M N Gould

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway
    Craig M Berchtold
    Department of Oncology, University of Wisconsin Madison, USA
    Cancer Res 65:8558-66. 2005
  2. pmc The gene desert mammary carcinoma susceptibility locus Mcs1a regulates Nr2f1 modifying mammary epithelial cell differentiation and proliferation
    Bart M G Smits
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    PLoS Genet 9:e1003549. 2013
  3. pmc An insulator loop resides between the synthetically interacting elements of the human/rat conserved breast cancer susceptibility locus MCS5A/Mcs5a
    Bart M G Smits
    McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53706, USA
    Nucleic Acids Res 40:132-47. 2012
  4. pmc A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer
    Stephanie E Nelson
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin, USA
    Breast Cancer Res 7:R357-64. 2005
  5. pmc Chemopreventive effects of celecoxib are limited to hormonally responsive mammary carcinomas in the neu-induced retroviral rat model
    Stephan Woditschka
    McArdle Laboratory for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison, WI 53706, USA
    Breast Cancer Res 10:R18. 2008
  6. pmc Freund's vaccine adjuvant promotes Her2/neu breast cancer
    Michelle S Cotroneo
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin Madison, Madison, WI, USA
    BMC Cancer 9:19. 2009
  7. pmc The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions
    Bart M G Smits
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin Madison, 1400 University Avenue, Madison, WI 53706, USA
    Breast Cancer Res 13:R81. 2011
  8. pmc The utility of comparative genetics to inform breast cancer prevention strategies
    Michael N Gould
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 183:409-12. 2009
  9. ncbi request reprint Radiobiological studies using synchrotron-produced ultrasoft X-rays
    M N Gould
    University of Wisconsin, Department of Oncology, Madison, WI 53705, USA
    J Radiat Res 40:66-73. 1999
  10. pmc Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression
    Adeline L Veillet
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin Madison, School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    Cancer Prev Res (Phila) 4:97-106. 2011

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway
    Craig M Berchtold
    Department of Oncology, University of Wisconsin Madison, USA
    Cancer Res 65:8558-66. 2005
    ..These results identify a calcium-dependent NF-kappaB pathway as a molecular target of perillyl alcohol activity in different cancer cell types...
  2. pmc The gene desert mammary carcinoma susceptibility locus Mcs1a regulates Nr2f1 modifying mammary epithelial cell differentiation and proliferation
    Bart M G Smits
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    PLoS Genet 9:e1003549. 2013
    ..Our data suggest that the non-protein coding locus Mcs1a regulates Nr2f1, which is a candidate modifier of differentiation, proliferation, and mammary cancer risk...
  3. pmc An insulator loop resides between the synthetically interacting elements of the human/rat conserved breast cancer susceptibility locus MCS5A/Mcs5a
    Bart M G Smits
    McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53706, USA
    Nucleic Acids Res 40:132-47. 2012
    ....
  4. pmc A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer
    Stephanie E Nelson
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin, USA
    Breast Cancer Res 7:R357-64. 2005
    ..Animal studies and protein modeling suggest that the Ile655Val polymorphism located in the transmembrane domain of the HER2 protein might influence breast cancer development by altering the efficiency of homodimerization...
  5. pmc Chemopreventive effects of celecoxib are limited to hormonally responsive mammary carcinomas in the neu-induced retroviral rat model
    Stephan Woditschka
    McArdle Laboratory for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison, WI 53706, USA
    Breast Cancer Res 10:R18. 2008
    ..The cyclooxygenase-2 inhibitor celecoxib (Celebrex) is a nonsteroidal anti-inflammatory drug and as such is a potential candidate for the prevention of hormonally nonresponsive breast cancer...
  6. pmc Freund's vaccine adjuvant promotes Her2/neu breast cancer
    Michelle S Cotroneo
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin Madison, Madison, WI, USA
    BMC Cancer 9:19. 2009
    ..We investigated whether the systemic inflammation induced by Freund's adjuvant (FA) promotes mammary carcinogenesis in a rat model in which cancer is induced by the neu oncogene...
