David Gough

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Coarse-grained modeling study of nonpeptide RGD ligand density and PEG molecular weight on the conformation of poly(γ-glutamyl-glutamate) paclitaxel conjugates
    Lili X Peng
    Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
    J Mol Model 17:2973-87. 2011
  2. ncbi Function of an implanted tissue glucose sensor for more than 1 year in animals
    David A Gough
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Sci Transl Med 2:42ra53. 2010
  3. ncbi Employment and career prospects for bioengineers
    David Gough
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093-0412, USA
    Nat Biotechnol 20:635-6. 2002
  4. ncbi Frequency characterization of blood glucose dynamics
    David A Gough
    Department of Bioengineering, University of California San Diego, San Diego, CA, USA
    Ann Biomed Eng 31:91-7. 2003
  5. ncbi Blood glucose dynamics
    Farbod N Rahaghi
    Department of Bioengineering, University of California San Diego, La Jolla, California 92093 0412, USA
    Diabetes Technol Ther 10:81-94. 2008
  6. ncbi Tissue window chamber system for validation of implanted oxygen sensors
    Milan T Makale
    Department of Bioengineering, University of California-San Diego, La Jolla 92093-0412, USA
    Am J Physiol Heart Circ Physiol 284:H2288-94. 2003
  7. ncbi Mass transfer and gas-phase calibration of implanted oxygen sensors
    Milan T Makale
    Department of Bioengineering, University of California San Diego, La Jolla, California 92093, USA
    Anal Chem 76:1773-7. 2004
  8. ncbi Variants of the tissue-sensor array window chamber
    Milan T Makale
    Dept. of Bioengineering, Univ. of California-San Diego, 9500 Gilman Dr, La Jolla, CA 92093-0412, USA
    Am J Physiol Heart Circ Physiol 289:H57-65. 2005

Research Grants

  1. INFRASTRUCTURE OF BIOENGINEERING DEVELOPMENT
    David Gough; Fiscal Year: 2002
  2. Mass Transfer to Glucose Sensor for Diabetes
    David A Gough; Fiscal Year: 2010
  3. Modeling Mass Transfer to Active Implants for Diabetes
    David Gough; Fiscal Year: 2009
  4. Mass Transfer to Glucose Sensor for Diabetes
    David Gough; Fiscal Year: 2009
  5. Validation of Long-Term Glucose Sensor in Tissues
    David Gough; Fiscal Year: 2007
  6. Modeling Mass Transfer to Active Implants for Diabetes
    David Gough; Fiscal Year: 2007
  7. BIOENG DVMT: CVD, STEM CELL
    David Gough; Fiscal Year: 2002
  8. Validation of Long-Term Glucose Sensor in Tissues
    David Gough; Fiscal Year: 2004
  9. Mass Transfer to Glucose Sensor for Diabetes
    David A Gough; Fiscal Year: 2010

Collaborators

  • Milan T Makale
  • Lili X Peng
  • Farbod N Rahaghi
  • Peter C Chen
  • Lei Yu
  • Sanjib K Das
  • Stephen B Howell
  • Michael C Jablecki
  • Amy G Tsai
  • Joe T Lin
  • Richard E Calou

