D Gozal

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Obstructive sleep apnea in the formerly preterm infant: an overlooked diagnosis
    Preeti B Sharma
    Section of Pediatric Pulmonary Medicine, Department of Pediatrics, Comer Children s Hospital, University of Chicago Chicago, IL, USA
    Front Neurol 2:73. 2011
  2. pmc TNF-α and temporal changes in sleep architecture in mice exposed to sleep fragmentation
    Navita Kaushal
    Department of Pediatrics, Section of Pediatric Sleep Medicine, The University of Chicago, Chicago, IL, USA
    PLoS ONE 7:e45610. 2012
  3. doi request reprint Novel pharmacological approaches for treatment of obstructive sleep apnea in children
    Leila Kheirandish-Gozal
    University of Chicago, Comer Children s Hospital, Pritzker School of Medicine, Biological Sciences Division, Department of Pediatrics, Chicago, IL 60637, USA
    Expert Opin Investig Drugs 22:71-85. 2013
  4. pmc Chemoreceptors, baroreceptors, and autonomic deregulation in children with obstructive sleep apnea
    David Gozal
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL, USA
    Respir Physiol Neurobiol 185:177-85. 2013
  5. pmc Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels
    Abdelnaby Khalyfa
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL, USA
    Lipids Health Dis 9:18. 2010
  6. pmc Endothelial dysfunction in obese non-hypertensive children without evidence of sleep disordered breathing
    Rakesh Bhattacharjee
    Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Kentucky, USA
    BMC Pediatr 10:8. 2010
  7. pmc Two-dimensional differential in-gel electrophoresis proteomic approaches reveal urine candidate biomarkers in pediatric obstructive sleep apnea
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    Am J Respir Crit Care Med 180:1253-61. 2009
  8. pmc Cognitive function in prepubertal children with obstructive sleep apnea: a modifying role for NADPH oxidase p22 subunit gene polymorphisms?
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Illinois, USA
    Antioxid Redox Signal 16:171-7. 2012
  9. ncbi request reprint Sleep, sleep disorders and inflammation in children
    David Gozal
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL 60637, USA
    Sleep Med 10:S12-6. 2009
  10. pmc Sleep measures and morning plasma TNF-alpha levels in children with sleep-disordered breathing
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    Sleep 33:319-25. 2010

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. pmc Obstructive sleep apnea in the formerly preterm infant: an overlooked diagnosis
    Preeti B Sharma
    Section of Pediatric Pulmonary Medicine, Department of Pediatrics, Comer Children s Hospital, University of Chicago Chicago, IL, USA
    Front Neurol 2:73. 2011
    ..In the former preterm infant structural changes in the airway may play an important role along with adenotonsillar hypertrophy. A high level of clinical awareness is required to identify OSA in the formerly preterm infant...
  2. pmc TNF-α and temporal changes in sleep architecture in mice exposed to sleep fragmentation
    Navita Kaushal
    Department of Pediatrics, Section of Pediatric Sleep Medicine, The University of Chicago, Chicago, IL, USA
    PLoS ONE 7:e45610. 2012
    ....
  3. doi request reprint Novel pharmacological approaches for treatment of obstructive sleep apnea in children
    Leila Kheirandish-Gozal
    University of Chicago, Comer Children s Hospital, Pritzker School of Medicine, Biological Sciences Division, Department of Pediatrics, Chicago, IL 60637, USA
    Expert Opin Investig Drugs 22:71-85. 2013
    ..Adenotonsillar hypertrophy is the major pathophysiological contributor to OSA occurrence in children...
  4. pmc Chemoreceptors, baroreceptors, and autonomic deregulation in children with obstructive sleep apnea
    David Gozal
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL, USA
    Respir Physiol Neurobiol 185:177-85. 2013
    ....
  5. pmc Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels
    Abdelnaby Khalyfa
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL, USA
    Lipids Health Dis 9:18. 2010
    ..The purpose of this study was to measure FABP4 plasma levels, assess FABP4 allelic variants, and explore potential associations with fasting glucose and insulin levels in young school-age children with and without obesity...
  6. pmc Endothelial dysfunction in obese non-hypertensive children without evidence of sleep disordered breathing
    Rakesh Bhattacharjee
    Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Kentucky, USA
    BMC Pediatr 10:8. 2010
    ..It is unknown whether obesity causes endothelial dysfunction in children in the absence of OSAS. This study examines endothelial function in obese and non-obese children without OSAS...
  7. pmc Two-dimensional differential in-gel electrophoresis proteomic approaches reveal urine candidate biomarkers in pediatric obstructive sleep apnea
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    Am J Respir Crit Care Med 180:1253-61. 2009
    ..Sleep studies are laborious, expensive, inaccessible, and inconvenient for diagnosing obstructive sleep apnea (OSA) in children...
  8. pmc Cognitive function in prepubertal children with obstructive sleep apnea: a modifying role for NADPH oxidase p22 subunit gene polymorphisms?
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Illinois, USA
    Antioxid Redox Signal 16:171-7. 2012
    ..Thus, polymorphisms within the NOX gene or its functional subunits may account for important components of the variance in cognitive function deficits associated with OSA in children...