  7. pmc The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions
    Bart M G Smits
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin Madison, 1400 University Avenue, Madison, WI 53706, USA
    Breast Cancer Res 13:R81. 2011
    ..Here we describe mechanisms through which Mcs5a may reduce mammary carcinoma susceptibility...
  8. pmc The utility of comparative genetics to inform breast cancer prevention strategies
    Michael N Gould
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 183:409-12. 2009
    ..These and related findings have the potential to yield advancements both in translation-prevention research and in basic molecular genetics...
  9. ncbi request reprint Radiobiological studies using synchrotron-produced ultrasoft X-rays
    M N Gould
    University of Wisconsin, Department of Oncology, Madison, WI 53705, USA
    J Radiat Res 40:66-73. 1999
    ..e. equal total energies deposited), survival is not statistically different for the two treatments over a wide range of doses. Thus, imparting equal energies to smaller intranuclear volumes does not appear to modulate cell killing...
  10. pmc Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression
    Adeline L Veillet
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin Madison, School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    Cancer Prev Res (Phila) 4:97-106. 2011
    ..This allele-specific differential expression is environmentally controlled...
  11. ncbi request reprint Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression
    A Friedl
    Department of Pathology and Laboratory Medicine, Madison, WI 53792, USA
    Histochem J 31:433-41. 1999
    ..Lymphomas and thymic tumours were negative for NGAL immuno-labeling. Knowledge about the location of NGAL in normal cells and in disease states provides the first clues towards understanding its biological function...
  12. ncbi request reprint The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance
    M S Cotroneo
    Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA
    Oncogene 25:5011-7. 2006
    ..Together, these data suggest that one or more breast cancer-related genes are located within the dominantly acting WKy allele at the Mcs7 locus...
  13. pmc Genetic loci controlling breast cancer susceptibility in the Wistar-Kyoto rat
    H Lan
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53792, USA
    Genetics 157:331-9. 2001
    ..In addition, we identified an interaction between Mcs8 and a region on chromosome 6 termed Mcsm1 (modifier of Mcs), which had no significant main effect on mammary cancer susceptibility in this genetic analysis...
  14. ncbi request reprint On the statistical analysis of allelic-loss data
    M A Newton
    Department of Biostatistics, University of Wisconsin Madison, Clinical Science Center 53792, USA
    Stat Med 17:1425-45. 1998
    ..We illustrate these methods on allelic-loss data from induced rat mammary tumours and human bladder cancers...
  15. ncbi request reprint Identifying differential gene expression in monoterpene-treated mammary carcinomas using subtractive display
    E A Ariazi
    Department of Human Oncology, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    J Biol Chem 271:29286-94. 1996
    ..Together, these points demonstrate the unique utility of this new gene expression screen to identify altered gene expression in a complex in vivo environment...
  16. pmc Genetic identification of multiple loci that control breast cancer susceptibility in the rat
    L A Shepel
    Department of Human Oncology, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    Genetics 149:289-99. 1998
    ..The isolation of the Mcs genes may help elucidate novel mechanisms of carcinogenesis, provide information important for human breast cancer risk estimation, and also provide unique drug discovery targets for breast cancer prevention...
  17. pmc On the utility of pooling biological samples in microarray experiments
    C Kendziorski
    Department of Biostatistics and Medical Informatics and McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53703, USA
    Proc Natl Acad Sci U S A 102:4252-7. 2005
    ..The realized benefits in this case do not outweigh the price paid for loss of individual specific information. Pooling is beneficial when many subjects are pooled, provided that independent samples contribute to multiple pools...
  18. ncbi request reprint On parametric empirical Bayes methods for comparing multiple groups using replicated gene expression profiles
    C M Kendziorski
    Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI 53703, USA
    Stat Med 22:3899-914. 2003
    ..The methodology is used in a study of mammary cancer in the rat, where four distinct patterns of expression are possible...
  19. pmc Estrogen receptor-positive mammary tumorigenesis in TGFalpha transgenic mice progresses with progesterone receptor loss
    T A Rose-Hellekant
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, WI, USA
    Oncogene 26:5238-46. 2007
    ..Resulting tumors resemble a clinical phenotype of ER+/PR-, and when combined with a heterozygous p53 genotype, ER-/PR-...
