleep apnea in children: relative contributions of body mass index and adenotonsillar hypertrophy
    Ehab Dayyat
    Department of Pediatrics, Division of Pediatric Sleep Medicine, The University of Chicago, Chicago, IL 60637, USA
    Chest 136:137-44. 2009
  2. ncbi Temporal aspects of spatial task performance during intermittent hypoxia in the rat: evidence for neurogenesis
    David Gozal
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 South Preston St, Louisville, KY 40202 USA
    Eur J Neurosci 18:2335-42. 2003
  3. ncbi Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy
    David Gozal
    Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 S Preston St, Suite 204, Louisville, KY 40202, USA
    Circulation 116:2307-14. 2007
  4. pmc Prevalence of recurrent otitis media in habitually snoring school-aged children
    David Gozal
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 9:549-54. 2008
  5. ncbi Snoring during early childhood and academic performance at ages thirteen to fourteen years
    D Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
    Pediatrics 107:1394-9. 2001
  6. ncbi Snoring and obstructive sleep apnoea in children: why should we treat?
    David Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, USA
    Paediatr Respir Rev 5:S371-6. 2004
  7. ncbi Neurocognitive and behavioral morbidity in children with sleep disorders
    David Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Curr Opin Pulm Med 13:505-9. 2007
  8. pmc Systemic inflammation in non-obese children with obstructive sleep apnea
    David Gozal
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 9:254-9. 2008
  9. ncbi Objective sleepiness measures in pediatric obstructive sleep apnea
    D Gozal
    Kosair Children s Hospital Sleep Medicine and Apnea Center, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 108:693-7. 2001
  10. ncbi APOE epsilon 4 allele, cognitive dysfunction, and obstructive sleep apnea in children
    David Gozal
    Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, University of Louisville, Louisville, KY 40202, USA
    Neurology 69:243-9. 2007

Collaborators

Detail Information

Publications118 found, 100 shown here

  1. pmc Obstructive sleep apnea in children: relative contributions of body mass index and adenotonsillar hypertrophy
    Ehab Dayyat
    Department of Pediatrics, Division of Pediatric Sleep Medicine, The University of Chicago, Chicago, IL 60637, USA
    Chest 136:137-44. 2009
    ..The obesity epidemic has prompted remarkable changes in the proportion of obese children who are referred for habitual snoring. However, the contribution of obesity to adenotonsillar hypertrophy remains undefined...
  2. ncbi Temporal aspects of spatial task performance during intermittent hypoxia in the rat: evidence for neurogenesis
    David Gozal
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 South Preston St, Louisville, KY 40202 USA
    Eur J Neurosci 18:2335-42. 2003
    ....
  3. ncbi Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy
    David Gozal
    Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 S Preston St, Suite 204, Louisville, KY 40202, USA
    Circulation 116:2307-14. 2007
    ..However, it remains unclear whether endothelial dysfunction occurs in pediatric OSA and whether it is reversible on effective treatment of OSA...
  4. pmc Prevalence of recurrent otitis media in habitually snoring school-aged children
    David Gozal
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 9:549-54. 2008
    ..However, it remains unclear whether habitually snoring children have a higher prevalence of ROM and whether they require tympanostomy tube placement more frequently...
  5. ncbi Snoring during early childhood and academic performance at ages thirteen to fourteen years
    D Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
    Pediatrics 107:1394-9. 2001
    ..Obstructive sleep apnea syndrome in young children is associated with an adverse effect on learning. However, the long-term impact of sleep-disordered breathing (SDB) during early childhood on learning remains unknown...
  6. ncbi Snoring and obstructive sleep apnoea in children: why should we treat?
    David Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, USA
    Paediatr Respir Rev 5:S371-6. 2004
    ..More importantly, if timely diagnosis and intervention are not implemented, some of these morbid complications may not be completely reversible, leading to long-lasting residual consequences...
  7. ncbi Neurocognitive and behavioral morbidity in children with sleep disorders
    David Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Curr Opin Pulm Med 13:505-9. 2007
    ..Particular focus is given to pediatric obstructive sleep apnea...
  8. pmc Systemic inflammation in non-obese children with obstructive sleep apnea
    David Gozal
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 9:254-9. 2008
    ..The changes in levels of pro-inflammatory cytokine IL-6 , and the anti-inflammatory cytokine IL-10, both of which play a major role in atherogenesis, a major consequence of OSA, have not specifically been assessed in pediatric patients...
  9. ncbi Objective sleepiness measures in pediatric obstructive sleep apnea
    D Gozal
    Kosair Children s Hospital Sleep Medicine and Apnea Center, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 108:693-7. 2001
    ..Excessive daytime sleepiness (EDS) occurs frequently in adult patients with obstructive sleep apnea (OSA). However, the incidence of EDS in children with OSA is unknown...