  9. ncbi request reprint Sleep, sleep disorders and inflammation in children
    David Gozal
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL 60637, USA
    Sleep Med 10:S12-6. 2009
    ....
  10. pmc Sleep measures and morning plasma TNF-alpha levels in children with sleep-disordered breathing
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    Sleep 33:319-25. 2010
    ..Since, at any given level of apnea-hypopnea index, there is significant variability in EDS, we hypothesized that morning tumor necrosis factor (TNF)-alpha plasma levels may provide a biologic correlate of EDS...
  11. ncbi request reprint Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury
    W Xu
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    Spinal Cord 43:204-13. 2005
    ..Experimental laboratory investigation of the role and pathways of reactive oxygen species (ROS)-mediated motor neuron cell death in a mouse model of compression spinal cord injury...
  12. ncbi request reprint NF-kappaB induction during in vivo hypoxia in dorsocaudal brain stem of rat: effect of MK-801 and L-NAME
    E Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Appl Physiol (1985) 85:372-6. 1998
    ..Thus NMDA-receptor activation in the dorsocaudal brain stem during hypoxia elicits in NF-kappaB activity marked enhancements that are unaffected after NOS blockade...
  13. ncbi request reprint Nitric oxide modulates anoxia-induced gasping in the developing rat
    D Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Biol Neonate 73:264-74. 1998
    ..We postulate that higher NO brainstem concentrations may favor early autoresuscitation but be detrimental to overall survival during prolonged asphyxia...
  14. ncbi request reprint AMPA glutamate receptors and respiratory control in the developing rat: anatomic and pharmacological aspects
    G M Whitney
    Department of Pediatrics, Constance S Kaufman Pediatric Pulmonary Research Laboratory, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Am J Physiol Regul Integr Comp Physiol 278:R520-8. 2000
    ..Furthermore, the role of non-NMDA receptors in respiratory control of conscious neonatal rats appears to be limited to modest, albeit significant, regulation of breathing pattern...
  15. ncbi request reprint Hypoxia induces c-Fos protein expression in NMDA but not AMPA glutamate receptor labeled neurons within the nucleus tractus solitarii of the conscious rat
    D Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Neurosci Lett 262:93-6. 1999
    ..These data suggest a predominant role for NMDA but not for AMPA glutamate receptors in nTS mediated components of the hypoxic response...
  16. pmc Adverse cognitive effects of high-fat diet in a murine model of sleep apnea are mediated by NADPH oxidase activity
    D Nair
    Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, Chicago, IL, United States
    Neuroscience 227:361-9. 2012
    ..The cognitive deficits of obesity and westernized diets and those of sleep disorders that are characterized by IH during sleep are both mediated, at least in part, by excessive NADPH oxidase activity...
  17. ncbi request reprint Developmental differences in cortical and hippocampal vulnerability to intermittent hypoxia in the rat
    E Gozal
    Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    Neurosci Lett 305:197-201. 2001
    ....
  18. ncbi request reprint In vivo PDGF beta receptor activation in the dorsocaudal brainstem of the rat prevents hypoxia-induced apoptosis via activation of Akt and BAD
    N Simakajornboon
    Constance S Kaufman Pediatric Pulmonary Research Laboratory, Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Brain Res 895:111-8. 2001
    ..We conclude that PDGFR-dependent in vivo activation of both Akt and BAD during hypoxia prevents induction of apoptosis, and may contribute to the increased hypoxic tolerance of brainstem neurons...
  19. ncbi request reprint Brainstem activation of platelet-derived growth factor-beta receptor modulates the late phase of the hypoxic ventilatory response
    D Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana, USA
    J Neurochem 74:310-9. 2000
    ....
  20. ncbi request reprint Hypoxic ventilatory roll-off is associated with decreases in protein kinase C activation within the nucleus tractus solitarius of the rat
    D Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Brain Res 774:246-9. 1997
    ..Thus, alterations in PKC activity within the NTS which occur over time during hypoxia are isoform-selective and coincide with changes in ventilation...
  21. ncbi request reprint Cardiorespiratory responses to systemic administration of a protein kinase C inhibitor in conscious rats
    D Gozal
    Constance S Kaufman Pediatric Pulmonary Research Laboratory, Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Appl Physiol (1985) 84:641-8. 1998
    ..We postulate that PKC plays an important role in signal transduction pathways within brain regions underlying respiratory control...
  22. ncbi request reprint Myeloid-related protein 8/14 levels in children with obstructive sleep apnoea
    J Kim
    Dept of Paediatrics, University of Chicago, Chicago, IL 60637, USA
    Eur Respir J 35:843-50. 2010
    ..The short- and long-term consequences of elevated MRP8/14 on cardiovascular function in the context of paediatric OSA remain to be defined...
  23. ncbi request reprint Protein kinase C modulation of ventilatory response to hypoxia in nucleus tractus solitarii of conscious rats
    E Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    J Appl Physiol (1985) 84:1982-90. 1998
    ..These studies suggest that, in the adult rat, PKC activation in the NTS mediates essential components of the acute hypoxic ventilatory response...