Detail Information

Publications8

  1. ncbi Coarse-grained modeling study of nonpeptide RGD ligand density and PEG molecular weight on the conformation of poly(γ-glutamyl-glutamate) paclitaxel conjugates
    Lili X Peng
    Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
    J Mol Model 17:2973-87. 2011
    ..These results indicate that the PGG-PTX-PEG1000-npRGD(4) and PGG-PTX-PEG1000-npRGD(8) molecules are the most efficacious candidates and are further recommended for experimental preclinical studies...
  2. ncbi Function of an implanted tissue glucose sensor for more than 1 year in animals
    David A Gough
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Sci Transl Med 2:42ra53. 2010
    ..These results represent a milestone in the translation of the sensor system to human applications...
  3. ncbi Employment and career prospects for bioengineers
    David Gough
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093-0412, USA
    Nat Biotechnol 20:635-6. 2002
  4. ncbi Frequency characterization of blood glucose dynamics
    David A Gough
    Department of Bioengineering, University of California San Diego, San Diego, CA, USA
    Ann Biomed Eng 31:91-7. 2003
    ..This analysis provides key information for the design of clinical studies that include blood glucose dynamics and for the design of new glucose monitoring systems...
  5. ncbi Blood glucose dynamics
    Farbod N Rahaghi
    Department of Bioengineering, University of California San Diego, La Jolla, California 92093 0412, USA
    Diabetes Technol Ther 10:81-94. 2008
    ..An example of new insights is the observation that there are four time scales of blood glucose variations in individuals without diabetes, and these time scales are modified or lost in diabetes...
  6. ncbi Tissue window chamber system for validation of implanted oxygen sensors
    Milan T Makale
    Department of Bioengineering, University of California-San Diego, La Jolla 92093-0412, USA
    Am J Physiol Heart Circ Physiol 284:H2288-94. 2003
    ..Examples are given of sensor recordings and images of tissues with implanted oxygen sensor arrays...
  7. ncbi Mass transfer and gas-phase calibration of implanted oxygen sensors
    Milan T Makale
    Department of Bioengineering, University of California San Diego, La Jolla, California 92093, USA
    Anal Chem 76:1773-7. 2004
    ..This method provides a bridge between the complementary approaches of empirical calibration and model-based calculation for determining oxygen concentration from the sensor response...
  8. ncbi Variants of the tissue-sensor array window chamber
    Milan T Makale
    Dept. of Bioengineering, Univ. of California-San Diego, 9500 Gilman Dr, La Jolla, CA 92093-0412, USA
    Am J Physiol Heart Circ Physiol 289:H57-65. 2005
    ..These observations suggest new strategies for sensor design and operation. Window chamber variants are important tools for validation of implanted sensors...

Research Grants16

  1. INFRASTRUCTURE OF BIOENGINEERING DEVELOPMENT
    David Gough; Fiscal Year: 2002
    ..This is necessary to develop biomedical engineering at UCSD to its full potential and to provide a model of bioengineering education and research for the nation. ..
  2. Mass Transfer to Glucose Sensor for Diabetes
    David A Gough; Fiscal Year: 2010
    ..Mass transfer models will be constructed and predicted substrate fluxes will be compared with actual fluxes measured over the long term by implanted sensors. ..
  3. Modeling Mass Transfer to Active Implants for Diabetes
    David Gough; Fiscal Year: 2009
    ..This project will examine the permeability of tissues surrounding implanted devices to assess substrate supply to the implant. This information may accelerate implementation of these therapies. ..
  4. Mass Transfer to Glucose Sensor for Diabetes
    David Gough; Fiscal Year: 2009
    ..Mass transfer models will be constructed and predicted substrate fluxes will be compared with actual fluxes measured over the long term by implanted sensors. ..
  5. Validation of Long-Term Glucose Sensor in Tissues
    David Gough; Fiscal Year: 2007
    ..There is a crucial need to address the growing problem of diabetes. This project will further validate an implantable glucose sensor that will provide a basis for reliable detection of hypoglycemia and automatic insulin administration. ..
  6. Modeling Mass Transfer to Active Implants for Diabetes
    David Gough; Fiscal Year: 2007
    ..This project will examine the permeability of tissues surrounding implanted devices to assess substrate supply to the implant. This information may accelerate implementation of these therapies. ..
  7. BIOENG DVMT: CVD, STEM CELL
    David Gough; Fiscal Year: 2002
    ..This is necessary to develop biomedical engineering at UCSD to its full potential and to provide a model of bioengineering education and research for the nation. ..
  8. Validation of Long-Term Glucose Sensor in Tissues
    David Gough; Fiscal Year: 2004
    ..These studies will be carded out in addition to our continuing studies in hamsters and diabetic rats. These studies set the stage for trials in humans. ..
  9. Mass Transfer to Glucose Sensor for Diabetes
    David A Gough; Fiscal Year: 2010
    ..Mass transfer models will be constructed and predicted substrate fluxes will be compared with actual fluxes measured over the long term by implanted sensors. ..