  10. ncbi APOE epsilon 4 allele, cognitive dysfunction, and obstructive sleep apnea in children
    David Gozal
    Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, University of Louisville, Louisville, KY 40202, USA
    Neurology 69:243-9. 2007
    ..Considering the unique susceptibility of apolipoprotein E (ApoE) knock-out mice to an experimental model of OSA, we examined whether the APOE epsilon4 allele contributes to increased neurocognitive morbidity in pediatric OSA...
  11. ncbi Gasping and autoresuscitation in the developing rat: effect of antecedent intermittent hypoxia
    David Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Appl Physiol (1985) 92:1141-4. 2002
    ..001 vs. RARA). We conclude that both prenatal and early postnatal IH adversely affect gasping and related survival mechanisms...
  12. pmc C-reactive protein, obstructive sleep apnea, and cognitive dysfunction in school-aged children
    David Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 176:188-93. 2007
    ..Obstructive sleep apnea (OSA) in children is associated with substantial neurobehavioral and cognitive dysfunction. However, not all children with OSA exhibit altered cognitive performance...
  13. ncbi Sleep apnea in children--treatment considerations
    David Gozal
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Paediatr Respir Rev 7:S58-61. 2006
    ....
  14. ncbi Oxidant stress and inflammation in the snoring child: confluent pathways to upper airway pathogenesis and end-organ morbidity
    David Gozal
    Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, 570 S Preston Street, Suite 321, Louisville, KY 40202, USA
    Sleep Med Rev 10:83-96. 2006
    ..This hypothetical working model incorporates both dose-dependent disease severity components, as well as environmental and genetic elements of susceptibility...
  15. ncbi New concepts in abnormalities of respiratory control in children
    David Gozal
    Kosair Children s Hospital Research Institute, and Department of Pediatrics, University of Louisville, Kentucky 40202, USA
    Curr Opin Pediatr 16:305-8. 2004
    ..The explosion of technological breakthroughs in biology and medicine has facilitated our understanding of the fundamental mechanisms that govern the development of brain regions underlying respiratory control functions...
  16. ncbi Respiratory effects of gestational intermittent hypoxia in the developing rat
    David Gozal
    Kosair Children s Hospital Research Institute, University of Louisville, 570 S Preston Street, Ste 321, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 167:1540-7. 2003
    ..We conclude that gestational intermittent hypoxia elicits long-lasting alterations in the control of breathing. We postulate that such IH-induced respiratory plasticity may create selective vulnerability to hypoxia during development...
  17. ncbi Consequences of snoring and sleep disordered breathing in children
    David Gozal
    Division of Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Baxter Biomedical Research Building, Suite 321, 571 S Preston Street, Louisville, KY 40202, USA
    Pediatr Pulmonol Suppl 26:166-8. 2004
  18. ncbi Increased susceptibility to intermittent hypoxia in aging rats: changes in proteasomal activity, neuronal apoptosis and spatial function
    David Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
    J Neurochem 86:1545-52. 2003
    ....
  19. ncbi Increased upper airway collapsibility in children with obstructive sleep apnea during wakefulness
    David Gozal
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Am J Respir Crit Care Med 169:163-7. 2004
    ..Thus, upper airway dynamic testing during wakefulness in response to a topical airway anesthetic may provide a useful clinical adjunct to the evaluation of snoring children, with more accurate identification of those children with SDB...
  20. pmc Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much more
    David Gozal
    Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 177:369-75. 2008
    ....
  21. ncbi Circulating vascular endothelial growth factor levels in patients with obstructive sleep apnea
    David Gozal
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, KY 40202, USA
    Sleep 25:59-65. 2002
    ..Vascular endothelial growth factor (VEGF) has detectable levels in the circulation and its expression is highly regulated by oxygen tension. We therefore hypothesized that serum VEGF levels will be elevated in patients with OSA...
  22. pmc Metabolic alterations and systemic inflammation in obstructive sleep apnea among nonobese and obese prepubertal children
    David Gozal
    Kosair Children s Hospital Research Institute, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 177:1142-9. 2008
    ..In contrast, OSA in prepubertal children does not appear to correlate with the magnitude of such metabolic derangements...
  23. ncbi Plasma IGF-1 levels and cognitive dysfunction in children with obstructive sleep apnea
    David Gozal
    Kosair Children s Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville School of Medicine, 570 S Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 10:167-73. 2009
    ..Since IGF-1 is neuroprotective, we hypothesized that higher systemic IGF-1 levels may identify children at lower susceptibility for cognitive morbidity...