  24. ncbi request reprint High fat/refined carbohydrate diet enhances the susceptibility to spatial learning deficits in rats exposed to intermittent hypoxia
    A D Goldbart
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Brain Res 1090:190-6. 2006
    ..high fat refined carbohydrate diet (HF/RC) can induce similar deficits and associated changes in signaling pathways under normoxic conditions...
  25. doi request reprint Corticosteroids suppress in vitro tonsillar proliferation in children with obstructive sleep apnoea
    L Kheirandish-Gozal
    Department of Pediatrics, Division of Sleep Medicine, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY, USA
    Eur Respir J 33:1077-84. 2009
    ....
  26. ncbi request reprint Signaling pathways of the acute hypoxic ventilatory response in the nucleus tractus solitarius
    D Gozal
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 S Preston Street, Ste 321, Louisville, KY 40202, USA
    Respir Physiol 121:209-21. 2000
    ....
  27. pmc Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in rats
    R C Li
    Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Neuroscience 196:237-50. 2011
    ..Thus, exogenous GH may provide a viable therapeutic intervention to protect IH-vulnerable brain regions from SDB-associated neuronal loss and associated neurocognitive dysfunction...
  28. pmc Systemic inflammation in non-obese children with obstructive sleep apnea
    David Gozal
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 9:254-9. 2008
    ..The changes in levels of pro-inflammatory cytokine IL-6 , and the anti-inflammatory cytokine IL-10, both of which play a major role in atherogenesis, a major consequence of OSA, have not specifically been assessed in pediatric patients...
  29. ncbi request reprint Novel insights into congenital hypoventilation syndrome
    D Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Curr Opin Pulm Med 5:335-8. 1999
    ....
  30. ncbi request reprint Cognition, sleep and respiration in at-risk children treated for obstructive sleep apnoea
    H E Montgomery-Downs
    Division of Pediatric Sleep Medicine, Dept of Pediatrics, University of Louisville, Louisville, KY, USA
    Eur Respir J 25:336-42. 2005
    ....
  31. ncbi request reprint Snoring during early childhood and academic performance at ages thirteen to fourteen years
    D Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
    Pediatrics 107:1394-9. 2001
    ..Obstructive sleep apnea syndrome in young children is associated with an adverse effect on learning. However, the long-term impact of sleep-disordered breathing (SDB) during early childhood on learning remains unknown...
  32. ncbi request reprint Respiratory muscle training in neuromuscular disease: long-term effects on strength and load perception
    D Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Med Sci Sports Exerc 31:1522-7. 1999
    ..Deterioration of respiratory muscle function in patients with neuromuscular disorders is primarily responsible for the high morbidity and mortality associated with these diseases...
  33. ncbi request reprint Urinary protein expression patterns in children with sleep-disordered breathing: preliminary findings
    Jyoti Krishna
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Sleep Med 7:221-7. 2006
    ..The aim of this study was therefore to analyze proteins in human urine and assess whether differential expression of particular proteins is associated with the presence of OSA...
  34. ncbi request reprint Peripheral arterial tonometry events and electroencephalographic arousals in children
    Riva Tauman
    Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Sleep 27:502-6. 2004
    ..We investigated whether PAT events during sleep are associated with visually recognizable electroencephalographic arousals in healthy children and in children with sleep-disordered breathing...
  35. pmc Sleep fragmentation promotes NADPH oxidase 2-mediated adipose tissue inflammation leading to insulin resistance in mice
    S X L Zhang
    Section of Pediatric Sleep Medicine, Department of Pediatrics, The University of Chicago, Chicago, IL, USA
    Int J Obes (Lond) 38:619-24. 2014
    ....
  36. ncbi request reprint Potentiation of hypoxic ventilatory response by hyperoxia in the conscious rat: putative role of nitric oxide
    D Gozal
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Appl Physiol (1985) 85:129-32. 1998
    ..1 +/- 35.6 ml/min in hypoxia; +O2 vs. -O2: P not significant). We conclude that in the conscious rat nNOS activation mediates essential components of the HVR potentiation elicited by a previous short hyperoxic exposure...
  37. ncbi request reprint Mild sustained and intermittent hypoxia induce apoptosis in PC-12 cells via different mechanisms
    Evelyne Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston St, Suite 321, Louisville, KY 40202, USA
    Am J Physiol Cell Physiol 288:C535-42. 2005
    ....
  38. doi request reprint Obstructive sleep apnoea is associated with impaired pictorial memory task acquisition and retention in children
    L Kheirandish-Gozal
    Kosair Children s Hospital Research Institute and Division of Paediatric Sleep, Dept of Paediatrics, Medicine, University of Louisville, Louisville, KY, USA
    Eur Respir J 36:164-9. 2010
    ..Thus, both acquisition and retention of newly learned material are compromised. These findings confirm and expand on the presence of known cognitive deficits in children with OSA...
  39. pmc Leukocyte telomere length and plasma catestatin and myeloid-related protein 8/14 concentrations in children with obstructive sleep apnea
    JinKwan Kim
    Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, 5721 S Maryland Ave, Chicago, IL 60637, USA
    Chest 138:91-9. 2010
    ..Leukocyte telomere length (LTL) reflects not only chronologic age but also the burden of disease. We hypothesized that LTL would be decreased in children with OSA...