  20. ncbi request reprint Characterizing a rat Brca2 knockout model
    M S Cotroneo
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, WI 53706, USA
    Oncogene 26:1626-35. 2007
    ..The establishment of the rat Brca2 knockout model provides a means to study the role of Brca2 in increasing cancer susceptibility and inducing a novel ocular phenotype not previously associated with this gene...
  21. ncbi request reprint Genetic linkage mapping of 11 novel DNA markers and the ceruloplasmin (Cp) gene on rat chromosome 2
    L A Shepel
    Department of Human Oncology, University of Wisconsin Madison School of Medicine, 53792, USA
    Cytogenet Cell Genet 79:176-8. 1997
    ..To resolve the assignment and to localize the Cp gene on the rat genetic linkage map, we used linkage analysis to confirm that rat Cp lies on chromosome 2...
  22. pmc Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk
    David J Samuelson
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 104:6299-304. 2007
    ..The minor allele of rs6476643 increases risk, whereas the rs2182317 minor allele decreases risk. Both alleles have a high population frequency and a low penetrance toward breast cancer risk...
  23. ncbi request reprint Heterogeneous expression of the lipocalin NGAL in primary breast cancers
    S P Stoesz
    Department of Human Oncology, University of Wisconsin, Madison 53792, USA
    Int J Cancer 79:565-72. 1998
    ..NGAL levels were stratified as high or low in breast cancers from a cohort of node-positive patients with known outcome. No significant association between NGAL expression and disease-free or overall survival was observed...
  24. ncbi request reprint Fine mapping reveals multiple loci and a possible epistatic interaction within the mammary carcinoma susceptibility quantitative trait locus, Mcs5
    David J Samuelson
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, Wisconsin 53706 1599, USA
    Cancer Res 65:9637-42. 2005
    ..0, 7.5, and 4.5 Mb of rat chromosome 5, and the orthologous regions are on human chromosome 9 and mouse chromosome 4. These loci will provide unbiased candidate gene loci for evaluation in human case-control association studies...
  25. pmc ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias
    A R Moser
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Proc Natl Acad Sci U S A 90:8977-81. 1993
    ..Long-term grafts of Min/+ mammary glands also gave rise to focal alveolar hyperplasias, indicating that the presence of the Min mutation also has a role in the development of these lesions...
  26. ncbi request reprint Congenic rats reveal three independent Copenhagen alleles within the Mcs1 quantitative trait locus that confer resistance to mammary cancer
    Jill D Haag
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA
    Cancer Res 63:5808-12. 2003
    ..The identification of these independent loci within the Mcs1 COP allele provide a model of the genetic complexity of cancer...
  27. ncbi request reprint Physical evidence of Mcs5, a QTL controlling mammary carcinoma susceptibility, in congenic rats
    David J Samuelson
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison, 1400 University Avenue, Madison, WI 53706 1599, USA
    Carcinogenesis 24:1455-60. 2003
    ..Based on results presented here, the Mcs5 locus has been physically located within a congenic interval on rat chromosome 5 between markers D5Uwm8 and D5Rat26...
  28. ncbi request reprint Cloning and chromosomal localization of the rat Stat5 and Yy1 genes
    K S Chen
    Department of Human Oncology, University of Wisconsin, Madison 53792, USA
    Cytogenet Cell Genet 74:277-80. 1996
    ..Using fluorescence in situ hybridization, we have localized Stat5a to rat chromosome band 10q32.1 and Yy1 to rat chromosome band 6q32...
  29. pmc Cancer chemoprevention and therapy by monoterpenes
    M N Gould
    Department of Human Oncology, University of Wisconsin, Madison 53792, USA
    Environ Health Perspect 105:977-9. 1997
    ..In contrast, prevention of mammary cancer by polycyclic hydrocarbons such as 7,12-dimethylbenz[a]anthracene occur by the induction of detoxifying phase II hepatic enzymes...
  30. ncbi request reprint Neu-induced retroviral rat mammary carcinogenesis: a novel chemoprevention model for both hormonally responsive and nonresponsive mammary carcinomas
    Stephan Woditschka
    McArdle Laboratory for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison, WI 53706, USA
    Cancer Res 66:6884-91. 2006
    ..The model is useful for assessing the efficacy of chemopreventive agents, specifically those compounds that target hormonally nonresponsive tumors...