  24. doi The multiple challenges of obstructive sleep apnea in children: morbidity and treatment
    David Gozal
    Division of Pediatric Sleep Medicine, Department of Pediatrics, and Kosair Children s Hospital Research Institute, University of Louisville, Louisville, Kentucky, USA
    Curr Opin Pediatr 20:654-8. 2008
    ..In addition, the conceptual framework whereby a childhood condition such as OSA can be linked to specific adult diseases will be presented...
  25. pmc Obstructive sleep apnea in children: implications for the developing central nervous system
    David Gozal
    Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Semin Pediatr Neurol 15:100-6. 2008
    ....
  26. doi Obesity and excessive daytime sleepiness in prepubertal children with obstructive sleep apnea
    David Gozal
    Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Pediatrics 123:13-8. 2009
    ..However, it remains unclear whether obesity modifies the relative frequency of daytime symptoms such as excessive daytime sleepiness...
  27. ncbi In vivo PDGF beta receptor activation in the dorsocaudal brainstem of the rat prevents hypoxia-induced apoptosis via activation of Akt and BAD
    N Simakajornboon
    Constance S Kaufman Pediatric Pulmonary Research Laboratory, Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Brain Res 895:111-8. 2001
    ..We conclude that PDGFR-dependent in vivo activation of both Akt and BAD during hypoxia prevents induction of apoptosis, and may contribute to the increased hypoxic tolerance of brainstem neurons...
  28. ncbi Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury
    W Xu
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    Spinal Cord 43:204-13. 2005
    ..Experimental laboratory investigation of the role and pathways of reactive oxygen species (ROS)-mediated motor neuron cell death in a mouse model of compression spinal cord injury...
  29. ncbi Hypoxia induces c-Fos protein expression in NMDA but not AMPA glutamate receptor labeled neurons within the nucleus tractus solitarii of the conscious rat
    D Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Neurosci Lett 262:93-6. 1999
    ..These data suggest a predominant role for NMDA but not for AMPA glutamate receptors in nTS mediated components of the hypoxic response...
  30. ncbi AMPA glutamate receptors and respiratory control in the developing rat: anatomic and pharmacological aspects
    G M Whitney
    Department of Pediatrics, Constance S Kaufman Pediatric Pulmonary Research Laboratory, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Am J Physiol Regul Integr Comp Physiol 278:R520-8. 2000
    ..Furthermore, the role of non-NMDA receptors in respiratory control of conscious neonatal rats appears to be limited to modest, albeit significant, regulation of breathing pattern...
  31. ncbi Nitric oxide modulates anoxia-induced gasping in the developing rat
    D Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Biol Neonate 73:264-74. 1998
    ..We postulate that higher NO brainstem concentrations may favor early autoresuscitation but be detrimental to overall survival during prolonged asphyxia...
  32. ncbi NF-kappaB induction during in vivo hypoxia in dorsocaudal brain stem of rat: effect of MK-801 and L-NAME
    E Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Appl Physiol (1985) 85:372-6. 1998
    ..Thus NMDA-receptor activation in the dorsocaudal brain stem during hypoxia elicits in NF-kappaB activity marked enhancements that are unaffected after NOS blockade...
  33. ncbi Brainstem activation of platelet-derived growth factor-beta receptor modulates the late phase of the hypoxic ventilatory response
    D Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana, USA
    J Neurochem 74:310-9. 2000
    ....
  34. doi Corticosteroids suppress in vitro tonsillar proliferation in children with obstructive sleep apnoea
    L Kheirandish-Gozal
    Department of Pediatrics, Division of Sleep Medicine, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY, USA
    Eur Respir J 33:1077-84. 2009
    ....
  35. pmc Neuroglobin protects neurons against oxidative stress in global ischemia
    Richard Changxun Li
    Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    J Cereb Blood Flow Metab 30:1874-82. 2010
    ..Furthermore, CA1 neuronal injury was also markedly reduced. Thus, Ngb may confer protection against ischemia-reperfusion injury in the brain through its intrinsic antioxidant properties...
  36. ncbi Brainstem nitric oxide tissue levels correlate with anoxia-induced gasping activity in the developing rat
    D Gozal
    Kosair Children s Hospital Research Institute, Departments of Pediatrics, Pharmacology and Toxicology, University of Louisville School of Medicine, KY 40202, USA
    Biol Neonate 79:122-30. 2001
    ..We conclude that anoxia-induced gasping neurogenesis is modulated via NMDA-NO mechanisms in the developing rat. We postulate that higher NO brainstem concentrations may favor early autoresuscitation, but limit anoxic tolerance...