  40. pmc Development of pediatric sleep questionnaires as diagnostic or epidemiological tools: a brief review of dos and don'ts
    Karen Spruyt
    Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Sleep Med Rev 15:7-17. 2011
    ..e., how any questionnaire, inventory, log, or diary should be created and evaluated, and also provide illustrative examples to further underline the potential pitfalls that are inherently embedded in every step of tool development...
  41. pmc C-reactive protein, obstructive sleep apnea, and cognitive dysfunction in school-aged children
    David Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 176:188-93. 2007
    ..Obstructive sleep apnea (OSA) in children is associated with substantial neurobehavioral and cognitive dysfunction. However, not all children with OSA exhibit altered cognitive performance...
  42. ncbi request reprint The scoring of respiratory events in sleep: reliability and validity
    Susan Redline
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH, WA 44106 6033, USA
    J Clin Sleep Med 3:169-200. 2007
    ....
  43. ncbi request reprint Prevalence of epileptiform activity in healthy children during sleep
    Oscar Sans Capdevila
    Kosair Children s Hospital Sleep Medicine and Apnea Center, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 9:303-9. 2008
    ..This type of paroxysmal activity does not include the electroencephalographic (EEG) activity observed during a seizure. The prevalence of epileptiform activity in the general pediatric population is unknown...
  44. pmc Physical activity attenuates intermittent hypoxia-induced spatial learning deficits and oxidative stress
    David Gozal
    Department of Pediatrics, Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, 5721 South Maryland Avenue, MC 8000, Suite K 160, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 182:104-12. 2010
    ..Physical activity (PA) is now recognized as neuroprotective in models of neuronal injury and degeneration...
  45. ncbi request reprint Plasma IGF-1 levels and cognitive dysfunction in children with obstructive sleep apnea
    David Gozal
    Kosair Children s Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville School of Medicine, 570 S Preston Street, Suite 204, Louisville, KY 40202, USA
    Sleep Med 10:167-73. 2009
    ..Since IGF-1 is neuroprotective, we hypothesized that higher systemic IGF-1 levels may identify children at lower susceptibility for cognitive morbidity...
  46. ncbi request reprint The obesity epidemic and disordered sleep during childhood and adolescence
    David Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, University of Chicago, 5721 S Maryland Avenue, MC 8000, Suite K 160, Chicago, IL 60637, USA
    Adolesc Med State Art Rev 21:480-90, viii-ix. 2010
    ..In addition, the potential reciprocal roles of obesity and obstructive sleep apnea in the facilitation of their pathophysiology are also reviewed, along with their amplificatory effects on their respective morbidities...
  47. pmc Sleep assessments in healthy school-aged children using actigraphy: concordance with polysomnography
    Karen Spruyt
    Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Sleep Res 20:223-32. 2011
    ..Thus, caution is advocated in drawing definitive conclusions from ACT during evaluation of the sleep-disturbed child...
  48. pmc Sleep duration, sleep regularity, body weight, and metabolic homeostasis in school-aged children
    Karen Spruyt
    Department of Pediatrics, Comer Children s Hospital and Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Pediatrics 127:e345-52. 2011
    ..The goal was to explore the effects of duration and regularity of sleep schedules on BMI and the impact on metabolic regulation in children...
  49. ncbi request reprint New approaches to the diagnosis of sleep-disordered breathing in children
    David Gozal
    Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, IL 60637, USA
    Sleep Med 11:708-13. 2010
    ....
  50. doi request reprint Neurocognitive and endothelial dysfunction in children with obstructive sleep apnea
    David Gozal
    Department of Pediatrics, University of Chicago, 5721 S Maryland Ave, MC 8000, Suite K 160, Chicago, IL 60637, USA
    Pediatrics 126:e1161-7. 2010
    ..However, it is unclear whether these 2 frequent morbidities of OSAS in children represent similar or different underlying pathophysiological processes, because they have never been concurrently assessed in children...
  51. pmc Pediatric sleep questionnaires as diagnostic or epidemiological tools: a review of currently available instruments
    Karen Spruyt
    Department of Pediatrics, Comer Children s Hospital, The University of Chicago, 5721 S Maryland Avenue, MC 8000, Suite K 160 Chicago, IL 60637, USA
    Sleep Med Rev 15:19-32. 2011
    ....
  52. ncbi request reprint Autonomic alterations and endothelial dysfunction in pediatric obstructive sleep apnea
    Leila Kheirandish-Gozal
    Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, The University of Chicago, IL 60637, USA
    Sleep Med 11:714-20. 2010
    ....
  53. ncbi request reprint Sleep pressure correlates of cognitive and behavioral morbidity in snoring children
    Louise M O'Brien
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, KY 40202, USA
    Sleep 27:279-82. 2004
    ..A sleep pressure score (SPS) with a cutoff value of 0.25 was derived from analysis of a large cohort of snoring and control children. Neurocognitive batteries were applied to examine the potential effect of SPS...
  54. ncbi request reprint Sleep and neurobehavioral characteristics of 5- to 7-year-old children with parentally reported symptoms of attention-deficit/hyperactivity disorder
    Louise M O'Brien
    Kosair Children s Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 111:554-63. 2003
    ....