  31. pmc A short-term rat mammary carcinogenesis model for the prevention of hormonally responsive and nonresponsive in situ carcinomas
    Stephan Woditschka
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA
    Cancer Prev Res (Phila) 2:153-60. 2009
    ..Our prevention model represents a cost-efficient in vivo system to determine whether the preventive effects of a compound extend to hormonally nonresponsive mammary lesions, for which new chemoprevention approaches are needed...
  32. ncbi request reprint Genetically engineered rat models for breast cancer
    Bart M G Smits
    McArdle Lab for Cancer Research, University of Wisconsin Madison, Madison, WI 53706, USA
    Breast Dis 28:53-61. 2007
    ..In this review, we describe the efforts to generate genetically engineered rat models for breast cancer...
  33. ncbi request reprint Androgen-dependent mammary carcinogenesis in rats transgenic for the Neu proto-oncogene
    Philip A Watson
    University of Wisconsin Madison, McArdle Laboratory for Cancer Research, 53706, USA
    Cancer Cell 2:67-79. 2002
    ..Our results suggest crosstalk between the Neu proto-oncogene and AR signaling pathways in the growth of both the normal and cancerous mammary epithelium...
  34. ncbi request reprint Regions of H- and K-ras that provide organ specificity/potency in mammary cancer induction
    Kwanghee Kim
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Cancer Res 62:1241-5. 2002
    ..In addition, these in vivo mammary studies for the first time identify domains in the mostly homologous region of Ras (amino acids 1-169) that strongly influence the oncogenic potency/specificity of H-Ras...
  35. ncbi request reprint Decreased susceptibility to NMU-induced mammary carcinogenesis in transgenic rats carrying multiple copies of a rat ras gene driven by the rat Harvey ras promoter
    Todd A Thompson
    Environmental Toxicology Center, University of Wisconsin Madison, Madison, Wisconsin, WI 53706, USA
    Oncogene 21:2797-804. 2002
    ..These findings highlight the potential of Ras to function as a modifier gene in repressing mammary carcinogenesis...
  36. ncbi request reprint Rat mammary carcinogenesis induced by in situ expression of constitutive Raf kinase activity is prevented by tethering Raf to the plasma membrane
    Daniel R McFarlin
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA
    Carcinogenesis 24:1149-53. 2003
    ....
  37. ncbi request reprint Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer
    Maret Bauer
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Clinical Sciences Center K4 812, Madison, WI 53792 8550, USA
    Breast Cancer Res Treat 108:389-97. 2008
    ....

Research Grants60

  1. Characterizing a Breast Cancer Modifier Locus That Associates with Human Risk
    Michael N Gould; Fiscal Year: 2010
    ..Finally, the data to be generated may provide clinical markers of breast cancer risk and novel targets for chemoprevention. ..
  2. Secreted Proteins as Breast Cancer Prevention Markers
    Michael Gould; Fiscal Year: 2004
    ..abstract_text> ..
  3. Secreted Proteins as Breast Cancer Prevention Markers
    Michael Gould; Fiscal Year: 2007
    ..abstract_text> ..
  4. Induction and Selection for Loss of function Mutations
    Michael Gould; Fiscal Year: 2007
    ..abstract_text> ..
  5. Characterizing a Breast Cancer Modifier Locus That Associates with Human Risk
    Michael Gould; Fiscal Year: 2006
    ..Finally, the data to be generated may provide clinical markers of breast cancer risk and novel targets for chemoprevention. ..
  6. WKY RAT GENETIC MODEL FOR BREAST CANCER SUSCEPTIBILITY
    Michael Gould; Fiscal Year: 2000
    ..The accomplishment of our goal may provide: additional insight and reagents to better estimate the genetic risk of women for breast cancer; and new targets for the development of drugs to prevent breast cancer. ..
  7. ONCOGENE SPECIFICITY IN ORGAN-DEFINED CANCERS
    Michael Gould; Fiscal Year: 2000
    ....