  37. ncbi Cardiorespiratory responses to systemic administration of a protein kinase C inhibitor in conscious rats
    D Gozal
    Constance S Kaufman Pediatric Pulmonary Research Laboratory, Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Appl Physiol (1985) 84:641-8. 1998
    ..We postulate that PKC plays an important role in signal transduction pathways within brain regions underlying respiratory control...
  38. ncbi Signaling pathways of the acute hypoxic ventilatory response in the nucleus tractus solitarius
    D Gozal
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 S Preston Street, Ste 321, Louisville, KY 40202, USA
    Respir Physiol 121:209-21. 2000
    ....
  39. ncbi High fat/refined carbohydrate diet enhances the susceptibility to spatial learning deficits in rats exposed to intermittent hypoxia
    A D Goldbart
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Brain Res 1090:190-6. 2006
    ..high fat refined carbohydrate diet (HF/RC) can induce similar deficits and associated changes in signaling pathways under normoxic conditions...
  40. ncbi Platelet-activating factor receptor-deficient mice are protected from experimental sleep apnea-induced learning deficits
    Barry W Row
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    J Neurochem 89:189-96. 2004
    ..Collectively, these findings indicate that inflammatory signaling and neurobehavioral impairments induced by IH are mediated through PAF receptors...
  41. ncbi Hypoxemia and obesity modulate plasma C-reactive protein and interleukin-6 levels in sleep-disordered breathing
    Riva Tauman
    Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    Sleep Breath 11:77-84. 2007
    ..03) and correlated with AHI (r = 0.28, p = 0.003) and SpO(2) nadir (r = -0.24, p = 0.02). Children with SDB display significant severity-dependent increases in plasma CRP and IL-6 levels independent of obesity...
  42. ncbi Protein kinase C modulation of ventilatory response to hypoxia in nucleus tractus solitarii of conscious rats
    E Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    J Appl Physiol (1985) 84:1982-90. 1998
    ..These studies suggest that, in the adult rat, PKC activation in the NTS mediates essential components of the acute hypoxic ventilatory response...
  43. ncbi Hypoxic ventilatory roll-off is associated with decreases in protein kinase C activation within the nucleus tractus solitarius of the rat
    D Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Brain Res 774:246-9. 1997
    ..Thus, alterations in PKC activity within the NTS which occur over time during hypoxia are isoform-selective and coincide with changes in ventilation...
  44. ncbi Developmental differences in cortical and hippocampal vulnerability to intermittent hypoxia in the rat
    E Gozal
    Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    Neurosci Lett 305:197-201. 2001
    ....
  45. ncbi Intermittent hypoxic exposure during light phase induces changes in cAMP response element binding protein activity in the rat CA1 hippocampal region: water maze performance correlates
    A Goldbart
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Suite 321, 570 South Preston Street, Louisville, KY 40202, USA
    Neuroscience 122:585-90. 2003
    ..We suggest that CREB changes play an important role in the neurocognitive morbidity of SDB patients...
  46. ncbi Intermittent hypoxia induces time-dependent changes in the protein kinase B signaling pathway in the hippocampal CA1 region of the rat
    Aviv Goldbart
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Neurobiol Dis 14:440-6. 2003
    ..Thus, IH induces time-dependent biphasic changes in AKT survival pathways within the CA1 region that are temporally correlated with the initial increases and subsequent decreases in neuronal apoptosis...
  47. ncbi Sleep and neurobehavioral characteristics of 5- to 7-year-old children with parentally reported symptoms of attention-deficit/hyperactivity disorder
    Louise M O'Brien
    Kosair Children s Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 111:554-63. 2003
    ....
  48. pmc Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in rats
    R C Li
    Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Neuroscience 196:237-50. 2011
    ..Thus, exogenous GH may provide a viable therapeutic intervention to protect IH-vulnerable brain regions from SDB-associated neuronal loss and associated neurocognitive dysfunction...
  49. ncbi Cognition, sleep and respiration in at-risk children treated for obstructive sleep apnoea
    H E Montgomery-Downs
    Division of Pediatric Sleep Medicine, Dept of Pediatrics, University of Louisville, Louisville, KY, USA
    Eur Respir J 25:336-42. 2005
    ....
  50. ncbi Developmental patterns of NF-kappaB activation during acute hypoxia in the caudal brainstem of the rat
    N Simakajornboon
    Constance S. Kaufman Pediatric Pulmonary Research Laboratory, Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Brain Res Dev Brain Res 127:175-83. 2001
    ..We postulate that postnatal regulation of NF-kappaB complex expression and function may underlie fundamental genomic processes mediating developmental changes in neuronal hypoxic tolerance...