  55. ncbi request reprint Objective sleepiness measures in pediatric obstructive sleep apnea
    D Gozal
    Kosair Children s Hospital Sleep Medicine and Apnea Center, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 108:693-7. 2001
    ..Excessive daytime sleepiness (EDS) occurs frequently in adult patients with obstructive sleep apnea (OSA). However, the incidence of EDS in children with OSA is unknown...
  56. ncbi request reprint Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea
    W Xu
    Kosair Children s Hospital Research Institute, Department of Pediatrics, 215 Baxter Building I, 570 South Preston Street, University of Louisville, Louisville, KY 40202, USA
    Neuroscience 126:313-23. 2004
    ..Taken together, these findings suggest that the increased ROS production and oxidative stress propagation contribute, at least partially, to CIH-mediated cortical neuronal apoptosis and neurocognitive dysfunction...
  57. ncbi request reprint Morbidity of obstructive sleep apnea in children: facts and theory
    D Gozal
    Department of Pediatrics, Kosair Children s Hospital Sleep Medicine and Apnea Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Sleep Breath 5:35-42. 2001
    ....
  58. ncbi request reprint Developmental patterns of NF-kappaB activation during acute hypoxia in the caudal brainstem of the rat
    N Simakajornboon
    Constance S. Kaufman Pediatric Pulmonary Research Laboratory, Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Brain Res Dev Brain Res 127:175-83. 2001
    ..We postulate that postnatal regulation of NF-kappaB complex expression and function may underlie fundamental genomic processes mediating developmental changes in neuronal hypoxic tolerance...
  59. ncbi request reprint Passive motion of the extremities modifies alveolar ventilation during sleep in patients with congenital central hypoventilation syndrome
    D Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Am J Respir Crit Care Med 162:1747-51. 2000
    ..We speculate that such effect may provide future noninvasive ventilatory support strategies in patients with CCHS and mild phenotypic expression of their disease...
  60. ncbi request reprint Plasma C-reactive protein levels among children with sleep-disordered breathing
    Riva Tauman
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 113:e564-9. 2004
    ..We hypothesized that elevated CRP plasma levels would also be present among children with SDB...
  61. pmc Obstructive sleep apnea in children: relative contributions of body mass index and adenotonsillar hypertrophy
    Ehab Dayyat
    Department of Pediatrics, Division of Pediatric Sleep Medicine, The University of Chicago, Chicago, IL 60637, USA
    Chest 136:137-44. 2009
    ..The obesity epidemic has prompted remarkable changes in the proportion of obese children who are referred for habitual snoring. However, the contribution of obesity to adenotonsillar hypertrophy remains undefined...
  62. pmc A mixed cell culture model for assessment of proliferation in tonsillar tissues from children with obstructive sleep apnea or recurrent tonsillitis
    Laura D Serpero
    Division of Sleep Medicine, Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
    Laryngoscope 119:1005-10. 2009
    ..However, little is known on the determinants of lymphadenoid tissue proliferation in the pediatric upper airway...
  63. doi request reprint Catecholamine alterations in pediatric obstructive sleep apnea: effect of obesity
    Ayelet B Snow
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Pediatr Pulmonol 44:559-67. 2009
    ..Moreover, urinary catecholamine excretion is altered in obese patients. We hypothesized that morning urine catecholamine levels would be correlated with the severity of obstructive sleep apnea and degree of obesity in children...
  64. doi request reprint Nocturnal polysomnographic characteristics of habitually snoring children initially referred to pediatric ENT or sleep clinics
    Rakesh Bhattacharjee
    Department of Pediatrics, University of Louisville, KY 40202, USA
    Sleep Med 10:1031-4. 2009
    ..To determine clinical and polysomnographic characteristics of children initially referred by primary care physicians (PCP) to either otolaryngology or sleep clinics for a history of habitual snoring...
  65. pmc Increased cellular proliferation and inflammatory cytokines in tonsils derived from children with obstructive sleep apnea
    JinKwan Kim
    Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatr Res 66:423-8. 2009
    ..01). Thus, T cells are in a highly proliferative state in the tonsils of children with OSA and are associated with increased production of proinflammatory cytokines and TRX, when compared with children with RI...
  66. pmc Erectile dysfunction in a murine model of sleep apnea
    Galia K Soukhova-O'Hare
    Kosair Children s Hospital Research Institute, University of Louisville, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 178:644-50. 2008
    ..Erectile dysfunction (ED) is frequent in obstructive sleep apnea syndrome (OSAS). Chronic intermittent hypoxia (CIH), one of the hallmarks of OSAS, could mediate ED...
  67. ncbi request reprint Sleep pressure score: a new index of sleep disruption in snoring children
    Riva Tauman
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Kentucky 40202, USA
    Sleep 27:274-8. 2004
    ..We hypothesized that sleep architecture and arousal indexes may be altered relative to the severity of sleep-disordered breathing (SDB)...
  68. ncbi request reprint Neurobehavioral correlates of sleep-disordered breathing in children
    Louise M O'Brien
    Department of Pediatrics, Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, Universtiy of Louisville, KY 40202, USA
    J Sleep Res 13:165-72. 2004
    ..Furthermore, total arousal index was negatively correlated with neurocognitive abilities, suggesting a role for sleep fragmentation in pediatric SDB-induced cognitive dysfunction...