  8. FACTORS CONTROLLING SUSCEPTIBILITY TO MAMMARY CANCER
    Michael Gould; Fiscal Year: 2006
    ..Knowledge of these genes and their function will provide unique insights into the etiology of breast cancer. ..
  9. WKY RAT GENETIC MODEL FOR BREAST CANCER SUSCEPTIBILITY
    Michael Gould; Fiscal Year: 2001
    ..The accomplishment of our goal may provide: additional insight and reagents to better estimate the genetic risk of women for breast cancer; and new targets for the development of drugs to prevent breast cancer. ..
  10. Induction and Selection for Loss of function Mutations
    Michael Gould; Fiscal Year: 2006
    ..abstract_text> ..
  11. FACTORS CONTROLLING SUSCEPTIBILITY TO MAMMARY CANCER
    Michael Gould; Fiscal Year: 2005
    ..Knowledge of these genes and their function will provide unique insights into the etiology of breast cancer. ..
  12. Induction and Selection for Loss of function Mutations
    Michael Gould; Fiscal Year: 2005
    ..abstract_text> ..
  13. ONCOGENE SPECIFICITY IN ORGAN-DEFINED CANCERS
    Michael Gould; Fiscal Year: 1999
    ....
  14. Breast Cancer GWAS: Function and Environmental Interactions
    Michael A Newton; Fiscal Year: 2010
    ..This model will also provide functional information underlying genetic/environmental risk that could lead to strategies for risk reduction to this disease. ..
  15. Secreted Proteins as Breast Cancer Prevention Markers
    Michael Gould; Fiscal Year: 2006
    ..abstract_text> ..
  16. WKY RAT GENETIC MODEL FOR BREAST CANCER SUSCEPTIBILITY
    Michael N Gould; Fiscal Year: 2010
    ..It is also possible that it will provide risk markers for human breast cancer. Broadly, it will also likely provide new insights for interpretation of the results of genome-wide association studies for common diseases. ..
  17. WKY RAT GENETIC MODEL FOR BREAST CANCER SUSCEPTIBILITY
    Michael Gould; Fiscal Year: 2005
    ..abstract_text> ..
  18. Characterizing a Breast Cancer Modifier Locus That Associates with Human Risk
    Michael Gould; Fiscal Year: 2009
    ..Finally, the data to be generated may provide clinical markers of breast cancer risk and novel targets for chemoprevention. ..
  19. Secreted Proteins as Breast Cancer Prevention Markers
    Michael Gould; Fiscal Year: 2005
    ..abstract_text> ..
  20. WKY RAT GENETIC MODEL FOR BREAST CANCER SUSCEPTIBILITY
    Michael Gould; Fiscal Year: 2004
    ..abstract_text> ..
  21. FACTORS CONTROLLING SUSCEPTIBILITY TO MAMMARY CANCER
    Michael Gould; Fiscal Year: 2009
    ..Knowledge of these genes and their function will provide unique insights into the etiology of breast cancer. ..
  22. WKY RAT GENETIC MODEL FOR BREAST CANCER SUSCEPTIBILITY
    Michael Gould; Fiscal Year: 2009
    ..It is also possible that it will provide risk markers for human breast cancer. Broadly, it will also likely provide new insights for interpretation of the results of genome-wide association studies for common diseases. ..
  23. Breast Cancer GWAS: Function and Environmental Interactions
    Michael Gould; Fiscal Year: 2009
    ..This model will also provide functional information underlying genetic/environmental risk that could lead to strategies for risk reduction to this disease. ..
  24. WKY RAT GENETIC MODEL FOR BREAST CANCER SUSCEPTIBILITY
    Michael Gould; Fiscal Year: 2006
    ..abstract_text> ..
  25. FACTORS CONTROLLING SUSCEPTIBILITY TO MAMMARY CANCER
    Michael Gould; Fiscal Year: 2007
    ..Knowledge of these genes and their function will provide unique insights into the etiology of breast cancer. ..
  26. Characterizing a Breast Cancer Modifier Locus That Associates with Human Risk
    Michael Gould; Fiscal Year: 2009
    ..Finally, the data to be generated may provide clinical markers of breast cancer risk and novel targets for chemoprevention. ..