  51. pmc Plasma C-reactive protein in nonobese children with obstructive sleep apnea before and after adenotonsillectomy
    Leila Kheirandish-Gozal
    Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, KY 40202, USA
    J Clin Sleep Med 2:301-4. 2006
    ..Plasma CRP levels in snoring children have yielded conflicting results, such that it remains unclear whether OSA is mechanistically involved in such elevations of CRP...
  52. ncbi Intranasal steroids and oral leukotriene modifier therapy in residual sleep-disordered breathing after tonsillectomy and adenoidectomy in children
    Leila Kheirandish
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 117:e61-6. 2006
    ..We hypothesized that combined therapy with the leukotriene receptor antagonist montelukast and intranasal budesonide would result in normalization of residual SDB after T&A...
  53. ncbi The scoring of respiratory events in sleep: reliability and validity
    Susan Redline
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH, WA 44106 6033, USA
    J Clin Sleep Med 3:169-200. 2007
    ....
  54. ncbi Correlates of sleep and pediatric bipolar disorder
    Rochelle C Mehl
    Department of Pediatrics, Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, University of Louisville, KY 40202, USA
    Sleep 29:193-7. 2006
    ..To determine, based on a large community sample, the prevalence and associated sleep characteristics of children with a bipolar mood disturbance behavioral profile...
  55. ncbi Reciprocal interactions between spontaneous and respiratory arousals in adults with suspected sleep-disordered breathing
    Riva Tauman
    Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    Sleep Med 7:229-34. 2006
    ..The aim of the present study was to assess the interactions between respiratory and spontaneous arousals in adults with suspected SDB, and to examine whether the SPS and the Epworth sleepiness scale (ESS) are correlated...
  56. ncbi Urinary protein expression patterns in children with sleep-disordered breathing: preliminary findings
    Jyoti Krishna
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Sleep Med 7:221-7. 2006
    ..The aim of this study was therefore to analyze proteins in human urine and assess whether differential expression of particular proteins is associated with the presence of OSA...
  57. pmc Endothelial dysfunction in obese non-hypertensive children without evidence of sleep disordered breathing
    Rakesh Bhattacharjee
    Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Kentucky, USA
    BMC Pediatr 10:8. 2010
    ..It is unknown whether obesity causes endothelial dysfunction in children in the absence of OSAS. This study examines endothelial function in obese and non-obese children without OSAS...
  58. ncbi Vascular endothelial growth factor in the cerebrospinal fluid of infants who died of sudden infant death syndrome: evidence for antecedent hypoxia
    Kimberly L Jones
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Pediatrics 111:358-63. 2003
    ..The vascular endothelial growth factor (VEGF) gene is highly sensitive to changes in tissue partial oxygen tension, and changes in genomic and protein expression occur even after changes in oxygenation within the physiologic range...
  59. ncbi Neurocognitive dysfunction in children with sleep disorders
    Leila Kheirandish
    Child and Youth Project and Division of Paediatric Sleep Medicine, Department of Paediatrics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Dev Sci 9:388-99. 2006
    ..This article takes a critical look at the current literature on these issues, reviews the major findings and discusses such findings in conjunction with those derived from pertinent animal models...
  60. ncbi Sleep pressure correlates of cognitive and behavioral morbidity in snoring children
    Louise M O'Brien
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, KY 40202, USA
    Sleep 27:279-82. 2004
    ..A sleep pressure score (SPS) with a cutoff value of 0.25 was derived from analysis of a large cohort of snoring and control children. Neurocognitive batteries were applied to examine the potential effect of SPS...
  61. ncbi Sleep pressure score: a new index of sleep disruption in snoring children
    Riva Tauman
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Kentucky 40202, USA
    Sleep 27:274-8. 2004
    ..We hypothesized that sleep architecture and arousal indexes may be altered relative to the severity of sleep-disordered breathing (SDB)...
  62. doi Neurocognitive and endothelial dysfunction in children with obstructive sleep apnea
    David Gozal
    Department of Pediatrics, University of Chicago, 5721 S Maryland Ave, MC 8000, Suite K 160, Chicago, IL 60637, USA
    Pediatrics 126:e1161-7. 2010
    ..However, it is unclear whether these 2 frequent morbidities of OSAS in children represent similar or different underlying pathophysiological processes, because they have never been concurrently assessed in children...
  63. ncbi Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea
    W Xu
    Kosair Children s Hospital Research Institute, Department of Pediatrics, 215 Baxter Building I, 570 South Preston Street, University of Louisville, Louisville, KY 40202, USA
    Neuroscience 126:313-23. 2004
    ..Taken together, these findings suggest that the increased ROS production and oxidative stress propagation contribute, at least partially, to CIH-mediated cortical neuronal apoptosis and neurocognitive dysfunction...