  69. ncbi request reprint Serum proteomic patterns associated with sleep-disordered breathing in children
    Zahoor A Shah
    Department of Pediatrics, University of Louisville, Kentucky 40202, USA
    Pediatr Res 59:466-70. 2006
    ..Identification and sequencing of those differentially expressed proteins discovered through proteomic strategies may lead to future development of serum-based diagnostic tests for OSA in snoring children...
  70. pmc Unbiased categorical classification of pediatric sleep disordered breathing
    Karen Spruyt
    Department of Pediatrics and Comer Children s Hospital, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Sleep 33:1341-7. 2010
    ..Although recognizable entities clearly exist under the SDB spectrum, neither the number of SDB categories nor their specific criteria have been critically defined...
  71. ncbi request reprint Intranasal steroids and oral leukotriene modifier therapy in residual sleep-disordered breathing after tonsillectomy and adenoidectomy in children
    Leila Kheirandish
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 117:e61-6. 2006
    ..We hypothesized that combined therapy with the leukotriene receptor antagonist montelukast and intranasal budesonide would result in normalization of residual SDB after T&A...
  72. ncbi request reprint Apolipoprotein E-deficient mice exhibit increased vulnerability to intermittent hypoxia-induced spatial learning deficits
    Leila Kheirandish
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, KY 40202, USA
    Sleep 28:1412-7. 2005
    ....
  73. ncbi request reprint Proteomic analysis of CA1 and CA3 regions of rat hippocampus and differential susceptibility to intermittent hypoxia
    Evelyne Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40204, USA
    J Neurochem 83:331-45. 2002
    ..These findings provide initial insights into mechanisms underlying differences in susceptibility to hypoxia in neural tissue, and may allow for future delineation of interventional strategies aiming to enhance neuronal adaptation to IH...
  74. ncbi request reprint Health-related quality of life and depressive symptoms in children with suspected sleep-disordered breathing
    Valerie McLaughlin Crabtree
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, KY 40202, USA
    Sleep 27:1131-8. 2004
    ..However, the impact of SDB on mood and quality of life and the confounder effect of obesity in this setting are unclear...
  75. ncbi request reprint Obstructive sleep apnea in children
    D Gozal
    Kosair Children s Hospital Sleep Medicine Center, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA
    Minerva Pediatr 52:629-39. 2000
    ..This review provides a detailed and current description of OSA in children, and focuses on the integrative elements necessary for increasing the awareness and diagnostic yield of the community practitioner...
  76. ncbi request reprint Glucose administration before exercise modulates catecholaminergic responses in glycogen-depleted subjects
    D Gozal
    Department of Pediatrics, University of Tulane School of Medicine, New Orleans, Louisiana 70112, USA
    J Appl Physiol (1985) 82:248-56. 1997
    ..We speculate that the magnitude of insulin surge after acutely increased Glc before exercise in GD subjects may exert dissociative effects on adrenal-dependent glycogenolysis and on sympathetic responses...
  77. ncbi request reprint The effect of chronic or intermittent hypoxia on cognition in childhood: a review of the evidence
    Joel L Bass
    Department of Pediatrics, Newton Wellesley Hospital, MassGeneral Hospital for Children, Harvard Medical School, Newton, Massachusetts 02462, USA
    Pediatrics 114:805-16. 2004
    ....
  78. ncbi request reprint Reciprocal interactions between spontaneous and respiratory arousals in adults with suspected sleep-disordered breathing
    Riva Tauman
    Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    Sleep Med 7:229-34. 2006
    ..The aim of the present study was to assess the interactions between respiratory and spontaneous arousals in adults with suspected SDB, and to examine whether the SPS and the Epworth sleepiness scale (ESS) are correlated...
  79. doi request reprint Dietary and physical activity patterns in children with obstructive sleep apnea
    Karen Spruyt
    Division of Pediatric Sleep Medicine, Department of Pediatrics, and Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY, USA
    J Pediatr 156:724-30, 730.e1-730.e3. 2010
    ..To assess dietary and physical activity patterns and morning circulating blood levels of the orexigenic hormones ghrelin and visfatin in children with either obesity, obstructive sleep apnea (OSA), or both conditions...
  80. pmc Obstructive sleep apnea in children: implications for the developing central nervous system
    David Gozal
    Kosair Children s Hospital Research Institute and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Semin Pediatr Neurol 15:100-6. 2008
    ....
  81. ncbi request reprint Increased morning brain natriuretic peptide levels in children with nocturnal enuresis and sleep-disordered breathing: a community-based study
    Oscar Sans Capdevila
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 121:e1208-14. 2008
    ..Habitual snoring and obstructive sleep apnea have been associated with bed-wetting in children, and effective obstructive sleep apnea treatment may improve enuresis...
  82. ncbi request reprint Autonomic dysfunction in children with sleep-disordered breathing
    Louise M O'Brien
    Kosair Children s Hospital Research Institute, and Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Sleep 28:747-52. 2005
    ..To measure sympathetic responses in children with and without sleep-disordered breathing...