  27. WKY RAT GENETIC MODEL FOR BREAST CANCER SUSCEPTIBILITY
    Michael Gould; Fiscal Year: 2007
    ..abstract_text> ..
  28. Characterizing a Breast Cancer Modifier Locus That Associates with Human Risk
    Michael Gould; Fiscal Year: 2007
    ..Finally, the data to be generated may provide clinical markers of breast cancer risk and novel targets for chemoprevention. ..
  29. Breast Cancer GWAS: Function and Environmental Interactions
    MICHAEL N contact GOULD; Fiscal Year: 2011
    ..This model will also provide functional information underlying genetic/environmental risk that could lead to strategies for risk reduction to this disease. ..
  30. Induction and Selection for Loss of function Mutations
    Michael Gould; Fiscal Year: 2004
    ..abstract_text> ..
  31. FACTORS CONTROLLING SUSCEPTIBILITY TO MAMMARY CANCER
    Michael Gould; Fiscal Year: 1990
    ..In addition, the identification of enhancer or suppressor gene products may lead to the development of new strategies in the prevention and treatment of this disease...
  32. FACTORS CONTROLLING SUSCEPTIBILITY TO MAMMARY CANCER
    Michael Gould; Fiscal Year: 1993
    ..cDNAs of candidate genes will then be cloned and characterized. Characterization will include an initial assay. Positive sequence will then be tested in vivo for MCS activity screen using a cell culture/in vitro using a transgenic model...
  33. WKY RAT GENETIC MODEL FOR BREAST CANCER SUSCEPTIBILITY
    Michael Gould; Fiscal Year: 1999
    ..The accomplishment of our goal may provide: additional insight and reagents to better estimate the genetic risk of women for breast cancer; and new targets for the development of drugs to prevent breast cancer. ..
  34. FACTORS CONTROLLING SUSCEPTIBILITY TO MAMMARY CANCER
    Michael Gould; Fiscal Year: 1999
    ..Such a gene also may serve as a target for the development of chemoprevention agents. ..
  35. FACTORS CONTROLLING SUSCEPTIBILITY TO MAMMARY CANCER
    Michael Gould; Fiscal Year: 1991
    ..In addition, the identification of enhancer or suppressor gene products may lead to the development of new strategies in the prevention and treatment of this disease...
  36. FACTORS CONTROLLING SUSCEPTIBILITY TO MAMMARY CANCER
    Michael Gould; Fiscal Year: 1992
    ..In addition, the identification of enhancer or suppressor gene products may lead to the development of new strategies in the prevention and treatment of this disease...
  37. WKY RAT GENETIC MODEL FOR BREAST CANCER SUSCEPTIBILITY
    Michael Gould; Fiscal Year: 2003
    ..abstract_text> ..
  38. Induction and Selection for Loss of function Mutations
    Michael Gould; Fiscal Year: 2003
    ..abstract_text> ..
  39. Secreted Proteins as Breast Cancer Prevention Markers
    Michael Gould; Fiscal Year: 2003
    ..abstract_text> ..
  40. WKY RAT GENETIC MODEL FOR BREAST CANCER SUSCEPTIBILITY
    Michael Gould; Fiscal Year: 2002
    ..The accomplishment of our goal may provide: additional insight and reagents to better estimate the genetic risk of women for breast cancer; and new targets for the development of drugs to prevent breast cancer. ..
  41. FACTORS CONTROLLING SUSCEPTIBILITY TO MAMMARY CANCER
    Michael Gould; Fiscal Year: 2002
    ..Such a gene also may serve as a target for the development of chemoprevention agents. ..
  42. ONCOGENE SPECIFICITY IN ORGAN-DEFINED CANCERS
    Michael Gould; Fiscal Year: 2001
    ....
  43. FACTORS CONTROLLING SUSCEPTIBILITY TO MAMMARY CANCER
    Michael Gould; Fiscal Year: 2001
    ..Such a gene also may serve as a target for the development of chemoprevention agents. ..
  44. FACTORS CONTROLLING SUSCEPTIBILITY TO MAMMARY CANCER
    Michael Gould; Fiscal Year: 2000
    ..Such a gene also may serve as a target for the development of chemoprevention agents. ..