  64. ncbi Sleep in children with attention deficit/hyperactivity disorder
    L M O'Brien
    Department of Pediatrics, Kosair Children s Hospital Sleep Medicine and Apnea Center, University of Louisville School of Medicine, Louisville, KY 40202, US
    Minerva Pediatr 56:585-601. 2004
    ..This review addresses both these issues and provides a concise yet timely assessment of the potential links between sleep disorders and ADHD...
  65. pmc A mixed cell culture model for assessment of proliferation in tonsillar tissues from children with obstructive sleep apnea or recurrent tonsillitis
    Laura D Serpero
    Division of Sleep Medicine, Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
    Laryngoscope 119:1005-10. 2009
    ..However, little is known on the determinants of lymphadenoid tissue proliferation in the pediatric upper airway...
  66. pmc Green tea catechin polyphenols attenuate behavioral and oxidative responses to intermittent hypoxia
    Isabel C Burckhardt
    Kosair Children s Hospital Research Institute, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 177:1135-41. 2008
    ..We hypothesized that green tea catechin polyphenols (GTPs) may attenuate IH-induced neurobehavioral deficits by reducing IH-induced NADPH oxidase expression, lipid peroxidation, and inflammation...
  67. ncbi Cerebral oximetry improves detection of sickle cell patients at risk for nocturnal cerebral hypoxia
    Ashok B Raj
    Department of Pediatrics, Division of Hematology, School of Medicine, University of Louisville, Louisville, Kentucky, USA
    Pediatr Pulmonol 41:1088-94. 2006
    ..71 (0.66-0.81) vs. SCD 0.59 (0.52-0.65); P = 0.011]. Our findings suggest that SCD patients may be at increased risk of cerebral hypoxia during both wakefulness and sleep...
  68. ncbi Plasma C-reactive protein levels among children with sleep-disordered breathing
    Riva Tauman
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 113:e564-9. 2004
    ..We hypothesized that elevated CRP plasma levels would also be present among children with SDB...
  69. ncbi Domoic acid lesions in nucleus of the solitary tract: time-dependent recovery of hypoxic ventilatory response and peripheral afferent axonal plasticity
    Zixi Cheng
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Neurosci 22:3215-26. 2002
    ..The adult brainstem/NTS has self-repairing capabilities and will compensate for functional losses after structural damage by rewiring of its neural circuitry...
  70. ncbi Neurobehavioral implications of habitual snoring in children
    Louise M O'Brien
    Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 114:44-9. 2004
    ..However, PS has not been well evaluated, and it is unknown whether PS is associated with serious morbidity. This study investigated whether PS is associated with neurobehavioral deficits in children...
  71. ncbi Prevalence of epileptiform activity in healthy children during sleep
    Oscar Sans Capdevila
    Kosair Children s Hospital Sleep Medicine and Apnea Center, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 9:303-9. 2008
    ..This type of paroxysmal activity does not include the electroencephalographic (EEG) activity observed during a seizure. The prevalence of epileptiform activity in the general pediatric population is unknown...
  72. ncbi Impaired control of renal sympathetic nerve activity following neonatal intermittent hypoxia in rats
    Galia K Soukhova-O'Hare
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    Neurosci Lett 399:181-5. 2006
    ..We conclude that postnatal intermittent hypoxia causes long-lasting impairment in chemoreceptor and baroreceptor control of renal nerve activity...
  73. ncbi The effect of chronic or intermittent hypoxia on cognition in childhood: a review of the evidence
    Joel L Bass
    Department of Pediatrics, Newton Wellesley Hospital, MassGeneral Hospital for Children, Harvard Medical School, Newton, Massachusetts 02462, USA
    Pediatrics 114:805-16. 2004
    ....
  74. ncbi Cardiovascular complications of obstructive sleep apnea syndrome: evidence from children
    Rakesh Bhattacharjee
    Kosair Children s Hospital Research Institute, Louisville, KY 40202, USA
    Prog Cardiovasc Dis 51:416-33. 2009
    ..In this review, we will present the specific cardiovascular complications that have thus far been described in children with OSAS, with reference to pertinent mechanisms, and potential implications...
  75. ncbi Postnatal intermittent hypoxia alters baroreflex function in adult rats
    Galia K Soukhova-O'Hare
    Department of Pediatrics, Kosair Children s Hospital Research Institute, 570 S Preston St, Suite 321, University of Louisville, Louisville, Kentucky 40202, USA
    Am J Physiol Heart Circ Physiol 290:H1157-64. 2006
    ..001) and vagal axon varicose contacts by 56% (P < 0.001) compared with controls. We conclude that reduction of vagal efferent projections in cardiac ganglia could be a cause of long-term modifications in baroreflex function...