  83. ncbi request reprint Oxidant stress and inflammation in the snoring child: confluent pathways to upper airway pathogenesis and end-organ morbidity
    David Gozal
    Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, 570 S Preston Street, Suite 321, Louisville, KY 40202, USA
    Sleep Med Rev 10:83-96. 2006
    ..This hypothetical working model incorporates both dose-dependent disease severity components, as well as environmental and genetic elements of susceptibility...
  84. ncbi request reprint Adipokines in children with sleep disordered breathing
    Riva Tauman
    Kosair Children s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Sleep 30:443-9. 2007
    ..Therefore, we aimed to examine associations between circulating adipokines levels, insulin resistance, and measures of SDB in children...
  85. pmc Impaired spatial working memory and altered choline acetyltransferase (CHAT) immunoreactivity and nicotinic receptor binding in rats exposed to intermittent hypoxia during sleep
    Barry W Row
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Behav Brain Res 177:308-14. 2007
    ..However, compensatory mechanisms may also be activated in other brain regions, and may provide potential therapeutic targets for the cognitive impairments associated with SDB...
  86. ncbi request reprint Cyclooxygenase 2 and intermittent hypoxia-induced spatial deficits in the rat
    Richard C Li
    Kosair Children s Hospital Research Institute, 570 South Preston Street, Suite 321, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 168:469-75. 2003
    ..We conclude that IH induces upregulation and activation of COX-2 in rat cortex and that COX-2 may play a role in IH-mediated neurobehavioral deficits...
  87. doi request reprint Adenotonsillectomy outcomes in treatment of obstructive sleep apnea in children: a multicenter retrospective study
    Rakesh Bhattacharjee
    Department of Pediatrics, University of Chicago, Comer Children s Hospital, 5721 S Maryland Avenue, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 182:676-83. 2010
    ..Although success rates are likely lower than previously estimated, factors that promote incomplete resolution of OSAS after AT remain undefined...
  88. ncbi request reprint Obesity rather than severity of sleep-disordered breathing as the major determinant of insulin resistance and altered lipidemia in snoring children
    Riva Tauman
    Division of Pediatric Sleep Medicine and Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatrics 116:e66-73. 2005
    ..This study was done to prospectively assess the relative contribution of SDB and obesity to metabolic disturbances in a large cohort of snoring children...
  89. doi request reprint The multiple challenges of obstructive sleep apnea in children: diagnosis
    Leila Kheirandish-Gozal
    Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
    Curr Opin Pediatr 20:650-3. 2008
    ..To review some of the inherent problems in defining the diagnosis of pediatric obstructive sleep apnea (OSA) and propose a novel approach to clinical evaluation and referral of habitually snoring children...
  90. pmc Sleep-disordered breathing and verbal skills in school-aged community children
    Sarah Morsbach Honaker
    Division of Pediatric Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, Kentucky, USA
    Dev Neuropsychol 34:588-600. 2009
    ..Although overall cognitive performances of SBD children remain in normative range, their problematic verbal skills may ultimately adversely affect academic performances or socioemotional behaviors...
  91. pmc Endothelial progenitor cells and vascular dysfunction in children with obstructive sleep apnea
    Leila Kheirandish-Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, The University of Chicago, 5721 S Maryland Avenue, MC 8000, Suite K 160, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 182:92-7. 2010
    ..Endothelial dysfunction is a potential complication of obstructive sleep apnea syndrome (OSAS) in children ascribed to systemic inflammatory changes. However, not all children with OSAS will manifest endothelial dysfunction...
  92. ncbi request reprint Consequences of snoring and sleep disordered breathing in children
    David Gozal
    Division of Sleep Medicine, Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Baxter Biomedical Research Building, Suite 321, 571 S Preston Street, Louisville, KY 40202, USA
    Pediatr Pulmonol Suppl 26:166-8. 2004
  93. pmc Effects of late gestational high-fat diet on body weight, metabolic regulation and adipokine expression in offspring
    A Khalyfa
    Sections of Pediatric Sleep Medicine, Hematology Oncology, and Pediatric Pulmonology, Department of Pediatrics, Pritzker School of Medicine, Comer Children s Hospital, The University of Chicago, Chicago, IL, USA
    Int J Obes (Lond) 37:1481-9. 2013
    ..We hypothesized that high-fat diet (HFD) during late gestation would lead increased risk for insulin resistance and hyperlipidemia via associated epigenetic alterations in tissue adipocytokine genes...
  94. ncbi request reprint Pulmonary manifestations of neuromuscular disease with special reference to Duchenne muscular dystrophy and spinal muscular atrophy
    D Gozal
    Constance S Kaufman Pediatric Pulmonary Research Laboratory, Section of Pediatric Pulmonology, Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana, USA
    Pediatr Pulmonol 29:141-50. 2000
    ....
  95. ncbi request reprint Intermittent hypoxic exposure during light phase induces changes in cAMP response element binding protein activity in the rat CA1 hippocampal region: water maze performance correlates
    A Goldbart
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Suite 321, 570 South Preston Street, Louisville, KY 40202, USA
    Neuroscience 122:585-90. 2003
    ..We suggest that CREB changes play an important role in the neurocognitive morbidity of SDB patients...