  76. ncbi Apolipoprotein E-deficient mice exhibit increased vulnerability to intermittent hypoxia-induced spatial learning deficits
    Leila Kheirandish
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, KY 40202, USA
    Sleep 28:1412-7. 2005
    ....
  77. pmc Two-dimensional differential in-gel electrophoresis proteomic approaches reveal urine candidate biomarkers in pediatric obstructive sleep apnea
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    Am J Respir Crit Care Med 180:1253-61. 2009
    ..Sleep studies are laborious, expensive, inaccessible, and inconvenient for diagnosing obstructive sleep apnea (OSA) in children...
  78. ncbi Novel insights into congenital hypoventilation syndrome
    D Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Curr Opin Pulm Med 5:335-8. 1999
    ....
  79. ncbi Mild sustained and intermittent hypoxia induce apoptosis in PC-12 cells via different mechanisms
    Evelyne Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston St, Suite 321, Louisville, KY 40202, USA
    Am J Physiol Cell Physiol 288:C535-42. 2005
    ....
  80. ncbi Excitotoxic preconditioning elicited by both glutamate and hypoxia and abolished by lactate transport inhibition in rat hippocampal slices
    A Schurr
    Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Neurosci Lett 307:151-4. 2001
    ..These results indicate that excitotoxic PC and hypoxic PC share similar mechanisms that possibly involve lactate production and its neuronal utilization...
  81. ncbi Potentiation of hypoxic ventilatory response by hyperoxia in the conscious rat: putative role of nitric oxide
    D Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Appl Physiol (1985) 85:129-32. 1998
    ..1 +/- 35.6 ml/min in hypoxia; +O2 vs. -O2: P not significant). We conclude that in the conscious rat nNOS activation mediates essential components of the HVR potentiation elicited by a previous short hyperoxic exposure...
  82. ncbi Respiratory muscle training in neuromuscular disease: long-term effects on strength and load perception
    D Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Med Sci Sports Exerc 31:1522-7. 1999
    ..Deterioration of respiratory muscle function in patients with neuromuscular disorders is primarily responsible for the high morbidity and mortality associated with these diseases...
  83. ncbi Passive motion of the extremities modifies alveolar ventilation during sleep in patients with congenital central hypoventilation syndrome
    D Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Am J Respir Crit Care Med 162:1747-51. 2000
    ..We speculate that such effect may provide future noninvasive ventilatory support strategies in patients with CCHS and mild phenotypic expression of their disease...
  84. pmc Endothelial progenitor cells and vascular dysfunction in children with obstructive sleep apnea
    Leila Kheirandish-Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, The University of Chicago, 5721 S Maryland Avenue, MC 8000, Suite K 160, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 182:92-7. 2010
    ..Endothelial dysfunction is a potential complication of obstructive sleep apnea syndrome (OSAS) in children ascribed to systemic inflammatory changes. However, not all children with OSAS will manifest endothelial dysfunction...
  85. ncbi Adipokines in children with sleep disordered breathing
    Riva Tauman
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Sleep 30:443-9. 2007
    ..Therefore, we aimed to examine associations between circulating adipokines levels, insulin resistance, and measures of SDB in children...
  86. ncbi Sleep, sleep disorders and inflammation in children
    David Gozal
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL 60637, USA
    Sleep Med 10:S12-6. 2009
    ....
  87. ncbi Autonomic dysfunction in children with sleep-disordered breathing
    Louise M O'Brien
    Kosair Children s Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Sleep 28:747-52. 2005
    ..To measure sympathetic responses in children with and without sleep-disordered breathing...
  88. ncbi Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats
    Stephen R Reeves
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, Suite 204, 570 South Preston St, Louisville, KY 40202, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1664-71. 2006
    ..e., metaplasticity) and markedly differ from previously reported increased neural plasticity changes induced by CIH in adult rats...
  89. ncbi Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins
    Jon B Klein
    Core Proteomics Laboratory, University of Louisville, Kentucky 40202, USA
    J Biol Chem 280:31870-81. 2005
    ..We concluded that Akt phosphorylates VCP in vitro and in vivo, and VCP phosphorylation releases it from ubiquitinated substrate protein(s) possibly allowing ubiquitinated protein(s) to be degraded by the proteosome...
  90. ncbi Persistence of obstructive sleep apnea syndrome in children after adenotonsillectomy
    Riva Tauman
    Kosair Children s Hospital Research Institute and the Department of Pediatrics, Division of Pediatric Sleep Medicine, University of Louisville, Louisville, Kentucky, USA
    J Pediatr 149:803-8. 2006
    ..To investigate the relative contribution of various risk factors to the surgical outcome of adenotonsillectomy for obstructive sleep apnea syndrome in children...
  91. ncbi Cyclooxygenase 2 and intermittent hypoxia-induced spatial deficits in the rat
    Richard C Li
    Kosair Children s Hospital Research Institute, 570 South Preston Street, Suite 321, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 168:469-75. 2003
    ..We conclude that IH induces upregulation and activation of COX-2 in rat cortex and that COX-2 may play a role in IH-mediated neurobehavioral deficits...
  92. ncbi Obesity rather than severity of sleep-disordered breathing as the major determinant of insulin resistance and altered lipidemia in snoring children
    Riva Tauman
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 116:e66-73. 2005
    ..This study was done to prospectively assess the relative contribution of SDB and obesity to metabolic disturbances in a large cohort of snoring children...
  93. ncbi Periodic limb movement disorder of sleep in children
    Valerie McLaughlin Crabtree
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville School of Medicine, 571 S Preston Street, Louisville, KY 40202, USA
    J Sleep Res 12:73-81. 2003
    ..We postulate that rather than a direct relationship between ADHD and PLMD, this link may be mediated by the presence of reduced REM sleep and more importantly by the sleep fragmentation associated with PLM-induced arousals...
  94. ncbi Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat
    Barry W Row
    Kosair Children s Hospital Research Institute, University of Louisville, Baxter Biomedical Research Building, Suite 321, 570 South Preston Street, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 167:1548-53. 2003
    ..Collectively, these findings indicate that the IH exposure is associated with increased oxidative stress, which is likely to play an important role in the behavioral impairments observed in a rodent model of sleep-disordered breathing...
  95. ncbi Psychiatric symptoms in children with insomnia referred to a pediatric sleep medicine center
    Anna Ivanenko
    Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 571 S Preston Street Suite 321, Louisville, KY 40202, USA
    Sleep Med 5:253-9. 2004
    ..To assess the frequency and nature of clinical and psychiatric symptoms in children referred to a pediatric sleep center for evaluation of insomnia...
  96. ncbi Spatial pre-training attenuates hippocampal impairments in rats exposed to intermittent hypoxia
    Barry W Row
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Baxter Biomedical Research Building, Suite 321, 570 South Preston Street, Louisville, KY 40202, USA
    Neurosci Lett 339:67-71. 2003
    ..Further, IH-induced decreases in CREB phosphorylation were attenuated by pre-training. We conclude that prior exposure to the water maze behavioral requirements attenuates the behavioral deficits occurring after IH exposure...
  97. ncbi Nocturnal body position in sleeping children with and without obstructive sleep apnea
    Ehab Dayyat
    Kosair Children s Hospital Sleep Medicine and Apnea Center, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatr Pulmonol 42:374-9. 2007
    ..Although tonsillar size is not associated with positional differences in breathing, the presence or absence of obesity markedly modifies the effect of body position on respiratory disturbance...
  98. ncbi Behavioural and neurocognitive implications of snoring and obstructive sleep apnoea in children: facts and theory
    Louise M O'Brien
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, KY 40202, USA
    Paediatr Respir Rev 3:3-9. 2002
    ..This paper reviews the available information and attempts to provide the rationale for early diagnosis and treatment of OSA in children...
  99. pmc Effects of late gestational high-fat diet on body weight, metabolic regulation and adipokine expression in offspring
    A Khalyfa
    Sections of Pediatric Sleep Medicine, Hematology Oncology, and Pediatric Pulmonology, Department of Pediatrics, Pritzker School of Medicine, Comer Children s Hospital, The University of Chicago, Chicago, IL, USA
    Int J Obes (Lond) 37:1481-9. 2013
    ..We hypothesized that high-fat diet (HFD) during late gestation would lead increased risk for insulin resistance and hyperlipidemia via associated epigenetic alterations in tissue adipocytokine genes...
  100. pmc Sleep fragmentation promotes NADPH oxidase 2-mediated adipose tissue inflammation leading to insulin resistance in mice
    S X L Zhang
    Section of Pediatric Sleep Medicine, Department of Pediatrics, The University of Chicago, Chicago, IL, USA
    Int J Obes (Lond) 38:619-24. 2014
    ....
  101. doi Obstructive sleep apnoea is associated with impaired pictorial memory task acquisition and retention in children
    L Kheirandish-Gozal
    Kosair Children s Hospital Research Institute and Division of Paediatric Sleep, Dept of Paediatrics, Medicine, University of Louisville, Louisville, KY, USA
    Eur Respir J 36:164-9. 2010
    ..Thus, both acquisition and retention of newly learned material are compromised. These findings confirm and expand on the presence of known cognitive deficits in children with OSA...