  96. ncbi request reprint Congenital central hypoventilation syndrome: an update
    D Gozal
    Constance S Kaufman Pediatric Pulmonary Research Laboratory, Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Pediatr Pulmonol 26:273-82. 1998
    ..For the pediatrician, CCHS children represent an unique clinical challenge in coordinating the diagnostic and therapeutic procedures required to enhance the patients' quality of life...
  97. ncbi request reprint A novel mouse model for assessment of male sexual function
    G K Soukhova-O'Hare
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    Physiol Behav 91:535-43. 2007
    ..The data demonstrate that CSP pressure monitoring is a valid technique for assessment of sexual function in freely moving mice...
  98. ncbi request reprint Glucocorticoid receptor subunit expression in adenotonsillar tissue of children with obstructive sleep apnea
    Aviv D Goldbart
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, 570 South Preston Street, Suite 321, Louisville, KY 40202, USA
    Pediatr Res 57:232-6. 2005
    ..These findings along with the high GCR-alpha:GCR-beta ratio suggest a favorable profile for topical steroid therapy in snoring children with adenotonsillar hypertrophy...
  99. ncbi request reprint Oxygen therapy for bronchiolitis
    Joel L Bass
    Department of Pediatrics, Newton Wellesley Hospital, Harvard Medical School, 2014 Washington St, Boston, MA 02462, USA
    Pediatrics 119:611. 2007
  100. pmc Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea
    Ehab Dayyat
    Department of Pediatrics, Division of Sleep Medicine and Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY, USA
    Chest 135:1142-9. 2009
    ..The abundant expression of leukotrienes (LTs) and their receptors in adenotonsillar tissues of children with obstructive sleep apnea (OSA) suggest that LT antagonists could be useful in treating OSA...
  101. ncbi request reprint Nocturnal body position in sleeping children with and without obstructive sleep apnea
    Ehab Dayyat
    Kosair Children s Hospital Sleep Medicine and Apnea Center, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatr Pulmonol 42:374-9. 2007
    ..Although tonsillar size is not associated with positional differences in breathing, the presence or absence of obesity markedly modifies the effect of body position on respiratory disturbance...

Research Grants21

  1. Oxidative stress in a murine model of sleep apnea
    David Gozal; Fiscal Year: 2009
    ..Given the increasing prevalence of both OSAS and obesity in our society, it is therefore imperative to identify the underlying factors that contribute to the adverse behavioral outcomes associated with the disease. ..
  2. Oxidative stress in a murine model of sleep apnea
    David Gozal; Fiscal Year: 2010
    ..Given the increasing prevalence of both OSAS and obesity in our society, it is therefore imperative to identify the underlying factors that contribute to the adverse behavioral outcomes associated with the disease. ..
  3. Postnatal Brain Susceptibility to Intermittent Hypoxia
    David Gozal; Fiscal Year: 2006
    ....
  4. NEUROCOGNITIVE FUNCTION IN SNORING CHILDREN
    David Gozal; Fiscal Year: 2005
    ..Such approaches may lead to timely recognition of SDB and prevention of its associated morbidities. ..
  5. Postnatal Brain Susceptibility to Intermittent Hypoxia
    David Gozal; Fiscal Year: 2005
    ....
  6. NEUROCOGNITIVE FUNCTION IN SNORING CHILDREN
    David Gozal; Fiscal Year: 2004
    ..Such approaches may lead to timely recognition of SDB and prevention of its associated morbidities. ..
  7. Postnatal Brain Susceptibility to Intermittent Hypoxia
    David Gozal; Fiscal Year: 2004
    ....
  8. NEUROCOGNITIVE FUNCTION IN SNORING CHILDREN
    David Gozal; Fiscal Year: 2003
    ..Such approaches may lead to timely recognition of SDB and prevention of its associated morbidities. ..
  9. Postnatal Brain Susceptibility to Intermittent Hypoxia
    David Gozal; Fiscal Year: 2003
    ....
  10. REM SLEEP DEPRIVATION, HYPOXIA, AND HIPPOCAMPAL FUNCTION
    David Gozal; Fiscal Year: 2002
    ..abstract_text> ..
  11. Postnatal Brain Susceptibility to Intermittent Hypoxia
    David Gozal; Fiscal Year: 2002
    ....
  12. REM SLEEP DEPRIVATION, HYPOXIA, AND HIPPOCAMPAL FUNCTION
    David Gozal; Fiscal Year: 2001
    ..abstract_text> ..
  13. NEUROCOGNITIVE FUNCTION IN SNORING CHILDREN
    David Gozal; Fiscal Year: 2006
    ..Such approaches may lead to timely recognition of SDB and prevention of its associated morbidities. ..
  14. Cognitive Function in Snoring Children
    David Gozal; Fiscal Year: 2010
    ....
  15. REM SLEEP DEPRIVATION, HYPOXIA, AND HIPPOCAMPAL FUNCTION
    David Gozal; Fiscal Year: 2003
    ..abstract_text> ..
  16. REM SLEEP DEPRIVATION, HYPOXIA, AND HIPPOCAMPAL FUNCTION
    David Gozal; Fiscal Year: 2000
    ..abstract_text> ..